广西黑衣壮族中老年人群高血压患病率调查

目的探讨广西黑衣壮族中老年人群高血压的患病情况及其影响因素.方法采用整群抽样方法对657例≥40岁黑衣壮族人群的血压、身高、体重、体重指数、血脂及载脂蛋白进行测定,并将其结果与520例当地的汉族人群作比较.结果黑衣壮族人群高血压的患病率明显高于汉族人群(32.9%比24.6%,P＜0.01),黑衣壮族人群单纯收缩期高血压的患病率也明显高于汉族人群(16.7%比5.2%,P＜0.001).黑衣壮族和汉族人群高血压患病率受总胆固醇、甘油三酯、年龄、性别、饮酒、民族和体重指数的影响.黑衣壮族和汉族人群高血压知晓率为7.9%比19.5%(P＜0.01),治疗率4.2%比13.3%(P＜0.01),控制率1.4%比9.4%(P＜0.01).结论广西黑衣壮族中老年人群高血压患病率显著高于汉族,而高血压知晓率、治疗率和控制率则显著低于汉族.     

广西白裤瑶族与汉族人群血脂谱及其影响因素比较

白裤瑶族人群的总胆周醇、高密度脂蛋白胆固醇、低密度脂蛋白胆同醇、载脂蛋白(Apo)A1和ApoB水平低于当地的汉族人群(均P<0.01),甘油三酯水平和ApoA1/ApoB与汉族人群比较差异无统计学意义.两民族人群血脂异常均与体重指数、腰围、总能量和总脂肪呈正相关,与体力活动和总膳食纤维呈负相关.汉族人群血脂异常还与年龄和饮酒呈正相关,而白裤瑶族人群则与年龄和饮酒无关.     

广西白裤瑶族40岁以上人群的血脂水平调查

目的 了解广西白裤瑶族40岁及以上人群的血脂水平. 方法 采用分层随机整群抽样方法对485例白裤瑶族40岁及以上人群的饮食摄入量、生活习惯等进行流行病学调查,对血压、身高、体质量、体质指数(BMI)、腰围、血脂及载脂蛋白(apo)进行测定,并将结果与501例当地的汉族人群进行比较. 结果 白裤瑶族的文化程度、身高、体质量、腰围、血压、高脂血症患病率以及总能量、总脂肪、总蛋白质、食物胆固醇和食盐的摄入量明显低于汉族(P<0.01或P<0.05),而自裤瑶族碳水化合物、植物蛋白和总食物纤维的摄入量则显著高于汉族(P<0.01).白裤瑶族与汉族比较,血清总胆固醇(4.43±0.90)mmol/L比(4.96±1.04)mmol/L,高密度脂蛋白胆固醇(1.73±0.42)mmol/L比(2.01±0.49)mmol/L,低密度脂蛋白胆固醇(2.62±0.75)mmol/L比(2.72±0.78)mmol/L,apo Al(1.36±0.33)g/L比(1.48±0.24)g/L和apo B(0.86±0.23)g/L比(0.95±0.22)g/L,显著低于汉族(P<0.01或P<0.05);三酰甘油和apoAl/apo B比值与汉族比较,差异无统计学意义. 结论 白裤瑶族和汉族人群的血脂水平存在明显差异,可能与他们的饮食习惯、生活方式和体力活动不同有关.     

柳州市10408成人中高血压患病率调查

目的　了解柳州市成人中高血压患病情况 ,为人群干预作基线调查。方法　整群抽样市区常居人口 10 40 8人 ,平均年龄 3 7 4± 10 7岁。调查一般人口学指标 ,测定血压 ,体重指数 ,腰围及血液有关生化参数。结果　本组人群高血压标化患病率为 16.97% ,男 19 56% ,女 14 2 3 % ;一级高血压占 72 0 5% ,二级占 2 2 40 % ,三级占 5 55% ;高血压组中空腹血糖受损、糖尿病及血脂异常的检出率显著高于血压正常组 (P <0 0 0 1) ;超重组、肥胖组高血压患病率均显著高于BMI正常组 ,其OR值分别为 3 93、10 85;腰围增大组高血压患病率显著高于腰围正常组 ,OR值为 5 2 9。结论　柳州市成人高血压患病率已达到较高水平 ,高血压病人常伴有糖代谢及脂代谢异常 ,年龄、超重或肥胖是影响高血压患病率的重要因素。应采取干预措施以降低其危险因素和心血管病的发生率     

