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1.
Combined Hepatectomy and Radiofrequency Ablation for Multifocal Hepatocellular Carcinomas: Long-term Follow-up Results and Prognostic Factors 总被引:1,自引:1,他引:0
Choi D Lim HK Joh JW Kim SJ Kim MJ Rhim H Kim YS Yoo BC Paik SW Park CK 《Annals of surgical oncology》2007,14(12):3510-3518
Background For multifocal hepatocellular carcinomas (HCCs) that are untreatable with resection only, locoregional therapies added to
hepatectomy have been introduced. However, some preliminary reports have documented average survival results and relatively
high complication rates. We evaluated the long-term survival results and safety of combined hepatectomy and radiofrequency
ablation (RFA) in patients with HCCs and assessed the prognostic factors affecting their survival.
Methods A total of 53 patients who had 148 HCCs in their livers underwent hepatectomy combined with ultrasound-guided intraoperative
RFA. The mean diameter of the 82 resected tumors was 4.8 cm (range 1.3–21.0 cm) and that of 66 ablated tumors was 1.5 cm (range
0.8–3.5 cm). We evaluated the primary effectiveness rates, survival rates, and complications. In addition, we assessed the
prognostic factors associated with the survival rates using Cox proportional hazard models.
Results The primary effectiveness rate of RFA was 98% (65 of 66). Local tumor progression was observed in two (3%) ablation zones
of 65 tumors with complete primary effectiveness. The cumulative survival rates at 1, 2, 3, 4, and 5 years were 87, 83, 80,
68, and 55%, respectively. Patients with smaller resected tumors (≤5 cm) demonstrated better survival results (P = 0.004). No procedure-related deaths occurred. We observed hepatectomy-related complications in 4 patients (8%, 4 of 53)
and an RFA-related complication in 1 patient (2%, 1 of 53).
Conclusions Combined hepatectomy and RFA is an effective and safe treatment modality for multifocal HCCs. Resected tumor size was a significant
prognostic predictor of long-term survival. 相似文献
2.
Kelvin K. Ng Ronnie T. Poon Chung-Mau Lo Jimmy Yuen Wai Kuen Tso Sheung-Tat Fan 《Journal of gastrointestinal surgery》2008,12(1):183-191
Background Radiofrequency ablation (RFA) is an effective local ablation therapy for hepatocellular carcinoma (HCC) with favorable long-term
outcome. There is no data on the analysis of recurrence pattern and its influence on long-term survival outcome after RFA
in HCC patients.
Aim of Study To evaluate the tumor recurrence pattern and its influence on long-term survival in patients with HCC treated with RFA.
Patients and Methods From April 2001 to January 2005, 209 patients received RFA using internally cooled electrode as the sole treatment modality
for HCC. Among them, 117 patients (56%) had unresectable HCC because of bilobar disease, poor liver function, and/or high
medical risk for resection; whereas 92 patients (44%) underwent RFA as the primary treatment for small resectable HCC. The
ablation procedure was performed through percutaneous (n = 101), laparoscopic (n = 17), or open approaches (n = 91). The tumor recurrence pattern and long-term survival were analyzed. Multivariate analysis was carried out to identify
independent prognostic factors affecting the overall survival of patients.
Results The mortality and morbidity rates were 0.9 and 15.7%, respectively. Complete tumor ablation was achieved in 192 patients (92.7%).
With a median follow-up period of 26 months, local recurrence occurred in 28 patients (14.5%). Same segment and different
segment intrahepatic recurrence occurred in 30 patients (15.6%) and 78 patients (40.6%), respectively. Twenty patients (10.4%)
developed distant extrahepatic metastases. The overall 1-, 3-, and 5-year survival rates were 87.2, 66.6, and 42%, respectively.
Different segment intrahepatic recurrence and distant recurrence after RFA carried significant poor prognostic influence on
overall survival outcome. Using multivariate analysis, Child–Pugh grade (risk ratio [RR] = 2.918, 95% confident interval [CI]
1.704–4.998, p = 0.000), tumor size (RR = 1.231, 95% CI 1.031–1.469, p = 0.021), and pattern of recurrence (risk ratio [RR] = 1.464, 95% CI 1.156–1.987, P = 0.020) were identified as independent prognostic factors for overall survival.
