对氟苯甲醛缩乙醇胺席夫碱合成、表征及抑菌活性的测试

通过对氟苯甲醛与乙醇胺的反应，合成了对氟苯甲醛缩乙醇胺席夫碱，并对其进行了元素分析、核磁共振氢谱、红外光谱、紫外光谱表征。抑菌实验表明，该席夫碱对金黄色葡萄球菌和革兰氏阴性菌均有较好的抑制作用。     

2,4-二羟基苯乙酮席夫碱化合物的合成

席夫碱是一种重要的化学分析试剂和有机合成中间体。本文用间苯二酚合成2,4－二羟基苯乙酮,然后与不同芳胺反应,合成了6种新的2,4－二羟基苯乙酮席夫碱化合物,利用紫外光谱、红外光谱、核磁共振和元素分析等方法确定了它们的结构,并对反应条件的选择进行了初步探索。     

芳胺与芳醛希夫碱化合物的合成与表征

以3-硝基-4-羟基吡啶为原料,经过溴化、硝化、还原等反应,合成了5-溴-3,4-二氨基吡啶。然后分别以各种芳氨和芳醛为原料,以无水甲醇和离子液体为溶剂,合成了6种新型杂环希夫碱化合物6a～6f。所得化合物用IR和1 H NMR进行了确证,并考察了离子液体等对希夫碱收率的影响因素。     

D-氨基葡萄糖Schiff碱的制备及抑制真菌性能研究

以D-氨基葡萄糖盐酸盐与对甲氧基苯甲醛、对甲基苯甲醛反应合成了两种新的D-氨基葡萄糖席夫碱(对甲氧基苯甲醛缩D-氨基葡萄糖席夫碱、对甲基苯甲醛缩D-氨基葡萄糖席夫碱),收率分别为67.9%、74.6%。使用UV1、HNMR和IR对产物进行了结构表征。测试了两种席夫碱甲醇饱和溶液对香蕉炭疽病菌、芒果炭疽病菌、芒果蒂腐病菌、芒果焦腐病菌、番木瓜炭疽病菌等植物病原真菌的抑菌性能。结果表明,对甲氧基苯甲醛缩D-氨基葡萄糖席夫碱对香蕉炭疽病菌、芒果蒂腐病菌、芒果焦腐病菌具有很强的抑菌活性,对甲基苯甲醛缩D-氨基葡萄糖席夫碱对香蕉炭疽病菌、芒果炭疽病菌具有很强的抑菌活性。     

新型Schiff碱基液晶化合物的合成及表征

以十一烯酸、对羟基苯甲酸、4-羟基苯甲醛、4-甲氧基苯胺为原料,经酰氯化、酯化和席夫碱反应合成中间体和未见文献报道的液晶化合物.通过红外光谱、核磁共振、元素分析等对化合物的结构进行表征.最后利用偏光显微镜测试目标产物的液品性能.结果表明:两种烯酸衍生物均具有向列相液品特性,化合物液晶相宽度为18℃,而增加刚性结构的长度后,合成的液晶化合物的液晶相宽度提高了近100℃,达到115℃,具有广阔的应用前景.     

多环芳烃蒄的合成方法及研究进展

综述了多环芳烃蒄的合成方法,对各个合成方法进行了说明及总结。蒄结构独特,具有很好的电子转移能力及良好的电致发光效应,结合实际对其应用做了展望。     

Synthesis and characterization of novel Schiff base polyurethanes

Eight different types of novel polyurethanes (PUs) were synthesized through the polyaddition reaction of 4,4′‐(ethane‐1,2‐diylidenedinitrilo)diphenol and 4,4′‐(pentane‐1,5‐diylidenedinitrilo)diphenol with four different diisocyanates: 4,4′‐diphenylmethane diisocyanate, toluene 2,4‐diisocyanate, isophorone diisocyanate, and hexamethylene diisocyanate. The resulting PUs were soluble in polar, aprotic solvents. Structures of the diols and PUs were established with ultraviolet–visible, fluorescence, Fourier transform infrared (FTIR), ¹H‐NMR, and ¹³C‐NMR spectroscopy data. FTIR and NMR spectral data indicated the disappearance of both hydroxyl and isocyanate groups in the PUs. The thermal properties were investigated with thermogravimetry and differential scanning calorimetry. The weight losses, glass transitions, onset temperatures, and crystalline melting temperatures were measured. All the PUs exhibited semicrystalline and amorphous morphologies, as indicated by X‐ray diffraction. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009.     

