Unequal-area facility layout by genetic search

This paper applies genetic optimization with an adaptive penalty function to the shape-constrained unequal-area facility layout problem. We implement a genetic search for unequal-area facility layout, and show how optimal solutions are affected by constraints on permitted department shapes, as specified by a maximum allowable aspect ratio for each department. We show how an adaptive penalty function can be used to find good feasible solutions to even the most highly constrained problems. We describe our genetic encoding, reproduction and mutation operators, and penalty evolution strategy. We provide results from several test problems that demonstrate the robustness of this approach across different problems and parameter settings.     

Motor recovery after stroke depends on intact sustained attention: A 2-year follow-up study.

The functional recovery of 47 right-brain-damaged stroke patients was studied over a 2-year period. The researchers hypothesized that sustained attention capacity should predict the degree of motor and functional recovery over this period because of a proposed privileged role of sustained attention in learning-based recovery of function. As predicted, significant correlations were found between sustained attention capacity at 2 months and functional status (including the Barthel Index) at 2 years. This relationship was shown to exist independently of 2-month functional status. Furthermore, compared with a left-brain-damaged group of cerebrovascular accident (CVA) patients, the right-brain CVA group did not recover functional ability as well over the 2-year period. This increasing difference in functional status over a 2-year period was mirrored by an emerging difference in sustained attention capacity, in favor of the left-brain CVA group. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The effect of family variables on child weight change.

Analyzed the effects of family variables (e.g., family size, family weight composition, parental weight) on child weight loss in a series of family-based, behaviorally oriented weight control programs for children from 102 families. Results show that the amount of relative weight change was related to initial treatment success, the number of children in the family, and the gender of the child. Children who were more successful lost more weight initially, had fewer siblings, and were female. It is suggested that family size may interact with treatment to determine weight change, possibly by reducing the amount of time a parent has to spend promoting behavior change or the effectiveness of parents in managing their children. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Involvement and persuasion: Types, traditions, and the evidence.

This article is a reply to R. E. Petty and J. T. Cacioppo's (see record 1990-19685-001) critique of our meta-analysis in which we concluded that research has established 3 different types of involvement with distinctly different effects on persuasion (B. T. Johnson and A. H. Eagly; see record 1990-01215-001). We first correct their summary of our review. In response to their claim that outcome-relevant and value-relevant involvement are best reduced to a single construct, we assert that this proposal fails to account for existing research findings and provides only a highly speculative account of the processes that might mediate the impact of involvement on persuasion. We then reaffirm our earlier conclusion that the effects of outcome-relevant involvement are especially unstable when messages contain weak arguments. In fact, this conclusion is underscored by 4 studies that Johnson conducted after completing the meta-analysis. Finally, we explain how the methodological features of our review that Petty and Cacioppo fault are consistent with established principles of meta-analytic reviewing. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Consumption effects of electricity decarbonization: Evidence from California and the Pacific Northwest

This paper estimates the price-induced impacts of decarbonization policy on CO₂ emissions in California and the Pacific Northwest. We document that retail demands for electricity and natural gas by customer class are highly price-inelastic. Based on the heat rates of natural-gas-fired generation, we find that a 10% electricity rate increase due to electricity decarbonization may not have the consumption effects of further reducing the region’s CO₂ emissions.     

Triethanolamine Stabilization of Methotrexate-β-Cyclodextrin Interactions in Ternary Complexes

The interaction of methotrexate (MTX) with beta-cyclodextrin (β-CD) in the presence of triethanolamine (TEA) was investigated with the aim to elucidate the mechanism whereby self-assembly cyclodextrin systems work in association with this third component. Solubility diagram studies showed synergic increment of the MTX solubility to be about thirty-fold. Experiments using 2D ROESY and molecular modeling studies revealed the inclusion of aromatic ring III of the drug into β-CD cavity, in which TEA contributes by intensifying MTX interaction with β-CD and stabilizes MTX:β-CD:TEA ternary complex by electrostatic interaction. The maintenance of these interactions in solid phase was also studied in ternary MTX:β-CD:TEA and comparisons were made with freeze dried binary MTX:β-CD and physical mixtures. FTIR studies evidenced that MTX–β-CD interaction remained in solid ternary complexes, which was also supported by thermal (differential scanning calorimetry (DSC), thermogravimetric analysis (TG)/first derivative of TG analysis (DTG) and C,N,H elementary analysis) and structural (X-ray diffraction analysis, (XRD)) studies, mainly regarding the increment of drug stability. The efficient in vitro drug dissolution studies successfully demonstrated the contribution of ternary complexes, which highlights the importance of this possible new raw material for further applications in drug delivery systems.     

