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AIMS: Having demonstrated previously the efficacy of topiramate--a sulfamate-substituted fructopyranose derivative-as pharmacotherapy for treating alcohol dependence, promoting abstinence and reducing the harmful psychosocial consequences of drinking, we investigated whether topiramate also promoted 'safe' levels of drinking: < or = 1 and < or = 2 standard drinks/day for women and men, respectively, among alcohol-dependent individuals. DESIGN, SETTING AND PARTICIPANTS: In a double-blind, randomized, controlled, 12-week clinical trial conducted in San Antonio, Texas, 75 alcohol-dependent adults received topiramate and 75 received placebo as an adjunct to weekly standardized medication compliance management. MEASUREMENTS: For this secondary analysis of data from that trial, we calculated, based on self-reports, specific intervals of up to 30 days of continuous 'safe' drinking for each subject. FINDINGS: The average longest 'safe' drinking period was 16.7 days for topiramate recipients versus 8.9 days for placebo recipients. By day 50 of treatment, 44% versus 26.4% had achieved > or = 7 and 30.8% versus 10% had achieved > or = 14 continuous 'safe' drinking days. Similarly, topiramate increased the relative likelihood of continuous 'safe' drinking from 77% for > or = 7 days [relative risk (RR) for achieving continuous 'safe' drinking = 1.77] to threefold for > or = 14 days (RR = 3.37) and fourfold for > or = 28 days (RR = 4.07). Thus, participants who received topiramate were more likely to achieve longer periods of 'safe' drinking compared with those who received placebo. CONCLUSIONS: For alcohol-dependent individuals who drank within an abstinence-oriented treatment program, topiramate promoted 'safe' drinking. Topiramate's potential to decrease the public health consequences of hazardous drinking needs to be established in future long-term studies. 相似文献
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Matthew R. Pearson Megan Kirouac Katie Witkiewitz 《Addiction (Abingdon, England)》2016,111(10):1733-1734
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Vincenzo Bagnardi Emanuele Sorini Davide Disalvatore Valentina Assi Giovanni Corrao Renzo De Stefani Collaborative ‘Alcohol less is better’ Group 《Addiction (Abingdon, England)》2011,106(1):102-110
Aims To evaluate differences in the individual alcohol consumption after a community‐based prevention programme. Design settings and participants ‘Alcohol, less is better’ is a controlled intervention trial. The intervention adopted a community approach, based on the active involvement of community leaders and institutional or volunteer organizations. Between 1999 and 2006, 2.5 years of activities aiming at informing and sensitizing the community on the harmful effects of alcohol on social life and health were carried out in 10 selected small Italian communities, involving a total of 123 235 individuals. Eight communities were chosen as control group. Measurements Changes in self‐reported individual alcohol consumption before and after the intervention were assessed on a random sample of intervention (n = 3382) and control (n = 2644) populations, using telephone and mailed surveys. Linear and log‐linear models for repeated measures were used to evaluate differences between intervention and control samples. Findings Overall, a significant reduction (P < 0.001) of individual self‐reported alcohol consumption was observed in the intervention sample (?1.1 drinks/week) relative to control sample (+0.3 drinks/week). The reduction was significantly greater in males than in females (P for heterogeneity = 0.016). In the young (15–24‐year‐olds) intervention and control samples showed opposite trends (?0.4 drinks/week and +1.7 drinks/week, respectively). Conclusions A coordinated community‐based intervention can reduce alcohol consumption in the general population. 相似文献
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Aims To examine correlates of general practitioners’ (GP) activity delivery of brief alcohol interventions to patients with particular reference to their ‘working style’. Design A postal questionnaire survey. Setting and participants All 75 GPs in the Community Primary Health Care Centre of the City of Tampere, Finland. Measurements Measures of working style classifying GPs into ‘problem solving’ versus ‘technological’, self‐reported brief advice activity and other demographic details. Findings and conclusions Of the respondents (response rate 85%) 45% (29/64) reported carrying out brief alcohol interventions. Male GPs provided brief interventions more often than female GPs (71% versus 36%, P = 0.017). The respondents had mainly positive attitudes to brief interventions for excessive drinkers. The working style typology did not show any relationship with brief intervention activity. 相似文献
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AIM: To reflect on the divergence and overlap between alcohol and illicit drugs with respect to both current policies and policy research. RESULTS: For demand reduction, there is considerable overlap in programs and services for prevention and even more clearly for treatment. For supply controls there is mostly divergence, reflecting the difference in legal status. Research generally follows the same pattern. However, a cross-cutting research agenda on the supply side has merit. CONCLUSION: Even in a prohibition regime, law-enforcement agencies have considerable discretion. A systematic, pragmatic, 'evidence-based' use of that discretion to reduce harm is possible. It can be accomplished only by a continuing program of policy research that measures the harms of drug use and drug enforcement, assesses the effects of current policies on both these sources of social cost and explores alternative strategies. There is a similarly important project for alcohol and tobacco control policy. The goal for research on alcohol and tobacco is to document the extent to which supply controls can be effective in reducing harm; the additional goal for illicit drugs is to document just how much the current ideologically driven approach is costing the public. 相似文献
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Aims To evaluate cost-effectiveness of eight interventions for reducing alcohol-attributable harm and determine the optimal intervention mix.
Methods Interventions include volumetric taxation, advertising bans, an increase in minimum legal drinking age, licensing controls on operating hours, brief intervention (with and without general practitioner telemarketing and support), drink driving campaigns, random breath testing and residential treatment for alcohol dependence (with and without naltrexone). Cost-effectiveness is modelled over the life-time of the Australian population in 2003, with all costs and health outcomes evaluated from an Australian health sector perspective. Each intervention is compared with current practice, and the most cost-effective options are then combined to determine the optimal intervention mix.
