手部不同部位的交感神经皮肤反应

目的 探讨手部不同部位交感神经皮肤反应(sympathetic skin responses,SSR)的差别和临床意义.方法 以64例健康志愿者为研究对象,采用神经肌电图电刺激方法引出SSR,分别在掌心、示指和小指指腹记录潜伏期和波幅,并进行统计学分析.结果 60例志愿者中(4例未能入选)掌心、示指和小指指腹均可记录到SSR波形,三者潜伏期分别为(1.37±O.16)s、(1.54±0.24)s和(1.60±0.25)s,三者差异有统计学意义(P<0.01);波幅分别为(3.85±2.55)mV、(2.24±1.63)mV和(2.51±2.00)mV,三者差异有统计学意义(P<0.05);但示、小指间SSR潜伏期和波幅差异无统计学意义(P>0.05).结论 SSR潜伏期稳定,是判定SSR正常与否的可靠检测指标;示、小指指腹亦可作为SSR记录部位,可能分别代表正中神经和尺神经通路上的交感神经皮肤反应.     

脱细胞异体真皮在阴茎增粗效果下对原发性早泄的影响

目的探讨应用人脱细胞异体真皮(human acellular dermal mantrix,HADM)在阴茎增粗方案中治疗男性原发性早泄的疗效及安全性。方法采用回顾性分析我院2017年3月~2019年8月收治的94例原发性早泄患者,通过阴茎神经电生理结果划分阴茎皮肤高敏感型及混合型早泄患者作为本次课题研究对象,评估内容包括手术前后阴茎体感诱发电位(DNSEP/GPSEP)潜伏期、阴茎交感皮肤反应(PSSR)潜伏期、阴茎中段周径(疲软)、中国早泄指数-5评分(CIPE-5)、阴道内射精潜伏期(IELT)、国际勃起功能评分问卷-5(IIEF-5)以及患者与性伴侣的满意度。结果对比患者术前及术后3月各项指标,除IIEF-5外,术后患者阴茎中段周径(疲软)明显增粗、阴茎体感诱发电位(DNSEP/GPSEP)潜伏期、阴茎交感皮肤反应(PSSR)潜伏期、IELT明显延长、CIPE-5及性伴侣的满意度明显改善,有统计学意义(P<0.05)。结论在应用脱细胞异体真皮阴茎增粗方案中,治疗男性原发性阴茎皮肤高敏感型及混合型早泄效果显著,患者阴道内射精潜伏期时间明显增长,同时,性生活质量显著提升,并发症极少,安全有效。因此,值得在当今临床中应用和推广。     

不同刺激间隔对全麻患者经颅磁刺激运动诱发电位监测的影响

目的 评价不同刺激间隔对全麻患者经颅磁刺激运动诱发电位（TMS-MEP）监测的影响。方法 择期脊髓手术患者20例，ASAⅠ或Ⅱ级，静脉注射异丙酚2mg／kg、芬太尼2μg，kg、氯化琥珀胆碱2mg／kg麻醉诱导，气管插管后机械通气，持续输注异丙酚5mg·kg^-1·h^-1、芬太尼1μg·kg^-1·h^-1维持麻醉至试验结束。在麻醉前、后分别记录2、5、10ms（分别为500、200、100Hz）刺激间隔下4次刺激引出的复合肌肉动作电位（CMAP）的波幅和潜伏期。结果 麻醉前：与2ms相比，5ms刺激间隔下CMAP波幅差异无统计学意义（P〉0．05），与2In8和5In8相比，10ms刺激间隔下CMAP波幅减小（P〈0．05）；麻醉后：与2ms相比，5、10ms刺激间隔下CMAP波幅减小（P〈0．05），与5ms相比，10ms刺激间隔下CMAP波幅减小（P〈0．05）。麻醉前、后各刺激间隔下CMAP潜伏期差异无统计学意义（P〉0．05）。麻醉后5ms刺激间隔下2例患者未记录到CMAP，10ms刺激间隔下4例患者未记录到CMAP。结论 采用2ms刺激间隔下对全麻患者4次经颅磁刺激可在靶肌肉上记录到最大的CMAP波幅，更适用于全麻患者术中施行经颅磁刺激运动诱发电位监测，可有效对抗异丙酚静脉麻醉对运动诱发电位的抑制作用，增加运动诱发电位监测的准确性。     

阴茎背神经选择性切断术对阴茎头体感诱发电位的影响

目的 研究阴茎背神经选择性切断术对阴茎头体感诱发电位(GPSEP)的影响.方法 原发性早泄(PPE)患者21例,分别检测手术前及术后1个月、3个月GPSEP的潜伏期和波幅变化.结果 阴茎背神经选择性切断术后患者的GPSEP潜伏期比术前显著延迟(P<0.05),GPSEP振幅也较术前降低,差异具有统计学意义(P<0.05).结论 阴茎背神经选择性切断术可降低PPE患者GPSEP.     

