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目的:比较普通粉碎和超微粉碎对黄连解毒汤中栀子苷和小檗碱溶出量的影响.方法:用HPLC法测定.结果:超微粉碎可增加栀子苷和小檗碱的溶出量,在超声提取下超微细粉中栀子苷和小檗碱含量分别比细粉提高26.26%和37.07%.结论:超微粉碎没有改变黄连解毒汤固有的药效学物质,但对黄连解毒汤中栀子苷和小檗碱溶出量而言,超微粉碎有重大意义. 相似文献
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采用高效液相色谱法测定灌胃给予黄连解毒散超微细粉和细粉的家兔血浆中黄芩苷的浓度,血药浓度-时间数据经药代动力学分析软件(Pharmaceutical Kinetics Software,PKS)处理,比较黄连解毒散超微细粉和普通细粉中黄芩苷在家兔体内的药代动力学参数。结果如下:黄连解毒散超微细粉组、普通细粉组黄芩苷的药代动力学最佳模型均为二室开放模型。黄连解毒散超微细粉主要药动学参数:Ka=0.497 h-1,t1/2α=2.556 h,t1/2β=8.46 h,AUC0→∞=3.401μg.h/mL,Vd=6.752 L/kg,Tpeak=3.005 h,Cmax=0.311μg/mL;黄连解毒散普通细粉主要药动学参数:Ka=0.419 h-1,t1/2α=2.74 h,t1/2β=5.83 h,AUC0→∞=2.611μg.h/mL,Vd=12.890 L/kg,Tpeak=3.645 h,Cmax=0.215μg/mL。与细粉比较,黄连解毒散超微细粉中黄芩苷的相对生物利用度提高了30.26%。上述结果表明,黄连解毒散经超微粉碎后吸收相增大,可显著提高其有效成分黄芩苷的生物利用度。 相似文献
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观察了黄连解毒散超微粉对人工诱发鸡大肠杆菌病的治疗效果.通过人工诱发建立鸡大肠杆菌病模型,用黄连解毒散超微粉进行治疗,同时设黄连解毒散散剂对照和氟苯尼考西药对照,观察临床症状、体质量变化及血清超氧化物歧化酶活性和内毒素含量变化.结果表明,黄连解毒散超微粉、黄连解毒散散剂和西药氟苯尼考的治愈率和有效率差异不显著;黄连解毒散超微粉和黄连解毒散散剂降低血清内毒素含量,提高超氧化物歧化酶活性,增加体质量的作用显著优于西药氟苯尼考.黄连解毒散超微粉对人工鸡大肠杆菌病有很好的疗效,与其散剂比较,使用剂量可以节省一半. 相似文献
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超微粉碎对黄连解毒散体外抑菌效果的影响 总被引:1,自引:0,他引:1
分别采用超微粉碎技术和普通粉碎技术将黄连解毒散制成超细微粉和细粉,应用管碟法进行体外抑菌试验,比较超微粉碎对黄连解毒散体外抑菌效果的影响。结果表明黄连解毒散超细微粉比细粉温水浸泡提取液和醇提取液的抑菌圈均大,差异显著(P<0.01)。说明超微粉碎可明显提高黄连解毒散的体外抑菌效果。 相似文献
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目的:本次主要对黄连解毒散超微粉运用于人工诱发鸡大肠杆菌病治疗中的效果进行探讨.方法:利用人工诱发鸡大肠杆菌病的模型,给予黄连解毒散超微粉治疗,并且设氟苯尼考西药与黄连解毒散散剂对比分析,对其疗效进行分析对比.结果:三种治疗方式治疗人工诱发鸡大肠杆菌病所取得的有效性与治疗率之间对比差异不明显,P>0.05,无统计学有意义.结论:黄连解毒散超微粉运用于人工诱发鸡大肠杆菌病治疗中的效果,其与黄连解毒散散剂对比,应用剂量可减少一半. 相似文献
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魏静 《四川畜牧兽医学院学报》2009,(4):28-32
在现代法律秩序中,商会自治规范是制定法的基础和必要的补充,甚至在某些方面替代了制定法;商会自治规范主要包括商会组织规范、行为规范、惩罚规范以及争端解决规范等;其效力仅及于其内部成员;商会自治规范和制定法之间存在冲突,但也存在整合的基础。 相似文献
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以国际标准强毒R株人工感染非免疫产蛋鸡,定时扑杀,分别从鼻窦、眶下孔、气管、肺、气囊、卵巢和输卵管分离MG,并收集感染鸡所产蛋分离MG。结果表明,人工感染48小时后上、下呼吸道及肺已被全面感染,96小时气囊已被感染,120小时输卵管已能分离到MG,卵巢始终分离不到MG。人工感染鸡自144小时便能在其所产蛋中分离出MG。药物治疗能在72小时内消除感染,油乳剂苗则需24天后逐渐降低蛋内MG分离率,药物卵内注射、种蛋药浴、高温处理均能杀死卵内MG,但以研制的种蛋浸泡剂药浴效果为最好。 相似文献
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本文概述了猪的毛色类型、猪的毛色遗传模式,着重综述了猪毛色基因分子基础的研究进展,指出存在问题并就未来发展方向做了思考。 相似文献
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REASONS FOR PERFORMING STUDY: Centesis of the bicipital bursa using an 8.9 cm long spinal needle has been reported but the alternative of employing a 3.8 cm long hypodermic needle requires validation. OBJECTIVE: To compare the efficacy of 2 different methods of centesis of the bicipital bursa and to evaluate the usefulness of ultrasonographic imaging to determine the location of solution administered when centesis of the bursa is attempted. METHODS: For Trial 1, 6 clinicians, who had no previous experience of centesis of the bicipital bursa, attempted to inject a solution composed of an aqueous radiopaque contrast medium and physiological saline solution (PSS) into the bicipital bursae of 2/12 horses using the previously described distal approach to inject one bursa and a proximal approach to inject the contralateral bursa. The bicipital tendon and bursa were examined ultrasonographically before and after injection; and both shoulders were examined radiographically to identify the location of the medium. In Trial 2, another 6 clinicians, also with no previous experience of centesis, repeated Trial 1, using 6 horses, but the radiopaque contrast medium was mixed with air instead of PSS. RESULTS: Accuracy of centesis using the proximal approach was 39% and that of the distal approach 28%. Ultrasonographic examination of the shoulder allowed the location of solution and air to be accurately predicted in all 12 shoulders examined. CONCLUSIONS: Clinicians who have had no previous experience performing centesis of the bicipital bursa are unlikely to be successful in centesis using either approach. Radiographic examination after injecting a radiopaque contrast medium may be necessary to assess the success of centesis especially if bursal fluid is not obtained during centesis. Injecting air along with the radiopaque contrast medium provides more accurate ultrasonographic confirmation of centesis and better radiographic definition than does injection without air. 相似文献
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