全文获取类型
收费全文 | 188篇 |
免费 | 18篇 |
国内免费 | 41篇 |
学科分类
数理化 | 247篇 |
出版年
2023年 | 1篇 |
2022年 | 4篇 |
2021年 | 8篇 |
2020年 | 9篇 |
2019年 | 5篇 |
2018年 | 4篇 |
2017年 | 6篇 |
2016年 | 8篇 |
2015年 | 2篇 |
2014年 | 9篇 |
2013年 | 7篇 |
2012年 | 15篇 |
2011年 | 23篇 |
2010年 | 8篇 |
2009年 | 15篇 |
2008年 | 9篇 |
2007年 | 14篇 |
2006年 | 12篇 |
2005年 | 8篇 |
2004年 | 15篇 |
2003年 | 8篇 |
2002年 | 9篇 |
2001年 | 1篇 |
2000年 | 2篇 |
1999年 | 6篇 |
1998年 | 8篇 |
1997年 | 4篇 |
1996年 | 9篇 |
1995年 | 6篇 |
1994年 | 4篇 |
1993年 | 2篇 |
1991年 | 1篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 2篇 |
排序方式: 共有247条查询结果,搜索用时 484 毫秒
21.
现代加筋土技术应用与研究进展 总被引:39,自引:0,他引:39
对土工合成材料研究与应用概况、加筋土的国内外应用与研究进展、加筋土基本理论研究进展进行了综合分析,提出了今后研究工作的重点。 相似文献
22.
23.
Ma G Huang F Pu X Jia L Jiang T Li L Liu Y 《Chemistry (Weinheim an der Bergstrasse, Germany)》2011,17(41):11657-11666
Platinum phenanthroline complexes inhibit amyloid-β (Aβ) aggregation and reduce Aβ-caused neurotoxicity [Proc. Natl. Acad. Sci., 2008, 105, 6813-6818]. In this study, we investigated the interactions of Aβ(1-16) with [PtCl(2)(phen)] (phen=1,10-phenanthroline) using HPLC, ESI-MS, and NMR spectroscopy , and characterized the identity of products using tandem mass spectrometry. Results indicated that the phenanthroline ligand could induce noncovalent interactions between Aβ peptide and platinum complexes, leading to rapid Aβ platination. Multiple products were generated in the reaction, in which His6/His14 chelation was preferentially formed. Coordination of Asp7, His13, and Lys16 was also detected in other products. The majority of products were monoplatinated adducts with binding of the {Pt(phen)} scaffold, which impeded intermolecular interactions between Aβ peptides. Moreover, noncovalent interactions were confirmed by the interaction between Aβ peptide and [Pt(phen)(2)]Cl(2). The synergistic roles of the phen ligand and platinum(II) atom in the inhibition of Aβ aggregation are discussed. 相似文献
24.
Wang Q Zhu L Li G Tu C Pang Y Jin C Zhu B Zhu X Liu Y 《Macromolecular bioscience》2011,11(11):1553-1562
A novel type of drug carrier capable of controlled drug release is proposed. It consists of an acid-sensitive doubly hydrophilic multiarm hyperbranched copolymer with a hyperbranched polyamidoamine core and many linear poly(ethylene glycol) arms. Using pH-sensitive acylhydrazone linkages, the polymer forms unimolecular micelles that can encapsulate hydrophobic drugs. Due to their amphiphilicity, the drug-loaded unimolecular micelles can self-assemble into multimolecular micelles that show acid-triggered intracellular delivery of the hydrophobic drugs. 相似文献
25.
Total synthesis of tropane alkaloids (-)-cocaine and (-)-ferruginine were accomplished in nine steps each and in 55% and 46% overall yields, respectively, starting from the known Betti base derivative (+)-(7aR,10R,12S)-10-(1H-benzotriazol-1-yl)-7a,8,9,10-tetrahydro-12-phenyl-12H-naphtho[1,2-e]pyrrolo[2,1-b][1,3]oxazine. In this novel route, RCM reaction and 1,3-dipolar cycloaddition were employed as key steps for the enantioselective construction of tropane skeleton and the regioselective introduction of 3-bromo-2-isoxazoline ring as masked cis-2,3-disubstituents. To obtain the desired precursor (2S,5R)-2-allyl-5-vinylpyrrolidine for RCM reaction, we developed a general and practical method for the preparation of enantiopure cis-2,5-disubstituted pyrrolidines bearing alkene- and/or alkyne-containing substituents. We also offered two highly efficient pathways for the conversion of the 3-bromo-2-isoxazoline ring into the desired cis-2,3-disubstituted groups in (-)-cocaine and (-)-ferruginine. 相似文献
26.
