加味甘麦大枣汤治疗癫痫48例疗效观察

运用加味甘麦大枣汤治疗４８例经脑电图确诊的癫痫患者。结果；痊愈２８例；显效１２便，有效６例，无效２例，总有效率９５．８％。属风痰闭阻和心脾两虚者疗效较好。认为病病机与脏躁证相似，加味甘大枣汤有祛风化痰，补中缓急功效，标本兼顾，祛邪而不伤正，疗效较好。     

逍遥散合甘麦大枣汤治疗恶性肿瘤相关性抑郁症55例

目的：观察逍遥散合甘麦大枣汤治疗恶性肿瘤相关性抑郁症的治疗效果。方法：针对不同癌症患者实施不同方案的化疗或放疗,并对选取的患者进行必要的心理疏导,有目的、有计划的采取心理暗示和行为干预。在上述治疗的基础上,对55例肿瘤抑郁症患者服用逍遥散合甘麦大枣汤加减进行治疗。结果：治愈13例,显效15例,有效18,无效9例,总有效率840／0。治疗前后HAMD评分均值分别为27．7±3．2、13．87±4．1,治疗后分值明显降低,P〈0．01,差异有显著性。结论：服用逍遥散合甘麦大枣汤加减,疏肝与健脾兼顾,养血与安神并举,心肝脾三脏通调,应用于肿瘤性抑郁症收到了较为满意的疗效,可为同道借鉴。     

加味甘麦大枣汤治疗抑郁症临床观察

目的：观察比较甘麦大枣汤和西酞普兰治疗抑郁症的疗效及不良反应。方法：将31例抑郁症患者随机分成治疗组16例和对照组15例。治疗组口服加味甘麦大枣汤,对照组给予西酞普兰,以汉密顿抑郁量表分别观察2组治疗抑郁症的疗效,并记录药物不良反应。2组疗程均为4周。结果：有效率比较,组间差异无显著性意义;药物不良反应发生率对照组多于治疗组。结论：加味甘麦大枣汤治疗抑郁症的疗效与西酞普兰相当,是一个疗效确切且耐受性好的抗抑郁组方。     

加味甘麦大枣汤配合针刺治疗癔病性瘫痪二十八例

加味甘麦大枣汤配合针刺治疗癔病性瘫痪二十八例４５７４００河南省南乐县精神病医院李英才，郭学民，赵国朝癔病属祖国医学＂郁症＂、＂脏躁＂等病范畴，多发于青壮年，以女性居多。癔病性瘫痪以肢痿为主征．目前用西药对症处理疗效欠佳．笔者自１９８３至１９９１年间，...     

情志疾病心肝求甘麦大枣奇功收：胡建华运用加味甘麦大枣汤治疗神经精神疾？

胡建华教授长期从事神经精神疾病的临床和研究，他认为精神系统疾病与主，肝两脏关系密切，以在甘麦大枣汤基础上加用菖蒲，远志和丹参组成的加味甘麦大枣汤为基础方，治疗植物神经功能紊乱，精神分裂症和多发性抽动－秽语综合征疗效显著。     

情志疾病心肝求 甘麦大枣奇功收──胡建华运用加味甘麦大枣汤治疗神经精神疾病的经验

胡建华教授长期从事神经精神疾病的临床和研究，他认为精神系统疾病与心、肝两脏关系密切，以在甘麦大枣汤基础上加用菖蒲、远志和丹参组成的加味甘麦大枣汤为基础方，治疗植物神经功能紊乱、精神分裂症和多发性抽动──秽语综合征疗效显著。     

甘麦大枣汤治疗抑郁症50例

抑郁症是临床上的常见病、多发病,属于中医郁证范畴.笔者应用甘麦大枣汤加味治疗抑郁症50例,收到良好效果,现报道如下.     

“加味甘麦大枣汤”治疗抑郁症32例临床研究

目的：观察比较自拟加味甘麦大枣汤和盐酸氟西汀治疗抑郁症的疗效及不良反应。方法：采用开放性对照研究方法,将70例抑郁症患者随机分成治疗组和对照组各35例。治疗组口服加味甘麦大枣汤,200mL/d,分2次服;对照组给予盐酸氟西汀,每日早晨1次,每次20mg。以汉密顿抑郁量表及副反应观察量表分别观察2组治疗抑郁症的疗效及不良反应。2组疗程均为6周。结果：总有效率治疗组为84.4%,对照组为83.9%,组间差异无显著性意义;药物不良反应发生率对照组多于治疗组。结论：加味甘麦大枣汤是一个疗效确切且耐受性好的抗抑郁组方。     

