Glycogen-rich clear cell carcinoma of the breast: A case report and review of the literature

A case of glycogen-rich clear cell carcinoma (GRCC) which arose in the right breast of a 35-year-old Japanese woman is reported. Light microscopic examination of the tumor revealed solid alveolar proliferation of clear cells containing abundant glycogen. Electron microscopy identified aggregates of glycogen particles and numerous empty glycogen lakes. This case is reported with a discussion on the other 42 GRCC cases reported in the international literature.     

Unique pineal gland metastasis of clear cell renal carcinoma: case report and review of the literature

The metastatic involvement of the pineal gland is an extremely unusual event; it has a 4% incidence in patients with disseminated neoplasias. Most metastatic pineal lesions are asymptomatic. Only in a small number of cases the symptoms produced by metastatic involvement of this organ precede those of the primary tumor or those of another metastatic site. To our knowledge the herein reported case is the first in which the pineal gland was apparently the unique metastatic site of a primitive kidney carcinoma and where the symptoms produced by metastasis in the pineal region were the first sign of the disease.     

Hyalinizing clear cell carcinoma: case series and comprehensive review of the literature

BACKGROUD:

Hyalinizing clear cell carcinoma (HCCC) is an uncommon malignant salivary gland tumor that was characterized only recently as a distinct entity. Because of its histologic similarity to several other primary and metastatic tumors and its purported favorable clinical outcome after local resection, it is important to recognize the features of this unusual tumor.

METHODS:

The authors present 8 new, fully characterized cases of HCCC and systematically reviewed 44 other cases of HCCC reported in the English language literature from 1980 to 2008. Historic cases were reviewed, and available data regarding morphology, special stains, demographics, clinical presentation, radiographic findings, management, and outcomes were extracted. Data from the current series were compared with the earlier published literature.

RESULTS:

To the best of the authors' knowledge, this was the largest reviewed series of HCCC and included a total of 52 cases. The findings, which included key histologic features, clinical presentation, and outcome, generally were consistent with what was reported previously. However, the current review revealed that 25% of patients reported in the literature had metastatases at initial presentation, including 10 of 44 patients who had metastases to regional lymph nodes and 1 patient who had metastasis to the lung. The authors were unable to identify any specific histologic features that would predict this behavior.

CONCLUSIONS:

The current results indicated that HCCC is less indolent than was believed previously; therefore, regional lymph node dissection should be considered in conjunction with wide local excision for patients with HCC. Cancer 2009. © 2008 American Cancer Society.     

肾透明细胞癌阴道转移1例报告及文献回顾

肾细胞癌阴道转移临床少见,肾细胞癌阴道转移的常见途径是泌尿系统、淋巴循环,血行转移少见.转移部位多见于肺、脑、肾上腺等,阴道转移罕见.本例肾癌术后1年余发现阴道转移,且病理类型与术前基本相似,主要为透明细胞癌,考虑应为血行转移.我院2015年收治1例,现报告如下. 1 病例资料 患者女,51岁,既往于2014年6月主因查体发现左肾占位性病变10天来我院求治,既往发现糖尿病病史2年,血糖控制尚可.行CT检查示:左肾类圆形软组织密度影,根据强化方式考虑肾癌.大小约5 cm×6 cm.B超检查示:左肾中下极可见大小约5.0cm×6.2cm,向包膜外突起,内部回声分布不均匀.彩色多普勒超声(CDFI):其内可见短条状血流信号.遂在全麻下行经腹腹腔镜下左肾癌根治术,术后病理回报示:左肾透明细胞性肾细胞癌,核分级1-2级,癌组织未侵及肾被膜.     

尿道透明细胞癌一例并文献复习

目的:提高对尿道透明细胞癌（CCA）的认识。方法:回顾性分析2019年4月滨州医学院附属即墨医院收治的1例尿道CCA患者临床资料,并进行文献复习。结果:该患者为36岁女性,因间歇性肉眼血尿1个月就诊,术前经综合检查诊断为尿道癌,行腹腔镜下膀胱根治性切除术+输尿管皮肤造口+全尿道切除+阴道前壁切除及阴道重建术+盆腔淋巴结...     

