早期妊娠合并细菌性阴道病的检测分析

细菌性阴道病 (ｂａｃｅｒｉａｌＶａｇｉｎｏｓｉｓ,ＢＶ)是育龄妇女最常见的阴道感染性疾病之一 ,严重影响孕妇的健康。本文对人工流产妇女进行了ＢＶ检查 ,现报道如下。临床资料　检测对象 :1999年 11月～2 0 0 0年 8月 31日 ,对前来济南市妇幼保健院生殖健康科门诊进行人工流产的妇女进行细菌性阴道病检查共 12 10例 ,年龄最小的 17岁 ,最大 48岁 ,平均 32岁。孕龄 5～ 8周 ,孕次 1～ 11次。检测方法和ＢＶ诊断标准　 (1)用消毒棉签自阴道口内 4ｃｍ处 ,阴道壁采集分泌物 ;(2 )直接涂于精密ｐＨ试纸上 ,30秒后读ｐＨ值 ;(3)在阴道分泌物…     

细菌性阴道病的治疗

细菌性阴道病是育龄妇女最常见的阴道感染性疾病,是一种性传播性疾病。目前其治疗方法较多,分系统性治疗和阴道局部治疗两类,主要药物有甲硝唑、氯林可霉素、青霉素类、喹诺酮类、乳酸及乳酸杆菌制剂等。本文就其治疗的原理和目的、治疗方法分类、不同治疗方案及其评价和尚存在的问题作一综述。     

细菌性阴道病的诊断

细菌性阴道病是一种常见的妇科疾病,可以通过性传播。虽然目前该病有多种诊断手段,但在临床上仍然采用四个综合的临床体征指标,即①异常的阴道分泌物;②阴道pH值大于4.5;③氨试验阳性;④在阴道液湿片中找到线索细胞。上述四项指标存在其中三项就可诊断细菌性阴道病。另外革兰染色法比较其它实验室的方法具有低费用,易于操作,重复性好和设备简单等优点,所以当细菌性阴道病的诊断在临床上不能确立时,可用该法进行最后的诊断。     

细菌性阴道病治疗的现代观点

细菌性阴道病（ＢＶ）是生育期妇女最常见的疾病之一，在性病高危人群更为多见。由于５０％的ＢＶ患者可无临床症状，因而不仅患者而且临床医师易忽视对ＢＶ的诊治。ＢＶ与盆腔炎有关早为人们所认识，近年的研究表明与妇产科手术后感染、早产、产后子宫内膜炎、宫颈癌亦密...     

复方苦参凝胶辅助治疗妊娠期细菌性阴道病的临床研究分析

目的 探讨复方苦参凝胶辅助治疗妊娠期细菌性阴道病(BV)的临床效果.方法 选取2016年10月至2018年1月首都医科大学附属复兴医院诊治的130例妊娠期BV患者作为研究对象.采用随机数字表法将其分为联合组(n=65)和对照组(n=65).对照组给予甲硝唑栓和乳杆菌活菌胶囊的常规治疗,联合组在常规治疗基础上加用复方苦参...     

细菌性阴道病的诊断及治疗

1　概述细菌性阴道病 (ＢａｃｔｅｒｉａｌＶａｇｉｎｏｓｉｓ,ＢＶ)最早由Ｇａｒｄｎｅｒ等首先报道 ,是由于阴道内以加特纳杆菌等多种微生物增加为主 ,大量的厌氧菌取代了正常的乳酸杆菌 ,致使阴道内菌群失调所致的女性下生殖道感染性疾病。ＢＶ多见于中轻年育龄妇女 ,发病率高 ,其发病人数远多于阴道滴虫及真菌感染。由于阴道分泌物增多 ,有鱼腥臭味 ,患者心理负担加重。同时 ,由于ＢＶ可并发绒膜羊膜炎、宫颈炎、子宫内膜炎、产褥感染及低体重儿等 ,故对ＢＶ的正确防治十分重要。2　病因及发病机理阴道内的常住菌有乳酸杆菌、表皮葡萄球…     

细菌性阴道病的研究进展

细菌性阴道病是以加特纳菌及某些氧厌氧菌引起的混合感染性疾病。发病率高,可经性传播。并可引起早产、羊水感染、产后子宫内膜炎、绒毛膜羊膜炎、子宫颈癌等并发症,其原因可能与病原体合成的酶及代谢产物有关。目的多采用临床标准诊断该病,辅以实验室检查。积极治疗是必要的,多采用灭滴灵和氯林可霉素,孕妇患该病以局部用药较好。     

细菌性阴道病的诊疗进展

细菌性阴道病(BV)是一种常见且可治疗的疾病,他与正常的1阴道菌群失调有关,在女性的下生殖道疾病中最为常见.对患者的自尊、性生活和整体生活质量都造成影响.因此规范化的诊疗尤为重要.本文将通过对各国指南及最新调查研究进行总结,对BV的规范化诊治提供参考.     

