Q开关Nd:YAG激光联合咪喹莫特乳膏治疗扁平疣的疗效观察

目的观察Q开关Nd:YAG激光联合咪喹莫特乳膏治疗面部扁平疣的临床疗效。方法将62例扁平疣患者随机分成治疗组(32例)和对照组(30例),治疗组使用Q开关532 nm Nd:YAG激光治疗,后期外用喹莫特乳膏,对照组单外用咪喹莫特乳膏,观察疗效。结果治疗组的痊愈率为78.1%,总有效率为96.9%,对照组的痊愈率为46.7%,总有效率为76.7%,2组疗效差异均有统计学意义(P0.01)。结论 Q开关Nd:YAG联合咪喹莫特乳膏治疗扁平疣疗效好,值得临床推广。     

调Q倍频Nd∶YAG激光治疗太田痣

目的 观察特殊波长激光对太田痣的治疗效果。方法 选择特殊波长(Q1064)的激光治疗太田痣,每次治疗间隔为2个月。结果 治疗5次以上、4次、3次、2次和1次的显效率分别为:100％、87.5％、68.1％、40％,一般需治疗3—5次以上治愈率为37.5％,5次以上治愈率为80％。结论 特殊波长激光治疗太田痣有明显疗效,且并发症少,操作简单、方便,易控制,比现有的常规治疗方法优点更多。     

Q-开关Nd:YAG激光治疗扁平疣72例疗效观察

笔者于1999年11月～2001年12月采用Q-开关Nd:YAG激光治疗扁平疣72例,取得满意效果,现报告如下。1病例与方法病例选择:72例扁平疣患者均为笔者所在医院门诊患者,其中男26例,女46例,年龄8～35岁,病程均>半年,皮疹数目在50枚以上,分布以面部为主。所有患者既往接受过3种以上的治疗,未见好转,皮疹数目不减少或仍在增多。治疗方法:所有患者均采用Q-开关Nd:YAG激光机(MedliteⅣ)治疗,治疗前照相作为评价资料。对于小儿或对痛觉敏感者,治疗前1h于病变部位涂表面麻醉药膏(5%ELMA,Sweden),常规消毒。激光治疗参数设定:波长532nm,光斑2mm,频率5…     

Q开关Nd:YAG激光仪联合维A酸霜治疗扁平疣186例临床观察

2001年9月～2003年3月笔者应用Q开关Nd：YAG激光仪(武汉奇致公司生产)联合维A酸霜(重庆华邦制药有限公司生产)治疗扁平疣186例，取得了满意疗效，现报告如下。     

维A酸霜联合重组人干扰素α-2b凝胶治疗扁平疣65例疗效观察

目的：观察维A酸霜联合可重组人干扰素α-2b凝胶治疗扁平疣的疗效。方法：将患行随机的分成两组，治疗组外涂维A酸霜和重组人干扰素α-2b凝胶，对照组外涂维A酸霜，疗程8周。结果：治疗组有效率92．31％，对照组有效率72.55％，两组差异有显著性（P〈0．05）。结论：维A酸霜联合重组人干扰素α-2b凝胶治疗翩平疣效果优于对照组。     

重组干扰素α-2b凝胶联合异维A酸凝胶外用治疗扁平疣83例

我科于2007年1-8月应用0.1%异维A酸凝胶(安素丝：北京诺华制药有限公司)和重组干扰素α-2b乳膏(商品名:商品名为尤靖安,合肥兆峰科大药业有限公司生产)治疗扁平疣取得满意疗效,现将临床观察结果报告如下。     

异维A酸联合重组人干扰素α-2b凝胶治疗扁平疣45例

我科于2003年1月—2005年12月使用异维A酸胶囊联合重组人干扰素α-2b凝胶治疗扁平疣,取得较满意疗效,现报道如下。1资料与方法1.1病例选择90例皆来自我科门诊就诊的患者,根据典型皮损确诊为扁平疣。排除妊娠期及哺乳期女性患者,并嘱育龄期女性患者严格遵守停药1年后方可怀孕。9     

