Effects of Lewis acid catalysts on the hydrogenation and cracking of two-ring aromatic and hydroaromatic structures related to coal

Little is known about the hydrogenation of fused aromatic nuclei during the liquefaction of coal under the influence of Lewis acid catalysts. This study was conducted to establish the effects of catalyst acidity on the activity and selectivity of Lewis acid catalysts, the sources of hydrogen involved in hydrogenation and cracking, and the relations between reactant structure and reactivity. Two-ring aromatic and hydroaromatic compounds were used to simulate some of the structural units present in coal. The catalysts examined were ZnCl₂ and AlCl₃. ZnCl₂ is less active than AlCl₃ for both hydrogenation and cracking but it does not promote the formation of tars via Scholl condensation: Methyl or hydroxyl substitution of the reactants greatly enhances their reactivity towards hydrogenation and cracking. The source of hydrogen consumed during hydrogenation depends on the choice of catalyst. In the presence of AlCl₃, Scholl condensation of aromatic nuclei serves as the principal source of hydrogen. Molecular hydrogen is used exclusively, though, when hydrogenation is catalysed by ZnCl₂. The formation of reaction products and the trends in reactant reactivity can be interpreted on the basis of carbonium ion mechanisms. The results of this study provide a basis for assessing the extent of hydrogenation occurring during the liquefaction of coal using ZnCl₂ or AlCl₃.     

Some of the properties of wood–plastic composites

In this study some of the important properties of experimentally manufactured wood–plastic composites (WPC) were determined. Specimen having 60% and 80% particle and fiber of radiata pine (Pinus radiata ) were mixed with polypropylene (plastic) and four different additives, namely Structor TR 016 which is coupling agent, CIBA anti-microbial agent (IRGAGUARD F3510) as fungicide, CIBA UV filter coating (TINUVIN 123S), CIBA blue pigment (Irgalite), and their combinations. Based on the initial finding of this work static bending properties of the samples enhanced as above chemicals were added into both particle and fiber-based specimens. Thickness swelling of the samples were also improved with having additives in the panels. Micrographs taken on scanning electron microscope (SEM) revealed that coupling agent and pigment resulted in more homogeneous mixture of wood and plastic together. Two surface roughness parameters average roughness (R_a) and maximum roughness (R_max) used to evaluate surface characteristics of the samples showed that particle based samples had rougher surface characteristics than those of fiber based ones. No significant influence of chemicals added in the samples was found on surface roughness values of the samples manufactured from particle and fiber of radiata pine.     

New Circulating Circular RNAs with Diagnostic and Prognostic Potential in Advanced Colorectal Cancer

Circular RNAs (circRNAs) are a group of special endogenous long non-coding RNAs which are highly stable in the circulation, and, thus, more suitable as new biomarkers of colorectal cancer (CRC). The aim of our study was to explore the plasma expression levels of four circRNAs: has_circ_0001445, hsa_circ_0003028, hsa_circ_0007915 and hsa_circ_0008717 in patients with CRC and to evaluate their associations with clinicopathological characteristics and the clinical outcome of the patients. CircRNAs were extracted from patients’ plasma obtained prior to chemotherapy. Their expression levels were measured by qPCR and calculated applying the 2^−ΔΔCt method. The levels of all four circRNAs were significantly increased in the plasma of CRC patients. At the optimal cut-off values hsa_circ_0001445 and hsa_circ_0007915 in plasma could significantly distinguish between patients with or without metastatic CRC with 92.56% sensitivity and 42.86% specificity, and with 86.07% sensitivity and 57.14% specificity, respectively. The mean overall survival (OS) of patients with high/intermediate expression of hsa_circ_0001445 was 30 months, significantly higher in comparison with the mean OS of the patients with low expression—20 months (log-rank test, p = 0.034). In multivariate Cox regression analysis, the low levels of hsa_circ_0001445 were also associated with shorter survival (HR = 1.59, 95% CI: 1.02–2.47, p = 0.040). A prognostic significance of hsa_circ_0001445 for patients with metastatic CRC was established.     

Development of a semi-quantitative food frequency questionnaire for use in United Arab Emirates and Kuwait based on local foods

Background  

The Food Frequency Questionnaire (FFQ) is one of the most commonly used tools in epidemiologic studies to assess long-term nutritional exposure. The purpose of this study is to describe the development of a culture specific FFQ for Arab populations in the United Arab Emirates (UAE) and Kuwait.     