佛山市普君街道办事处老年高血压患病率调查

目的　探讨广东佛山市普君街道办事处老年高血压患病率情况。方法　按统一方法对佛山市禅城区普君街道办事处 6 0岁以上常住居民 3382人进行现场问卷调查 ,同时测量人体基本参数如血压、身高、体重等 ,并进行餐后 2小时血糖测定 ,以及空腹血糖、血脂常规、血尿酸等测定。结果　高血压粗患病率 4 0 0 % ,标化率为 4 0 0 % ,较佛山 1993年 (5 1 5 % )明显下降。单纯收缩期高血压 (ISH)粗患病率 2 1 3% ,标化率为 2 2 1%。女性患病率高于男性。新检出高血压患者占高血压病患者总数的 4 0 1% ,ISH占高血压病患者总数的 5 3 9% ,随年龄增长高血压患病率增高。老年人群平均收缩压 (SBP)为 12 6± 17mmHg、舒张压 (DBP)为 77± 8mmHg、脉压 (PP)为 4 9± 11mmHg。高血压组的年龄、血压、体重、体重指数、餐后 2小时血糖、空腹血糖、尿酸及血脂 (总胆固醇、甘油三酯 )与非高血压组比较有差异 ,(P <0 0 1～ 0 0 5 )。结论　高血压与多种危险因素有密切相关 ,佛山市老年人高血压患病率高 ,应当重视开展高血压的社区防治。     

柳州市10408成人中高血压患病率调查

目的了解柳州市成人中高血压患病情况,为人群干预作基线调查.方法整群抽样市区常居人口10408人,平均年龄37.4±10.7岁.调查一般人口学指标,测定血压,体重指数,腰围及血液有关生化参数.结果本组人群高血压标化患病率为 16.97%,男 19.56%,女 14.23 %;一级高血压占72.05%,二级占22.40%,三级占5.55%;高血压组中空腹血糖受损、糖尿病及血脂异常的检出率显著高于血压正常组(P<0.001);超重组、肥胖组高血压患病率均显著高于BMI正常组,其OR值分别为3.93、10.85;腰围增大组高血压患病率显著高于腰围正常组,OR值为5.29.结论柳州市成人高血压患病率已达到较高水平,高血压病人常伴有糖代谢及脂代谢异常,年龄、超重或肥胖是影响高血压患病率的重要因素.应采取干预措施以降低其危险因素和心血管病的发生率.     

广州市荔湾区中老年人群高血压患病率及心血管危险因素的调查和分析

为了解广州市中老年人群高血压患病率及心血管相关因素的情况 ,我们于 2 0 0 0年 5～ 10月在对广州市高血压、糖尿病流行病调查基础上 ,对 6 5 34名 4 5岁以上中老年人的高血压患病率及其他心血管危险因素进行分析 ,现报道如下。　　一、资料和方法　　 1.对象 :荔湾区是广州市老城区 ,人口 4 7万。我们采用整群抽样 ,以荔湾区所属 4个社区卫生服务中心所辖居委会、政府机关、学校及医院等 6 5 34名 4 5岁以上居民为调查对象。年龄 4 5～ 98岁 ,男 2 5 0 5名 ,女 4 0 2 9名 ;其中 6 0岁以上老年人为 30 2 7名。　　 2 .方法 :调查内容包括一…     