Conclusion The tumor recurrence pattern after RFA carries significant prognostic value in relation to overall survival. Long-term regular
surveillance and aggressive treatment strategy are required for patients with different segment intrahepatic recurrence to
optimize the benefits of RFA. 相似文献
3.
Liang HH Chen MS Peng ZW Zhang YJ Zhang YQ Li JQ Lau WY 《Annals of surgical oncology》2008,15(12):3484-3493
Background Whether percutaneous radiofrequency ablation (PRFA) is as effective as repeat hepatectomy for recurrent small hepatocellular
carcinoma (HCC) in the long-term remains unknown.
Methods We included 110 patients into this study. Each patient had fewer than three recurrent HCCs, with the largest tumor less than
5 cm in diameter. Sixty-six patients with 88 tumors were treated by PRFA and 44 patients with 55 tumors were treated by repeat
hepatectomy.
Results The 1-, 2-, 3-, 4-, and 5-year overall survival rates after repeat hepatectomy and PRFA were 78.6%, 56.8%, 44.5%, 30.7%, and
27.6%, and 76.6%, 48.6%, 48.6%, 39.9%, and 39.9%, respectively (P = 0.79). The 1-, 2-, 3-, 4-, and 5-year overall survival rates after the initial hepatectomy for the two groups were 95.4%,
79.1%, 65.0%, 50.4%, and 42.9%, and 98.5%, 85.0%, 70.8%, 58.7%, and 55.6%, respectively, (P = 0.18). Subgroup analyses showed that there was no significant difference between the overall survivals of the two groups
of patients when the interval of tumor recurrence from the initial hepatectomy was ≤1 year (P = 0.74) or >1 year (P = 0.69), and for recurrent tumor ≤3 cm (P = 0.62) or >3 cm (P = 0.57). Major complications happened significantly more often after repeat hepatectomy than PRFA (30 of 44 versus 2 of 66,
P < 0.05). The interval of recurrence from the initial hepatectomy, the diameter of the recurrent tumor and the serum albumin
level were significant prognostic factors for overall survival.
Conclusion PRFA was as effective as repeat hepatectomy in the treatment of recurrent small HCC. PRFA had the advantage over repeat hepatectomy
in being less invasive. 相似文献
4.
经皮射频消融治疗复发性肝癌的预后分析 总被引:1,自引:0,他引:1
目的 探讨影响经皮射频消融(PRFA)治疗复发性肝癌预后的影响因素.方法 1999年1月至2008年12月共有82例复发性肝癌患者(单个肿瘤最大径≤7 cm;多个肿瘤者最大径≤5 cm且肿瘤数目≤3个)接受PRFA治疗,收集其临床及病理学特征等12项可能影响预后的因素作回顾性单因素与多因素分析.结果 全组患者1、3、5年生存率分别是75.8%、43.9%、34.5%(从PRFA术后算起)和95.1%、63.2%、46.6%(从初次手术算起);单因素分析显示初次肿瘤大小、复发期限长短、复发肿瘤数目、复发肿瘤大小、血清谷氨酰转肽酶(GGT)和白蛋白(ALB)水平与复发性肝癌行PRFA的预后有相关性(P<0.05);进一步行Cox模型多因素分析得出与预后相关因素为复发期限长短、复发肿瘤大小、血清GGT与ALB水平(P<0.05).结论 PRFA治疗复发性肝癌疗效确切,复发期限、复发肿瘤大小、血清GGT与ALB水平为其显著性预后影响因子. 相似文献
5.
Lam VW Ng KK Chok KS Cheung TT Yuen J Tung H Tso WK Fan ST Poon RT 《Annals of surgical oncology》2008,15(3):782-790
Background Complete ablation rates after a single session of radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) vary from
48% to 97%. Limited data are available regarding risk factors and prognostic significance of incomplete ablation.
Methods Between April 2001 and March 2006, 298 patients underwent RFA of 393 HCC nodules with an intent of complete ablation after
a single session. Risk factors for incomplete ablation and its effect on overall survival were analyzed.
