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71.
Cristina Cadenas-Sanchez María Medrano Lide Arenaza Maria Amasene Maddi Oss Idoia Labayen 《Nutrients》2021,13(4)
Dietary habits have been linked with health in childhood. However, few studies have examined the association between healthy dietary patterns and physical fitness. Therefore, the aim of this study was to examine the associations of adherence to the Mediterranean dietary pattern (MDP) and breakfast quality with physical fitness in children. Further to this, we examined the role of physical activity in these associations. A total of 175 children (86 girls, 9.7 ± 0.3 years) participated. Adherence to MDP and breakfast quality were assessed by the KIDMED questionnaire and 24 h recall, respectively. Cardiorespiratory fitness, muscular strength, and speed–agility were assessed. Physical activity was evaluated by wrist-worn accelerometers. Greater adherence to the MDP was related with higher cardiorespiratory fitness, lower-limbs muscular strength, and speed–agility (all β ≥ 0.189, all p ≤ 0.02). No significant associations were observed between breakfast quality and physical fitness (all p > 0.05). However, all the significant associations disappeared after adjusting for physical activity (all p > 0.05). Our study sheds light on the relevance of adhering to the MDP over physical fitness in school children. However, there is no association between breakfast quality and physical fitness. Furthermore, physical activity seems to explain, at least partially, these findings. 相似文献
72.
Maria Hernandez Sergio Recalde Jorge Gonzlez-Zamora Valentina Bilbao-Malav Manuel Senz de Viteri Jaione Bezunartea Maite Moreno-Ordua Idoia Belza Jesús Barrio-Barrio Patricia Fernandez-Robredo Alfredo García-Layana 《Nutrients》2021,13(5)
Age-related macular degeneration (AMD) is a multifactorial disease of the retina featured by dysfunction of retinal pigmented epithelial (RPE) and loss of photoreceptor cells under oxidative stress and inflammatory conditions. Vitamin D and antioxidants have beneficial effects against retinal degenerative diseases, such as AMD. We investigated the impact of associating vitamin D (ND) with a nutritional antioxidant complex (Nutrof Total®; N) on oxidative stress and inflammation-like induced conditions by H2O2 and LPS, respectively, in human retinal epithelial (ARPE-19) and human retinal endothelial (HREC) cells. Application of either N or ND treatments to H2O2-induced media in ARPE-19 cells counteracted late apoptosis, attenuated oxidative DNA damage, and increased cell proliferation. Significant reduction in the expression levels of MCP1, IL-8, and IL6 cytokines was observed following application of either N or ND treatments under LPS-induced conditions in ARPE-19 cells and in MCP-1 and IL12p70 cytokine levels in HREC cells. ND and not N revealed significant downregulation of IFNγ in ARPE-19 cells, and of IL-6 and IL-18 in HREC cells. In conclusion, adding vitamin D to Nutrof Total® protects in a synergistic way against oxidative and inflammatory stress-induced conditions in retinal epithelial and endothelial cells. 相似文献
73.
74.
Sierra M Alonso A Odero MD Gonzalez MB Lahortiga I Pérez JJ García JL Gutiérrez NC Calasanz MJ San Miguel JF Hernández JM 《Leukemia research》2006,30(8):943-948
The incidence of chromosomal abnormalities in acute myeloid leukemia (AML) differs according to geographical regions in Spain. We analyse 1,271 consecutive patients diagnosed of AML between 1995 and 2002 in three different regions of Spain: northern, central and southern. There were 624 males (55%) and 505 females (45%). Age ranged between 1 month and 94 years with a median of 61 years. Abnormal karyotypes were observed in 64% of cases. Numerical abnormalities as sole cytogenetic changes were detected in 15% of patients, while structural aberrations were present in 28% of cases, and both abnormalities were found in 22% of patients. A significantly higher proportion of t(15;17) was observed in the south of Spain (21.6%) than in the central (17%) or northern regions (12.6%) (p=0.03). By contrast, patients from the south of Spain showed lower incidence of t(8;21) (0%, compared to 1.6% and 3.6% in central and northern areas, respectively, p=0.04). These differences were maintained in the age-adjusted analysis. Trisomy 8 showed similar incidence in southern and central areas, while the incidence in the northern area was lower (14% and 10%, respectively, p=0.04). Other chromosomal abnormalities, such as inv(16) or 11q23 rearrangements, were found at similar frequencies in the three regions. 相似文献
75.
