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《中国组织工程研究与临床康复》2008,12(42):I0001
杨豪,男,1956年生,中共党员,河南郑州市人,1984年毕业于河南中医学院并留校。现为教授,博士生导师,河南省中医院、河南中医学院第二附属医院党委书记、副院长、骨伤学科的学术带头人。1986年获“河南省优秀教师”称号,2003年获“抗非”优秀共产党员干部,2004年获河南中医学院优秀党务工作者称号,2005年获“郑州市优秀教师”称号。 相似文献
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1病例报道
患者,女,62岁,孕7产5,末次产1979年3月。产后半年在当地乡卫生院放置宫内节育器(IUD),术后无特殊不适,49岁绝经,近一年常感腰痛和下腹部坠胀。2012年5月13日患者来我站取环。主诉:上环33年,绝经13年要求取环。追问患者有无取环史,自述“近2年先后到附近不同的乡卫生院取环3次(患者属吊庄乡,居住偏僻,就医条件差),但均未取出”。 相似文献
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《中国组织工程研究与临床康复》2008,12(51):I0004
王卫明,男,1970年出生,医学博士,硕士研究生导师,2001年破格晋升副主任医师;2004年入选辽宁省“百千万人才工程”千人层次人选;2005年破格晋升主任医师;2006年获大连市青年科技奖;2007年获“大连市优秀专家”称号;2008年奥运火炬手。 相似文献
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Modulation of emotion by cognition and cognition by emotion 总被引:2,自引:0,他引:2
Blair KS Smith BW Mitchell DG Morton J Vythilingam M Pessoa L Fridberg D Zametkin A Sturman D Nelson EE Drevets WC Pine DS Martin A Blair RJ 《NeuroImage》2007,35(1):430-440
In this study, we examined the impact of goal-directed processing on the response to emotional pictures and the impact of emotional pictures on goal-directed processing. Subjects (N=22) viewed neutral or emotional pictures in the presence or absence of a demanding cognitive task. Goal-directed processing disrupted the BOLD response to emotional pictures. In particular, the BOLD response within bilateral amygdala and inferior frontal gyrus decreased during concurrent task performance. Moreover, the presence of both positive and negative distractors disrupted task performance, with reaction times increasing for emotional relative to neutral distractors. Moreover, in line with the suggestion of the importance of lateral frontal regions in emotional regulation [Ochsner, K. N., Ray, R. D., Cooper, J. C., Robertson, E. R., Chopra, S., Gabrieli, J. D., et al. (2004). For better or for worse: neural systems supporting the cognitive down-and up-regulation of negative emotion. NeuroImage, 23(2), 483-499], connectivity analysis revealed positive connectivity between lateral superior frontal cortex and regions of middle frontal cortex previously implicated in emotional suppression [Beauregard, M., Levesque, J., and Bourgouin, P. (2001). Neural correlates of conscious self-regulation of emotion. J. Neurosci., 21 (18), RC165.; Levesque, J., Eugene, F., Joanette, Y., Paquette, V., Mensour, B., Beaudoin, G., et al. (2003). Neural circuitry underlying voluntary suppression of sadness. Biol. Psychiatry, 53 (6), 502-510.; Ohira, H., Nomura, M., Ichikawa, N., Isowa, T., Iidaka, T., Sato, A., et al. (2006). Association of neural and physiological responses during voluntary emotion suppression. NeuroImage, 29 (3), 721-733] and negative connectivity with bilateral amygdala. These data suggest that processes involved in emotional regulation are recruited during task performance in the context of emotional distractors. 相似文献
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目的:观察洁尔阴含漱预防口腔溃疡的临床效果.方法:接受化疗的乳腺癌患者50例应用洁尔阴含漱预防口腔溃疡,并与同期住院的50例进行对照.结果:观察组口腔溃疡发生率为40%,以Ⅰ~Ⅱ度为主,无Ⅲ~Ⅳ度;口腔溃疡发生率明显低于对照组(P<0.05).结论:洁尔阴舍漱预防化疗所致口腔溃疡有较好的效果. 相似文献
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子宫肌瘤腹腔镜剥除与开腹剥除的配对研究 总被引:4,自引:0,他引:4
目的对比研究腹腔镜与开腹行子宫肌瘤剔除的优点和风险。方法收集2002年5月~2004年5月间48例子宫肌瘤(浆膜下或肌壁间)手术病人。所有病人分成腹腔镜组和开腹组,测定两组的手术时间、手术出血量、术后最高体温、体温恢复正常天数、下床活动时间、肛门排气时间、住院天数、术后用镇痛药与否、术后3d白细胞分类及计数正常与否、术后有无并发症,并进行1∶1的配对研究。结果两组病人无手术并发症,腹腔镜组无中转开腹手术。腹腔镜组手术出血量、术后体温恢复时间、下床活动时间、肛门排气时间、住院天数、镇痛药使用率和血常规正常时间较开腹组少;但手术时间较长,考虑与手术操作熟练程度有关。结论腹腔镜下子宫肌瘤剔除术是一种安全有效的手术方法,较开腹手术损伤小、出血少、恢复快。 相似文献
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Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin 总被引:2,自引:0,他引:2
