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Zang Xu臧旭 Zhang Shu-ying张淑英 Zhang Shu-hua张淑华Lu Ying-jie路英杰 Wang Wei-jun王维钧 Yin Zhao-yan尹昭炎Shi Yi-fan史轶繁 Wang Zhi-zhong王直中Pituitary Adenoma Cooperative Group Capital Hospital Beijing 《中华医学杂志(英文版)》1983,96(9):647-654
Analysis of 60 pituitary adenomas with acro-
megaly iiS made. All 60 surgical specimens are
studied by both light and electron microscopy.
By light microscopy we classified the adenomas
into strong acidophilic cell (16 cases) and weak
acidophilic cell (20 cases), stem cell (2 cases)
and mixed cell type adenomas (22 cases). By
electron micros.copy we classified them into
densely granulated (14 cases) and sparsely granu-
lated growth hormone (GH) cell adenomas (212
cases) in which there are fibrous bodies near
the indented part of the nucleus which are of
diagnostic value, corresponding to the round
lucent area near the indented nucleus seen by
light microscopy. The densely granulated and
sparsely granulated GH cells may coexist within
1 adenoma (4 cases). Some adenomas may con-
tain 2-3 kinds of secretory granules and are
called multiple functional adenomas, in this
series 18 had GH-;-PRL prolactin), 1 GH+ACTH
and l GH+PRL+ACTH. Strong acidophilic cells
correspond to densely granulated GH cells while
weak acidophilic celIs correspond to sparsely
granulated GH cells. The number of strong or
weak acidophilic cells and number of secretory
granules are not directly proportional to the GH
blood level. By electron microscopy GH, PRL
and ACTH secretory granules have characteristic
features which are not absolute. Correct diagnosis
is based upon combining the clinical symptoms
and signs, blood hormone levels and secretory
granule morphology. F'ibrous body diagnostic
value and their genesis and development are dis-
cussed. 相似文献
3.
臧旭 《中国神经精神疾病杂志》1983,(4)
报告接种鼠脑制的流行性乙型脑炎疫苗后脑脊髓炎4例的尸检材料。均表现为中枢神经系统白质的血管周围有淋巴细胞浸润,例1为亚急性发病的成年人,血管周围尚有脱髓鞘和出血灶。3例急性发病的儿童均有胸腺增大、肾上腺缩小和淋巴网状细胞增生。这4例均为鼠脑引起的变态反应性脑脊髓炎,其中3例属早期病变。 相似文献
4.
利用伴有肢端肥大症的垂体腺瘤30例的手术切除的瘤组织,做电镜检查,并做免疫细胞化学染GH。对比了滴染法与小盒长期浸泡法染GH的优缺点。在电镜下对垂体GH细胞腺瘤可分为多分泌颗粒、少分泌颗粒或多与少分泌颗粒混合性细胞腺瘤。在免疫细胞化学染GH中,可分为GH强阳性和弱阳性细胞或二者的混合,在电镜下的多分泌颗粒细胞相当免疫细胞化学染色中的GH强阳性细胞,少分泌颗粒细胞相 相似文献
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In 200 autopsies of stroke cases, there were
99 cerebral hemorrhages including hypertensive
cerebral hemorrhage 78, cerebral blood vessel
anomalies 7, anemia 5, leukemia 4, tuberculous
meningitis 2, septicemic, cerebral hemorrhage l,
severe jaundice complicated by cerebral hemor-
thage l and posttraumatic subdural hemorrhage
1. There were 53 cerebral infarctions in which
there were cerebral embolisms 48, cerebral
thrombosis 4 and cerebral venous thrombosis l.
There were also hypertensive encephalopathy
15, cerebral tumors 33 including primary brain
tumors complicated by hemorrhage 2, metastatic
choriocarcinoma 25 and other matastatic carci-
nomas 6.
According to our autopsies cerebral he-
morrhage is the most frequent cause of stroke
with cerebral embolism ranking second while
cerebral thrombosis is much less important. Ce-
rebral atherosclerosis developed progressively
over a very long course and it does not trigger
strokes if it is without complications. 相似文献
7.
Ge Qin-sheng葛秦生 Xu Ling徐苓 Wang Hui-lan王慧兰 Gu Chun-xia谷春霞Lin Shou-qing林守清 Xu Yong-ding徐庸定 Yu Ke-min 于可敏 Xie Yu-zhang解毓章Shi Yi-fan 史轶繁 Zang Xu臧旭 and Yin Zhao-yan尹昭炎PUMC 《中华医学杂志(英文版)》1985,98(8):543-550
Hypperprolactinemia and its relation to galactorrhea,
amenorrhea and pituitary tumor were studied in 355
cases. Hyperprolactinemia was found in 135 cases,
and its incidences in the 3 groups (galactorrhea
with amenorrhea, galactorrhea with menstruation and
amenorrhea without galactorrhea) were 78.2u/o (111/
142), 21.7% (18/83) and 4.6:vo(6/130) respectively, the
differences being statistically significant (p<0.01).
Of the hyperprolactinemia cases 9570 had galactor-
thea, and about half of them were discovered during
examination. Therefore, pressing the breasts for
milk should be a routine procedure during gyno
cologic examination. There were 60 pituitary ma
croadenomas in this series; the incidence of
hyperprolactinemia was 39.3To (53/153) and amenor
thea with galactorrhea was 37.3%(53/'142). There
fore, prolactinoma is the most important cause of
galactorrhea, amenorrhea and hyperprolactinemia.
Some prolactinomas may not be accompanied by
amenorrhea, galactorrhea or hyperprolactinemia. 42
cases of hyperprolactinemia, half with pituitary
tumors, were treated with bromocriptine. Menstrua
tion resumed in 95.2%, biphasic basal body tempera.
ture (BBT) in 90.5%, and 70.6To infertile patients
became pregnant. The present study shows that the
important cause of amenorrhea is functional dis
turbance in the hypothalamic-pituitary-ovarian axis.
Once prolactin level is lowered, functional distur-
bances can be corrected very quickly. 相似文献
8.
臧旭 《临床与实验病理学杂志》1988,(1)
日常外检中常遇到的垂体疾病是垂体腺瘤,它约占颅内肿瘤的11%,近年来,由于内分泌学检查方法的发展,CT的广泛应用和外科手术治疗方法的改进,垂体腺瘤的诊断符合率和疗效有很大的提高。 相似文献
9.
利用垂体泌乳素细胞腺瘤30例的手术切除的瘤组织,做了电镜检查和免疫细胞化学的检查,在电镜下可分为多分泌颗粒PRL细胞腺瘤和少分泌颗粒PRL细胞腺瘤以及二者的混合。用免疫细胞化学染PRL,少分泌颗粒的PRL细胞有特点:PRL阳性物质大都呈一边界清楚的团块,其中有棕黄色的颗粒,它们的大小、形状变异大,但都位于核的一侧,在核有凹陷而且胞浆多的一侧。这个PRL阳性团块相当于电镜下的泌乳素小体。瘤细胞内PRL阳性物质少甚或阴性的 相似文献
10.
甲状腺低功所致垂体促甲状腺素、催乳素混合腺癌很罕见。本例的临床及实验室主要特征为:甲状腺低功,闭经,溢乳,视力左0.1,右0.3,双颞侧偏盲,血清T_4、T_3U值下降及PRL升高,甲状腺微粒抗体增加,TRH对TSH刺激试验呈过强反应。术后肿瘤超微结构检查发现瘤细胞内有TSH、PRL分泌颗粒及微小管。术后视功能迅速恢复,1个半月后月经来潮,溢乳停止,血TSH、PRL接近正常。 相似文献