佛山市普君街道办事处老年高血压患病率调查

目的探讨广东佛山市普君街道办事处老年高血压患病率情况.方法按统一方法对佛山市禅城区普君街道办事处60岁以上常住居民3382人进行现场问卷调查,同时测量人体基本参数如血压、身高、体重等,并进行餐后2小时血糖测定,以及空腹血糖、血脂常规、血尿酸等测定.结果高血压粗患病率40.0%,标化率为40.0%,较佛山1993年(51.5%)明显下降.单纯收缩期高血压(ISH)粗患病率21.3%,标化率为22.1%.女性患病率高于男性.新检出高血压患者占高血压病患者总数的40.1%,ISH占高血压病患者总数的53.9%,随年龄增长高血压患病率增高.老年人群平均收缩压(SBP)为126±17 mmHg、舒张压(DBP)为77±8 mmHg、脉压(PP)为49±11 mmHg.高血压组的年龄、血压、体重、体重指数、餐后2小时血糖、空腹血糖、尿酸及血脂(总胆固醇、甘油三酯)与非高血压组比较有差异,(P<0.01～0.05).结论高血压与多种危险因素有密切相关,佛山市老年人高血压患病率高,应当重视开展高血压的社区防治.     

广西白裤瑶族中老年人群的血压及其影响因素

目的了解广西白裤瑶族中老年人群的血压及其影响因素。方法采用分层随机整群抽样方法,对485例白裤瑶族中老年人群的血压、饮食和生活方式等进行流行病学调查,另选501例当地的汉族人群进行比较。结果白裤瑶族人群的体力活动、碳水化合物和膳食纤维摄入量高于汉族人群,而受教育水平、身高、腰围、体重、体重指数、总能量、总脂肪、蛋白质、胆固醇和钠盐摄入量则低于汉族人群;白裤瑶族人群的收缩压、舒张压、脉压和高血压患病率低于汉族人群(P<0.05,P<0.01)。两民族人群高血压与年龄、体力活动、体重指数、腰围、总能量,总脂肪和钠盐摄入量呈正相关,与教育水平和总食物纤维摄入量呈负相关(P<0.05,P<0.01);此外,白裤瑶族人群高血压还与甘油三酯呈正相关,汉族人群高血压与饮酒呈正相关(P<0.05)。结论白裤瑶族和汉族人群的血压水平及其危险因素存在差异,可能与他们的饮食结构、生活方式、体力活动、钠盐摄入和遗传因素不同有关。     

绍兴市人群2003年高血压调查分析

目的　了解绍兴市人群高血压流行特点与趋势。方法　采用多阶段抽样方法 ,随机抽取绍兴市城乡各 2个社区和行政村 ,对 15岁以上自然人群 10 38名居民进行高血压流行病学调查。结果　绍兴市居民高血压患病率 2 7 2 6 % ,标化患病率 19 6 0 % ,较 1990年增长 10个百分点 ,每年几乎以 1%的速度递增。高血压患病率随年龄的增长而逐年上升 ,与 1990年相比 ,高血压患病年龄前移了 5年。城乡居民的高血压患病率基本一致 (患病率分别为 2 7 0 8%、2 7 4 4 % ,标化患病率为 19 75 %、2 0 11% )。血脂、血糖、体重指数、高血压家族史、饮酒和尿酸等因素与高血压密切相关。结论　绍兴市居民高血压患病率呈明显上升趋势 ;血脂、血糖、体重指数、高血压家族史、饮酒和尿酸等是高血压的危险因素 ;提示加强高血压的社区综合干预十分必要     

广西百色市不同民族高血压患病率及其与代谢综合征的关系

用分层整群抽样法调查居住在广西百色市壮族3 000名,苗族1 102名,瑶族1 283名,检测其身高、体重、血压、空腹血糖(FBG)和血脂水平,并与2 000名该市汉族居民比较.结果 显示,壮族居民高血压和代谢综合征(MS)患病率高,其超重、血糖、血脂异常率高,苗族、瑶族居民高血压和MS患病率低,其超重、血糖、血脂异常率低,壮、苗、瑶族居民对高血压知晓率、治疗率和控制率均较汉族者低.

