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1.
The novel fatty acids (Z)-6-nonadecenoic acid (1) and (Z)-17-pentacosenoic acid (2) were characterized in the spongeGeodia gibberosa. These fatty acids were mainly found in phosphatidylethanolamine and phosphatidylcholine. 相似文献
2.
The very long-chain fatty acids, (5E,9Z)-6-bromo-5,9-tetracosadienoic, (5E,9Z)-6-bromo-23-methyl-5,9-tetracosadienoic, (5E,9Z)-6-bromo-5,9-pentacosadienoic and (5E,9Z)-6-bromo-24-methyl-5,9-pentacosadienoic acids, were identified in the phospholipids (mainly phosphatidylethanolamine) of
the spongeAgelas sp. Structure elucidation was accomplished by means of mass spectrometry and chemical transformations, including deuteration
with Wilkinson's catalyst. All of the sterols from the sponge had the Δ5,7 nucleus, with 24-methylcholesta-5,7,22-trien-3β-ol
(ergosterol) and 24-ethylcholesta-5,7,22-trien-3β-ol being the most abundant. 相似文献
3.
Ching T. Hou Harold Gardner Wanda Brown 《Journal of the American Oil Chemists' Society》1998,75(11):1483-1487
Hydroxy fatty acids are important industrial materials. We isolated a microbial culture, Clavibacter sp. ALA2, which converts linoleic acid to many polyhydroxy fatty acids. Structures of the products were determined as: 12,13,17-trihydroxy-9(Z)-octadecenoic
(THOA, main product), 12-[5-ethyl-2-tetrahydrofuranyl]-7,12-dihydroxy-9(Z)-dodecenoic (ETDDA), and 12-[5-ethyl-2-tetrahydrofuranyl]-12-hydroxy-9(Z)-dodecenoic
(ETHDA) acid. The yield of THOA was 25% and the relative amount of the products were THOA/ETDDA/ETHDA =9:1.3:1. The structures
of the hydroxy unsaturated fatty acids resemble those of plant self-defense substances. 相似文献
4.
N-acyl-1H-1,2,3-benzotriazoles were prepared in good yields by the reaction of benzotriazole and thionyl chloride with olefinic fatty acids under mild reaction conditions. The new compounds 1-(undec-10-enoyl)-1H-1,2,3-benzotriazole (5a),1-[(Z)-octadec-9-enoyl]-1H-1,2,3-benzotriazole (5b), 1-[(9Z,12R)-12-hydroxyoctadec-9-enoyl]-1H-1,2,3-benzotriazole (5c), 1-[(9R,12Z)-9-hydroxyoctadec-12-enoyl]-1H-1,2,3-benzotriazole (5d) formed were characterized on the basis of elemental analysis and spectral data. All the newly synthesized compounds (5a-5d) were screened for their antimicrobial activity and showed good antifungal activity. 相似文献
5.
Mary J. Garson Mary P. Zimmermann Max Hoberg Rundi M. Larsen Christopher N. Battershill Peter T. Murphy 《Lipids》1993,28(11):1011-1014
Preliminary investigation of the phospholipid fatty acid composition of the tropical marine spongeAmphimedon terpenensis by gas chromatography/mass spectrometry revealed the presence of some novel brominated fatty acids. Two new brominated fatty
acids, (5E, 9Z)-6-bromo-5,9-tetracosadienoic acid (2a) and (5E, 9Z)-6-bromo-5,9-pentacosadienoic acid (3a) were subsequently isolated from a chloroform/methanol (3∶1, vol/vol) extract of the
sponge and characterized as their methyl esters 2b and 3b. The known brominated fatty acid (5E, 9Z)-6-bromo-5,9-hexacosadienoic acid (4a) was also isolated. The new fatty acid methyl esters were confirmed as brominated δ5,9
acid derivatives by chemical ionization mass spectrometry. The position of the bromine substituent was determined to be C-6
by nuclear magnetic resonance techniques while the stereochemistry of the two double bonds was deduced by nuclear Overhauser
enhancement difference spectroscopy. The biosynthetic implications of the co-occurrence of the three brominated acids are
discussed. 相似文献
6.
