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目的 调查严重急性呼吸综合征冠状病毒2(SARS-CoV-2)奥密克戎变异株流行期间上海方舱医院军队医务人员的心理健康状况及其影响因素。方法 采用9项患者健康问卷抑郁自评量表(PHQ-9)、7项广泛性焦虑障碍(GAD-7)量表、阿森斯失眠量表(AIS)对上海方舱医院的540名军队医务人员进行问卷调查,了解军队医务人员的心理健康状况,并采用logistic回归分析探讨其影响因素。结果 共回收有效问卷536份,回收有效率为99.3%(536/540)。上海方舱医院军队医务人员的抑郁、焦虑及失眠症状发生率分别为45.5%(244/536)、26.1%(140/536)和59.5%(319/536)。logistic回归分析结果显示,是否常驻上海、每日浏览信息中负面信息占比、进入方舱后饮食状况是抑郁、焦虑、失眠的影响因素(P均<0.05),年龄、对未来上海的信心是抑郁和失眠的影响因素(P均<0.05),每日花费在疫情相关信息上的时间是失眠的影响因素(P=0.021)。结论 SARS-CoV-2奥密克戎变异株流行期间上海方舱医院军队医务人员的抑郁、焦虑及失眠发生率较高,应定期持续监测... 相似文献
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目的探讨p16基因上游序列-869bp中是否含有核基质结合元件,并分析p16基因上游序列在急性白血病细胞组与对照组内与核基质蛋白结合的情况。方法DNA-蛋白质杂交(Southwestern blot)技术。结果p16基因上游序列与核基质蛋白的结合在急性白血病组与对照组间存在差异。结论p16基因外显子1α上游–869bp片段可以与核基质蛋白结合,表明该片段存在MAR序列,对p16基因表达调控具有重要意义,急性白血病细胞核基质蛋白成分的改变影响其与p16基因外显子1α上游–869bp片段MAR序列的结合,提示核基质蛋白成分的改变可能抑制p16基因的表达,促进急性白血病的发生。 相似文献
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帕金森病随年龄的增长而呈进行性加重,其症状虽不致命,但降低了患者的日常生活质量。目前西药治疗本病疗效欠佳且不良反应多,探寻新疗法迫在眉睫。本文报道了一例巧妙运用经方合方与对药治疗多年受帕金森病困扰患者的成功案例。其中柴胡龙骨牡蛎汤、补中益气汤及当归芍药散的经方合方运用是主要特色,通过经方合方的加减变化,以及蕴含的对药思想,治疗帕金森病的运动和非运动症状,体现了灵活运用经方在病机复杂的帕金森病治疗的重要意义。经何裕民教授、朱生樑主任医师的点评,肯定了运用中医经方和对药治疗帕金森病的疗效,通过对诊治过程中思路及方药等进行分析,指出了几点不足及注意要点,启发了笔者思考,收获良多。 相似文献
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Objective To investigate the variation of bone marrow complement level in cytopenia pa-tients with positive BMMNC-Coombs test(CBCPC), and probe the role of complement in destroying hemato-poietic cells of CBCPC patients. Methods One hundred and twenty-four patients with CBCPC and twenty-three healthy donors as controls were enrolled in this study. The levels of CI-150, C3, C4, C5b-9 were tested with ELISA. The auto-antibodies on bone marrow hematupoietic cells (BMHC) were examined with flow cy-tometry. Results The level of C5b-9 in bone marrow(BM) of untreated CBCPC patients [(119.8 ± 54.0)μg,/L] was significantly higher than that of recovered patients [(100.7 ± 33.4) μg/L] or normal controls [(93.9 ± 28.8) μg/I.] (P < 0.05). The levels of CH50 in BM of untreated or recovered CBCPC patients [(33.3 ± 11.5) kU/L, (30.8 ± 10.3) kU/L] were significantly higher than that of normal controls [(24.1 ±6.4) kU/L] (P < 0.05). The level of C3 in BM of untreated or recovered CBCPC patients [(4.9 ± 2.2) mg/ L], (5.0 ± 3.5) mg/L] was significantly lower than that of normal controls [(7.0 ± 5.6) mg/L] (P < 0.05). The level of complement in peripheral blood was consistent with that in BM. CH50 in BM of CBCPC patients was negatively correlated with their C3 (r = - 0. 303, P = 0. 007) and positively correlated with their C5b-9(r = 0. 241, P = 0. 003) levels. The level of C5h-9 in BM of CBCPC patients was higher in the BMHC-IgM positive group [(117.6 ± 55.7) μg/L] than in the BMHC- IgM negative group [(99.2 ± 26.2)μg/L] (P < 0. 05). The positive rate of CD34+ -IgG or CD34 + -IgM of CBCPC patients was positively corre-lated with their C5 b-9 level (r = 0. 593, P = 0.000, r = 0. 326, P = 0. 049). The reticulocyte percentage (r =0. 421, P = 0.000) and serum indirect bilirubin level (r = 0. 230, P = 0. 032) of CBCPC patients were posi-tively correlated with their CHSO level. Conclusions The hematocytopenia of CBCPC patients might be re-lated to the hematopoietic cells destruction caused by auto-antibedy activated complements. 相似文献
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新生血管的形成和恶性肿瘤的发生、发展、浸润和转移密切相关,血管内皮生长因子(vascular endothelial growth factor,VGF)和自身特异性受体结合刺激内皮细胞增殖和移行,其他促血管生成因子完全或部分通过VEGF发挥作用,VEGF水平的高低已成为一些实体瘤的独立预后因素。近年有关文献表明,VEGF在恶性血液病细胞株有异常高表达,通过自分泌和旁分泌途径,参与恶性血液病的发病过程。它与恶性血液病的关系日受人们关注和重视。 相似文献
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免疫相关性全血细胞减少症(IRP)是一种因B淋巴细胞功能亢进,产生抗自身造血细胞抗体导致骨髓造血衰竭的自身免疫性疾病[1-2].研究发现,自身抗体主要是通过激活巨噬细胞和(或)溶解补体,吞噬和(或)溶解大量骨髓造血细胞介导骨髓衰竭[3-6].临床研究发现部分IRP患者骨髓幼红细胞上存在EPO受体(EPOR)自身抗体,其EPOR检测水平明显低于正常人和骨髓红系细胞膜自身抗体阴性的IRP患者,且这部分IRP患者在临床治疗过程中应用常规剂量的EPO疗效不佳甚至无效[7],说明自身抗体介导骨髓造血衰竭还存在其他途径.EPOR自身抗体能否直接抑制骨髓造血功能,目前尚无文献报道.为此,我们作了以下研究. 相似文献
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