N-（2-（7-氯-4-氧代-2-苯氨基喹唑啉-3（4H）-基）乙基）酰胺的合成

研究了N-（2-（7-氯-4-氧代-2-苯氨基喹唑啉-3（4 H）-基）乙基）酰胺的合成方法。以4-氯-2-氨基苯甲酸为起始原料,通过氮杂-Wittig反应合成关键中间体7-氯-3-氨乙基-2-苯氨基喹唑啉酮,再以酰胺类似物为先导,根据活性亚结构拼接原理,将活性基团喹唑啉酮乙基导入酰胺基中,设计合成一系列含喹唑啉酮乙基的新型酰胺类似物,并通过IR、1 HNMR、MS及元素分析等对其结构进行确证。     

2-苯基喹唑啉-4-酮的Vilsmeier反应研究

以邻氨基苯甲酸、苯甲酸酐和乙酸为原料,经过绿色合成方法合成了2-苯基喹唑啉-4-酮,然后对2-苯基喹唑啉-4-酮进行了Vilsmeier反应研究。用IR对其结构进行了表征。考察了反应时间、反应温度和投料配比对Vilsmeier反应的影响。结果表明,反应时间为4 h,反应温度为80~90℃,原料POCl3与2-苯基喹唑啉-4-酮的摩尔比为1.5：1为最佳的反应条件,收率可达67.8%。     

2-甲基-3-甲苯基喹唑啉-4-酮盐酸盐的合成研究

以邻氨基苯甲酸为原料，以不同的中间体和不同的脱水剂对2-甲基-3-甲苯基喹唑啉-4-酮的合成进行研究比较，寻找较佳的合成路径。     

6-乙酰氧基-4(3氢)-喹唑啉酮的合成

以2-氨基-5-羟基苯甲酸为原料,与甲酰胺环合得到6-羟基-4(3氢)-喹唑啉酮,再用乙酸酐酯化得到6-乙酰氧基-4(3氢)-喹唑啉酮。研究了每步反应的投料比和反应温度对收率、纯度的影响。结果表明,①6-羟基-4(3氢)-喹唑啉酮的最佳工艺条件为:2-氨基-5-羟基苯甲酸与甲酰胺的摩尔比是1∶15,温度160℃,反应时间4 h;②6-乙酰氧基-4(3氢)-喹唑啉酮的最佳工艺条件为:6-羟基-4(3氢)-喹唑啉酮与乙酸酐的摩尔比是1∶1.2,温度80℃,反应时间3 h;两步反应的总产率达96%,产物纯度>99.0%。     

(4-(嘧啶-2-基)哌嗪基)(2-苯基喹唑啉)甲酮 合成工艺的改进

开发了一种(4-(嘧啶-2-基)哌嗪基)(2-苯基喹唑啉)甲酮新的合成工艺,以苯甲酰氯、苯胺等为起始原料,经酰胺化、取代、杂化成环、水解、缩合等反应制备得到(4-(嘧啶-2-基)哌嗪基)(2-苯基喹唑啉)甲酮,并对其结构用1H NMR和MS进行了表征。该工艺操作简便、环保、安全,所用原料均廉价易得,制备成本低,适合规模化生产。     

(4-(嘧啶-2-基)哌嗪基)(2-苯基喹唑啉)甲酮的绿色合成

采用4-氯-2-苯基喹啉、嘧啶哌嗪等为原料,经过取代、水解、缩合等反应,绿色合成方法合成了(4-(嘧啶-2-基)哌嗪基)(2-苯基喹唑啉)甲酮,并对其结构用1HNMR和MS进行了表征。     

3-(2-乙酰苯并呋喃)-喹唑啉酮类衍生物的合成研究

文章根据文献中对抗球虫活性物质的生物活性和结构关系的研究,保留常山碱中与生物活性相关的喹唑啉酮结构部位,合成了一系列3-(2-乙酰苯并呋喃)-喹唑啉酮类衍生物,获得了一些合成相关喹唑啉酮类抗球虫化合物有意义的研究结果。     

一类新的有机颜料—吡唑并喹唑啉酮颜料

1960年拜耳公司首先提出以吡唑并喹唑啉酮为偶合组份的偶氮染料,随后该公司又相继发表了一些含不同基团的偶氮染料专利。二十年后巴斯夫公司也提出用吡唑并喹唑啉酮为偶合组份制备的中性染料和有机颜料,特别重要的是把吡唑并喹唑啉酮颜料推向实用阶段,并以商品为Sico投入市场。吡唑并喹唑啉酮颜料是单偶氢化合物,它是以吡唑并喹唑啉酮作偶合组份,同取代的苯胺或多环和杂环胺反应而得。这类颜料有四种异构体形式,而最重要的是其中的活泼氢原子     