重组人干扰素α-2b乳膏联合阿昔洛韦膏等治疗扁平疣疗效观察

目的观察重组人干扰素α-2b乳膏等联合阿昔洛韦膏治疗扁平疣的疗效。方法患者随机分成三组。第一组采用重组人干扰素α-2b乳膏联合阿昔洛韦膏交替外用,第二组单独应用重组人干扰素α-2b乳膏外用,第三组单独应用阿昔洛韦膏外用,共30天。三组患者均同时口服病毒灵、多抗甲素。结果治疗结束后第1,2月末观察结果,联合用药与单一用药有效率比较差异有显著性(P<0.05)。结论重组人干扰素α-2b乳膏联合阿昔洛韦膏等治疗扁平疣经济、实用、疗效好、副作用小。     

调Q倍频Nd：YAG激光治疗太田痣

目的：观察特殊波长激光对太田痣的治疗效果。方法：选择特殊波长（Q1064）的激光治疗太田痣，每次治疗间隔为2个月。结果：治疗5次以上、4次、3次，2次和1次的显效率分别为：100％、87．5％、68．1％、40％，一般需治疗3－5次以上治愈率为37．5％，5次以上治愈率为80％。结论：特殊波长激光治疗太田有明显疗效，且并发症少，操作简单，方便，易控制，比现有的常规治疗方法优点更多。     

Q开关Nd:YAG激光治疗错误文眉103例疗效观察

目的:观察Q型YAG激光祛除错误文眉的疗效.方法:选用波长1.064μm,工作电压340～400V,调Q脉冲式Nd:YAG激光机治疗103例错误文眉.结果:痊愈83例,占80.58%;显效18例,占17.48%;有效2例,占1.94%;总有效率98%.结论:应用Q型YAG 1.064μm波长祛除错误文眉,疗效满意,不留疤痕,是目前祛除错误文眉的安全、高效方法.     

Q开关Nd:YAG激光治疗双侧太田痣3例

报告3例双侧太田痣。患者均为女性,1例为早发型,2例为迟发型。皮损特点是蓝褐色斑疹,主要累及巩膜及受三叉神经支配的面部皮肤,无自觉不适。其中1例患者父亲及妹妹均患此病。予Q开关Nd:YAG激光(波长1064nm)治疗,疗效满意。     

Q开关Nd:YAG激光和585nm脉冲染料激光治疗色素性、血管性皮肤病1686例

目的评估Q开关Nd:YAG激光和585nm脉冲染料激光治疗色素性皮肤病和血管性皮肤病的疗效。方法分别采用Q开关Nd:YAG激光治疗色素性皮肤病400例、585nm脉冲染料激光治疗血管性皮肤病1177例,并采用二者治疗病毒疣109例,观察疗效。结果Q开关Nd:YAG激光对色素性皮肤病的有效率由高到低依次为:雀斑(100%)、文身(87.50%)、脂溢性角化(84.60%)、斑痣(46.70%)、咖啡斑(40.40%);585nm脉冲染料激光对血管性皮肤病的有效率由高到低为:蜘蛛痣(98.30%)、草莓状血管瘤(91.40%)、红斑期酒渣鼻(83.30%)及颜面毛细血管扩张(80.00%);二者对病毒疣的有效率分别为:寻常疣90.10%、尖锐湿疣66.70%、扁平疣52.60%。结论Q开关Nd:YAG激光治疗色素性皮肤病、585nm脉冲染料激光治疗血管性皮肤病及二者治疗病毒疣疗效较好。     

Q开关Nd:YAG 1 064 nm激光对表皮葡萄球菌活性及结构的影响

 目的:探讨不同能量密度的Q开关Nd:YAG 1 064 nm激光对表皮葡萄球菌的菌体活性及结构的影响。方法: 临床获取毛囊炎标本,用胰蛋白胨大豆肉汤琼脂平板（TSA）培养获取菌落,基因测序进行鉴定,确定表皮葡萄球菌后进行培养,使用Q开关Nd:YAG 1 064 nm激光对菌体进行照射。实验组：激光光斑直径2 mm,脉宽≤8 ns,根据不同能量密度159、191、222、254、287 J/cm2分设5组;对照组不予激光照射。以菌落计数法评估菌体活性,并利用透射电镜观察菌体结构的改变。激光能量与菌落数的相关性采用Pearson相关分析。结果:实验组菌落计数分别为（234 500±12 554）、（89 200±10 485）、（52 200±6 214）、（26 200±4 157）、（8 300±2 213） CFU/mL,对照组菌落数为（276 400±13 150) CFU/mL,各组间差异有统计学意义（F=1 536.97, P<0.05）。激光能量与菌落数呈负相关（r=-0.90,P<0.05）。能量密度在191 J/cm2以上时,对菌体结构有破坏作用,能量越大,破坏程度越大。结论: Q开关Nd:YAG 1 064 nm激光对表皮葡萄球菌有抑菌和结构破坏作用。     