Rectal small cell carcinoma: a case report and review of the literature

We present a rare case of small cell carcinoma of the rectum presenting with rectal bleeding and discomfort in a fit 51-year-old gentleman. Our patient was treated with a combination of chemotherapy and radiotherapy and remains alive and free of disease 6 years after diagnosis. Our patient experience and review of the literature is presented highlighting the uncertainties regarding the biological behaviour and management.     

肾透明细胞癌合并肾上腺神经鞘瘤1例病例报告

目的:探讨肾透明细胞癌同期合并肾上腺神经鞘瘤临床诊疗过程中的特征,以提高对肾透明细胞癌同期合并肾上腺神经鞘瘤的诊治水平。方法:回顾性分析我院一例肾透明细胞癌合并肾上腺神经鞘瘤患者的临床资料,并检索中国知网、万方等数据库,对相关文献进行分析归纳其临床特点。结果:本例患者行腹腔镜下肾根治术及肾上腺肿物切除术,术后恢复良好,随访至今未发现复发及转移。结论:肾上腺神经鞘瘤在临床上属于少见病例,同期合并肾透明细胞癌的更是罕见。此患者在诊治过程中,需要与肾癌合并肾上腺转移瘤相鉴别。患者治疗的最佳方式是手术切除,由于存在复发及转移的可能性术后应该严密随访。     

Primary clear cell carcinoma of the nasopharynx： a case report

Primary dear cell carcinoma of the nasopharynx is a rare and locally invasive minor salivary gland neoplasm, only two cases have been reported yet in the literature. Now a 57-year man, with primary nasopharyngeal clear carcinoma,received radiotherapy and chemotherapy. After treatment, the mass of nasopharynx visibly reduced. Follow-up two months and repeated MRI, CT, abdominal B-ultrasonograpy, electronic nasopharyngoscopy, no tumor recurrence or metastasis.     

Squamous cell carcinoma of the rectum: a case report and review of the literature

Squamous cell carcinoma of the colon and rectum are extremely rare neoplasms. Many questions regarding their histogenesis and biological behaviour remain unanswered. Surgery is the most effective therapy, and adjuvant chemotherapy and radiotherapy should be considered, especially for node-positive patients. We present a patient with squamous cell carcinoma of the middle rectum who underwent abdominoperineal resection and postoperative adjuvant chemotherapy. The pertinent literature is reviewed.     

Small cell carcinoma of the esophagus: a case report and review of the literature

We present a case of small cell esophageal carcinoma (SCEC) treated with alternated chemotherapy (including cisplatin, etoposide, vincristine, cyclophosphamide and doxorubicin) and irradiation (36 Gy) followed by surgery. Despite a pathological complete response, the patient died of regional disease recurrence 29 months after the diagnosis. We reviewed the available literature on SCEC with regard to the incidence, clinical symptoms, radiological signs, diagnostic workup, therapeutic modalities and prognosis of this malignancy.     

乳头状肾细胞癌4例报道及文献复习

目的:探讨乳头状肾细胞癌(PRCC)的临床和病理特征。方法:对4例乳头状肾细胞癌临床表现、病理特征及免疫组化表型进行观察分析并文献复习。结果:肿瘤组织呈乳头状或管状结构排列,乳头中心及间质内有泡沫细胞浸润,有明显出血坏死。结论:乳头状肾细胞癌诊断依赖病理特征及免疫表型,并需与其他有乳头状结构的肾恶性肿瘤进行鉴别。     

Central granular cell odontogenic tumour: report of the first malignant case and review of the literature

Granular cell odontogenic tumours (GCOT) are rare neoplasms that usually manifest a benign clinical behaviour. We document the first case of GCOT exhibiting clinico-pathological features of malignancy that occurred in the maxilla of a 40-year-old male. The lesion appeared as an intra-oral polypoid mass and, at CT scan, as a poorly demarcated radiolucency eroding the cortical plate. Histologically, the tumour consisted of clusters of granular cells, exhibiting nuclear pleomorphism, prominent nucleoli and mitotic figures, and spindle cells in a collagenous stroma containing cementicles and strands of odontogenic epithelium. Morphologic transition from fibroblast-like to granular cells was frequently detected. The tumour cells extensively invaded the oral and respiratory mucosae and the adjacent soft tissues and exhibited vimentin and CD 68 immunoreactivity and high (21%) Ki 67 immunolabeling but not cytokeratins, E.M.A. actin, desmin, myosin or S-100 protein positivity. The patient experienced tumour recurrence 16 months after radical surgery. While the histogenesis of GCOT remains to be clarified, we document the existence of a malignant counterpart of this tumour and propose the name of malignant GCOT or granular cell odontogenic sarcoma for such entity.     

