A uniqueness theorem for anticommutation relations and commutation relations of quantum spin systems

Under quite natural assumptions we prove that a classical spin lattice has essentially two natural quantum extensions: The quantum spin lattice and the Fermi system. Moreover we derive a transformation from a commuting pair of Fermi systems to a purely anticommuting Fermi system.     

Microcionamides A and B, bioactive peptides from the philippine sponge Clathria (Thalysias) abietina

Microcionamides A (1) and B (2) have been isolated from the Philippine marine sponge Clathria (Thalysias) abietina. These new linear peptides are cyclized via a cystine moiety and have their C-terminus blocked by a 2-phenylethylenamine group. Their total structures, including absolute stereochemistry, were determined by a combination of spectral and chemical methods. Compound 1 was shown to slowly isomerize about the C-36/C-37 double bond when stored in DMSO. Microcionamides A (1) and B (2) exhibited significant cytotoxicity against the human breast tumor cells lines MCF-7 and SKBR-3 and displayed inhibitory activity against Mycobacterium tuberculosis H(37)Ra.     

Unprecedented in situ oxidative ring cleavage of isoxazolidines: diastereoselective transformation of nitronic acids and derivatives into 3-hydroxymethyl 4-nitro tetrahydrofurans and pyrrolidines

[reaction: see text] Nitronic acids undergo an intramolecular 1,3-dipolar cycloaddition to unactivated double bonds, and the resulting isoxazolidines spontaneously evolve by an unprecedented in situ oxidative ring cleavage. The extension of this transformation to silyl nitronates results in a general diastereoselective construction of hydroxymethyl nitro functionalized tetrahydro-furans and -pyrrolidine having up to four consecutive stereogenic centers.     

Highly selective formation of linear esters from terminal and internal alkenes catalysed by palladium complexes of bis-(di-tert-butylphosphinomethyl)benzene

The methoxycarbonylation of terminal or internal alkenes catalysed by palladium complexes of bis-(di-tert-butylphosphinomethyl)benzene under mild conditions leads to linear esters in 99% selectivity via a hydride mechanism.     

Interaction of a laminin derived peptide with phosphatidyl choline/phosphatidyl glycerol

The physicochemical interactions between an active peptide sequence derived from laminin and phospholipids have been studied. The main aim is to determine the suitability of this peptide fragment to be linked to liposome's with the purpose to develop targeting devices. Results indicate that this peptide is able to insert in lipid monolayers and also to form monomolecular layers at an air/water interface. Besides, miscibility studies carried out through compression isotherms of mixed monolayers [dipalmitoyl phosphatidylcholine (DPPC)/peptide], indicate a strong interaction at 60-80% DPPC molar composition. Studies carried out with lipid bilayers indicate that the interaction is restricted to the external face of the vesicles. Moreover, the presence of this peptide in the incubation media promotes a low level of carboxyfluorescein (CF) leakage and no fusion of vesicles. These results indicate that the association of this sequence to vesicles do not produce damage of the bilayer and can be used as potential targeting vector.     

A New Technique for Ill-Conditioned Linear Systems

The technique we propose for solving ill-conditioned linear systems consists of two steps. First we compute the regularized solution on some values of the regularization parameter . Then we use these solutions either to extrapolate at =0 or to estimate the regularized solution with determined by the generalized cross validation or by the L-curve method.     

The Sura-EISCAT-WIND Experiments: Ionospheric Influence on the Response of a Decameter Interferometer with a Superlong Baseline

Results of the 1999 experiments on receiving radio-frequency signals from the SURA and EISCAT facilities on the WIND spacecraft at 5475 kHz are presented. Power and frequency distortions imposed by near-Earth plasmas on the response of SURA-EISCAT, an active decameter radio interferometer with a superlong baseline of 2000 km, are studied. Quasi-oscillatory variations in the intensity of the received radiation with a period of several tenths of a second and the corresponding maximum in the intensity fluctuation spectrum are observed during synchronized operation of the facilities under both quiet and perturbed geophysical conditions including the occurrence of mid-latitude F spread. Variations in the mean frequency of the spectral line both because of the motion of the spacecraft and the large-scale traveling ionospheric disturbances are detected. The obtained results are compared with the modern theoretical concept of propagation of short radio waves in a randomly irregular ionospheric plasma. The possibility to realize the limiting angular resolution of a ground-based decameter interferometer with a superlong baseline for observations of discrete space radio sources is discussed.