Abstract：

There were 3 000 Zhuangs,1 102 Miaos, and 1 283 Yaos in Baise City of Guangxi,who were enrolled in this population sampling stratfying survey. Height, weight, blood pressure, fasting blood glucose, and lipids were determined, and compared with those of 2 000 Hans of the same town. The prevalence of hypertension and metablic syndrome in Zhuang inhabitants was high, so were the disorders of glycemia and lipidemia, while in Miao and Yao minorities, the prevalences were comparatively lower. The awareness, treatment, and control of hypertension in these minorities were insufficient.     

Diet, lifestyle, and blood pressure of the middle-aged and elderly in the Guangxi Bai Ku Yao and Han populations

BACKGROUND: Bai Ku Yao is an isolated subgroup of the Yao minority in China. Little is known about the association of diet and lifestyle with the prevalence of hypertension in this population. METHODS: A total of 485 subjects of Bai Ku Yao and 501 participants of Han Chinese aged 40-89 were surveyed using stratified randomized cluster sampling. Information on diet and lifestyle was collected by using standard questionnaires. Blood pressure (BP) and serum lipid levels were measured. RESULTS: Physical activity levels, carbohydrate, vegetal protein, and dietary fiber intake were higher in Bai Ku Yao than in Han, whereas educational level, height, weight, body mass index (BMI), waist circumference, and total energy, fat, protein, dietary cholesterol, and salt intake were higher in Han than in Bai Ku Yao. Systolic, diastolic, and pulse pressure (PP) levels and the prevalence of hypertension (21.9% vs. 28.9%, P < 0.05)were lower in Bai Ku Yao than in Han. Hypertension was positively correlated with age, physical activity,BMI, and waist circumference, as well as with total energy, fat, and salt intake, and negatively associated with educational levels and dietary fiber intake in both ethnic groups (P < 0.05 for all). Hypertension was also positively correlated with triglycerides (TGs) in Bai Ku Yao and alcohol consumption in Han (P < 0.05 for each). CONCLUSIONS: The differences in BP levels and the prevalence of hypertension among the middle-aged and elderly between Bai Ku Yao and Han might result from different dietary patterns, lifestyle choices, physical activity levels, sodium intake, and even genetic factors.     

Association of methylenetetrahydrofolate reductase C677T polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations

Objectives The association of methylenetetrahy-drofolate reductase(MTHFR) gene polymorphism and serum lipid profiles is still controversial in diverse ethnics.Bai Ku Yao is an isolated subgroup of the Yao minority in China. The aim of the present study was to eveluate the association of MTHFR C677Tpolymorphism and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations.Methods A total of 780 subjects of Bai Ku Yao and 686 participants of Han Chinese were randomly selected from our previous stratified randomized cluster samples.Genotyping of the MTHFR C677T was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis,and then confirmed by direct sequencing.Results The levels of serum total cholesterol(TC),high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol(LDL-C), apolipoprotein(Apo) AI and ApoB were lower in Bai Ku Yao than in Han(P<0.05-0.001).The frequency of C and T alleles was 77.4%and 22.6%in Bai Ku Yao,and 60.9%and 39.1%in Han(P<0.001);respectively.The frequency of CC,CT and TT genotypes was 58.7%,37.3%and 4.0%in Bai Ku Yao,and 32.6%,56.4%and 11.0%in Han(P< 0.001);respectively.The levels of TC and LDL-C in both ethnic groups were significant differences among the three genotypes(P<0.05-0.01).The T allele carriers had higher serum TC and LDL-C levels than the T allele noncarriers. The levels of ApoB in Han were significant differences among the three genotypes(P<0.05).The T allele carriers had higher serum ApoB levels as compared with the T allele noncarriers. The levels of TC,TG and LDL-C in Bai Ku Yao were correlated with genotypes(P<0.05-0.001),whereas the levels of LDL-C in Han were associated with genotypes(P< 0.001).Serum lipid parameters were also correlated with sex, age,body massindex,alcohol consumption,cigarette smoking, and blood pressure in the both ethnic groups.Conclusions The differences in serum TC,TG,LDL-C and ApoB levels between the two     