邻氨基苯甲酸一锅法合成喹唑啉酮化合物研究进展

喹唑啉酮化合物具有广泛的生物活性,在医药、农药、离子检测等方面有重要应用。以邻氨基苯甲酸为原料一锅法合成喹唑啉酮化合物的方法,原料低廉易得,操作简单高效。该文综述了近些年邻氨基苯甲酸一锅法合成喹唑啉酮化合物的方法,希望能给研究者们提供一些参考和帮助。     

喹唑啉酮的一种催化合成优化

本论文围绕铜催化Ullmann交叉偶联反应制备喹唑啉酮衍生物进行研究,建立了一种铜催化邻卤代苯甲酸与胍反应合成喹唑啉酮的新方法。研究了催化剂、碱、溶剂等反应条件对该催化体系活性的影响,并筛选出了最优的反应条件:20 mol%Cu I为催化剂,Cs2CO3为碱,DMF为溶剂。该催化体系简单、高效,无需任何的配体或添加剂,反应条件温和,可以用于构建多样化的分子。     

生物弹性体的研究进展Ⅱ.聚氨酯

介绍了聚氨酯生物弹性体的结构特点,结合这些结构特点列举了对聚氨酯生物弹性体进行性能调控,以满足不同生物需求的分子设计方法。综述了改善聚氨酯生物弹性体生物相容性的方法,包括表面改性和本体改性等。指出了聚氨酯生物弹性体的发展方向。     

单、双螺杆泵的对比及应用

通过分析常见的单螺杆泵、双螺杆泵的结构特点,阐述这两种螺杆泵的工作原理,并将单螺杆泵、双螺杆泵这两种泵进行对比,总结出两种螺杆泵各自不同的特点和优越性。同时针对单螺杆泵在应用中产生振动的问题,分析其产生振动的原因,提出了防止单螺杆泵振动应采取的几种方法与措施;并针对双螺杆泵在应用中对含沙量比较敏感提出一定的防治措施,为以后在油田中的应用中合理选择螺杆泵提供一定的依据。     

安克锰锌在荔枝树上施用的残留代谢消解规律与安全性评价

安克锰锌是烯酰吗啉两个异构体和代森锰锌组成的多元混合制剂。试样经粉碎、溶剂浸泡提取、混合柱净化,用气相色谱测定烯酰吗啉和代森锰锌母体(CS2),液相色谱测定代谢物乙撑硫脲(ETU)。仪器最低检出量:烯酰吗啉为1.436×10-12g,代森锰锌母体1.326×10-10g,ETU2.5×10-10g,最低检出浓度依次为0.02、0.025、0.02mg/kg,方法回收率依次为86.4%～90.8%、89.2%～95.9%、89.10%～95.13%;标准偏差为0.53～4.34;变异系数为0.58%～4.62%。安克锰锌在果皮中的消解方程广西和广东分别为C=1.2719e-0.1975T和C=1.045e-0.1972T,半衰期(T/2)均为3.5d;土壤中分别为C=0.8734e-0.1187T和C=0.6171e-0.1146T,半衰期(T/2)=6d;最高剂量250倍、最多施3次,最短距收期7d,在果肉中均未检出,果皮和土壤中的残留仅分别为0.1385～0.1745mg/kg和0.3105～0.3415mg/kg,均低于欧共体规定代森锰锌MRL值0.5mg/kg。     

Effect of NaBH4 concentration on the characteristics of PtRu/C catalyst for the anode of DMFC prepared by the impregnation method

PtRu/C catalysts were prepared using an aqueous co-impregnation method with NaBH₄ as a reducing agent. In order to investigate the effect of the reducing agent concentration, metal ions were reduced in different NaBH₄ concentrations for which the molar ratios of NaBH₄ to metal ions were controlled to 1, 2, 5, 15, 50, and 250. The electrochemical properties were studied by cyclic voltammetry in a 0.5 M H₂SO₄ solution. The surface compositions and oxidation states of the catalysts were observed by X-ray photoelectron spectroscopy (XPS). According to the X-ray diffraction (XRD) results, Pt (fcc) peak shifts were observed and crystal sizes were calculated. The electro-catalytic activities of the prepared catalysts for methanol electro-oxidation were estimated using linear sweep voltammetry. Unit cell tests were carried out to compare the direct methanol fuel cell performances. The NaBH₄ concentration was found to affect the dispersion and the surface composition of the prepared PtRu particles. Optimum molar ratios of NaBH₄ to metal ions were 5 and 15 for methanol electro-oxidation.     