Results Two hundred seventy-three (91.6%) underwent complete tumor ablation, whereas the other 25 (8.4%) underwent incomplete tumor
ablation after a single session of RFA. By multivariate analysis, tumor size >3 cm (P = .049) was found to be the only independent risk factor for incomplete ablation. There was no statistically significant
difference in overall survival between patients with complete and incomplete ablation. By univariate analysis, no previous
transarterial chemoembolization (TACE), preoperative serum alfa-fetoprotein ≤100 μg/mL, and complete response after further
treatment of incomplete ablation were associated with better overall survival in patients with incomplete ablation.
Conclusions This study demonstrated that incomplete ablation after RFA of HCC was associated with tumor size >3 cm. Our data also suggest
that aggressive further treatment of tumors with incomplete ablation aiming at complete tumor response improves overall survival. 相似文献
6.
Percutaneous thermal ablation for recurrent hepatocellular carcinoma after hepatectomy 总被引:7,自引:0,他引:7
Lu MD Yin XY Xie XY Xu HX Xu ZF Liu GJ Kuang M Zheng YL 《The British journal of surgery》2005,92(11):1393-1398
BACKGROUND: Tumour ablation using a thermal energy source has shown promising results, and is particularly suitable for recurrent hepatocellular carcinoma (HCC). The present study evaluated long-term outcomes after percutaneous thermal ablation for recurrent HCC following liver resection. METHODS: Radiofrequency ablation or microwave ablation was used to treat a total of 124 tumour nodules (0.9-7.0 cm in diameter) in 72 patients with recurrent HCC. RESULTS: Complete ablation of 119 (96.0 per cent) of 124 tumour nodules was achieved. There was no treatment-related death and the major complication rate was 4 per cent. During a mean(s.d.) follow-up of 27.9(17.8) months, local recurrence developed in 16 (13.6 per cent) of 118 successfully treated tumour nodules. Distant recurrence developed in 60 (85 per cent) of 71 patients, of whom 26 had repeat metachronous distant recurrence. With repeated ablation for both local and distant recurrence, the 1-, 3- and 5-year overall survival rates after initial ablation were 75, 43 and 18 per cent respectively. Patients with a serum alpha-fetoprotein level greater than 200 ng/ml before treatment had significantly poorer survival than those with a lower level (P = 0.034) and multivariate analysis identified preablation AFP level as an independent prognostic factor (P = 0.054). CONCLUSION: With their advantages of preservation of non-tumorous liver tissue and easy repetition, percutaneous thermal ablative therapies were particularly suitable for recurrent HCC and improved long-term survival. 相似文献
7.
Suh KS 《Journal of Hepato-Biliary-Pancreatic Surgery》2005,12(5):365-370
Background/Purpose Systematic hepatectomy for small hepatocellular carcinoma (HCC) is a widely preferred modality, but evidence concerning its
benefits is lacking. The aim of this study was to document hepatic resection for small HCC in Korea, and to determine whether
patient survival or the pattern of tumor recurrence was influenced by the methods used.
Methods Ten major hospitals that perform hepatectomy for HCC in Korea were surveyed for surgeons' opinions concerning systematic hepatectomy
and current trends in hepatic resection for small HCC. An analysis was also performed of 119 patients who underwent curative
hepatectomy for small HCC (size < 5 cm) between January 2000 and December 2002 at Seoul National University Hospital. Seventy-four
of these 119 patients underwent anatomical resection (AR) and 45 had a nonanatomical resection (NAR). Recurrence-free survival,
recurrence pattern, overall survival rates, and the risk factors for recurrence were analyzed.
Results In the survey, eight of ten surgeons preferred systematic hepatectomy and considered it to aid prognosis. No significant difference
was found between the AR and NAR groups in terms of the clinicopathologic findings, except that the presence of underlying
hepatic cirrhosis was more prevalent in the NAR group. The postoperative morbidity rate was higher in the NAR group (33.3%
vs 27.0%), but this difference was not statistically significant. The respective 1- and 3-year recurrence-free survival rates
were 78.1% and 49.7% in the AR group, and 68.9% and 46.5% in the NAR group (P > 0.05). The corresponding 1- and 3-year overall survival rates were 88.8% and 80.8% in the AR group and 91.0% and 71.4%
in the NAR group (P > 0.05).
Conclusions Although systematic hepatectomy seems to be superior to nonanatomical hepatectomy from the oncological and anatomical aspects,
this superiority is not reflected by the recurrence patterns or the survival and recurrence rates of the two procedures. Postoperative
recurrence appears, rather, to be related to the underlying liver condition. 相似文献
8.