苯佐卡因缩芳醛席夫碱的合成及其抑菌活性

以苯佐卡因和芳醛为原料合成了3种标题化合物,用IR、1HNMR和元素分析对产物的结构进行了确证。采用滤纸片法测试了3种标题化合物对大肠杆菌、金黄色葡萄球菌及铜绿假单胞菌的抑菌性能。实验结果表明,标题化合物对所试3种细菌均有一定的抑菌活性能。其中,苯佐卡因缩水杨醛席夫碱对铜绿假单胞菌的抑菌效果最好,其抑菌圈直径达16.8 mm。     

新型席夫碱大环化合物的合成与应用研究

以水杨醛、1,2-二溴乙烷、邻苯二胺、对苯二胺、4,4’-二氨基二苯甲烷、4,4’-二氨基二苯醚、联苯胺为原料,经取代、缩合成环,得到一系列新型的席夫碱大环化合物,并对席夫碱大环进行还原,得到结构更稳定,柔韧性更好的仲胺大环。并通过IR、1HNMR和ESI/MS对其结构进行了表征。离子识别研究表明:大环化合物对Na+、Mg2+、Li+无明显作用,对Fe3+和Cu2+有作用。初步生物活性测试表明:席夫碱大环在一定浓度下具有抑菌活性。     

1-甲酰基苯并三唑席夫碱的合成及荧光性能

以苯并三唑、甲醛、伯胺为原料,合成了3种新的1-甲酰基苯并三唑席夫碱,分别简称为FBTTS、FBTSC和FBTAP。其最佳反应条件是以TBAB为相转移催化剂,三氯甲烷作溶剂,反应温度控制在50~55℃。通过IR、元素分析等检测手段,确证了3种新席夫碱的相应结构,并对其荧光性能进行了初步测试。     

双1,3,4-噻二唑Schiff碱的合成及其生物活性研究

用2-氨基-5-巯基-1,3,4-噻二唑与1,3-二溴丙烷和一系列取代苯甲醛反应,合成了7种未见文献报道的Schiff碱,并用元素分析、红外光谱、核磁共振氢谱对化合物进行了表征,生物活性实验证明,该类化合物具有明显的植物激素活性。     

聚合长链席夫碱盐的合成与性能

在0℃和弱酸催化下利用乙二醛和乙二胺合成聚合长链席夫碱,再用FeCl3掺杂上述中间产物制得聚合长链席夫碱铁盐。阐述了聚合长链席夫碱的合成机理,分析了合成温度对反应的影响以及掺杂剂用量对产物电导率的影响,并表征产物的结构与组成。当掺杂剂FeCl3的用量达到饱和掺杂率时,该方法制得的聚合长链席夫碱铁盐,其电导率为3.02×10-3S/cm。     

含二茂铁基Shift碱的合成

本文由呋喃甲酸经酯化、酰肼化反应得到呋喃甲酸酰肼,再由乙酰二茂铁与呋喃甲酸酰肼在乙醇溶剂中反应得到含二茂铁基的呋喃甲酸酰腙,以红外光谱、核磁共振谱对产品进行确定。     

New Pyrrole Derivatives as Promising Biological Agents: Design,Synthesis, Characterization,In Silico,and Cytotoxicity Evaluation

The current study describes the synthesis, physicochemical characterization and cytotoxicity evaluation of a new series of pyrrole derivatives in order to identify new bioactive molecules. The new pyrroles were obtained by reaction of benzimidazolium bromide derivatives with asymmetrical acetylenes in 1,2-epoxybutane under reflux through the Huisgen [3 + 2] cycloaddition of several ylide intermediates to the corresponding dipolarophiles. The intermediates salts were obtained from corresponding benzimidazole with bromoacetonitrile. The structures of the newly synthesized compounds were confirmed by elemental analysis, spectral techniques (i.e., IR, ¹H-NMR and ¹³C-NMR) and single-crystal X-ray analysis. The cytotoxicity of the synthesized compounds was evaluated on plant cells (i.e., Triticum aestivum L.) and animal cells using aquatic crustaceans (i.e., Artemia franciscana Kellogg and Daphnia magna Straus). The potential antitumor activity of several of the pyrrole derivatives was studied by performing in vitro cytotoxicity assays on human adenocarcinoma-derived cell lines (i.e., LoVo (colon), MCF-7 (breast), and SK-OV-3 (ovary)) and normal human umbilical vein endothelial cells (HUVECs). The obtained results of the cytotoxicity assessment indicated that the tested compounds had nontoxic activity on Triticum aestivum L., while on Artemia franciscana Kellogg nauplii, only compounds 2c and 4c had moderate toxicity. On Daphnia magna, 4b and 4c showed high toxicity; 2a, 2b, and 2c moderate to high toxicity; only 4a and 4d were nontoxic. The compound-mediated cytotoxicity assays showed that several pyrrole compounds demonstrated dose- and time-dependent cytotoxic activity against all tested tumor cell lines, the highest antitumor properties being achieved by 4a and its homologue 4d, especially against LoVo colon cells.     