加味甘麦大枣汤治疗儿童恐怖症15例

儿童恐怖症近年有增多趋势,而临床治疗报道较为少见。笔者数年来对15例患儿采用自拟甘麦大枣汤治疗,取得较好疗效。现报告如下。1资料与方法1.1一般资料本组15例均为我院2001年3月～2005年5月门诊病例,男性10例,女性5例;年龄最小5岁,最大11岁,平均7.42岁;病程最短3d,最长30d,平     

自拟内异消方联合亮丙瑞林治疗子宫内膜异位症的有效性和安全性

目的：探讨自拟内异消方联合亮丙瑞林治疗子宫内膜异位症（EMs）的有效性和安全性。方法将82例EMs患者按随机数字表法分为2组各41例,治疗组采用自拟内异消方联合亮丙瑞林治疗,对照组单用亮丙瑞林治疗。血清CA125和RANTES采用酶联免疫吸附法检测。评价治疗前后盆腔症状和体征评分。结果治疗结束后3个月,治疗组盆腔症状评分[(0.4±0.2)分比(0.6±0.3)分;t＝3.552,P＝0.001]和体征评分[(0.8±0.4)分比(1.1±0.6)分;t＝2.664,P＝0.009]显著低于对照组;血清 CA125[(26.4±11.9)U/ml 比(33.9±12.8)U/ml;t＝2.012,P＝0.048]、RANTES[(34.3±14.1)ng/L 比(43.7±16.8)ng/L;t＝2.744,P＝0.008]显著低于对照组。治疗组总有效率显著高于对照组（90.2%比73.2%;χ2＝3.998,P＝0.046）,不良反应发生率显著低于对照组（7.3%比24.4%;χ2＝4.479,P＝0.034）。随访12个月,治疗组复发率低于对照组（16.2%比46.7%;χ2＝5.954,P＝0.015）。结论自拟内异消方联合亮丙瑞林能降低 EMs患者血清CA125和RANTES水平,减轻症状和体征,其疗效和安全性优于单用亮丙瑞林。     

中药治疗膝骨关节炎临床疗效和安全性的系统评价

目的：系统评价中药治疗膝骨关节炎的临床疗效和安全性.方法：运用计算机检索中国知网、万方数据库、维普数据库2000年1月至2012年9月收录的国内公开发表的中药治疗膝骨关节炎的临床研究文献,并进行Meta分析.结果：共检索出590篇相关文献,通过筛选最终有32篇文献纳入研究,涉及2 950例患者.纳入文献Jadad评分普遍不高,最高分为2分;32篇文献均说明了基线资料具有可比性;3篇文献采用随机数字表进行分组,3篇文献按就诊顺序随机分组,其余各篇随机方法未说明;各篇均未描述随机分配方案的隐藏方法;l篇文献采用单盲,l篇文献采用双盲,其余各篇均未描述盲法;各篇均未描述病例失访或退出情况.对32篇文献进行合并分析显示,治疗组和对照组的有效率分别为64.01％和43.96％,治疗组的临床疗效优于对照组（Z =6.850,P=0.000）,比数比=2.35,95％可信区间为1.84 ～3.01.20篇文献提及对用药安全性的观察,其中15篇文献记录了患者用药后不良反应发生情况.治疗组不良反应发生率低于对照组（Z=8.870,P=0.000）,比数比=0.14,95％可信区间为0.09～0.21.纳入疗效分析的32篇文献及纳入安全性评价的15篇文献的漏斗图均呈倒漏斗形,图形两侧分布均匀,提示纳入文献发表性偏倚不明显.结论：中药治疗膝骨关节炎疗效优于非甾类消炎药,且不良反应较少.但由于纳入的文献在方法学上存在问题,Meta分析得出的结论有一定的局限性,中药治疗膝骨关节炎的疗效和安全性还需要大样本、多中心、随机双盲的临床对照试验来进一步验证.     

丹参川芎嗪辅助治疗电弧烧伤的疗效分析

目的：评价丹参川芎嗪辅助治疗电弧烧伤患者的临床疗效。方法本研究为随机对照研究。将符合纳入标准的50例电弧烧伤患者按随机数字表法分为2组各25例,对照组视全身情况进行补液、抗休克、抗感染及局部清创磨痂等治疗,治疗组在对照组基础上加用丹参川芎嗪静脉滴注,(10 ml/d,共7 d)。结果7 d时[(25.7±3.1)%比(21.3±3.0)%;t＝5.122,P＝0.000]和14 d时[(60.3±8.6)%比(53.8±10.8)%;t＝2.434,P＝0.022]治疗组创面愈合率显著高于对照组;21 d时2组创面愈合率比较,差异无统计学意义[(99.4±1.7)%比(98.7±2.7)%;t＝1.163,P＝0.265]。治疗组、对照组愈合时间分别为(18.9±2.5)d、(20.3±2.2)d,2组比较差异有统计学意义(t＝-1.216,P＝0.020)。结论采用丹参川芎嗪辅助治疗电弧烧伤可提高术后7、14 d的创面愈合率、缩短愈合时间。     

Chinese herbal medicine for subacute thyroiditis: a systematic review of randomized controlled trials

Objective

To evaluate the effectiveness and safety of Chinese herbal medicine (CHM) in the treatment of subacute thyroiditis.