Diode Laser Welding of Polyethylene

A high-power diode laser (HPDL) was used to weld high-density polyethylene (HDPE) sheets. Laser-welded joints were fabricated with different values of laser power and scan speed. Hot-tool welding was also employed to fabricate joints to make a comparison between this consolidated technology and HPDL welding. Initially, laser heating tests were carried out to study the laser–material interaction. Furthermore, welding tests were carried out and tensile mechanical tests were performed to characterize joints and sound specimens. A similar material behavior was recognized for all the specimens. While the laser process resulted in lower strength and ductility, in comparison to the tool-welding process, the aesthetics of the laser-welded joints were remarkable. The best values of the process parameters were individuated for the laser welding and were used to fabricate a closed structure having sharp edges. The same geometry cannot be obtained by any other welding technology.     

Two Types of Domain Boundaries in Lanthanum Magnesium Niobate

Microstructural studies of the domain boundaries in the complex perovskite compound lanthanum magnesium niobate (La[Mg_2/3Nb_1/3]O₃, LMN) were conducted using transmission electron microscopy. Both the 1:1 chemical ordering of B-site cations and the tilting of oxygen octahedra affected the domain boundaries. Two types of domain boundaries were observed. In addition to the presence of antiphase boundaries, which were insensitive to the crystallographic planes, ferroelastic domain boundaries that were caused by the phase transition due to the tilting of oxygen octahedra also were present. In some grains, only one type of oxygen tilting was present, which resulted in a single domain in one grain. Two or three domains were observed in a grain where the walls were parallel to the {110} plane. Many domains also were observed in a grain that had boundaries whose linear characteristics were gradually reduced.     

Fabrication of Piezoelectric Ceramic/Polymer Composite Transducers Using Fused Deposition of Ceramics

The fused deposition of ceramics (FDC) technique was used to fabricate piezoelectric ceramic skeletons for the development of piezoelectric composite transducers with 2–2 connectivity for medical imaging. The green parts were designed to have 30 vol% lead zirconate titanate ceramic (PZT-5H) in the final composites. Physical characterization of the sintered samples revealed that 96% of the theoretical density was achieved. Optical microscopy showed that defects due to the FDC mode of deposition, such as small roads and bubbles, were eliminated, because of improvements in powder processing. The electromechanical properties of the final composites were similar to the properties that were obtained for conventionally made composites. A matching layer and a backing layer, as well as wires and an inductor, were added to each FDC composite to fabricate a functional medical imaging transducer. The devices were tested in water using a steel target 3.5 cm thick. Echoes from the target could be detected with all the transducers that were fabricated using FDC. The sensitivities of the transducers were similar to that of a commercial transducer. However, the ringing was much longer than that for a commercial transducer, because the backing layer was not optimized in the transducers that were fabricated using FDC.     

Enhancement of Physico-mechanical Properties of Plywood Surface with Urethane Acrylate (M-1200) by UV Curing Method

Several UV-curable formulations containing urethane acrylate (M-1200) oligomer with a trifunctional monomer, trimethylol propane triacrylate (TMPTA), and photoinitiator Irgcure-369 were developed to improve the surface of plywood. Thin polymer films were prepared on glass plate with these formulated solutions and finally applied on polished plywood surface to modify the surface, and both were cured under UV-radiation. The properties of UV-cured thin films were studied as a function of UV-radiation intensities. Pendulum hardness (PH) and gel content were found to increase with the increase of TMPTA concentration up to a certain level and with further increase of monomer concentration the physical properties were decreased. The polymer-coated surface yielded enhanced physico-mechanical properties compared to that of unmodified surface.     

民用工业中复合材料桁架的应用和发展

本文叙述了复合材料桁架的构造、分类和计算方法,突出了复合材料桁架的优越性能和在民用工业中的应用前景;在分析大量文献资料的基础上阐述复合材料桁架杆件的多种加工工艺,并比较不同截面形式对杆件性能的影响;探讨复合材料杆件的破坏机理和分析方法,介绍节点的类型和各自的特点,提出节点及连接部位存在的关键问题;根据国内外复合材料桁架的研究和应用现状,阐述了复合材料桁架的性能和不同的设计方法,总结归纳影响复合材料桁架性能的关键因素和设计中存在的一些问题,并提出改进杆件设计、节点设计和优化复合材料桁架的建议。     

松节油酸酐二酯化合物增塑性能的研究

用松节油酸酐二酯类化合物与邻苯二甲酸二辛酯(DOP)对比,研究它们与聚氯乙烯(PVC)树脂的相容性、加工热稳定性及增塑聚氯乙烯的物理性能。结果表明,松节油酸酐二丁酯、二辛酯可作为主增塑剂,其增塑性能类似于邻苯二甲酸二辛酯。