Prognostic factors after repeat hepatectomy for recurrent hepatocellular carcinoma. 总被引:14,自引:1,他引:13
M Shimada K Takenaka K Taguchi Y Fujiwara T Gion K Kajiyama T Maeda K Shirabe K Yanaga K Sugimachi 《Annals of surgery》1998,227(1):80-85
OBJECTIVE: The aims of this study were to identify prognostic factors in patients who developed recurrent hepatocellular carcinoma (HCC) after repeat hepatectomy and to elucidate the role of multicentric occurrence in the second tumor after a first hepatectomy. SUMMARY BACKGROUND DATA: A repeat hepatectomy for recurrent HCC has been established as the most effective treatment modality, whenever it is possible. However, the prognostic factors for recurrent HCC after repeat hepatectomy have yet to be clarified. METHODS: Forty-one patients who underwent a curative repeat hepatectomy were retrospectively studied. Patient survival and disease-free survival after recurrence were univariately and multivariately analyzed using 38 clinicopathologic variables. The histologic grade of HCC at repeat hepatectomy was also compared with that at first hepatectomy. RESULTS: Patient survival after repeat hepatectomy did not differ substantially from that in 312 patients undergoing primary hepatectomy. However, the disease-free survival after repeat hepatectomy was significantly lower than that in patients with only a primary hepatectomy (p < 0.05). Multivariate analysis revealed only portal vein invasion in the first hepatectomy to be an independent and significantly poor prognostic factor. Regarding multicentric occurrence at repeat hepatectomy, only 6 of 40 patients (15%) whose specimens could be evaluated histologically were determined to be Edmondson and Steiner's Grade 1. CONCLUSIONS: The only prognostic factor identified in patients with recurrent HCC after repeat hepatectomy was portal vein invasion in the first hepatectomy. Most second tumors after the first hepatectomy are considered to be caused by metastatic recurrence, not by multicentric occurrence. 相似文献
9.
Surgical Resection Versus Radiofrequency Ablation in the Treatment of Small Unifocal Hepatocellular Carcinoma 总被引:1,自引:0,他引:1
M. Abu-Hilal J. N. Primrose A. Casaril M. J. W. McPhail N. W. Pearce N. Nicoli 《Journal of gastrointestinal surgery》2008,12(9):1521-1526
Background Hepatocellular carcinoma (HCC) has a high worldwide prevalence and mortality. While surgical resection and transplantation
offers curative potential, donor availability and patient liver status and comorbidities may disallow either. Interventional
radiological techniques such as radiofrequency ablation (RFA) may offer acceptable overall and disease-free survival rates.
Materials and Methods Sixty-eight cirrhotic patients matched for age, sex, tumor size, and Child–Pugh grade with small (1–5 cm) unifocal HCC were
studied retrospectively to find determinants of overall and disease-free survival in those treated with surgical resection
and RFA between 1991 and 2003.
Results Multivariate analysis using Cox proportional regression modeling showed that overall survival was related to tumor recurrence
(p = 0.010), tumor diameter (p = 0.002), and treatment modality (p = 0.014); overall p = 0.008. Recurrence was independently related to the use of RFA over surgery (p = 0.023) on multivariate analysis; overall p = 0.034.
Conclusion Surgical resection offers longer disease-free survival and potentially longer overall survival than RFA in patients with small
unifocal HCC. 相似文献
10.
Radiofrequency Ablation Versus Surgical Resection for the Treatment of Hepatocellular Carcinoma in Cirrhosis 总被引:2,自引:0,他引:2
Alfredo Guglielmi Andrea Ruzzenente Alessandro Valdegamberi Silvia Pachera Tommaso Campagnaro Mirko D’Onofrio Enrico Martone Paola Nicoli Calogero Iacono 《Journal of gastrointestinal surgery》2008,12(1):192-198
Background and Aims Percutaneous radiofrequency ablation (RFA) demonstrated good results for the treatment of hepatocellular carcinoma (HCC) in
cirrhotic patients; it is still not clear whether the overall survival and disease-free survival after RFA are comparable
with surgical resection. The aims of this study are to compare the overall survival and disease-free survival in two groups
of cirrhotic patients with HCC submitted to surgery or RFA.