前列腺与会阴盆底联系的电刺激研究

目的　探讨前列腺炎疼痛产生的神经机理以及疼痛产生与盆底肌功能障碍的关系。　方法　电刺激大鼠前列腺 ,记录腰骶神经反射性动作电位和肛门外括约肌的肌电变化。　结果　电刺激大鼠前列腺后 ,同侧生殖股、髂腹股沟、髂腹下、股外侧皮神经的动作电位阳性率分别为 93 .3 % ,55.5% ,16.6%和 10 .0 % ,潜伏期 4～ 8ms ,波幅 2 0～ 180 μV ;横断颈髓后动作电位下降至 (95.4± 13 .7) % ;动物死亡后动作电位立即消失 ;切除腰骶交感干后动作电位波幅下降至 (2 5.8± 9.7) % ;93 .3 %大鼠在肛门括约肌记录到较为恒定的复合肌肉动作电位 ,潜伏期 (13 .2± 4.7)ms。　结论　前列腺受刺激后可通过脊髓反射经生殖股、髂腹股沟神经等腰骶神经传出 ,引起会阴、盆底肌肉收缩并形成会阴部的牵涉痛。前列腺炎疼痛与神经 盆底肌功能障碍密切相关 ,从调节神经肌肉功能着手治疗前列腺疼痛是十分有前景的策略     

黄芪对兔周围神经再灌注损伤的保护作用

目的　探讨黄芪注射液对家兔周围神经缺血再灌注损伤的影响。方法　 40只家兔建立周围神经再灌注模型 ,随机分成 5组 :对照组、缺血组、再灌注组、黄芪治疗Ⅰ组、黄芪治疗Ⅱ组 ,动态观察坐骨神经相应各项指标变化。结果　随制成血再灌注时间延长 ,缺血组、再灌注组运动神经传导速度分别减慢为 ( 4 .10 2± 0 .992 )m/s、( 5 .898± 8.891)m /s ,动作电位波幅分别降低为( 4 .2 71± 1.0 71)mV、( 2 .2 5 2± 1.5 2 7)mV ,潜伏期延长为 ( 1.92 1± 0 .2 0 4)ms、( 2 .3 93± 0 .2 3 1)ms ;组织超氧化物歧化酶 (SOD)活性降低分别为 ( 18.93± 9.88) μU/L、( 2 8.13± 9.72 ) μU /L、脂质过氧化产物丙二醛 (MDA)含量增加 ( 1.2 9± 0 .2 1) μmol/L、( 4 .2 9± 0 .14 ) μmol/L(P <0 .0 5 ) ,病理改变加重。黄芪Ⅰ组相对缺血组、黄芪Ⅱ组相对再灌注组神经传导速度增快 ( 3 .182± 0 .83 9)ms、( 3 .2 71± 1.0 13 )ms ,动作电位波幅增高 ( 1.867± 0 .5 12 )mV、( 2 .467± 0 .2 19)mV ,潜伏期缩短( 1.3 17± 0 .3 2 4)ms、( 2 .3 87± 0 .175 )ms ;组织SOD活性增加 ( 10 .64± 0 .79) μU/L、( 13 .94± 0 .83 )μU/L ,脂质过氧化产物MDA含量降低 ( 1.69± 0 .0 1)mol/L、( 1.0 6± 0 .2 0 )mol/L ( P <     

