心先安佐治婴幼儿急性毛细支气管炎观察及护理

目的探讨心先安在治疗婴幼儿急性毛细支气管炎中的临床疗效及护理方法.方法112例急性毛细支气管炎患儿随机分为治疗组及对照组,在相同的基础治疗条件下,治疗组应用心先安每次2～5 mg/kg,静滴,每天2次.结果治疗组痊愈41例(73.2%),好转10例(17.9%),无效5例(8.9%),总有效91.1%.对照组痊愈34例(60.7%),好转8例(14.3%),无效14例(25%),总有效75%.两组相比差异显著(x2=5.13,P＜0.05).结论心先安佐治婴幼儿急性毛细支气管炎疗效确切,且安全、可靠.细致的观察和护理是治疗成功的关键之一.     

环磷腺苷葡胺治疗76例病毒性心肌炎的疗效观察

目的观察环磷腺苷葡胺治疗76例病毒性心肌炎的临床疗效。方法76例病毒性心肌炎患者随机分为治疗组及对照组,对照组予维生素C、能量合剂等常规治疗,治疗组在常规治疗基础上给予环磷腺苷葡胺180 mg加入5%葡萄糖250 ml静滴,每日1次。结果治疗组痊愈28例(73.68%),好转7例(18.42%),无效3例(7.89%),总有效率为92.10%;对照组痊愈16例(42.10%),好转11例(28.95%),无效11例(28.95%),总有效率为71.05%;两组相比,痊愈率和总有效率差异有统计学意义(P<0.05)。治疗组治疗后心搏出量(SV)、每分钟输出量(CO)、心排血指数(CI)及射血分数(EF)有明显改善,与治疗前比较,差异有统计学意义(P<0.05);与对照组比较,差异有统计学意义(P<0.05)。结论环磷腺苷葡胺治疗病毒性心肌炎疗效确切,且安全、可靠。     

急性病毒性心肌炎80例综合治疗的疗效观察

目的 评价在常规治疗基础上应用1，6-二磷酸果糖（FDP），心先安，黄芪注射液联合治疗急性病毒性心肌炎的疗效。方法 80例急性病毒性心肌炎病人按入院顺序随机分为两组，对照组40例在青霉素，维生素C、病毒唑抗感染及抗病毒治疗基础上辅助加用GIS（10%GS500ml,RI8u-12u，氯化钾1g-1.5g)静滴，1次/天，连用2周，治疗组40例在常规治疗基础上加用FDP5g-10g入注射用水50ml-100ml静滴，1次/天；心先安90mg-150mg，黄芪注射液20ml-40ml入5%GS250ml中缓慢静滴，1次/天，连用1周-2周为1疗程，观察临床症状，体征，心电图，心功能等改变情况。结果 对照组40例显效14例，有效13例，无效12例，死亡1例，总有效率67.5%；治疗组40例显效25例，有效14例，无效1例，总有效率92.9%。经Ridit分析法检验两组疗效差别显。结论 FDP、心先安，黄芪注射液治疗急性病毒性心肌炎能有效预防心衰，减少心律失常发生率，且无任何副作用。是一种安全，有效的治疗方法，值得临床推广。     

中西医结合治疗急性病毒性心肌炎45例疗效观察

目的探讨中西医结合治疗急性病毒性心肌炎的疗效和可行性。方法将77例急性病毒性心肌炎患者随机分为治疗组(45例)和对照组(32例)。对照组:单纯应用西医综合疗法;治疗组在西医治疗的基础上加用黄芪注射液和丹参注射液。比较两组的疗效。结果治疗组:45例中,治愈35例,好转8例,无效2例,总有效率95.56%;对照组:32例中,治愈17例,好转6例,无效9例,总有效率71.88%。两组总有效率比较有统计学意义(χ2=8.56,P<0.01)。结论中西医结合治疗急性病毒性心肌炎明显优于单纯西药治疗。     