Association of the LIPG 584C&gt;T polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations

Objectives Endotheliallipase(EL) is a major determinantof high-density lipoprotein-cholesterol(HDL-C) metabolism,but the association of endothelial lipase gene (LIPG) polymorphism and serum HDL-C levels is scarce and conflicting in diverse populations.Bai Ku Yao is an isolated subgroup of the Yao minority in China.This study was designed to detect the association of LIPG 584C>T(rs2000813) polymorphism and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Methods A total of 645 subjects of Bai Ku Yao and 638 participants of Han Chinese were randomly selected from our previous stratified randomized cluster samples.Genotyping of the LIPG584C>T was performed by polymerse chain reaction and restriction fragment length polymorphism combined with gel electrophoresis,and then confirmed by direct sequencing. Results The levels of serum total cholesterol(TC),HDL-C, low-density lipoprotein cholesterol(LDL-C) and apolipoprotein (Apo) AI and ApoB were lower in Bai Ku Yao than in Han(P<0.05-0.001).The frequency of C and T alleles was 73.5%and 26.5%in Bai Ku Yao,and 67.9%and 32.1%in Han(P<0.01).The frequency of CC,CT and TT genotypes was 50.4%,46.2%and 3.4%in Bai Ku Yao,and 41.4%, 53.1%and 5.5%in Han(P<0.01);respectively.Serum HDL-C levels in both ethnic groups were different among the three genotypes(P<0.05 for each).Serum TC levels in both ethnic groups were also different between CC and CT/TT types(P< 0.05 for each).The T allele carriers had higher serum HDL-C and TC levels than the T allele noncarriers.Multivariate logistic regression analysis showed that the levels of HDL-C and ApoB were correlated with genotype in Bai Ku Yao(P< 0.05 for each),whereas the levels of TC and HDL-C were associated with genotype in Han Chinese(P<0.05 and P< 0.01).Serum lipid parameters were also correlated with gender, age,weight,body massindex,alcohol consumption, cigarette smoking,and blood pressure in the both ethnic groups.Conclusions The frequency of LIPG 584     

Polymorphism of rs1044925 in the acyl-CoA:cholesterol acyltransferase-1 gene and serum lipid levels in the Guangxi Bai Ku Yao and Han populations

Background The association of rs1044925 polymorphism in the acyl- CoA:cholesterol acyltransferase-1(ACAT-1) gene and serum lipid profiles is not well known in different ethnic groups.Bai Ku Yao is a special subgroup of the Yao minority in China.The present study was carried out to clarify the association of rs1044925 polymorphism in the ACAT-1 gene and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Methods A total of 626 subjects of Bai Ku Yao and 624 participants of Han Chinese were randomly selected from our previous stratified randomized cluster samples.Genotyping of rs 1044925 polymorphism in the ACAT-1 gene was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis,and then confirmed by direct sequencing.Results The levels of serum total cholesterol(TC),high-density lipoprotein cholesterol (HDL-C),apolipoprotein(Apo) AI and ApoB were lower in Bai Ku Yao than in Han(P<0.01 for all).The frequency of A and C alleles was 79.0%and 21.0%in Bai Ku Yao,and 87.3%and 12.7%in Han(P<0.001);respectively.The frequency of AA,AC and CC genotypes was 63.2%,31.4% and 5.2%in Bai Ku Yao,and 75.6%,23.2%and 1.1%in Han(P<0.001);respectively.The levels of TC,LDL-C and ApoB in Bai Ku Yao but not in Han were different between the AA and AC/CC genotypes in females but not in males (P<0.05 for all).The C allele carriers had lower serum TC, LDL-C and ApoB levels as compared with the C allele non-carriers. The levels of TC,LDL-C and ApoB in Bai Ku Yao but not in Han were correlated with genotypes in females but not in males(P<0.05 for all).Serum lipid parameters were also correlated with sex,age,body massindex,alcohol consumption, cigarette smoking,and blood pressure in both ethnic groups(P<0.05-0.001).Conclusions These results suggest that the polymorphism of rs1044925 associated with female serum TC,LDL-C and ApoB levels in the Bai Ku Yao population.The C allele carriers had more favorable serum TC,LDL     

