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A study of the spatial and temporal evolution of auto-ignition kernels using time-resolved tomographic OH-LIF 总被引:1,自引:0,他引:1
Jhon Pareja Ayane Johchi Tao Li Andreas Dreizler Benjamin Böhm 《Proceedings of the Combustion Institute》2019,37(2):1321-1328
In this paper, the spatial and temporal evolution of auto-ignition kernels from methane jets propagating into a NOx-vitiated, high-turbulence, hot air co-flow was studied by means of time-resolved tomographic laser-induced fluorescence of OH (Tomo OH-LIF). Measurements were performed using a burst dye laser system at 10 kHz for volumetric laser illumination and a multi-camera arrangement (8-views) for detection of the fluorescence signal. Auto-ignition kernels were detected three-dimensionally and tracked using a robust algorithm based on the intensity gradient of the volumetrically reconstructed signals. The size and location of the detected kernels were evaluated for operating conditions with different Reynolds numbers of the fuel jet. Results showed that auto-ignition randomly occurred with high probability in a well defined fairly axisymmetric radial region with strong fluctuations in the main direction of the flow. The increase of the Reynolds number of the fuel jet resulted in a radial spread of the location of auto-ignition events. The statistical evaluation of the orientation and growth of auto-ignition kernels with respect to the mean flow field showed that the kernels were oriented tangentially to the flow and temporally evolve towards this preferential direction as the ignition events progressed. 相似文献
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Katoh Katsumi Fukui Satomi Haba Ayane Higashi Eiko Saburi Tei Okada Ken 《Journal of Thermal Analysis and Calorimetry》2022,147(13):7563-7571
Journal of Thermal Analysis and Calorimetry - Nitrocellulose (NC) is prone to spontaneous decomposition with exothermic heat release and thus is generally evaluated for stability during the storage... 相似文献
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Taku Aiga Dr. Yoshiyuki Manabe Keita Ito Tsung-Che Chang Dr. Kazuya Kabayama Shino Ohshima Prof. Yoshie Kametani Ayane Miura Hiroto Furukawa Dr. Hiroshi Inaba Prof. Kazunori Matsuura Prof. Koichi Fukase 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(40):17858-17864
Co-assembling vaccines composed of a lipidated HER2-derived antigenic CH401 peptide and either a lipophilic adjuvant, Pam3CSK4, α-GalCer, or lipid A 506, were evaluated as breast cancer vaccine candidates. This vaccine design was aimed to inherit both antigen multivalency and antigen-specific immunostimulation properties, observed in reported self-adjuvanting vaccine candidates, by using self-assembly and adjuvant-conjugated antigens. Under vaccination concentrations, respective lipophilic adjuvants underwent co-assembly with lipidated CH401, which boosted the anti-CH401 IgG and IgM production. In particular, α-GalCer was responsible for the most significant immune activation. Therefore, the newly developed vaccine design enabled the optimization of adjuvants against the antigenic CH401 peptide in a simple preparatory manner. Overall, the co-assembling vaccine design opens the door for efficient and practical self-adjuvanting vaccine development. 相似文献
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Masaaki Komatsuda Ayane Suto Hiroki Kondo Jr Hiroyuki Takada Kenta Kato Bunnai Saito Junichiro Yamaguchi 《Chemical science》2022,13(3):665
We have discovered a ring-opening fluorination of bicyclic azaarenes. Upon treatment of bicyclic azaarenes such as pyrazolo[1,5-a]pyridines with electrophilic fluorinating agents, fluorination of the aromatic ring is followed by a ring-opening reaction. Although this overall transformation can be classified as an electrophilic fluorination of an aromatic ring, it is a novel type of fluorination that results in construction of tertiary carbon–fluorine bonds. The present protocol can be applied to a range of bicyclic azaarenes, tolerating azines and a variety of functional groups. Additionally, mechanistic studies and enantioselective fluorination have been examined.A ring-opening fluorination of bicyclic azaarenes was developed. Although this overall transformation can be classified as an electrophilic fluorination of aromatics, it is a novel type of fluorination that results in construction of tert-C–F bonds. 相似文献
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Moeko Itoga Masako Yamanishi Taro Udagawa Ayane Kobayashi Keiko Maekawa Yoshiji Takemoto Hiroshi Naka 《Chemical science》2022,13(30):8744