模拟膈神经脉冲电刺激促进周围神经再生的研究

目的　研究膈神经生物电脉冲 (BIPN)对周围神经再生的促进作用。方法　新西兰家兔 18只平均分为 3组 ,切断双侧坐骨神经后端端缝合予以电刺激。A组以BIPN刺激与无刺激对照 ;B组以BIPN刺激与方波脉冲刺激对照 ;C组以方波脉冲刺激与无刺激对照。刺激 4周后行足底溃疡直径、神经电生理、胫前肌肌湿重、组织学和电镜超微结构检测。结果　A、B组BIPN侧足底溃疡直径分别为 (16.3 3± 17.17)mm和 (2 2 .3 3± 7.5 0 )mm ,均优于对照侧 (P <0 .0 1,P <0 .0 5 ) ;复合肌肉诱发电位 (CMAP)潜伏期分别为 (1.98± 0 .2 0 )ms和 (1.92± 0 .16)ms ,均优于对照侧 (P <0 .0 5 ) ;A组CMAP波幅为 (0 .18± 0 .0 7)mV ,优于对照侧 (P <0 .0 5 ) ;远端有髓纤维通过率分别为 (62 .44± 6.68) %和 (5 4.48± 5 .0 5 ) % ,均优于对照侧 (P <0 .0 1) ;胫前肌肌湿重分别为(1.67± 0 .2 4)g和 (1.71± 0 .2 5 )g ,均优于对照侧 (P <0 .0 1) ;超微结构观察示BIPN侧再生髓鞘成熟度优于方波脉冲侧 ,更优于无刺激侧。结论　膈神经电脉冲能较明显地促进周围神经再生。     

改良SS-cream对家兔脊髓体感诱发电位的影响

目的研究局部使用改良SS-霜(Re-SS)对脊髓体感诱发电位(SSEP)的影响。方法体重2.5~3.0kg雄性新西兰大白兔40只,随机分为治疗组和安慰剂组。各组动物在阴茎局部涂抹药物前及使用后10、30和60min分别测定电刺激阴茎头诱发SSEP潜伏期(onset,N1)和波幅变化。结果使用Re-SS后30min的SSEP潜伏期(Onest)比用药前和安慰剂显著延迟(P<0.05)。使用Re-SS后各时间点的SSEP潜伏期(N1)比用药前显著延长(P<0.05),用药后30min、60min比安慰剂SSEP潜伏期(N1)延长(P<0.05)。Re-SS组SSPE振幅表现出不同程度降低,但是无显著差异(P>0.05)。结论Re-SS可降低阴茎头感觉神经兴奋性,可能有利于延迟早泄患者的射精反射,延长射精潜伏期,需要进一步的临床研究。     

节段性血管阻断对脊髓传导功能的影响

目的 :探讨阻断节段性血管对脊髓传导功能的影响 ,分析节段性血管阻断时脊髓缺血的高危因素。方法 :对31例胸段脊柱侧凸前路凸侧开胸患者游离节段性血管 ,在距离椎间孔 2 0cm处阻断T5～T1 1的节段性血管 ,于阻断前 5min ,阻断后 2、7、1 2及 1 7min分别记录SEP ,用基本波形、P40潜伏期、P40波幅 (峰 峰 ,峰 基 )对SEP的变化进行评价。结果 :P40波幅 (峰 峰 )在阻断 2min时显著降低 ,平均下降 0 64μV(2 6 1 2 % ) ,而P40潜伏期在 2min及7min显著延长 ,分别延长 1 2 2ms(3 39% )和 0 81ms(2 76 % )。SEP波形在血管阻断后 2、7、1 2及 1 7min时无明显变化 ,均为Ⅲ级或Ⅳ级。结论 :脊柱侧凸前路手术中 ,对于无血管畸形的患者 ,阻断单侧多根节段性血管可暂时影响脊髓传导功能 ,主要发生在阻断后前 7min内 ,此后脊髓传导功能恢复正常 ,并不导致临床上脊髓缺血性功能损害。     

探讨腕管综合征电生理分期的定量指标

目的　探讨并制定腕管综合征早、中、晚 3期电生理的分期定量指标 ,为临床分期提供电生理依据。方法　对临床诊断为腕管综合征患者的 74例 12 0侧 ,测定拇短展肌的肌电图 (EMG) ,正中神经远端运动电位的潜伏期 (distalmotorlatency ,DML) ,1～ 3指的感觉电位 (SNAP) ,以及环指在正中、尺神经上SNAP潜伏期的差值及感觉神经传导速度 ,并对其结果进行分析。结果　早期 :EMG( -)。DML <4 5ms。感觉电位 :正中、尺神经环指感觉电位潜伏期差值异常 (≥ 0 4ms) ,1～ 3指中至少有 1指的波幅较健侧下降超过 1/2。中期 :EMG(± )。DML≥ 4 5ms。感觉电位 :1～ 3指的感觉电位可引出 ,但传导速度减慢 ( <40 0ms)。晚期 :EMG( )。DML明显延长或消长。感觉电位 :1～ 4指中至少有 1指的感觉电位消失。结论　早期和中期腕管综合征的分期指标为DML ,而中期和晚期腕管综合征的分期指标为运动或感觉电位的存在与否。     