Methods Two hundred cirrhotic patients with HCCs smaller than 6 cm were included in this retrospective study: 109 underwent RFA and
91 underwent surgical resection at a single Division of Surgery of University of Verona.
Results Median follow-up time was 27 months. Overall survival was significantly longer in the resection group in comparison with the
RFA group with a median survival of 57 and 28 months, respectively (P = 0.01). In Child–Pugh class B patients and in patients with multiple HCC, survival was not significantly different between
the two groups. In patients with HCC smaller than 3 cm, the overall survival and disease-free survival for RFA and resection
were not significantly different in univariate and multivariate analysis. Whereas in patients with HCC greater than 3 cm,
surgery showed improvement in outcome in both univariate and multivariate analysis.
Conclusions Surgical resection significantly improves the overall survival and disease-free survival in comparison with RFA. In a selected
group of patients (Child–Pugh class B, multiple HCC, or in HCC ≤3 cm), the results between the two treatments did not show
significant differences. 相似文献
11.
Masaki Ueno Kazuhisa Uchiyama Satoru Ozawa Takayuki Nakase Naoki Togo Shinya Hayami Hiroki Yamaue 《Surgery today》2009,39(8):675-681
Purpose To evaluate the prognostic impact of various therapeutic modalities, such as repeat hepatectomy, ablation therapy, and transcatheter
arterial chemoembolization (TACE) therapy, used to treat single nodular recurrent hepatocellular carcinoma (HCC).
Methods Thirty-two patients with single nodular intrahepatic recurrence after curative primary resection of HCC were enrolled in this
study. The prognostic factors after recurrence were established using 13 clinicopathologic variables, including the therapeutic
modalities; namely, repeat hepatectomy, ablation therapy, or TACE therapy.
Results Of the 32 patients, 9 underwent repeat hepatectomy, 10 underwent ablation therapy, and 13 underwent TACE therapy. The therapeutic
modality was the only prognostic factor. In comparison with TACE therapy, the relative risks associated with ablation therapy
and repeat hepatectomy were 0.19 and 0.29, respectively. The 5-year survival rates after single nodular recurrence were 57%
in the ablation therapy group, 29% in the repeat hepatectomy group, and 0% in the TACE therapy group.
Conclusions Repeat hepatectomy and ablation therapy are more effective than TACE therapy for improving the prognosis of patients with
single nodular intrahepatic recurrent HCC. 相似文献
12.
巨大肝癌的外科治疗 总被引:3,自引:0,他引:3
目的 探讨巨大肝癌(直径≥10cm)手术切除的安全性、可行性和治疗结果。方法 分析我院手术治疗大肝癌103例的效果。比较巨大肝癌与直径<10cm一般肝癌切除组(34例)、以及巨大肝癌的切除组(68例)和非切除组(35例)的手术并发症、生存率。结果 巨大肝癌切除组与一般肝癌切除组的手术时间与出血量均无明显差异,手术并发症、死亡率三组间也无差异。一般肝癌组、巨大肝癌切除组与非切除组术后1、3、5年生存率分别为78.64%、53.73%、23.76%;72.8%、47.84%、21.26%及32.56%、11.37%、5.45%。后两者差异有显著的统计学意义(P<0.05)。结论 对巨大肝癌的手术切除应持积极态度,一期切除能获得良好的治疗效果,如同时施行综合治疗可提高巨大肝癌远期疗效。 相似文献
13.
Ferrero A Viganò L Polastri R Ribero D Lo Tesoriere R Muratore A Capussotti L 《World journal of surgery》2005,29(9):1101-1105
In recent decades liver resection has become a safe procedure; however, the outcome of hepatectomies in aged cirrhotic patients
is often uncertain. To elucidate early and long-term outcomes of hepatectomy for HCC in the elderly, we studied 241 cirrhotic
patients who underwent liver resection for HCC between 1985 and 2003. According to their age at the time of surgery, patients
were divided into two groups: aged > 70 years (64 patients) and aged ≤ 70 years (177 patients). Operative mortality was 3.1%
in the elderly and 9.6% in the younger group (p = 0.113). Postoperative morbidity and liver failure rates were higher in the younger group (42.4% versus 23.4%, p = 0.0073; 12.9% versus l.6%, p = 0.0065). Five-year survival rates are 48.6% in the elderly group and 32.3% in the younger group (p = 0.081). Considering only radical resections in Child-Pugh A patients, survival remains similar in the two groups (p = 0.072). Disease-free survival is not different in the two groups. A survival analysis performed according to the tumor
diameter shows a better survival for elderly Child-Pugh A patients with HCC larger than 5 cm radically resected (50.8% versus 16.1% 5-year survival, p = 0.034). In univariate analysis, tumor size is not a prognostic factor in the elderly, whereas younger patients with large
tumors have a worse outcome. Age by itself is not a contraindication for surgery, and selected cirrhotic patients with HCC
who are 70 years of age or older could benefit from resection, even in the presence of large tumors. Long-term results of
liver resections for HCC in the elderly may be even better than in younger patients. 相似文献
14.