银翘散加减治疗小儿风热犯心型病毒性心肌炎临床观察

目的:观察小儿病毒性心肌炎中医治疗临床疗效并分析其机制。方法:将58例病毒性心肌炎患儿随机分为治疗组和对照组,每组各29例,两组均给予一般治疗,治疗组患儿在其基础上给予中药银翘散,并随证加减;对照组给予肌肉注射干扰素、口服辅酶Q10及维生素E,疗程均为4周,疗程结束后观察两组患儿临床疗效及心肌酶谱改善效果。结果:治疗组总有效率(93.1%)显著高于对照组总有效率(75.9%),治疗组心肌酶谱改善效果显著好于对照组,两组差异对比均有统计学意义(P<0.05)。结论:银翘散加减治疗小儿风热犯心型病毒性心肌炎,疗效确切,可广泛应用于临床。     

心先安佐治婴幼儿急性毛细支气管炎观察及护理

目的：探讨心先安在治疗婴幼儿急性毛细支气管炎中的临床疗效及护理方法。方法：112例急性毛细支气管炎患儿随机分为治疗组及对照组，在相同的基础治疗条件下，治疗组应用心先安每次2～5mg／kg，静滴，每天2次。结果：治疗组：痊愈41例（73．2％），好转10例（17．9％），无效5例（8．9％），总有效91．1％。对照组痊愈34例（60．7％），好转8例（14．3％），无效14例（25％），总有效75％。两组相比差异显著（x^2=5．13，P〈0．05）。结论：心先安佐治婴幼儿急性毛细支气管炎疗效确切，且安全、可靠。细致的观察和护理是治疗成功的关键之一。     

中西医结合治疗儿童病毒性心肌炎疗效观察

目的探讨中药黄芪注射液治疗儿童病毒性心肌炎的临床疗效.方法将120例患儿分成治疗组60例,对照组60例.治疗组除常规治疗基础上加用黄芪注射液,每日一次,连用21天.结果治疗组显效36例(60%),有效20例(33%),无效4例(7%);对照组60例,显效8例(13%),有效36例(60%),无效16例(27%).2组治疗效果差异有统计学意义(P<0.05).结论加用黄芪注射液治疗科提高小儿病毒性心肌炎的疗效,值得推广.     

参麦注射液治疗68例小儿病毒性心肌炎的临床疗效观察

目的 探讨参麦注射液治疗小儿病毒性心肌炎的临床疗效.方法 回顾性分析笔者所在医院68例小儿病毒性心肌炎患儿的病例资料,所有患儿均应用参麦注射液进行治疗,2周为1个疗程.结果 68例患儿,治愈63例(92.6%),有效3例(4.4%),无效2例(2.9%),总有效率为97%.所有患儿均未发生明显不良反应.结论 参麦注射液治疗小儿病毒性心肌炎疗效肯定,值得临床推广.     

黄芪治疗儿童病毒性心肌炎疗效观察

目的 探讨黄芪注射液治疗儿童病毒性心肌炎的临床疗效.方法 将住院患病毒性心肌炎的患儿随机分成治疗组和对照组,对照组采用常规治疗,治疗组在常规治疗基础上加用黄芪注射液.结果 治疗组30例,显效18例(60%),有效10例(33%),无效2例(7%);对照组30例,显效4例(13%),有效18例(60%),无效8例(27%),两组结果经χ2检验,χ2=3.92,P＜0.05,治疗组明显优于对照组.结论 黄芪注射液可显著提高治疗病毒性心肌炎的疗效,值得推广.     

黄芪注射液联合病毒唑治疗小儿病毒性心肌炎临床疗效观察

目的:观察黄芪注射液联合病毒唑治疗小儿病毒性心肌炎的临床疗效。方法:选择78例病毒性心肌炎患儿,随机分为观察组和对照组,各39例。在常规治疗基础上,对照组给予单纯病毒唑治疗,观察组给予黄芪注射液联合病毒唑治疗。比较两组患者心肌酶谱值改善情况、治疗效果和不良反应发生情况。结果:观察组心肌酶谱值改善较对照组明显。对照组患儿治疗总有效率为74.36%,观察组患儿治疗总有效率为92.31%;观察组治疗总有效率明显高于对照组,差异具有统计学意义(P<0.05)。两组患者治疗过程中均未出现严重药物不良反应。结论:黄芪注射液联合病毒唑治疗小儿病毒性心肌炎效果较好,可有效降低心肌酶谱值,安全性高。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.