Q开关Nd:YAG激光联合红花逍遥片治疗黄褐斑临床观察

目的探讨Q开关Nd:YAG激光联合红花逍遥片治疗黄褐斑的疗效和安全性。方法将210例黄褐斑患者随机分为3组,每组各70例。治疗组予Q开关Nd:YAG激光治疗联合红花逍遥片口服;对照1组单纯予Q开关Nd:YAG激光治疗;对照2组单纯口服红花逍遥片。Q开关Nd:YAG激光治疗每周1次连续10周,后2周1次再治疗6周,共16周。红花逍遥片口服2片,3次/d连续16周。分别于5,10和16周时评价临床疗效。结果 16周时治疗组有效率为90.00%,对照1组为80.00%,对照2组为41.00%,差异有统计学意义(P均0.01);治疗组不良反应发生率为26.00%,对照1组为21.00%,对照2组为17.00%,差异无统计学意义(P0.05)。结论 Q开关Nd:YAG激光联合红花逍遥片治疗黄褐斑比两者单独应用效果好。     

Nd:YAG激光治疗尿道内尖锐湿疣的疗效观察

目的评价Nd:YAG激光治疗尿道内尖锐湿疣(CA)的疗效。方法96例尿道内CA患者随机分为治疗组55例,采用Nd:YAG激光治疗;对照组41例,采用CO2激光治疗,两组术后均予卡介菌多糖核酸治疗,比较两组的治愈率及复发率。结果两组一次性治愈率差异有显著性(P<0.05),治疗组(92.45%)高于对照组(71.05%)。两组复发率差异有显著性(P<0.05),治疗组(7.55%)低于对照组(28.95%)。结论Nd:YAG激光治疗尿道内尖锐湿疣治愈率高、复发率低,优于CO2激光,是治疗尿道内尖锐湿疣安全、有效的方法。     

Minimally Invasive Surgery for Axillary Osmidrosis Using a Combination of Subcutaneous Tissue Removal and a 1,444-nm Nd:YAG Laser

Many treatment modalities have been developed for axillary osmidrosis. It is well known that the surgical treatment has the best results. However, there is a high possibility of side effects. The 1,444-nm lipolysis laser has been recently introduced to remove the apocrine glands. So far, subdermal coagulation treatment with a 1,444-nm Nd:YAG laser may be the least invasive and most effective therapy for axillary osmidrosis. However, according to our previous experience, the recurrence rate was 20%~30%. This emphasizes the need for combination of surgical method and non-surgical method and we combined subcutaneous tissue removal and photothermocoagulation with a 1,444-nm Nd:YAG laser. Three patients for bilateral axillary osmidrosis were enrolled. After an incision of about one-third the length of the widest transverse diameter, the apocrine glands were separated from the skin. And then apocrine glands within the marked area were destroyed by irradiation with a 1,444-nm Nd:YAG laser thereafter. All patients exhibited no relapse of axillary osmidrosis and were satisfied with the treatment results. A combination of subcutaneous tissue removal and Interstitial laser photothermocoagulation with a 1,444-nm Nd:YAG laser could be an effective treatment for mild to moderate axillary osmidrosis.     

Efficacy and Safety of 1,064 nm Q-switched Nd:YAG Laser Treatment for Removing Melanocytic Nevi

Background

Until recently, the removal of melanocytic nevi has been performed with a CO₂ laser or Er:YAG laser. These lasers have been useful for removing affected spots. However, enlargement of spots or some sequelae, including depressed or hypertrophic scars, could develop as unwanted results. The Q-switched Nd:YAG laser has been used to remove deep-seated melanocytes, such as Ota nevus or tattoos. However, there have been no previous experiments performed to test the efficacy and safety of this laser treatment for melanocytic nevi.