乙酰二茂铁谷氨酸Schiff碱的合成

由乙酰二茂铁和谷氨酸合成乙酰二茂铁谷氨酸Schiff碱,优化了反应条件。实验结果表明,当原料物质的量比为1∶1.5、反应温度为50℃、反应时间为7h、pH值为7～8时,产品收率最高。     

2-羟基-4-甲氧基苯乙酮席夫碱化合物的合成

以2-羟基-4-甲氧基苯乙酮与3-硝基苯胺为原料，在一定条件下，通过加成-脱水反应制备2-羟基-4-甲氧基苯乙酮席夫碱，探讨了合成反应的影响因素，利用元素分析、红外光谱确定其结构，产品的收率为84％。     

Design,Synthesis, In Silico and In Vitro Studies for New Nitric Oxide-Releasing Indomethacin Derivatives with 1,3,4-Oxadiazole-2-thiol Scaffold

Starting from indomethacin (IND), one of the most prescribed non-steroidal anti-inflammatory drugs (NSAIDs), new nitric oxide-releasing indomethacin derivatives with 1,3,4-oxadiazole-2-thiol scaffold (NO-IND-OXDs, 8a–p) have been developed as a safer and more efficient multitarget therapeutic strategy. The successful synthesis of designed compounds (intermediaries and finals) was proved by complete spectroscopic analyses. In order to study the in silico interaction of NO-IND-OXDs with cyclooxygenase isoenzymes, a molecular docking study, using AutoDock 4.2.6 software, was performed. Moreover, their biological characterization, based on in vitro assays, in terms of thermal denaturation of serum proteins, antioxidant effects and the NO releasing capacity, was also performed. Based on docking results, 8k, 8l and 8m proved to be the best interaction for the COX-2 (cyclooxygense-2) target site, with an improved docking score compared with celecoxib. Referring to the thermal denaturation of serum proteins and antioxidant effects, all the tested compounds were more active than IND and aspirin, used as references. In addition, the compounds 8c, 8h, 8i, 8m, 8n and 8o showed increased capacity to release NO, which means they are safer in terms of gastrointestinal side effects.     

Synthesis of Fluorinated Polycyclic Aromatic Hydrocarbons Through a Photochemical Cyclization

Chromatographic determination of polycyclic aromatic compounds (PACs) is commonly performed with internal standards. Presently, perdeuterated PACs are widely used as internal standards, although they possess several disadvantages. Fluorinated PACs can be used instead to avoid those drawbacks. The synthesis of 12 three- to five-ring PACs containing up to three fluorine atoms is described here together with extensive spectral data.     

多环芳烃的前线轨道理论及降解预测应用

多环芳烃是一个全球性的污染物,存在于许多环境介质中。本文详细介绍了前线轨道理论及其对多环芳烃的应用,并综述了国外对多环芳烃使用前线轨道理论计算并预测降解反应方向和产物的研究,同时,对未来多环芳烃的理论研究进行了展望。     

二茂铁基席夫碱及盐的合成与导电性能

中性条件下,以二茂铁甲醛和对苯二胺为原料,合成了二茂铁基席夫碱,考查了反应温度和时间对产率的影响,并测得其本征态室温电导率σ＝1.26×10-9 S·cm-1。利用Fe3+、Al3+、Ti3+盐对二茂铁基席夫碱进行了掺杂,探讨了掺杂量和掺杂温度对产物室温电导率的影响,研究了掺杂产物电导率与温度的变化关系,并用红外光谱、紫外光谱和电子探针对产物结构和组成进行了表征。结果表明：经金属盐掺杂后,电导率可提高4～5个数量级, 根据Arrhenius曲线得到了化合物的电活化能在0.09～1.54 eV范围内,表明了它们具有较好的半导体性能。