Marta Garaulet Antonio Martinez-Nicolas Jonatan R. Ruiz Kenn Konstabel Idoia Labayen Marcela González-Gross Ascensión Marcos Dénes Molnar Kurt Widhalm Jose Antonio Casajús Stefaan De Henauw Anthony Kafatos Christina Breidenassel Michael Sjöström Manuel J. Castillo Luis A. Moreno Juan A. Madrid Francisco B. Ortega 《Clinical nutrition (Edinburgh, Scotland)》2017,36(6):1558-1566
76.
77.
Cristina Cadenas-Sanchez Timm Intemann Idoia Labayen Ana B. Peinado Josep Vidal-Conti Joaquin Sanchis-Moysi Diego Moliner-Urdiales Manuel A. Rodriguez Perez Jorge Cañete Garcia-Prieto Jorge del Rosario Fernández-Santos Borja Martinez-Tellez Germán Vicente-Rodríguez Marie Löf Jonatan R. Ruiz Francisco B. Ortega 《Journal of Science and Medicine in Sport》2019,22(4):430-437
Objectives
Reference values are necessary for classifying children, for health screening, and for early prevention as many non-communicable diseases aggravate during growth and development. While physical fitness reference standards are available in children aged 6 and older, such information is lacking in preschool children. Therefore, the purposes of this study were (1) to provide sex-and age-specific physical fitness reference standards for Spanish preschool children; and (2) to study sex differences across this age period and to characterise fitness performance throughout the preschool period.Design
Cross-sectional.Methods
A total of 3179 preschool children (1678 boys) aged 2.8–6.4 years old from Spain were included in the present study. Physical fitness was measured using the PREFIT battery.Results
Age- and sex-specific percentiles for the physical fitness components are provided. Boys performed better than girls in the cardiorespiratory fitness, muscular strength, and speed-agility tests over the whole preschool period studied and for the different percentiles. In contrast, girls performed slightly better than boys in the balance test. Older children had better performance in all fitness tests than their younger counterparts.Conclusions
Our study provides age- and sex-specific physical fitness reference standards in preschool children allowing interpretation of fitness assessment. Sexual dimorphism in fitness tests exists already at preschool age, and these differences become larger with age. These findings will help health, sport, and school professionals to identify preschool children with a high/very low fitness level, to examine changes in fitness over time, and to analyse those changes obtained due to intervention effects. 相似文献78.
79.
The patient is a previously healthy 28-year-old woman with incidentally detected focal liver lesion. On CT, the tumor showed
brisk arterial enhancement and persistent hyperenhancement on portal and delayed phases. Histological study showed spindle
cells without atypia and immunohistochemical study was consistent with leiomyoma. 相似文献
80.
CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock 总被引:1,自引:1,他引:0
Sarrias MR Farnós M Mota R Sánchez-Barbero F Ibáñez A Gimferrer I Vera J Fenutría R Casals C Yélamos J Lozano F 《Proceedings of the National Academy of Sciences of the United States of America》2007,104(28):11724-11729
CD6 is a lymphocyte receptor that belongs to the scavenger receptor cysteine-rich superfamily. Because some members of the scavenger receptor cysteine-rich superfamily act as pattern recognition receptors for microbial components, we studied whether CD6 shares this function. We produced a recombinant form of the ectodomain of CD6 (rsCD6), which was indistinguishable (in apparent molecular mass, antibody reactivity, and cell binding properties) from a circulating form of CD6 affinity-purified from human serum. rsCD6 bound to and aggregated several Gram-positive and -negative bacterial strains through the recognition of lipoteichoic acid and LPS, respectively. The Kd of the LPS-rsCD6 interaction was 2.69 +/- 0.32 x 10(-8) M, which is similar to that reported for the LPS-CD14 interaction. Further experiments showed that membrane CD6 also retains the LPS-binding ability, and it results in activation of the MAPK signaling cascade. In vivo experiments demonstrated that i.p. administration of rsCD6 before lethal LPS challenge significantly improved mice survival, and this was concomitant with reduced serum levels of the proinflammatory cytokines TNF-alpha, IL6, and IL-1beta. In conclusion, our results illustrate the unprecedented bacterial binding properties of rsCD6 and support its therapeutic potential for the intervention of septic shock syndrome or other inflammatory diseases of infectious origin. 相似文献