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61.
Ezzidine Ibrahim Ibrahim Abd-ellah Leyla S. Shaw Ibrahim Alnaimi 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3-4):109-114
Abstract The formation and subsequent fragmentation of spirocyclodiphosph(V)azanes (II-III) has been studied by mass spectrometry using the link-field scan technique and structural inferencies are drawn from these data. 31P nmr measurements for compound (III) are also described. 相似文献
62.
Stig E. Friberg Ibrahim Kayali Tatang Suhery Linda D. Rhein F. Anthony Simion 《Journal of Dispersion Science and Technology》2013,34(3):337-347
Water uptake in natural and reaggregated stratum corneum was determined by weight difference after storage in an atmosphere of controlled relative humidity. Interlayer spacing in separated lipids as a function of their water content was determined by low-angle X-ray diffractometry. These values were used as a calibration curve to determine the water content of the lipid bilayers in reaggregated stratum corneum. The results revealed different behavior of the lipid models compared to natural lipids of the stratum corneum. The additional water taken up after reaggregation of equilibrated lipids and proteins, was equally partitioned between the protein and the natural lipid fraction, while the models gave a proportionally higher water uptake into the lipids at high relative humidity. It is obvious that the models, so far, do not mimic all the properties of the natural stratum corneum lipids. 相似文献
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65.
I. M. El-Deen H. K. Ibrahim 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3):733-740
Reaction of 2-mercapto-4-hydroxy-5H-[1]-benzopyrano-[4,3- d ]-pyrimidin-5-one ( 3 ) with phenyl isothiocyanate and methyl acrylate yielded the corresponding 2-(substituted)thio-4-hydroxy-5H-[1]-benzopyrano-[4,3- d ]-pyrimidin-5-ones ( 4 , 5 ). Hydrolysis and hydrazinolysis of 5 gave acid derivative 6 , and hydrazone 7 . Treatment of hydrazone 7 with ethyl acetoacetate, diethyl malonate, and phenyl isothiocyanate yielded the corresponding 2-(substituted)thio-4-hydroxy-5H-[1]-benzopyrano- [4,3- d ]-pyrimidin-5-ones ( 8 , 9 , and 11 ). Cyclization of 11 with 2 N NaOH led to 12 . 相似文献
66.
Moamen S. Refat Gehad G. Mohamed Mohamed Y. S. Ibrahim Hamada M. A. Killa Hammad Fetooh 《Russian Journal of General Chemistry》2013,83(12):2479-2487
Solid complexes have been prepared and characterized by IR, UV-Vis, elemental analysis, and 1H NMR. Indomethacin forms complexes with Cd(II), Ce(III), and Th(IV) ions in molar ratios (ligand: metal) (2: 1), (3: 1), and (4: 1), respectively. The IR spectra of the complexes suggest that the Indomethacin behaves as a monobasic monodentate ligand coordinated to the metal ions via the deprotonated carboxylate group. Prepared complexes exhibit higher antimicrobial activity against several microorganisms, compared to free ligand. 相似文献
67.
Eric D. Merkley Erin S. Baker Kevin L. Crowell Daniel J. Orton Thomas Taverner Charles Ansong Yehia M. Ibrahim Meagan C. Burnet John R. Cort Gordon A. Anderson Richard D. Smith Joshua N. Adkins 《Journal of the American Society for Mass Spectrometry》2013,24(3):444-449
Chemical cross-linking of proteins followed by proteolysis and mass spectrometric analysis of the resulting cross-linked peptides provides powerful insight into the quaternary structure of protein complexes. Mixed-isotope cross-linking (a method for distinguishing intermolecular cross-links) was coupled with liquid chromatography, ion mobility spectrometry and mass spectrometry (LC-IMS-MS) to provide an additional separation dimension to the traditional cross-linking approach. This method produced multiplet m/z peaks that are aligned in the IMS drift time dimension and serve as signatures of intermolecular cross-linked peptides. We developed an informatics tool to use the amino acid sequence information inherent in the multiplet spacing for accurate identification of the cross-linked peptides. Because of the separation of cross-linked and non-cross-linked peptides in drift time, our LC-IMS-MS approach was able to confidently detect more intermolecular cross-linked peptides than LC-MS alone. 相似文献
68.
