Substituted Amides and Hydrazides of Acylpyruvic Acids. Part 10. Synthesis,Antimicrobial and Analgesic Activity of 4-Aryl-2-arylamino-4-oxo-2-butenoic Acid Arylamides

Pharmaceutical Chemistry Journal -     

Synthesis and Antimicrobial Activity of β-N-(Benzoyl)Hydrazides of 4-Aryl-2-hydroxy-4-oxo-butenoic (Aroylpyruvic) Acids

A series of β-N-(4-methoxybenzoyl)- and β-N-(3-nitrobenzoyl)hydrazides of 4-aryl-2-hydroxy-4-oxo-2- butenoic (aroylpyruvic) acids was obtained with 52 – 88% yields using the reaction of decyclization of 5-aryl-2,3-dihydrofuran-2,3-diones by hydrazides of 4-methoxybenzoic and 3-nitrobenzoic acid hydrazides in dioxane. The synthesized compounds were characterized and tested for antibacterial activity.__________Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 3, pp. 21 – 22, March, 2005.     

Synthesis,Antimicrobial, and Analgesic Activity of 4-Aryl-2-N-morpholino-4-oxo-2-butenoic Acids

Pharmaceutical Chemistry Journal -     

Synthesis,Antimicrobial and Analgesic Activity of N-Substituted 2-Amino-4-aryl-4-oxo-2-butenoic Acids

Pharmaceutical Chemistry Journal -     

Substituted Amides and Hydrazides of Acylpyruvic Acids. Part 9. Synthesis,Antimicrobial and Analgesic Activity of Substituted 4-Aryl-3-halogen-2,4-dioxobutanoic Acid Amides

Pharmaceutical Chemistry Journal -     

Synthesis and Antimicrobial Activity of Pyrazole-4-carboxylic Acid Hydrazides and N-(4-Pyrazoyl)hydrazones of Aromatic and Heteroaromatic Aldehydes

Pharmaceutical Chemistry Journal -     

Synthesis and Antimicrobial Activity of 4-(4-Acetylphenyl)-3-Hydroxy-2H-Chromen-2-One Derivatives

Pharmaceutical Chemistry Journal - Reactions of 4-(4-bromoacetylphenyl)-3-hydroxy-2H-chromen-2-one with Py, 4-methylpyridine, quinoline, and benzo[f]quinoline produced quaternary salts; with...     

Synthesis,Properties, and Antimicrobial Activity of N-Aryl-7-Hydroxy-2-Imino-2H-Chromene-3-Carboxamides

Pharmaceutical Chemistry Journal - Aseries of previously unreported N-aryl-7-hydroxy-2-imino-2H-chromene-3-carboxamides were synthesized via the reaction of 2,4-dihydroxybenzaldehyde with...     

2—羟基—3—氨基—4—苯丁酸的合成

2-羟基 - 3-氨基 - 4-苯丁酸 (1 )是制备二肽免疫增强剂类抗癌新药乌苯美司的关键中间体 ,有多种合成方法 ,如 α-氨基苯乙酮法 [1]、α-氨基苯丙醛法 [2 ]、α-氨基苯丁腈法[3] 、苯丁烯酸甲酯法 [4 ] 、苯丙氨酸法 [5]和苹果酸二乙酯法 [6]等。以上各法均存在不同缺点 ,如α-氨基苯乙酮法 ,总收率不到 1 0 % ;α-氨基苯丙醛法和α-氨基苯丁腈法 ,均用剧毒氰化钾(钠 ) ;苯丁烯酸甲酯法用爆炸性的过氧化物 ;苯丙氨酸法合成步骤长 ,且用氢化铝锂和氰化钠等试剂 ;苹果酸二乙酯法中的烃化反应需在 - 78℃的低温下进行。上述各法均不适合工业化…     

Synthesis and Pharmacological Activity of 4-Aryl-1,5-benzo[b]diazepine-2-carboxylic Acid Arylamides

Pharmaceutical Chemistry Journal -     

Synthesis and Anticonvulsant Activity of N-Substituted 4-Amino-3-Nitrocoumarins

Pharmaceutical Chemistry Journal - The synthesis and anticonvulsant activity of new coumarin derivatives are reported. N-(3-Nitrocoumarin-4-yl)-4-aminobutyric acid (1a) at doses of 60 and 80 mg/kg...     

Synthesis and Antimicrobial Activity of 2-Iminocoumarin-3-carboxylic Acid Amides

Pharmaceutical Chemistry Journal -