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Li Q Dong C Deng A Katsumata M Nakadai A Kawada T Okada S Clayberger C Krensky AM 《Antimicrobial agents and chemotherapy》2005,49(1):388-397
Granulysin, a 9-kDa protein localized in human cytolytic T lymphocytes and natural killer cell granules, is cytolytic against tumors and microbes but not against red blood cells. Synthetic peptides corresponding to the central region of granulysin recapitulate the lytic activity of the intact molecule, and some peptides cause hemolysis of red blood cells. Peptides in which cysteine residues were replaced by serine maintain their activity against microbes but lose activity against human cells, suggesting their potential as antibiotics. Studies were undertaken to determine the mechanism of resistance of red blood cells to granulysin and sensitivity to a subset of granulysin-derived peptides. Granulysin lyses immature reticulocytes, which have mitochondria, but not red blood cells. Granulysin lyses U937 cells but not U937 cells lacking mitochondrial DNA and a functional respiratory chain (U937rho(o) degrees cells), further demonstrating the requirement of intact mitochondria for granulysin-mediated death. Peptide G8, which corresponds to helix 2/loop 2/helix 3, lyses red blood cells, while peptide G9, which is identical except that the cysteine residues were replaced by serine, does not lyse red blood cells. Granulysin peptide-induced hemolysis is markedly inhibited by an anion transporter inhibitor and by Na(+), K(+), and Ca(2+) channel blockers but not by Na(+)/K(+) pump, cotransport, or Cl(-) channel blockers. Although recombinant granulysin and G9 peptide do not induce hemolysis, they both competitively inhibit G8-induced hemolysis. The finding that some derivatives of granulysin are hemolytic may have important implications for the design of granulysin-based antimicrobial therapeutics. 相似文献
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H Mittler 《Die Rehabilitation》1989,28(1):38-42
An essential prerequisite for integrating disabled persons is their mobility. The special transport approach, both in terms of handling capacity and cost involved, is increasingly turning out to be unable to achieve future-oriented solutions in this context. Disabled people wish to use the transport services available to the general public. They therefore demand public transportation policies to provide for their access to the mainstream system, ideally independent of outside assistance. Deutsche Bundesbahn, the German federal railways, in the field of tension between the need to orient its business policies on economic and financial considerations and disabled persons' demands that vehicles and premises be designed in a barrier-free manner, seeks to achieve solutions that are responsive to users' needs and at the same time economically justifiable. On account of the 19th century infrastructure legacy and a wide range of rolling stock in long- and short-distance rail travel, this can however be realized only step by step. The facilities offered to disabled people so far range from free use of short-distance trains to the accessibility-oriented design of coaches for the Intercity Express, the future of the railways in the European rapid transit network. The various services and facilities provided are hoped to foster disabled persons' decision in favour of the environmentally compatible rail mode of travelling. 相似文献
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目的探讨地塞米松对多核白细胞诱导的角膜基质细胞胶原降解作用及机制。方法利用角膜基质细胞三维胶原凝胶培养模型,加入多核白细胞或其培养上清及不同浓度地塞米松,在MEM培养液中培养48h后,通过测定培养上清液中的羟脯氨酸(HYP)的量作为胶原降解的活性单位。免疫印记法分析MMP活性变化。结果在纤维蛋白溶酶原存在的情况下,多核白细胞单独无胶原降解作用,多核白细胞与角膜基质细胞混合培养,及多核白细胞培养上清均能增加角膜基质细胞胶原降解量,差异有显著性(P〈0.01);多核白细胞培养上清能够刺激角膜基质细胞MMP-1和MMP-3释放,地塞米松依浓度依赖关系减少角膜基质细胞胶原降解量,差异有显著性(P〈0.01)。结论多核白细胞促进角膜基质细胞胶原降解,地塞米松具有抑制多核白细胞诱导的角膜基质细胞胶原降解的作用。 相似文献