Natural versus wastewater derived dissolved organic carbon: implications for the environmental fate of organic micropollutants

The interaction of organic micropollutants with dissolved organic carbon (DOC) can influence their transport, degradation and bioavailability. While this has been well established for natural organic carbon, very little is known regarding the influence of DOC on the fate of micropollutants during wastewater treatment and water recycling. Dissolved organic carbon-water partition coefficients (K_DOC) for wastewater derived and reference DOC were measured for a range of micropollutants using a depletion method with polydimethylsiloxane disks. For micropollutants with an octanol-water partition coefficient (log K_OW) greater than 4 there was a significant difference in K_DOC between reference and wastewater derived DOC, with partitioning to wastewater derived DOC over 1000 times lower for the most hydrophobic micropollutants. The interaction of nonylphenol with wastewater derived DOC from different stages of a wastewater and advanced water treatment train was studied, but little difference in K_DOC was observed. Organic carbon characterisation revealed that reference and wastewater derived DOC had very different properties due to their different origins. Consequently, the reduced sorption capacity of wastewater derived DOC may be related to their microbial origin which led to reduced aromaticity and lower molecular weight. This study suggests that for hydrophobic micropollutants (log K_OW > 4) a higher concentration of freely dissolved and thus bioavailable micropollutants is expected in the presence of wastewater derived DOC than predicted using K_DOC values quantified using reference DOC. The implication is that naturally derived DOC may not be an appropriate surrogate for wastewater derived DOC as a matrix for assessing the fate of micropollutants in engineered systems.     

Creep behavior of the ternary 95.5Sn-3.9Ag-0.6Cu solder—Part I: As-cast condition

The compression creep behavior was studied for the ternary solder alloy 95.5Sn-3.9Ag-0.6Cu in the as-cast condition. Samples were tested under stresses of 2–45 MPa and temperatures of −25–160°C. There was a significant variability in the creep curve shape, strain magnitude, and steady-state strain-rate properties. A multivariable linear-regression analysis of the steady-state strain-rate data, using the sinh-law stress representation, indicated two mechanisms distinguished by low- and high-temperature regimes of −25–75°C and 75–160°C, respectively. The sinh-law stress exponent (n) and apparent-activation energy (ΔH) in the −25–75°C regime were 4.4 ± 0.7 kJ/mol and 25 ± 7 kJ/mol (63% confidence intervals), respectively. Those same parameters in the 75–160°C regime were 5.2±0.8 kJ/mol and 95±14 kJ/mol, respectively, for the high-temperature regime. The values of ΔH suggested a short-circuit diffusion mechanism at low temperatures and a lattice or bulk-diffusion mechanism at high temperatures. The stress dependency of the steady-state strain rate did not indicate a strong power-law breakdown behavior or a threshold stress phenomenon. Cracks and grain-boundary sliding were not observed in any of the samples. As the creep temperature increased, a coarsened particle boundary and particle depletion zone formed in the region of fine Ag₃Sn particles that existed between the Sn-rich phase areas. The coarsened particle boundary, as well as accelerated coarsening of Ag₃Sn particles, were direct consequences of the creep deformation process.     

Engineering Design Thinking,Teaching, and Learning

This paper is based on the premises that the purpose of engineering education is to graduate engineers who can design, and that design thinking is complex. The paper begins by briefly reviewing the history and role of design in the engineering curriculum. Several dimensions of design thinking are then detailed, explaining why design is hard to learn and harder still to teach, and outlining the research available on how well design thinking skills are learned. The currently most‐favored pedagogical model for teaching design, project‐based learning (PBL), is explored next, along with available assessment data on its success. Two contexts for PBL are emphasized: first‐year cornerstone courses and globally dispersed PBL courses. Finally, the paper lists some of the open research questions that must be answered to identify the best pedagogical practices of improving design learning, after which it closes by making recommendations for research aimed at enhancing design learning.     

Effects of blocking nitric oxide on learning in turtles (chrysemys picta).

Turtles (Chrysemys picta) were given the nitric oxide synthase inhibitor Nw-nitro-L-arginine methyl ester (L-NAME) or its inactive isomer NW-nitro-D-arginine methyl ester (D-NAME) and were trained on a negative patterning task or a simple go/no-go discrimination task. L-NAME impaired the learning of negative patterning but did not affect retention of the task if it had already been learned. D-NAME had no effect. Go/no-go discrimination learning was not affected by L-NAME. These findings support the notion that nitric oxide plays a role in complex configural learning in a reptile closely related to the ancestors of mammals. (PsycINFO Database Record (c) 2010 APA, all rights reserved)