Primary small cell bladder carcinoma: a case report and review of the current literature

Primary small cell bladder carcinoma is an extremely rare and highly aggressive tumor. Unfortunately, the optimal therapeutic strategy for the tumor is still unknown. Recently, a two-stage system for limited and extensive small cell bladder carcinoma has been suggested in analogy to the practiced staging and treatment of small cell lung carcinoma. We present a new case of small cell bladder carcinoma and discuss relevant current literature.     

Merkel细胞癌术后复发1例及相关文献复习

目的：探讨Merkel细胞癌的诊断、治疗及预后。方法：一位老年Merkel细胞癌患者，于2006年8月初发时先行化疗及放射治疗，1年后局部再发肿瘤，再次接受扩大性切除术及放疗和化疗。结果：术后1月Merkel细胞癌再次复发。结论：Merkel细胞癌是一种罕见且进展快的皮肤肿瘤。诊断主要依靠病理（包括免疫组化方法），即使综合治疗后仍有局部复发和远处转移的倾向，预后差。     

Primary squamous cell carcinoma of thyroid: a case report and review of literature

Background

Oral epithelial dysplasia (OED) has a malignant potential. Therapeutic options for OED remain both limited and without good evidence. Despite surgery being the most common method of treating OED, recurrence and potentially significant morbidity remain problematic. Consequently, there has been much interest in non-surgical treatments for OED. Cyclo-oxygenase (COX) up-regulation is known to occur in the dysplasia-carcinoma sequence and evidence now exists that COX-2 is a prognostic marker of malignant transformation in OED. COX-inhibitors are therefore considered a potential therapeutic strategy for treating this condition. We aimed to provide both proof of principal evidence supporting the effect of topical COX inhibition, and determine the feasibility of recruitment to an OED chemoprevention trial in the UK.

Methods

Recruitment of 40 patients with oral leukoplakia to 4 study arms was planned. The total daily dose of Aspirin would increase in each group and be used in the period between initial diagnostic and follow-up biopsies.

Results

During the 15-month recruitment period, 15/50 screened patients were eligible for recruitment, and 13 (87%) consented. Only 1 had OED diagnosed on biopsy. 16 patients were intolerant of, or already taking Aspirin and 16 patients required no biopsy. Initial recruitment was slow, as detection relied on clinicians identifying potentially eligible patients. Pre-screening new patient letters and directly contacting patients listed for biopsies improved screening of potentially eligible patients. However, as the incidence of OED was so low, it had little impact on trial recruitment. The trial was terminated, as recruitment was unlikely to be achieved in a single centre.

Conclusion

This feasibility trial has demonstrated the low incidence of OED in the UK and the difficulties in conducting a study because of this. With an incidence of around 1.5/100,000/year and a high proportion of those patients already taking or intolerant of Aspirin, a large multi-centred trial would be required to fulfil the recruitment for this study. The ability of topical non-steroidal anti-inflammatory drugs to modify COX and prostaglandin expression remains an important but unanswered question. Collaboration with centres in other parts of the world with higher incidences of the disease may be required to ensure adequate recruitment.

ISRCTN

31503555.     

鼻腔原发性移行细胞癌一例并文献复习

鼻腔移行细胞癌临床表现为鼻塞进行性加重及间断性出现脓血性分泌物、头痛和听力下降。巨检示质灰红色碎组织,质地中等。镜下见细胞呈巢状、乳头状排列,细胞核呈圆形或卵圆形,浸润性生长,嗜碱或透亮。免疫组织化学示P63、CK5/6、CK18、UroplakinIII、CerbB-2、p53和CEA均阳性,Ki-67阳性指数约30%,而S-100,Cga,Syn,Calponin均阴性。鼻腔原发移行细胞癌较为罕见,临床易误诊,其诊断和鉴别诊断主要依靠病理组织学结构和免疫组织化学检查。