细菌性阴道病影响阴道尖锐湿疣复发率的分析

在临床工作中，我们发现阴道尖锐湿疣（CA）的复发率与细菌性阴道病（BV）关系十分密切。现将我院性病科2001年1月-2003年12月诊治及随访的120例阴道CA患者的研究结果报道如下。     

The effect of treatment for vaginal yeast infection on the prevalence of bacterial vaginosis in early pregnancy

Both bacterial vaginosis and candidiasis are commonly seen in pregnancy, with marked differences in pregnancy outcome. The aim of this study was to assess the effect of antifungal treatment on the prevalence of bacterial vaginosis in early pregnancy. This prospective randomized study included 126 women in early pregnancy with heavy vaginal yeast colonization and 88 healthy controls. Vaginal flora was evaluated on initial visit and on two check-ups for the presence of bacterial vaginosis. Half of the heavily colonized patients received an antimycotic agent (clotrimazole). The prevalence of vaginosis was compared among the three groups. Xi (2)-test and Fisher's exact test were used for statistical analysis. Three of 72 (4.2%) yeast-free controls, two of 79 (2.5%) yeast infected but not treated patients, and nine of 63 (14.3%) infected and treated patients presented with bacterial vaginosis 4 weeks after the initial visit. There was a statistically significant increase in the prevalence of bacterial vaginosis (p<0.03) in yeast infected and treated patients as compared to colonized and untreated patients. Treatment of candidiasis in early pregnancy may contribute to an increased rate of bacterial vaginosis.     

妊娠期合并细菌性阴道炎对妊娠结局的临床影响分析

目的:研究妊娠期合并细菌性阴道炎对妊娠结局的临床影响,以及有效治疗对改善细菌性阴道炎导致的异常妊娠结果的作用。方法:细菌性阴道炎患者接受不同的临床治疗,并选50例健康患者作为对照组。将治疗组与未治疗组、未治疗组与对照组患者的流产、早产、胎膜早破、新生儿鹅口疮发生情况进行统计学分析及对比。结果:患者接受药物治疗后,治疗有效率为92.0%。治疗组异常妊娠结果发生率为4.0%,未治疗组异常妊娠结果发生率为28.0%。经检验,差异具统计学意义(χ~2=21.43,P0.01)。药物治疗能大大降低异常妊娠结果发生率。对照组异常妊娠结果发生率为2.0%,未治疗组异常妊娠结果发生率为28.0%。经检验,具统计学意义(χ~2=26.51,P0.01)。细菌性阴道炎能增加异常妊娠结果风险。结论:健康的阴道环境,有利于妊娠的正常进行。妊娠期合并细菌性阴道炎,能增加异常妊娠结果的发生率,有效治疗能有效改善细菌性阴道炎导致的异常妊娠结果。妊娠期妇女在确诊患有细菌性阴道炎后,应立即进行有效的治疗措施。     

乳酸菌阴道胶囊联合甲硝唑泡藤片治疗妊娠合并细菌性阴道病的疗效观察

目的:探讨乳酸菌阴道胶囊联合甲硝唑泡藤片治疗妊娠合并细菌性阴道病的疗效。方法:选择妊娠合并细菌性阴道病患者72例,随机分为联合组和对照组。两组患者均予以阴道放置甲硝唑阴道泡腾片200mg,每晚1次,连用7d。联合组患者在此基础上予以乳酸菌阴道胶囊阴道放置,每晚1枚,连用7d。观察两组患者治疗结束后1周的临床疗效,并随访比较两组患者治疗后3个月和6个月内复发率。结果:联合组患者治疗后的临床总有效率明显高于对照组(χ2=4.18,P<0.05)。两组治疗结束后随访3个月和6个月内,联合组的复发率均明显低于对照组(χ2=5.35和6.11,P<0.05)。结论:乳酸菌阴道胶囊联合甲硝唑泡藤片治疗妊娠合并细菌性阴道病具有较好疗效,能降低复发率,具有治疗和预防妊娠合并细菌性阴道病复发的双重作用。     

甲硝唑联合克林霉素在细菌性阴道炎患者中的应用效果探讨

目的:探讨甲硝唑联合克林霉素治疗细菌性阴道炎的临床疗效和安全性.方法:选择2010年1月～2011年12月在我院妇产科治疗的108例细菌性阴道炎患者为研究对象,随机将本研究入选患者分为对照组和实验组,对照组仅给予甲硝唑进行抗感染治疗,而实验组则在对照组治疗的基础上加用克林霉素对患者进行治疗,比较对照组和实验组的临床疗效、药物不良反应的发生情况及复发率.结果:实验组患者治疗总有效率(90.74%)明显高于对照组的(70.37%),而实验组患者治疗复发率(7.41%)明显低对照组的(25.93%),实验组和对照组患者间治疗总有效率和治疗复发率差异有显著性(P>0.05),但是实验组和对照组患者间不良反应发生率差异无显著性(P>0.05).结论:甲硝唑联合克林霉素是治疗细菌性阴道炎一种临床疗效确切的治疗方案,该方案具有不良反应少及复发率低等特点.     