Measurements Cost-effectiveness is measured in 2003 Australian dollars per disability adjusted life year averted.
Findings Although current alcohol intervention in Australia (random breath testing) is cost-effective, if the current spending of $71 million could be invested in a more cost-effective combination of interventions, more than 10 times the amount of health gain could be achieved. Taken as a package of interventions, all seven preventive interventions would be a cost-effective investment that could lead to substantial improvement in population health; only residential treatment is not cost-effective.
Conclusions Based on current evidence, interventions to reduce harm from alcohol are highly recommended. The potential reduction in costs of treating alcohol-related diseases and injuries mean that substantial improvements in population health can be achieved at a relatively low cost to the health sector. 相似文献
Methods Interventions include volumetric taxation, advertising bans, an increase in minimum legal drinking age, licensing controls on operating hours, brief intervention (with and without general practitioner telemarketing and support), drink driving campaigns, random breath testing and residential treatment for alcohol dependence (with and without naltrexone). Cost-effectiveness is modelled over the life-time of the Australian population in 2003, with all costs and health outcomes evaluated from an Australian health sector perspective. Each intervention is compared with current practice, and the most cost-effective options are then combined to determine the optimal intervention mix.
Measurements Cost-effectiveness is measured in 2003 Australian dollars per disability adjusted life year averted.
Findings Although current alcohol intervention in Australia (random breath testing) is cost-effective, if the current spending of $71 million could be invested in a more cost-effective combination of interventions, more than 10 times the amount of health gain could be achieved. Taken as a package of interventions, all seven preventive interventions would be a cost-effective investment that could lead to substantial improvement in population health; only residential treatment is not cost-effective.
Conclusions Based on current evidence, interventions to reduce harm from alcohol are highly recommended. The potential reduction in costs of treating alcohol-related diseases and injuries mean that substantial improvements in population health can be achieved at a relatively low cost to the health sector. 相似文献
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Winnie Wing-Yan Yuen Lynn Tran Carlos King-Ho Wong Eleanor Holroyd Catherine So-Kum Tang 《AIDS care》2016,28(7):816-824
Current HIV prevention interventions for female sex workers (FSWs) have tended to target the cognitive factors in changing their behaviors, yet little attention has been paid to the psychological factors that influence the behavior of women in sex work. This review aimed to explore the associations between the psychological health of FSWs and HIV risk. A total of eight studies published in English before July 2013 were identified and reviewed. FSWs had reported psychological issues, including depression, suicidal thoughts as well as lower quality of life, and the pooled prevalence of probable depression was as high as 62.4%. The majority of studies showed that higher scores in psychological health problems were associated with increased HIV risk behavior, in particular inconsistent condom use, or sexually transmitted infections. Among the five studies which measured symptoms of depression, four documented that higher depression scores were significantly associated with inconsistent condom use among FSWs with their clients and/or partners. Meta-analysis using a fixed-effects model was performed to examine the association between depression and inconsistent condom use and found that higher scores in depression were significantly associated with inconsistent condom use (odds ratio?=?2.57, p?.001). This review contends that future HIV preventive interventions should take psychological health of FSWs into consideration. 相似文献
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David T. Levy K. Michael Cummings Andrea C. Villanti Ray Niaura David B. Abrams Geoffrey T. Fong Ron Borland 《Addiction (Abingdon, England)》2017,112(1):8-17
The use of vaporized nicotine products (VNPs), especially e‐cigarettes and, to a lesser extent, pressurized aerosol nicotine products and heat‐not‐burn tobacco products, are being adopted increasingly as an alternative to smoking combusted products, primarily cigarettes. Considerable controversy has accompanied their marketing and use. We propose a framework that describes and incorporates patterns of VNP and combustible cigarette use in determining the total amount of toxic exposure effects on population health. We begin by considering toxicity and the outcomes relevant to population health. We then present the framework and define different measures of VNP use; namely, trial and long‐term use for exclusive cigarette smokers, exclusive VNP and dual (cigarette and VNP) use. Using a systems thinking framework and decision theory we considered potential pathways for current, former and never users of VNPs. We then consider the evidence to date and the probable impacts of VNP use on public health, the potential effects of different policy approaches and the possible influence of the tobacco industry on VNP and cigarette use. 相似文献
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Alcohol dependence: a public health perspective 总被引:5,自引:1,他引:5
Aims To review epidemiological research on alcohol dependence and to propose a public health approach to address this problem. Design and setting The research under review is basically constituted by general population surveys. Participants Individuals in the community 18 years of age and older. Measurement Twelve‐month rates of alcohol dependence are estimated using DSM criteria. Findings The prevalence of alcohol dependence has been stable in the United States, at around 6% for men and 2% for women. The risk of alcohol dependence begins at low levels of drinking and increases linearly with alcohol consumption. Mean group level of consumption shows some relationship to prevalence of dependence. Alcohol‐dependent individuals are responsible for about 50% of the social, legal and interpersonal alcohol‐related problems in society. Conclusion Alcohol dependence is present at relatively high levels in the community. Alcohol‐dependent individuals are responsible for a fair proportion of alcohol‐related problems in society. A public health approach to this problem, emphasizing prevention and group level interventions to lower prevalence levels, is warranted. 相似文献
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Alys Havard 《Addiction (Abingdon, England)》2016,111(10):1731-1732
Commentary to: Questioning the validity of the 4+/5+ binge or heavy drinking criterion in college and clinical populations 相似文献