Vasopressor hormone response following mesenteric traction during major abdominal surgery

Background : We investigated the vasopressor hormone response following mesenteric traction (MT) with hypotension due to prostacyclin (PGI₂) release in patients undergoing abdominal surgery with a combined general and epidural anesthesia. Methods : In a prospective, randomized, placebo-controlled study we administered 400 mg ibuprofen (i.v.) in 42 patients scheduled for abdominal surgery. General anesthesia was combined with epidural anesthesia (T4-L1). Before as well as 5, 15, 30, 45, and 90 min after MT we recorded plasma osmolality, hemodynamics and measured 6-keto-PGFlα (stabile metabolite of PGI₂), TXB₂ (stabile metabolite of thromboxane A₂) active renin, and arginine vasopressin (AVP) plasma concentrations by radioimmunoassay. Catecholamine levels were assessed by high-pressure liquid chromatography (HPLC) with electrochemical detection. Results : Following MT, arterial hypotension occurred along with a substantial PGI₂ release. This was completely abolished by ibuprofen administration. Although plasma levels of 6-keto-PGF_1α (1133 (708) vs. 60 (3) ng/L, median (median absolute deviation), P=0.0001, placebo vs. ibuprofen) remained significantly elevated, blood pressure was restored within 30 min after MT in the placebo group. At the same point in time plasma concentrations of TXB² (164 (87) vs. 58 (1) ng/L, P=0.0001), epinephrine (46 (33) vs. 14 (6) ng/L, P=0.001), AVP (41 ± (18) vs. 12 (7) ng/L, P=0.0004), and active renin (27 (12) vs. 12 (4) ng/L, P = 0.001) were significantly higher in placebo-treated patients. Conclusion : Under combined general and epidural anesthesia arterial hypotension following MT due to endogenous PGI₂ release is associated with enhanced release of AVP, active renin, epinephrine and thromboxane A₂, presumably contributing to hemodynamic stability within 30 min after MT.     

A Teaspoon Pump for Pumping Blood with High Hydraulic Efficiency and Low Hemolysis Potential

Abstract: Virtually all blood pumps contain some kind of rubbing, sliding, closely moving machinery surfaces that are exposed to the blood being pumped. These valves, internal bearings, magnetic bearing position sensors, and shaft seals cause most of the problems with blood pumps. The original teaspoon pump design prevented the rubbing, sliding machinery surfaces from contacting the blood. However, the hydraulic efficiency was low because the blood was able to "slip around" the rotating impeller so that the blood itself never rotated fast enough to develop adequate pressure. An improved teaspoon blood pump has been designed and tested and has shown acceptable hydraulic performance and low hemolysis potential. The new pump uses a nonrotating "swinging" hose as the pump impeller. The fluid enters the pump through the center of the swinging hose; therefore, there can be no fluid slip between the revolving blood and the revolving impeller. The new pump uses an impeller that is comparable to a flexible garden hose. If the free end of the hose were swung around in a circle like half of a jump rope, the fluid inside the hose would rotate and develop pressure even though the hose impeller itself did not "rotate"; therefore, no rotating shaft seal or internal bearings are required.     

A comparison of the inhibitory effects of four volatile anaesthetics on the metabolism of chlorzoxazone, a substrate for CYP2E1, in rabbits

Background: Halothane inhibits in vitro and in vivo activity of cytochrome P-450 (CYP) 2E1. There are several fluorinated volatile anaesthetics besides halothane, and most of them are defluorinated by CYP2E1. It is unclear whether other fluorinated anaesthetics inhibit the in vivo activity of CYP2E1.
Methods: We compared the inhibitory effects of therapeutic concentrations of four inhalational anaesthetics, halothane, enflurane, isoflurane, and sevoflurane, on chlorzoxazone metabolism in rabbits receiving artificial ventilation.
Results: All four inhalational anaesthetics decreased arterial blood pressure and increased plasma chlorzoxazone concentration. However, no significant differences in the plasma chlorzoxazone concentration were found between the four anaesthetics. The estimated chlorzoxazone clearance increased after beginning inhalation with all four agents, but no significant difference in clearance was noted between agents.
Conclusions: At therapeutic concentrations, the in vivo inhibitory effect on chlorzoxazone metabolism was similar for all four inhalational anaesthetics examined, even though their chemical characteristics and extent of hepatic metabolism differ considerably.     