吸毒人群细菌性阴道病的调查

目的：了解细菌性阴道病(BV)在女性吸毒者中的感染率。方法：对399例女性静脉吸毒者进行阴道分泌物涂片，用革兰染色细菌形态计分法进行BV的诊断和菌群分析。结果：在调查的399例女性吸毒者中，确诊BV150例，占37．59％，其中G^ 大杆菌缺如的144例，占96％。在136例中度菌群失调者中G 大杆菌缺如者120例，占88．24％。结论：作为我国HIV感染干预的重点人群一女性吸毒者中BV的发病率高达37．59％。     

Efficacy of povidone-iodine vaginal suppositories in the treatment of bacterial vaginosis

A prospective, randomized clinical trial was performed to study the efficacy of povidone iodine (Betadine) suppositories for the treatment of bacterial vaginosis (BV) in comparison to capsules containing lactobacilli (D?derlein Med). Seventy patients with BV included in the study were randomly assigned to be either treated with povidone iodine suppositories or lactobacilli. Patients were treated once a day for 5 days. Initial examinations took place on the first day of the study with follow-up examinations on days 8 and 15. The examinations included clinical parameters, patient evaluation, secretion screens, and quantitative and qualitative microbiological tests of vaginal flora. Both treatment groups showed improvement of clinical parameters, condition of secretions and subjective state of health. At day 15 there was a trend towards a better efficacy of the treatment with povidone iodine but this was not significant. However, patients with acute BV treated with povidone iodine had significantly better scores after 15 days. Both treatments were well tolerated. The microbiological examinations showed an increase of the mean number of lactobacilli in the vagina on day 8 after initiation of treatment with lactobacilli, but a decrease on day 15. Contrary to that the lactobacilli counts from patients treated with povidone iodine suppositories decreased after the first week but increased in the second one. Potentially pathogenic germs, e.g. Gardnerella, Bacteroides and Enterobacteria were reduced in a higher extent and with a longer lasting effect after treatment with povidone iodine suppositories than with capsules containing lactobacilli. The results of this study show that native lactobacilli rapidly re-colonize after the antiseptic treatment with povidone iodine. Therefore, there is no need to use lactobacilli in addition.     

乳酸菌阴道胶囊对妊娠晚期合并细菌性阴道病患者不良妊娠结局的预防作用

目的:探讨乳酸菌阴道胶囊对妊娠晚期合并细菌性阴道病(BV)患者不良妊娠结局的预防作用。方法:将94例妊娠晚期合并BV患者,根据就诊的门诊号顺序将其分为联合组48例和对照组46例。联合组患者予以乳酸菌阴道胶囊和甲硝唑栓联合治疗,对照组予以单纯的甲硝唑栓治疗。观察两组治疗7d后的临床疗效,并比较其不良妊娠结局。结果:治疗7d后,在临床总有效率方面联合组患者(95.83%)明显高于对照组(80.43%)(χ~2=5.39,P0.05);联合组患者在早产、胎膜早破和新生儿黄疸等不良妊娠结局发生率明显低于对照组(P0.05)。两组在产褥感染、低体重儿等不良妊娠结局发生率方面比较差异无统计学意义(P0.05)。结论:乳酸菌阴道胶囊辅助治疗妊娠晚期合并BV患者的疗效较确切,对其不良妊娠结局具有良好的预防作用,可减少其早产、胎膜早破和新生儿黄疸发生率。     

细菌性阴道病病因学研究进展

细菌性阴道病是育龄期妇女最常见的阴道感染性疾病。在过去的50年中已经发现多种能够引发BV的危险因素。然而,由于BV的复杂性以及缺乏可靠的动物模型,其病因至今为止仍不清楚。本文综述了BV病因学主要理论的进展:BV相关生物膜、正常阴道微生物群和宿主的免疫反应,BV是多种因素相互作用的结果。近年来有报道BV菌群对甲硝唑的耐药,BV的复发率也在不断增高,了解各种因素在BV的发病中的作用对于预防和治疗都有着重要作用。     

Personal digital assistants used to document compliance of bacterial vaginosis treatment

OBJECTIVE: The objective of this study was to estimate patient compliance with oral and vaginal metronidazole treatment of bacterial vaginosis using personal digital assistants (PDAs) and paper diaries. GOAL: The goal of this study was to assess a novel compliance documentation approach. STUDY: After each dose of intravaginal or oral metronidazole, 71 subjects recorded the time on a paper diary and answered questions on a PDA. All PDA entries were unknowingly time-date-stamped. Subjects returned for 2- and 6-week posttreatment examinations. Compliance was calculated using a repeated-measures multivariate analysis of variance (ANOVA). RESULTS: Mean patient compliance rates within the oral metronidazole group were greater with the paper diary compared with the PDA (68.3% and 50.0%, respectively, P = 0.001). The observed rate of compliance agreement for PDA versus paper diary was 69.0% (kappa = 0.4). The majority of noncompliant subjects reported they were compliant with the PDA and paper diary. CONCLUSIONS: PDAs could more accurately document true compliance rates and could be reasonable instruments to assess compliance in intravaginal antimicrobial drug or contraceptive trials.