Kentaroh Yamamoto MD Hiroshi Imamura MD Yutaka Matsuyama PhD Kiyoshi Hasegawa MD Yoshifumi Beck MD Yasuhiko Sugawara MD Masatoshi Makuuchi MD Norihiro Kokudo MD 《Annals of surgical oncology》2009,16(10):2795-2804
Background
Alpha-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) are well-known tumor markers of hepatocellular carcinoma (HCC). The aims of this study are to calculate the sensitivity/specificity of AFP and DCP measurement for the diagnosis of HCC, measure response rates of the markers following curative-intent resections, determine the correlations between the marker levels and clinicopathological prognostic variables, and determine the correlations between the marker levels before hepatectomy and those at diagnosis of recurrence. 相似文献15.
Repeat hepatectomy for recurrent hepatocellular carcinoma 总被引:4,自引:0,他引:4
BACKGROUND: Long-term prognosis of patients with hepatocellular carcinoma (HCC) after partial hepatectomy remains unsatisfactory because of the high incidence of recurrence in the liver remnant. Controversy exists about the efficacy of repeat hepatectomy for recurrent HCC patients. The purpose of this study was to retrospectively examine and clarify the significance of repeat hepatectomy in the treatment of recurrent HCC. METHODS: From January 1990 to December 2004, 84 patients with recurrent HCC underwent a second hepatectomy with curative intent. Survival rates in these 84 patients were analyzed retrospectively. RESULTS: After the second hepatectomy, the overall 5-year survival rate was 50% for the 84 patients included in this study; the corresponding recurrence-free survival rate was 10%. Multivariate analysis showed that the second hepatectomy performed between 1997 and 2004 (P < .001) and the absence of microscopic vascular invasion at the second hepatectomy (P = .001) were the significant and independent prognostic factors for overall survival after the second hepatectomy. The overall 5-year survival rate after the second hepatectomy was 80% in 46 patients who had both these prognostic factors. However, even in the subgroup with good long-term survival, the 5-year recurrence-free survival rate was only 6%. The more times hepatectomy was repeated, the shorter the recurrence-free interval became. CONCLUSIONS: Repeat hepatectomy for recurrent HCC had survival benefits, especially for patients without microscopic vascular invasion. However, the incidence of re-recurrence after the second hepatectomy was high, and the recurrence-free interval was short, even in the subgroup with survival benefits. The effectiveness of repeat hepatectomy for curing recurrent HCC is limited. 相似文献
16.
The survival of 200 patients (172 males, 28 females; mean age ± SD: 53.6 ± 12 years) who underwent hepatectomy for hepatocellular carcinoma (HCC) was analyzed retrospectively to identify prognostic determinants to guide patient selection for appropriate treatment. All patients studied had had complete macroscopic extirpation of their tumor, histologic information regarding their lesions and the adjacent non-tumorous liver parenchyma, and no evidence of residual or recurrent disease 30 days after surgery. Survival was analyzed with reference to 25 different clinical (n=7), serological (n=2), macroscopic (n=4), and histological (n=12) features of the resected specimens, by using multivariate analysis. Recurrent HCC was detected in 138 patients within a median follow-up period of 12.6 months. While 33 patients had extra-hepatic disease alone, in 74, the recurrence was confined to the hepatic remnant. Survival at 1, 3, and 5 years was 58%, 34%, and 26%, respectively. The presence of residual histologic disease at the resection margin was found to be the only important prognostic determinant (P < 0.02). The distance of the macroscopic resection margin, either at 1 or 2 cm, made no difference to the long-term outcome of our patients. Following hepatectomy, a detailed pathologic examination of the resected liver specimen is mandatory to verify the status of disease clearance, as the distance of the gross surgical margin is an unreliable index. 相似文献
17.