The development of chemoselective C(sp3)-H deuteration is of particular interest in synthetic chemistry. We herein report the α-selective, iridium(iii)-bipyridonate-catalyzed hydrogen(H)/deuterium(D) isotope exchange of alcohols using deuterium oxide (D2O) as the primary deuterium source. This method enables the direct, chemoselective deuteration of primary and secondary alcohols under basic or neutral conditions without being affected by coordinative functional groups such as imidazole and tetrazole. Successful substrates for deuterium labelling include the pharmaceuticals losartan potassium, rapidosept, guaifenesin, and diprophylline. The deuterated losartan potassium shows higher stability towards the metabolism by CYP2C9 than the protiated analogue. Kinetic and DFT studies indicate that the direct deuteration proceeds through dehydrogenation of alcohol to the carbonyl intermediate, conversion of [IrIII–H] to [IrIII−D] with D2O, and deuteration of the carbonyl intermediate to give the α-deuterated product.An α-selective, iridium(iii)-bipyridonate-catalyzed hydrogen isotope exchange of alcohols using D2O has been developed for the direct, chemoselective deuteration of primary and secondary alcohols, thereby providing deuterated bioactive molecules. 相似文献
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Hersa Milawati Dr. Yoshiyuki Manabe Takuya Matsumoto Dr. Masato Tsutsui Dr. Yoshihiro Ueda Ayane Miura Dr. Kazuya Kabayama Prof. Koichi Fukase 《Angewandte Chemie (International ed. in English)》2023,62(25):e202303750
We propose a de novo glycan display approach that combines metabolic labeling and a glycan-caging strategy as a facile editing method for cell-surface glycans. This method enables the introduction of antigen glycans onto cancer cells to induce immune responses through antibody recruiting. The caging strategy prevents the capture of α-rhamnose (an antigen glycan) by endogenous antibodies during the introduction of the glycan to the targeted cell surface, and subsequent uncaging successfully induces immune responses. Therefore, this study proposes a practical method for editing the cell-surface glycocalyx under promiscuous conditions, such as those in vivo, which paves the way for the development of glycan function analysis and regulation. 相似文献
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Rachida Ayane Abdellah Hamdaoui Bouazza Braikat Noureddine Tounsi Noureddine Damil 《Comptes Rendus Mecanique》2019,347(6):463-476
In this paper, we propose a new analytical formula to define the next branch in the Asymptotic Numerical Method (ANM) using the Padé approximants. The proposed formula is based on the computation of the relative error of two consecutive Padé approximants. This formula is obtained by developing the relative error with respect to the path parameter. An appropriate matrix formulation is adopted for the computation of this relative error. A comparison between the analytical formula proposed in this paper and the classical continuation Padé approximants using the step length computed numerically using dichotomy method is presented for examples of buckling structures. 相似文献
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Taku Aiga Yoshiyuki Manabe Keita Ito Tsung‐Che Chang Kazuya Kabayama Shino Ohshima Yoshie Kametani Ayane Miura Hiroto Furukawa Hiroshi Inaba Kazunori Matsuura Koichi Fukase 《Angewandte Chemie (International ed. in English)》2020,59(40):17705-17711
Co‐assembling vaccines composed of a lipidated HER2‐derived antigenic CH401 peptide and either a lipophilic adjuvant, Pam3CSK4, α‐GalCer, or lipid A 506, were evaluated as breast cancer vaccine candidates. This vaccine design was aimed to inherit both antigen multivalency and antigen‐specific immunostimulation properties, observed in reported self‐adjuvanting vaccine candidates, by using self‐assembly and adjuvant‐conjugated antigens. Under vaccination concentrations, respective lipophilic adjuvants underwent co‐assembly with lipidated CH401, which boosted the anti‐CH401 IgG and IgM production. In particular, α‐GalCer was responsible for the most significant immune activation. Therefore, the newly developed vaccine design enabled the optimization of adjuvants against the antigenic CH401 peptide in a simple preparatory manner. Overall, the co‐assembling vaccine design opens the door for efficient and practical self‐adjuvanting vaccine development. 相似文献
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Ayane Hibi Akihiro Moriyama Takehiro Himaki Junko Takahashi Hitoshi Iwahashi 《高压研究》2019,39(2):357-366
ABSTRACTHigh pressure-carbon dioxide processing (HPCDP) is used as a non-thermal technology for food pasteurization to produce newer flavors for bread. However, there is no evidence that this process does not produce undesirable toxic materials. To confirm the safety of high pressure carbon dioxide-processed food, we fed high pressure carbon dioxide-processed bread to mice and evaluated their health by monitoring body weight, stress biomarkers, and gut microbiota. There was no significant difference in the body weight of normal and HPCDP bread-fed mice. Similarly, no significant difference in expression of genes important for maintaining the health of the mice was found. Although the mice’s gut microbiota showed a significant difference between the control and the two bread-fed groups, there was no significant difference between the HPCDP and the normal bread-fed groups. Therefore, we found no conclusive evidence to suggest that the processed bread contained toxic materials in comparison to the unprocessed bread. 相似文献
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