Microspheres Based Detoxification System: A New Method in Convective Blood Purification

Abstract: A variety of protein-bound or hydrophobic substances, accumulating as a result of pathologic conditions such as exogenous or endogenous intoxications, are removed poorly by conventional detoxification methods because of low accessibility (hemodialysis), insufficient adsorption capabilities (hemosorption), low efficiency (peritoneal dialysis), or economic limitations (high-volume plasmapheresis). Combining advantages of existing methods with microspheric technology, a module-based system was designed. Major operating parameters of the latter can be modified to allow for adjustment to individual clinical situations. An extracorporeal blood circuit including a plasmafilter is combined with a secondary high-velocity plasma circuit driven by a centrifugal pump. Different microspheric adsorbers can be combined in one circuit or applied in sequence. Thus, a prolonged treatment can be tailored using specially designed selective adsorber materials. Comparing this system with existing methods (high-flux hemodialysis, molecular adsorbent recycling system), results from our in vitro studies and animal experiments demonstrate the superior efficiency of substance removal.     

Tissue perfusion in relation to cardiac output during continuous positive-pressure ventilation and administration of propranolol or verapamil

Background : Our objective was to determine whether administration of propranolol or verapamil modifies the hemodynamic adaptation to continuous positive-pressure ventilation (CPPV), in particular the regional distribution of cardiac output (CO).
Methods : General hemodynamics and regional blood flows assessed by microsphere technique (15 (μm) were recorded in 16 anesthetized pigs during spontaneous breathing (SB) and CPPV with 8 cm H₂O end-expiratory pressure (CPPV8) before and after intravenous administration of propranolol (0.3 mg · kg⁻¹ followed by 0.15 mg · kg⁻¹ · h⁻¹, n=8) or verapamil (0.1 mg · kg⁻¹ followed by 0.3 mg · kg⁻¹ · h⁻¹, n=8).
Results : CPPV8 depressed CO by 25% without shifts in its relative distribution with the exception of a noteworthy increase in adrenal perfusion. Propranolol increased arterial blood pressure, and due to a fall in heart rate, CO dropped by 25%. The kidneys and, to a lesser extent, the splanchic region and central nervous system received increased fractions of the remaining CO at the expense of skeletal muscle flow. Similar patterns were seen during SB and CPPV8 such that the combination of propranolol and CPPV8 depressed CO by 50%. The circulatory effects of verapamil were less evident but myocardial perfusion tended to increase.
Conclusions : The combination of propranolol or verapamil with CPPV does not result in any specific hemodynamic interaction in anesthetized pigs, except that the combined effect of propranolol and CPPV may severely reduce CO.     

Bariatric Surgery in Some "Central and East-European (former Eastern bloc)"Countries - Current Status and Prediction for the Next Millennium

Background: Obesity is increasing globallly, including in the formerly "Eastern Bloc" countries. Methods: A survey was made of obesity and bariatric surgery. Results: In the 8 East and Central European countries studied, with total population 300 million, roughly 43% of the population was overweight (BMI 25-30), 23% obese (BMI > 30), with about 15 million people morbidly obese (BMI > 40). From 0-10 morbidly obese individuals/100,000/year undergo bariatric surgery. Conclusion: Most countries were found to provide inadequate treatment for obesity.The majority of the morbidly obese are not treated effectively. However, health-care awareness of obesity and bariatric surgeons are slowly increasing.     

Volatile anaesthetics reduce adhesion of blood platelets under low-flow conditions in the coronary system of isolated guinea pig hearts

Background : Inhibitory effects of volatile anaesthetics on platelet aggregation have been demonstrated in several studies. However, the influence of volatile anaesthetics on intracoronary platelet adhesion has not been elucidated so far.
Methods : Isolated hearts of guinea pigs were perfused with buffer in the absence or presence of volatile anaesthetics (0.5 and 1 MAC) at constant coronary flow rates of 5 ml/min for 25 min, then 1 ml/min for 30 min and again 5 ml/min for 10 min. Before, during and after low-flow perfusion, a bolus of human platelets was applied into the coronary system. To simulate thrombogenic conditions, 0.3 U/ml human thrombin was infused during low-flow perfusion and reperfusion. The number of platelets sequestered to the endothelium was calculated from the difference between coronary in- and output of platelets. The myocardial production of lactate and consumption of pyruvate and coronary perfusion pressure were also determined.
Results : At a flow rate of 5 ml/min only about 3% of the applied platelets did not emerge from the coronary system, in any group. In contrast, 13.1±1.2% (mean±SEM) of infused platelets became adherent in low-flow perfusion in the control group without anaesthetic. The adherence was reduced with each 1 MAC isoflurane (to 6.2±1.2%), sevoflurane (to 4.4±0.9%) or halothane (to 3.2±1.5%) (each P <0.05 vs. control). Volatile anaesthetic, 0.5 MAC, did not inhibit platelet adhesion to a statistically significant extent in any case. Perfusion pressure and metabolic parameters were not statistically different between the control and the hearts exposed to anaesthetics.
Conclusion : Volatile anaesthetics in a concentration of 1 MAC can reduce the adhesion of platelets in the coronary system under reduced flow conditions. This action does not arise from vasodilation or inhibition of ischaemic stress.     