18.
Purpose
The risk factors of local recurrence after complete radiofrequency ablation (RFA) of hepatitis B-related small hepatocellular carcinoma (HCC), ≤3 cm, remains to be clarified. In this study, we evaluated the potential prognostic factors that affect recurrence. 相似文献19.
Anon Chotirosniramit Akkaphod Liwattanakun Sunhawit Junrungsee Wasana Ko-iam Trichak Sandhu Worakitti Lapisatepun 《肝胆外科与营养》2020,9(6):729
BackgroundHepatocellular carcinoma (HCC) presenting with macroscopic bile duct tumor thrombus (BDTT) is an uncommon event. The role of a curative hepatic resection and associated long-term outcomes remain controversial. In addition the necessity for bile duct resection is still unclear. The aim of this study was to evaluate outcomes of hepatectomy with a selective bile duct preservation approach for HCC with BDTT in comparison to outcomes without BDTT.MethodsA total of 22 HCC with BDTT patients who had undergone curative hepatic resection with a selective bile duct preservation approach at our institute were retrospectively reviewed. These were compared to group of 145 HCC without BDTT patients. The impact of curative surgical resection and BDTT on clinical outcomes and survival after surgical resection were analyzed.ResultsAll HCC with BDTT cases underwent major hepatectomy vs. 32.4% in the comparative group. Bile duct preservation rate was 56.5%. The 1-, 3- and 5-year survival rates of HCC with BDTT patients in comparison to the HCC without BDTT group were 81.8%, 52.8% and 52.8% vs. 73.6%, 55.6% and 40.7% (P=0.804) respectively. Positive resection margin, tumor size ≥5 cm and AFP ≥200 IU/mL were significant risk factors regarding overall survival. However, it is unclear whether presence of a bile duct tumor thrombus has an adverse impact on either recurrence free survival or overall survival.ConclusionsBile duct obstruction from tumor thrombus did not necessarily indicate an advanced form of disease. Tumor size and AFP had greater impact on long-term outcomes than bile duct tumor thrombus. Major liver resection with a selective bile duct preserving approach in HCC with BDTT can achieve favorable outcomes comparable to those of HCC without BDTT in selected patients. 相似文献
20.
目的:评价经皮射频消融术(RFA)治疗复发性肝癌的疗效及安全性。
方法:回顾性分析2008年5月—2014年3月期间79例行经皮RFA治疗的肝癌复发患者临床资料,79例患者复发病灶共106个,病灶大小0.8~5.0cm,平均(2.8±1.0)cm。
结果:消融治疗成功率为98.1%,肿瘤完全消融率94.2%。术后常见不良反应为发热(72.7%)、肝区疼痛(90.9%)、胃肠道症状(20.8%)、黄疸(6.5%),无肝功能衰竭、胆瘘、感染、出血等严重并发症,无围手术期死亡病例。术后住院时间1~5d,平均(2.2±1.0)d。术后随访7~64个月,平均(38±14)个月,54例出现复发,复发率70.1%。术后1、3年生存率分别为89.6%、66.2%。
结论:经皮RFA治疗复发性小肝癌是一种安全有效的微创治疗方法,可优先考虑作为该病治疗的术式选择。 相似文献
方法:回顾性分析2008年5月—2014年3月期间79例行经皮RFA治疗的肝癌复发患者临床资料,79例患者复发病灶共106个,病灶大小0.8~5.0cm,平均(2.8±1.0)cm。
结果:消融治疗成功率为98.1%,肿瘤完全消融率94.2%。术后常见不良反应为发热(72.7%)、肝区疼痛(90.9%)、胃肠道症状(20.8%)、黄疸(6.5%),无肝功能衰竭、胆瘘、感染、出血等严重并发症,无围手术期死亡病例。术后住院时间1~5d,平均(2.2±1.0)d。术后随访7~64个月,平均(38±14)个月,54例出现复发,复发率70.1%。术后1、3年生存率分别为89.6%、66.2%。
结论:经皮RFA治疗复发性小肝癌是一种安全有效的微创治疗方法,可优先考虑作为该病治疗的术式选择。 相似文献