Methods

Randomized controlled trials found in PubMed, Cochrane Library, and three Chinese databases were selected. RevMan 5.2 software was used to analyze the data with relative risk or mean difference, expressed with 95% of confidence interval. The quality of trials was assessed and graded the quality of evidence with GRADE profiler software.

Results

Twenty one studies were included. CHM was superior to Western Medicine (include prednisone and NSAIDs) in abating fever, relieving thyroid pain, recovering blood sedimentation, improving thyroid function, and preventing hypothyroidism (P<0.05), while no statistical differences were found in eliminating goiter and reducing relapse rate. CHM plus Western Medicine were superior to Western Medicine in abating fever, relieving thyroid pain, eliminating goiter, and reducing relapse rate, while no statistical differences (P>0.05) were found in recovering blood sedimentation and improving thyroid function. The incidence of adverse reactions in treatment group was lower than that in control group (relative risk was 0.12 and 95% confidence interval was 0.03-0.51). The methodological quality of trials is generally poor with a high risk of bias.

Conclusion

CHM (particularly CHM combined with Western Medicine) used to treat subacute thyroiditis may improve clinical symptoms and signs, reduce relapse rate, and alleviate the side effects of hormones. Due to poor methodological quality of included trials, further more high-quality studies are warranted to confirm the effectiveness and safety of CHM.     

导痰汤合菖蒲郁金汤对卒中后抑郁症的实验研究

目的观察导痰汤合菖蒲郁金汤对卒中后抑郁症(PSD)大鼠模型行为学能力及脑内神经递质含量的影响。方法将80只大鼠随机分为4组,即模型组、导痰汤合菖蒲郁金汤组(中药组)、氟西汀组及假手术组,每组20只。模型组、中药组、氟西汀组采用双侧颈总动脉永久性结扎后行为限制法制备大鼠PSD模型,假手术组仅做颈正中切口即缝合。造模成功后第2d模型组、假手术组均予0.9%氯化钠注射液灌胃,中药组予导痰汤合菖蒲郁金汤灌胃,氟西汀组予盐酸氟西汀水溶液灌胃,均连续给药28d。测定大鼠海马区5-羟色胺(5-HT)、去甲肾上腺素(NE)、多巴胺(DA)、5-羟基吲哚乙酸(5-HIAA)含量的变化,并进行糖水消耗试验。结果假手术组、中药组及氟西汀组糖水消耗量均高于模型组(P0.05),纯水消耗量均低于模型组(P0.05);假手术组、中药组及氟西汀组NE、DA、5-HT及5-HIAA含量均高于模型组(P0.05);中药组NE、5-HT及5-HIAA含量均低于假手术组(P0.05);氟西汀组NE、DA含量均低于假手术组(P0.05)。结论导痰汤合菖蒲郁金汤可以改善PSD大鼠的行为及脑内单胺类神经递质的含量。     

Efficacy of Chinese herbal medicine for lumbar disc herniation: a systematic review of randomized controlled trials

Objective

This is a review of the effects of Chinese herbal medicine (CHM) used alone to treat lumbar disc herniation (LDH).

METHORDS

A literature search of the following electronic databases from their inception to February 2013 was conducted: Chinese Biomedical databases, Chinese National Knowledge Infrastructure, Wanfang Database, China Science and Technology Journal Database, Cochrane Library, Web of Science, MEDLINE, and EMBASE. Randomized controlled trials where CHM had been used to treat LDH were selected. Data extraction, quality assessment, and data analysis were carried out by two independent reviewers.

Results

Of the 2415 studies identified, eight with complete data on 1146 patients were selected. The methodological quality was poor in all trials. Five studies reported that CHM was better than Western Medicine [OR=2.81, 95% CI (1.27, 6.18); OR=3.34, 95% CI (1.92, 5.79); OR=2.22, 95% CI (1.08, 4.57); OR=6.67, 95% CI (1.34, 33.28); and OR=1.94, 95% CI (1.23, 3.06)]. Two studies reported that the clinical outcome was better in CHM groups than in physiotherapy and placebo groups, [OR=3.02, 95% CI (1.08, 8.46); and OR=2.67, 95% CI (1.26, 5.64), respectively], whereas one study reported no difference between CHM and physiotherapy groups. One study reported that CHM resulted in higher Japanese Orthopedic Association scores [MD=7.78, 95% CI (6.67, 8.89)] than in a control group and another that participants treated with CHM had lower Visual Analogue Scale scores [MD= − 0.72, 95% CI (− 0.86, − 0.58)] than those in a control group. Three studies reported that the adverse effects of CHM and Western Medicine did not differ significantly [OR=0.10, 95% CI (0.01, 1.85); OR=0.19, 95% CI (0.01, 4.07); and OR=0.07, 95% CI (0.00, 1.32)].