Sazlinda Kamaruzaman Peter C. Hauser Mohd Marsin Sanagi Wan Aini Wan Ibrahim Salasiah Endud Hong Heng See 《Analytica chimica acta》2013
A simple adsorption/desorption procedure using a mixed matrix membrane (MMM) as extraction medium is demonstrated as a new miniaturized sample pretreatment and preconcentration technique. Reversed-phase particles namely polymeric bonded octadecyl (C18) was incorporated through dispersion in a cellulose triacetate (CTA) polymer matrix to form a C18-MMM. Non-steroidal anti-inflammatory drugs (NSAIDs) namely diclofenac, mefenamic acid and ibuprofen present in the environmental water samples were selected as targeted model analytes. The extraction setup is simple by dipping a small piece of C18-MMM (7 mm × 7 mm) in a stirred 10 mL sample solution for analyte adsorption process. The entrapped analyte within the membrane was then desorbed into 100 μL of methanol by ultrasonication prior to high performance liquid chromatography (HPLC) analysis. Each membrane was discarded after single use to avoid any analyte carry-over effect. Several important parameters, such as effect of sample pH, salting-out effect, sample volume, extraction time, desorption solvent and desorption time were comprehensively optimized. The C18-MMM demonstrated high affinity for NSAIDs spiked in tap and river water with relative recoveries ranging from 92 to 100% and good reproducibility with relative standard deviations between 1.1 and 5.5% (n = 9). The overall results obtained were found comparable against conventional solid phase extraction (SPE) using cartridge packed with identical C18 adsorbent. 相似文献
69.
Dadan Hermawan Izdiani Mohd Yatim Khaulah Ab Rahim Mohd Marsin Sanagi Wan Aini Wan Ibrahim Hassan Y. Aboul-Enein 《Chromatographia》2013,76(21-22):1527-1536
A simple solid phase extraction (SPE) method coupled with high performance liquid chromatography (HPLC) using UV detector and microemulsion electrokinetic chromatography (MEEKC) has been developed and compared for the quantitative determination of miconazole nitrate in pharmaceutical formulation. For HPLC method, two parameters were optimized, namely, the wavelength and the mobile phases. The optimized condition was at the 225 nm wavelength and the mobile phase of ACN:MeOH (90:10 v/v). There are seven MEEKC parameters that were optimized, in this research, which were applied to voltage, temperature, wavelength, sodium dodecyl sulfate (SDS) concentration, buffer pH, buffer concentration and butan-1-ol concentration. The optimum MEEKC condition was obtained using 86.35 % (w/w) 2.5 mM borate buffer pH 9, 0.25 % (w/w) SDS, 0.8 % (w/w) ethyl acetate, 6.6 % w/w butan-1-ol and 6.0 % (w/w) acetonitrile. The combination of SPE using a diol column with HPLC–UV and the MEEKC methods were successfully applied for the determination of miconazole nitrate in a pharmaceutical formulation with the recovery percentage of 98.35 and 92.50 %, respectively. 相似文献
70.
Radia Bouasla Hadjira Berredjem Malika Berredjem Malika Ibrahim‐Oualid Assia Allaoui Marc Lecouvey Nour‐Eddine Aouf 《Journal of heterocyclic chemistry》2013,50(6):1328-1332
A new series of chiral 5‐substituted bis‐oxazolidinones containing an acylsulfonamide moiety has been synthesized starting from chlorosulfonyl isocyanate, (l )‐ethyl lactate, and oxazolidin‐2‐ones. All the reactions were conducted at ambient temperature, and the N‐acylsulfonamide bis‐oxazolidin‐2‐ones were obtained with high yields within 2 h. Some of the newly synthesized compounds were evaluated in vitro against the virulent strain RH of Toxoplasma gondii and the human lymphocytes, and showed promising results. 相似文献