Identification of tet(M) in two Lactococcus lactis strains isolated from a Spanish traditional starter-free cheese made of raw milk and conjugative transfer of tetracycline resistance to lactococci and enterococci

Specific PCR and sequencing showed that a tet(M) gene was present in two tetracycline-resistant Lactococcus lactis strains isolated from a raw milk, starter-free cheese. Hybridisation experiments using as a probe an internal segment of the gene obtained by PCR associated tet(M) with plasmids of around the same size (30 kbp) in both strains. Molecular analysis of the tetracycline resistance loci, including the upstream and downstream regions of the genes, showed them to be identical to one other and to the tet(M) encoded by the conjugative transposon Tn916. Amplification of Tn916-derived segments suggested the transposon was complete in the two L. lactis strains. Further, curing of the tetracycline resistance was accompanied by a reduction in size of the plasmids comparable to that expected for Tn916. Tetracycline resistance could be transferred by conjugation to plasmid-free Lactococcus and Enterococcus strains. However, no plasmid DNA was detected among the transconjugants while both tet(M) and transposon-related sequences were amplified by PCR. This suggested that only the transposon was mobilized.     

Finite element analysis on implicitly defined domains: An accurate representation based on arbitrary parametric surfaces

In this paper, we present some novel results and ideas for robust and accurate implicit representation of geometric surfaces in finite element analysis. The novel contributions of this paper are threefold: (1) describe and validate a method to represent arbitrary parametric surfaces implicitly; (2) represent arbitrary solids implicitly, including sharp features using level sets and boolean operations; (3) impose arbitrary Dirichlet and Neumann boundary conditions on the resulting implicitly defined boundaries. The methods proposed do not require local refinement of the finite element mesh in regions of high curvature, ensure the independence of the domain’s volume on the mesh, do not rely on boundary regularization, and are well suited to methods based on fixed grids such as the extended finite element method (XFEM). Numerical examples are presented to demonstrate the robustness and effectiveness of the proposed approach and show that it is possible to achieve optimal convergence rates using a fully implicit representation of object boundaries. This approach is one step in the desired direction of tying numerical simulations to computer aided design (CAD), similarly to the isogeometric analysis paradigm.     

Nanoarchitectonics: Porous Hydrogel as Bio-sorbent for Effective Remediation of Hazardous Contaminants

The increasing use of heavy metals, dyes, and other metallic or chemical elements causes crucial environmental pollution. Sewage that contains these heavy metals and dyes is discharged into the atmosphere and goes directly into the food cycle, causing cancerous diseases and health deterioration in living organisms. The supreme concern of today’s research is to treat wastewater and effectively remove the hazardous dye molecules from aqueous media and other environmental matrices. Nowadays, technologies are applied to rectify organic and inorganic pollutants from sewage. Among them, adsorption is a fascinating way because it is environmentally friendly, feasible, and economical biomaterials. Chitosan (CS) as bio-sorbent is endowed with valuable characteristics, such as biodegradability, biocompatibility, high reactivity, low-cost, and functional groups (–OH and NH₂) on its surface. CS is used for many applications, either as a single component or composite form. The use of CS as bio-adsorbents is beneficial over regular adsorbents. Chitosan-based hydrogel is one of the very important bio-adsorbents. All these bio-adsorbents are highly used to eradicate toxic dyes, digest harmful industrial sewage, and eliminate pesticides, climatic hazardous waste, and contaminated materials from the environment.

     

Synthesis and Characterization of Sulfanilamide-Based Nonionic Surfactants and Evaluation of Their Nano-Vesicular Drug Loading Application

Nonionic surfactants are highly stable and cost-effective and receiving acceptance for applications in many diverse fields including drug delivery, due to their distinctive properties. Here, we report on the synthesis and characterization of sulfanilamide-based nonionic surfactants for nanoscale vesicular drug loading applications. Nonionic surfactants were synthesized through alkylation of sulfanilamide with alkyl halides that possessed diverse degrees of lipophilicity. They were explored for their nanovesicular drug loading with Cefixime as a hydrophobic model drug. Drug-loaded nanovesicles were characterized for surface morphologies, size, size distribution, surface charge, and drug loading efficiency using atomic force microscopy (AFM), dynamic light scattering (DLS), and UV–visible spectrophotometry. All of the synthesized nonionic surfactants revealed their CMC values in 0.055–0.035 mM range depending upon the lipophilic chain length of surfactants. They caused a decreased hemoglobin release and low toxicity against cell culture. They self-assembled and loaded an increased amount of drug in the form of nanorange spherical shape niosomal vesicles. Results of the current study verify these synthesized nonionic surfactants are hemocompatible, nontoxic, and capable of self-assembling into nanorange niosomal vesicles. These niosomal vesicles can be suggested as safe and highly efficient nanocarriers for hydrophobic drug loading and delivery.