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高分子化合物沿分子链(主链和侧链)排列多量可离解基团(每个链节可有1~2个)称聚电解质或聚离子[1]。聚电解质在水中可离解成两部分,若离解后,聚合物链带负电荷,称聚阴离子电解质或聚负离子;若带正电荷,称聚阳离子电解质或聚正离子。 相似文献
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二苯胺重氮盐(C6H5NHC6H4N2+ X-)与甲醛的缩合物重氮树脂,在光照下易与带侧链羟基的线型高分子形成亲墨性好的交联产物,被广泛用于阴图PS版的制备[1 5]。用于PS版感光剂,最重要的一项性能是热稳定性要好,即制备重氮树脂用的重氮盐热分解温度要高,热分解速度要慢。 相似文献
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生物体多器官的空间异质性导致环境污染物在生物体内的毒性分子机制错综复杂。基于传统化学和生物分析的环境毒理学研究,通常将研究对象看作“均一”整体,无法从空间上准确定位污染物及其代谢。以质谱成像和组学分析为基础的技术,同时对污染物、污染物代谢活化途径及其诱导的生物分子进行定性、定量和空间分析,从而确定污染物迁移、生物学效应及其毒性作用的靶器官,是目前最有前景的分析方法之一。本文综述了质谱成像和组学研究策略和特征,介绍了本课题组在相关领域取得的研究进展。同时简单展望了单细胞质谱成像、微流控芯片-质谱成像联合策略等先进技术在环境毒理研究中的潜在应用。 相似文献
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:The occurrence and development of breast cancer go through multiple processes,and the protein molecular information in its evolution is intricate and complex. The 4D-proteomics technique was used to investigate the tumor progression of MMTV-PyMT transgenic mice. The results of protein identification and differential expression analysis showed that a total of 5819 proteins were identified in 4D-proteomics analysis and 5667 proteins were quantifiable. Compared with 3-week-old tumors,a total of 270 differentially expressed proteins were found in the 5-week-old tumors,while 255 proteins in the 7-week-old tumors. We also detected 23 of proteins (such as,Srpk11 and Tinagl1)with gradual up-regulation and 35 of proteins (such as,Pdgfrb, Col1a2 and Col1a1)with gradual down-regulation during the tumor progression,including 3-,5-and 7-weeks. We also performed bioinformatics analysis,including subcellular localization,GO function analysis and pathway enrichment analysis. The results showed that the biological processes(immune regulation and lipid metabolism) and enrichment pathways (metabolic pathway)involved in differentially expressed proteins remained the same during the tumor progression,but some cellular components and molecular functions changed,such as,protein locations were extracellular region and membrane in 5-weeks-old tumors as well as cytoplasm in 7-weeks-old tumors. And important protein functions were protein binding functions in 5-weeks-old tumors as well as nucleotide binding in 7-weeks-old tumors. The acquired protein biomarkers and pathways could help with the accurate exploration of molecular mechanisms of tumor progression,screening of molecular targets of breast cancer,and evaluation of personalized treatment programs. © 2023, Youke Publishing Co.,Ltd. All rights reserved. 相似文献