Outcomes of transoral laser microsurgery and transoral robotic surgery in oropharyngeal squamous cell carcinoma

ObjectiveTransoral robotic surgery (TORS) has evolved to a standard therapy modality for oropharyngeal carcinoma, especially in T1/ T2 tumors involving the base of the tongue due to its advantages compared with open surgery. However, knowledge about its benefits compared with transoral laser microsurgery (TLM) are scarce. This study compares oncological and functional results of TLM or TORS in the treatment of oropharyngeal squamous cell carcinoma (OPSCC).MethodsThis retrospective analysis comprises all patients with OPSCC treated with TLM (n = 30) or TORS (n = 24) between April 2003 and May 2018 (follow-up 43 ± 38.3 months). Both treatment groups (TLM and TORS) were comparable in terms of the stage of the disease, prognosis-determining factors, and adjuvant therapy modalities.ResultsThere were no significant differences regarding to the resection status (p = 0.272), the rate of local- (p = 0.834) and distant- recurrence (p = 0.416), with a disease-free survival of 86.7 % and 87.5 %, respectively (p = 0.892). In addition, we could not confirm any differences regarding to operating time (p = 0.860), intraoperative blood loss (p = 0.660), inpatient stay (p = 0.585) and postoperative bleeding rate (p = 0.245). The frequency of tracheostomy and percutaneous endoscopic gastrostomy between both groups is comparable, with a longer duration of tube feeding in patients who have received TLM (p = 0.030).ConclusionIn conclusion, TORS allows for similar oncological outcomes compared with TLM at comparable perioperative risks. The postoperative swallowing function may benefit from TORS.     

Apheresis for idiopathic sudden hearing loss: reviewing the evidence

Plasmapheresis has been used for various conditions for a number of years. Recently, its application for idiopathic sudden hearing loss (ISHL) has met with increasing interest. ISHL affects about 10-20 per 100,000 persons per year, impairing not only their hearing but also their ability to interact socially and their quality of life. ISHL is thought to be a sequela of an underlying microvascular disorder caused by a local hyperviscosity syndrome in the cochlear vessels. Plasmapheresis can effectively lower plasma and whole blood viscosity, improve erythrocyte elasticity, and reduce aggregability. Thus, it may be effectively employed in the treatment of ISHL. This article will briefly outline the background against which apheresis procedures are used in the treatment of ISHL and review studies done to date. Furthermore, a broader basis for the use of apheretic applications in the treatment of ISHL will be suggested, correlating age-adjusted ISHL incidence and age-adjusted levels of macromolecular plasma proteins such as fibrinogen. In conclusion, plasmapheresis is a promising new treatment for ISHL but more basic data on ISHL, and on apheresis applications for ISHL, are needed to safely assess treatment outcomes and possible future applications.     

Idiopathic sudden hearing loss: contradictory clinical evidence, placebo effects and high spontaneous recovery rate--where do we stand in assessing treatment outcomes?

Idiopathic sudden hearing loss (ISHL) has an estimated incidence of 10-20/100,000 per year, impairing not only patients' hearing but also their ability to interact socially and their quality of life. Confronted with patients who demand successful treatment, physicians need to judge potential treatment options with regard to their reported efficiency, as well as their suitability for the individual patient. The dilemma of assessing treatment outcomes and options in ISHL will be discussed regarding a lack of knowledge of the disease's etiology, contradictory clinical evidence, high spontaneous recovery rate, and possible placebo effects. In conclusion, there is a dearth of structured research adhering to a common protocol, which makes comparison of trials and assessment of potential treatment outcomes difficult. Further research is warranted, taking some key recommendations into consideration.     

Spiradenokarzinom der Stirn

Spiradenocarcinomas are rare malignant tumors that originate from the sweat glands of the skin and demonstrate aggressive growth. We report the case of an 86-year-old female patient presenting with a growth on the forehead which had been apparent for 2 years. After surgical removal of the tumor, histological workup culminated in the diagnosis of a spiradenocarcinoma. Surgical margins were free of tumor on pathological examination. Metastasis was excluded by positron-emission tomography–computed tomography (PET-CT). Due to the advanced age of the patient and the absence of metastatic disease, no adjuvant therapy was performed. Six months postoperatively there is no evidence of relapse.     

Lesbarkeit von medizinischen Texten im Internetangebot deutscher HNO-Universitätskliniken

Background

A certain proportion of the population has limited literacy skills; therefore, it is important that any patient information published on the internet is readable to the majority of patients for whom the information is intended.

Materials and methods

Texts for 10 representative ear nose and throat (ENT) topics were extracted from each website of the 36 German ENT university hospitals. The texts were systematically analyzed by use of the German version of the Flesch ease of reading index. The texts of two topics were additionally analyzed with four more readability tools for the German language. Texts were analyzed in relation to the topic and to the geographical region.

Results

On average the texts of 185 websites consisted of 34 sentences and 401 words. Comparably, texts on cochlear implants showed the best readability scores and texts on middle ear pathology the worst. The results of the reading ease index and of the other reading analysis tools showed that all texts require a relatively high literacy level.

Conclusions

To fulfil the ambition of informing the general population about medical issues in an adequate way, a revision of most medical texts on websites of German ENT departments at university hospitals is recommended.     

Analysis of the dura involvement in cholesteatoma surgery

Objective

The involvement of the dura is a rare yet potentially life-threatening complication during cholesteatoma surgery. Thus, the knowledge about treatment and consequences of this issue is of great importance to every ear surgeon.

Hazard of CO2 laser-induced airway fire in laryngeal surgery: experimental data of contributing factors

In carbon dioxide (CO₂) laser surgery of the larynx, the potentially dangerous combination of laser-induced heat in an oxygen-enriched atmosphere typically occurs when jet ventilation is used or due to an insufficiently blocked endotracheal tube. Until now, no limitations for safe oxygen concentrations or laser intervals have been established. The aim of this study was to investigate and quantify the factors that may contribute to an airway fire in laryngeal laser surgery. Fat, muscle and cartilage were irradiated with a CO₂ laser at 2, 4, 6 and 8 W in five different oxygen concentrations with and without smoke exhaustion. The time to ignition was recorded for each different experimental setup. Fat burnt fastest, followed by cartilage and muscle. The elevation of laser energy or oxygen concentration reduced the time to inflammation of any tissue. The elevation of oxygen by 10 % increases the risk of inflammation more than the elevation of laser power by 2 W. Under smoke exhaustion, inflammation and burning occurred delayed or were even inhibited at lower oxygen concentrations. Lasing in more than 50 % oxygen is comparatively dangerous and can cause airway fire in less than 5 s, especially when laser energies of more than 5 W are applied. In equal or lower than 50 % oxygen, an irradiation interval of 5 s can be considered a comparatively safe time limit to prevent inflammation in laryngeal laser surgery. Smoke exhaustion should always be applied.