Objective

The objective of this study was to investigate the efficacy and safety of the 1,064 nm Q-switched Nd:YAG laser for removing melanocytic nevi, including congenital nevomelanocytic and acquired nevomelanocytic nevi.

Methods

Two thousand and sixty four Korean patients with small melanocytic nevi were treated with a Q-switched Nd:YAG laser from 2005 to 2009. High-resolution photographs were taken in identical lighting and positions before and after the six weeks of treatment to observe the procedural efficacy.

Results

About 70% of the nevi treated using a 1,064 nm Q-switched Nd:YAG laser were completely removed after one session. The other 30% were completely treated within three sessions. The appearance of sequelae such as hollow scars noticeably decreased compared to the results seen in CO₂ or Er:YAG laser treatments.

Conclusion

Use of the 1,064 nm Q-switched Nd:YAG laser is a safe and effective treatment modality for melanocytic nevi.     

Nd:YAG laser for effective treatment of multiple cylindroma of the scalp

The case presented illustrates the successful effect of the Nd:YAG laser in the treatment of multiple giant scalp tumours in a patient who would not accept surgical excisions. A 60‐year‐old woman with multiple cylindroma covering the whole scalp area was treated with a Nd:YAG laser in a cutting continuous mode. Postoperative healing by second intention within 3–4 weeks left limited superficial scars. No tendency to relapse was noted during a follow‐up of 4 years.     

A Pilot Study of Q-switched 1064-nm Nd:YAG Laser Treatment in the Keratosis Pilaris

Background

Keratosis pilaris (KP) is a keratinization disorder that is characterized by follicular hyperkeratosis, with surrounding erythema. Topical treatments are widely used, but their effects are limited.

Objective

To evaluate the effectiveness of the Q-switched 1064-nm Nd:YAG laser for the treatment of KP.

Methods

Total of 12 patients with KP were treated with a Q-switched 1064-nm Nd:YAG laser. Ten sessions of laser treatment were delivered once every two weeks. The entire lesions were treated with the following laser settings: 4.0~5.0 J/cm², 4-mm spot size, and three passes. Two dermatologists'' clinical evaluations and patients'' satisfaction were assessed between before treatment (baseline) and at 1 month after the last treatment.

Results

Eleven of the twelve patients showed more than grade 2 (>25%) improvement in texture and dyspigmentation in KP lesions, respectively. A half of the patients (50%) showed more than 50% improvement in the skin texture. Regarding dyspigmentation, five patients (41.7%) showed more than 50% improvement. Eleven out of twelve participants were satisfied (>25% of the Patients'' self assessment) with the procedure. No significant adverse effect was observed.

Conclusion

Although the Q-switched 1064-nm laser treatment may not be the first line therapy for KP, it might be a new treatment option for the patients with recalcitrant KP.     

Q开关Nd:YAG激光1064nm联合532nm波长治疗颧部褐青色痣临床观察

目的 观察Q开关Nd:YAG激光1064 nm联合532 nm波长治疗颧部褐青色痣的临床疗效及不良反应.方法 应用Q开关Nd:YAG激光1064 nm联合532 nm波长治疗70例患者,开始选择波长为1064 nm,光斑直径3～4 mm,能量密度3.5 ～ 4.5 J/cm2,频率10 Hz,脉宽10 ns.之后对某些疗效不佳且色素较浅层患者改用或交替选择532 nm波长,光斑直径3～4 mm,能量密度1.5～2.0 J/cm2,频率1～5Hz.治疗间隔时间为2～3个月,一般治疗3～4次.结果 治疗4次后治疗组有效率为100％,痊愈率为75.00％,疗效与治疗次数呈正相关.36例(51.43％)患者出现色素沉着,12例(17.14％)出现暂时性色素减退.结论 Q开关Nd: YAG激光1064 nm联合532 nm波长治疗颧部褐青色痣效果满意,虽然术后色素沉着发生率较高,但均能随时间逐渐消退,未见其他不良反应及并发症.