Synergistic interaction between the effects of propofol and midazolam with fentanyl on phrenic nerve activity in rabbits

Background: It has been shown that the depressive effects of both propofol and midazolam on consciousness are synergistic with opioids, but the nature of their interactions on other physiological systems, e. g. respiration, has not been fully investigated. The present study examined the effect of propofol and midazolam alone and in combination with fentanyl on phrenic nerve activity (PNA) and whether such interactions are additive or synergistic. Methods: PNA was recorded in 27 anaesthetised and artificially ventilated rabbits. In three groups, propofol, fentanyl and midazolam were administered intravenously in incremental doses to construct dose-response curves for the depressant effects of each one on PNA. In another two groups, the effect of pretreatment with either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. on the effects of propofol and fentanyl respectively on PNA were studied. Results: Propofol and fentanyl caused a dose-dependent depression of PNA with complete abolition at the highest total doses of 16 mg · kg^?1 i. v. and 32 μg · kg^?1 i. v., respectively. In contrast, midazolam in incremental doses to a total of 0.8 mg · kg^?1 reduced mean PNA by 63%, but approximately 12% of PNA remained at a total dose as high as 6.4 mg · kg^?1. The mean ED₅₀s, calculated from dose-response curves, were 5.4 mg · kg^?1, 3.9 μg · kg^?1 and 0.4 mg · kg^?1 for propofol, fentanyl and midazolam, respectively. Initial doses of either fentanyl 1 μg · kg^?1 i. v. or midazolam 0.05 mg · kg^?1 i. v. acted synergistically with subsequent doses of either propofol or fentanyl to abolish PNA at total doses of 8 mg · kg^?1 and 8 μg · kg^?1, respectively. Conclusion: Fentanyl has a synergistic interaction with both propofol and midazolam on PNA and hence potentially on respiration.     

Influence of dopexamine hydrochloride on haemodynamics and regulators of circulation in patients undergoing major abdominal surgery

Background: Catecholaminergic support is often used to improve haemodynamics in patients undergoing major abdominal surgery. Dopexamine is a synthetic vasoactive catecholamine with beneficial microcirculatory properties. Methods: The influence of perioperative administration of dopexamine on cardiorespiratory data and important regulators of macro- and microcirculation were studied in 30 patients undergoing Whipple pancreaticduodenectomy. The patients received randomized and blinded either 2 μg · kg^?1 · min^?1 of dopexamine (n=15) or placebo (n=15, control group). The infusion was started after induction of anaesthesia and continued until the morning of the first postoperative day. Endothelin-1 (ET-1), vasopressin, atrial natriuretic peptide (ANP), and catecholamine plasma levels were measured from arterial blood samples. Measurements were carried out after induction of anaesthesia, 2 h after onset of surgery, at the end of surgery, 2 h after surgery, and on the morning of the first postoperative day. Results: Cardiac index (CI) increased significantly in the dopexamine group (from 2.61±0.41 to 4.57±0.78 1 · min^?1 · m^?2) and remained elevated until the morning of the first postoperative day. Oxygen delivery index (DO₂I) and oxygen consumption index (VO₂I) were also significantly increased in the dopexamine group (DO₂I: from 416±91 to 717±110 ml/m² · m²; VO₂I: from 98±25 to 157±22 ml/m² · m²), being significantly higher than in the control group. pHi remained stable only in the dopexamine patients, indicating adequate splanchnic perfusion. Vasopressive regulators of circulation increased significantly only in the untreated control patients (vasopressin: from 4.37±1.1 to 35.9±12.1 pg/ml; ET-1: from 2.88±0.91 to 6.91±1.20 pg/ml). Conclusion: Patients undergoing major abdominal surgery may profit from prophylactic perioperative administration of dopexamine hydrochloride in the form of improved haemodynamics and oxygenation as well as beneficial influence on important regulators of organ blood flow.