四磺基钴酞菁/MCM-41的制备、表征及其催化性能 总被引:3,自引:0,他引:3
将四磺基钴酞菁(CoTSPc)通过共价结合连接在氨基化的介孔分子筛MCM-41孔道壁上,制成负载酞菁催化剂,对其进行了X射线衍射(XRD)和红外分析,并研究了其对巯基乙醇的催化氧化反应动力学.结果表明,负载酞菁催化剂有优良的催化性能,在液相反应过程中扩散阻力较小.这种负载催化剂有酶催化特点,即遵循米氏动力学规律,米氏常数Km为0.015mol/L.反应完成后,通过沉淀即可从反应体系中分离,解决了酞菁催化剂无法回收利用和对环境造成新的污染的问题.在工业生产和环境保护方面有着良好应用前景. 相似文献
27.
研究了一种用于功率合成的GW级高功率微波功率合成器。该合成器工作在X波段,输入微波由2路工作频率不同的X波段的微波源产生。为了满足输出功率和功率容量的要求,用于功率合成的微波源工作段波导的过模因子为12.7,这给功率合成器的设计带来了一定的困难。着重讨论了如何利用过模波导设计X波段高功率合成器,研究了如何抑制过模波导的高次模式并提高其功率容量和传输效率。设计的功率合成器单路传输效率达到99.0%以上,允许的最大输出功率达到5.6 GW以上,还可以按照需求适当增大高度,以进一步提高其功率容量而不影响传输效率。 相似文献
28.
29.
高功率、长脉冲是高功率微波技术发展的趋势,提高微波器件的功率容量成为一项重要的任务,使用过模器件可以有效提高微波源的功率容量,然而却会带来微波源中同时存在多种模式的问题。为了识别一个X波段长脉冲过模高功率微波源的输出主模TM01模式,设计了一种在线选模定向耦合器,进行了理论分析和模拟优化设计。当频率范围为9.2~9.6 GHz时,模拟结果显示该选模耦合器对TM01模的耦合度为-54 dB,在400 MHz带宽内定向性大于35 dB,对TM02模的抑制度大于15 dB,功率容量可达到3 GW以上。 相似文献
30.
Daliao Tao Zhiqin Wang Xiaoyu Huang Mingwei Tian Guolin Lu Ian Manners Mitchell A. Winnik Chun Feng 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(21):8309-8316
Fiber-like π-conjugated nanostructures are important components of flexible organic electronic and optoelectronic devices. To broaden the range of potential applications, one needs to control not only the length of these nanostructures, but the introduction of diverse functionality with spatially selective control. Here we report the synthesis of a crystalline-coil block copolymer of oligo(p-phenylenevinylene)-b-poly(2-vinylpyridine) (OPV5-b-P2VP44), in which the basicity and coordinating/chelating ability of the P2VP segment provide a landscape for the incorporation of a variety of functional inorganic NPs. Through a self-seeding strategy, we were able to prepare monodisperse fiber-like micelles of OPV5-b-P2VP44 with lengths ranging from 50 to 800 nm. Significantly, the exposed two ends of OPV core of these fiber-like micelles remained active toward further epitaxial deposition of OPV5-b-PNIPAM49 and OPV5-b-P2VP44 to generate uniform A-B-A and B-A-B-A-B segmented block comicelles with tunable lengths for each block. The P2VP domains in these (co-)micelles can be selectively decorated with inorganic and polymeric nanoparticles as well as metal oxide coatings, to afford hybrid fiber-like nanostructures. This work provides a versatile strategy toward the fabrication of narrow length dispersity continuous and segmented π-conjugated OPV-containing fiber-like micelles with the capacity to be decorated in a spatially selective way with varying functionalities. 相似文献