The proprotein convertase subtilisin/kexin type 9 geneE670G polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations

Background The association of E670G polymorphism in the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene and serum lipid profiles is inconsistent in dif- ferent ethnic groups.Bai Ku Yao is a special subgroup of the Yao minority in China.The present study was undertaken association of PCSK9 E670G polymorphism and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations.Methods A total of 649 subjects of Bai Ku Yao and 646 participants of Han Chinese were randomly selected from our previous stratified randomized cluster samples.Genotyping of the PCSK9 E670G polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis,and then confirmed by direct sequencing. Results The levels of serum total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C) and apolipoprotein(Apo) AI were lower in Bai Ku Yao than in Han(P<0.01 for all).The frequency of A and G alleles was 98.00%and 2.00%in Bai Ku Yao,and 95.20%and 4.80%in Han(P<0.01);respectively. The frequency of AA,AG and GG genotypes was 95.99%,4.01%and 0%in Bai Ku Yao,and 91.02%, 8.36%and 0.62%in Han(P<0.01);respectively.There were also significant differences in the genotypic and allelic frequencies between n and the ratio of ApoAI to ApoB in Han Chinese but not in Bai Ku Yao were different between the AA and AG/GG genotypes(P<0.05 for all).The G allele carriers had higher serum HDL-C and higher ApoAI to ApoB ratio than the G allele noncarriers.When serum lipid parameters in Han were analyzed according to sex,the G allele carriers had higher serum HDL and ApoAI levels in males (P<0.05),and lower ApoB level and higher ApoAI to ApoB ratio in females(P<0.05 for all).Multiple linear regression analysis showed that serum HDL-C levels were correlated with genotypes in both ethnic groups(P<0.05 each).Serum lipid parameters were also correlated with sex,age,body massindex,alcohol consump     

Peroxisome proliferator-activated receptor delta+294T&gt;C polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations

Objectives The association of peroxisome prolif-erator -activated receptor delta(PPARD) +294T>C polymorphism and serum lipid levels is inconsistent in several previous studies.Bai Ku Yao is an isolated association of PPARD +294T>C(rs2016520) polymorphism and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations.Methods A total of 609 subjects of Bai Ku Yao and 573 participants of Han Chinese were randomly selected from our previous stratified randomized cluster samples.Genotyping of the PPARD +294T>C polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing.Results The levels of serum total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),apolipoprotein(Apo) AI and ApoB were lower in Bai Ku Yao than in Han(P<0.001 for all).The frequency of T and C alleles was 77.50%and 22.50%in Bai Ku Yao,and 72.43%and 27.57%in Han (P<0.01);respectively.The frequency of TT,TC and CC genotypes was 60.59%,33.83%and 5.53%in Bai Ku Yao, and 52.18%,40.50%and 7.32%in Han(P<0.05);respectively. The levels of LDL-C,ApoB and the ratio of ApoAI to ApoB in Bai Ku Yao were different among the three genotypes in females but not in males(P<0.05 for all).The subjects with TT and TC genotypes had lower serum LDL-C and ApoB levels and higher the ratio of ApoAI to ApoB than the CC genotype in females.The levels of TC and ApoB in the total Han population were different among the three genotypes (P<0.05 for all).The C allele carriers had higher serum TC and ApoB levels than the C allele noncarriers.When serum lipid levels were analyzed according to sex,the difference in serum TC levels in Han was significant in males(P<0.01) but not in females,whereas the difference in serum ApoB levels was significant in females(P<0.05)but not in males. Serum TC and ApoB levels were correlated with genotypes in Han(P<0.05 for each) but not in Bai Ku Yao.Serum l