Conclusion

CHM may be more effective than other interventions for LDH; however, methodological weaknesses in the studies assessed in this review prevent a definitive conclusion. More high-quality large-scale studies are required to clarify this matter.     

Effects of Jianpi herbal suppository on hemorheology and CD62p in patients with ulcerative colitis

OBJECTIVE： To compare the effects of a Chinese herbal suppository （Jianpi suppository） and West- ern Medicine （mesalazine） on hemorheology and CD62p in patients with ulcerative colitis （UC）. METHODS： In a randomized trial, 120 mild to moderate UC patients were randomly divided into two equal groups. The Jianpi suppository group used Chinese herbal suppository rectally, while the me- salazine group was treated with mesalazine tablets orally. Two 15-day courses of treatment were car- ried out in both groups. Changes in the hemorheology and CD62p indices in patients were observed. RESULTS： The hemorheology and CD62p indices in the Jianpi suppository group decreased significantly more than those of the mesalazine group. CONCLUSION： Jianpi suppository is effective in improving the hypercoagulability of UC patients, and therefore may be worth using in clinical practice.     

Effects of Jianpi herbal suppository on hemorheology and CD62p in patients with ulcerative colitis

Objective

To compare the effects of a Chinese herbal suppository (Jianpi suppository) and Western Medicine (mesalazine) on hemorheology and CD62p in patients with ulcerative colitis (UC).

Methods

In a randomized trial, 120 mild to moderate UC patients were randomly divided into two equal groups. The Jianpi suppository group used Chinese herbal suppository rectally, while the mesalazine group was treated with mesalazine tablets orally. Two 15-day courses of treatment were carried out in both groups. Changes in the hemorheology and CD62p indices in patients were observed.

Results

The hemorheology and CD62p indices in the Jianpi suppository group decreased significantly more than those of the mesalazine group.

Conclusion

Jianpi suppository is effective in improving the hypercoagulability of UC patients, and therefore may be worth using in clinical practice.     

中药口服外敷配合Ilizarov外固定架手风琴技术治疗胫骨重度慢性骨髓炎

目的：评价中药口服外敷配合Ilizarov外固定器手风琴技术治疗胫骨重度慢性骨髓炎的疗效。方法78例重度胫骨慢性骨髓炎患者随机分为常规治疗组和联合治疗组各39例。2组所有患者均采用Ilizarov外固定架手风琴技术固定;联合治疗组口服中药。创面较大者,常规治疗组采用负压封闭引流,联合治疗组采用负压封闭引流,外敷生肌玉红膏。均治疗8周随访2年。对创面愈合时间、骨折愈合时间、引流时间进行比较。采用Paley标准评价功能和影像学结果、特种外科医院（Hospital for Special Surgery, HSS）膝关节评分评价膝关节功能、Baird-Jackson踝关节评分评价踝关节功能。结果联合治疗组创面愈合时间[(17.33±6.21)d 比(22.27±8.12)d;t＝3.018, P＝0.004]、骨折愈合时间[(32.25±6.02)周比(36.37±7.75)周;t＝2.623,P＝0.011]、引流时间[(17.01±4.66)d比(21.51±5.23)d;t＝4.012,P＜0.001]均较常规治疗组缩短。联合治疗组骨折愈合优良率（84.6%比53.8%;χ2＝7.282,P＝0.007)、功能恢复优良率为（92.3%比66.7%;χ2＝6.369,P＝0.012)均显著高于常规治疗组。联合治疗组HSS膝关节评分[(84.56±7.42)分比(78.81±5.33)分;t＝3.391,P＝0.002]、Baird-Jackson 踝关节评分[(85.01±8.21)分比(79.21±6.78)分;t＝3.402,P=0.024]均高于常规治疗组。结论口服骨愈汤、外敷生肌玉红膏配合Ilizarov外固定架手风琴技术可促进胫骨重度慢性骨髓炎患者关节功能恢复以及骨生长和创伤愈合。     

Observation on Treatment of Depression with Acupuncture and Chinese Medicine： A Report of 52 Cases

目的讨针灸与中药并用治疗抑郁症的效果.方法将98例抑郁症患者随机分为两组,治疗组52例,采用头皮针、电针(百会、神庭、太冲、内关、关元、足三里、三阴交)配中药逍遥散加味.对照组46例,采用中药逍遥散加味.结果治疗组总有效率为94.23%,对照组总有效率为78.26%,两组比较差异有统计学意义(P＜0.05).结论灸配合中药治疗抑郁症疗效显著.