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A. G. Kulkarni A. N. Suryakar A. S. Sardeshmukh D. B. Rathi 《Indian journal of clinical biochemistry : IJCB》2003,18(2):136-149
Oxidative stress plays an important role in the development of malarial anemia. The present study was undertaken to study
the role of oxidant and antioxidants in the patients ofPlasmodium falciparum malaria (n=25),Plasmodium vivax malaria (n=25) as against the normal control subjects (n=25). The parameters included are the hematological [hemoglobin,
erythrocyte adenosine deaminase (ADA) activity, ADP-induced platelet aggregation] and serum total lipid peroxide as an index
of oxidative stress and antioxidants [erythrocytic superoxide dismutase (SOD) activity, serum vitamin E] & serum iron.
Significant alterations in all above parameters were noted in both groups of malaria patients as compared to control subjects.
Maximum significant alterations in hematological parameters were noticed inP. falciparum infection as compared toP. vivax malaria (p<0.001). Substantial rise in serum total lipid peroxides and a significant reduction in antioxidants such as serum
vitamin E and serum iron were noted inP. falciparum malaria as compared toP. vivax malaria (p<0.001), whereas maximum decline in erythrocytic SOD activity was observed inP. vivax infection as compared toP. falciparum malaria (p<0.05). Follow-up examination revealed the restoration of the levels of all biochemical parameters to the normal
level after 20 days of antimalarial therapy.
The study specified severity ofP. falciparum malaria and also functional duality of oxidant. 相似文献
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