Iterative In Situ Click Chemistry Creates Antibody‐like Protein‐Capture Agents

Special agents for protein capture : Iterative in situ click chemistry (see scheme for the tertiary ligand screen) and the one‐bead–one‐compound method for the creation of a peptide library enable the fragment‐based assembly of selective high‐affinity protein‐capture agents. The resulting ligands are water‐soluble and stable chemically, biochemically, and thermally. They can be produced in gram quantities through copper(I)‐catalyzed cycloaddition.

     

Resonance behavior of the sensitivity of acoustic-wave chemical gas sensors

The effect of the resonance enhancement of the sensitivity of acoustic-wave chemical sensors is the-oretically predicted and substantiated experimentally. This enhancement is due to the peculiarities of the excitation of standing waves in the multilayer structure of the sensors. The obtained results provide the basis for the purposeful regulation of sensor sensitivity by selecting their design parameters. The effect discovered also offers promise from the standpoint of methodology: at the resonance conditions, sound velocity in the adsorbent film can be measured to a high precision. These experiments provide information on the elastic, dielectric, viscous-flow, and other properties of film materials and on their phase composition.     

Synthesis of vicinal bishydroxylamine

Reduction of 2,3-dimethyl-2,3-dinitrobutane with Zn in aqueous ethanol in the presence of NH₄Cl affords 2,3-bis(hydroxylamino)-2,3-dimethylbutane together with 2,3-diamino-2,3-dimethylbutane and complex Zn salts. A modified procedure was developed for the synthesis of bishydroxylamine, which involves reduction in a Zn/NH₄Cl/THF−H₂O system. Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1539–1545, August, 1999.