Anneli Hase O. Harva Tuula Pakkanen 《Journal of the American Oil Chemists' Society》1974,51(4):181-183
It was shown that two bicyclic fatty acids present in Finnish tall oil were formed from (5Z, 9Z, 12Z)-5, 9, 12-octadecatrienoic
acid, pinolenic acid (I). Under the alkaline conditions of sulfate pulping, pinolenic acid forms conjugated isomers which
undergo Diels-Alder cyclization during the heating in the tall oil distillation. The cyclization products, here called cyclopinolenic
acids, are bicyclic fatty acids and stereoisomers of 4-(5-pentyl-3a, 4,5,7a-tetrahydro-4-indanyl) butanoic acid (IV and V). 相似文献
7.
Gilles Barnathan Pierre Doumenq Jean-Michel Njinkoué Joseph Mirallès Cécile Debitus Claude Lévi Jean-Michel Komprobst 《Lipids》1994,29(4):297-303
The fatty acid composition of phospholipids from the New Caledonian spongeCinachyrella aff.schulzei Keller was studied. More than 60 fatty acids were identified as methyl esters andN-acyl pyrrolidides by gas chromatography and gas chromatography/mass spectrometry. Two isoprenoid fatty acids also were shown
to be present, namely 4,8,12-trimethyltridecanoic and 5,9,13-trimethyltetradecanoic acids. The unusual 6-tetradecenoic, 6-pentadecenoic,
12-nonadecenoic and 26-methylheptacosanoic (iso-28∶0) acids were found for the first time in sponge phospholipids. A series of six n−7 monoenoic long-chain fatty acids (C23 to C28) were identified, including the rare 16-tricosenoic, 18-pentacosenoic and 21-octacosenoic acids. Fifteen fatty acids possessing
the typical 5,9 dienoic moiety accounted for 30% of the total fatty acid mixture. Two new fatty acids were identified, namely
5(Z)-octacosenoic and 27-methyl-5(Z),9(Z)-octacosadienoic (iso-5,9-29∶2). Based on gas chromatography/Fourier transform infrared experiments, the double bonds were assigned the (Z) configuration.
For part 2 of this series, see Reference 1. 相似文献
8.
In order to identify new structures and especially those involved as biosynthetic intermediates, the fatty acid composition
of whole phospholipids from two Senegalese marine sponges from the order Axinellida,Trikentrion loeve andPseudaxinella cf.lunaecharta, has been investigated by analytical gas chromatography and gas chromatography/mass spectrometry. Several new fatty acids
were identified as methyl esters andN-acyl pyrrolidies, namely 16-eicosenoic, 11-tetracosenoic, 5-pentacosenoic, 11-hexacosenoic, 11-oxtacosenoic, 23-triacontenoic,
17,21-hexacosadienoic, 19,23-octacosadienoic, 9,23-triacontadienoic, 5,9,21-hexacosatrienoic, and 5,9,25-triacontatrienoic.Trikentrion loeve andP. cf.lunaecharta contain fifteen 25.7% of the total acid mixture) and thirteen (30.4%) °5,9 fatty acids, respectively. Based on gas chromatography/Fourier
transform infrared experiments, the double bonds were assigned the (Z) configuration. Biosynthesis of dienoic and trienoic
demospongic acids possessing an n-5 or an n-7 terminal double bond is discussed. 相似文献
9.
以3-苯硫基丙块1为原料经5步反应合成了(Z)-5-甲基-3苯硫甲基-5-氢呋喃-2-酮8和(Z)-5-甲基-3-苯硫甲叉基4,5-二氢呋喃-2-酮9。合成的关键步骤是在三甲基氯硅烷(TMSCl)/NaI/H2O/CH3CN体系中5-苯硫基-3-戊炔-2-酮3一步完成的碘氢化和去共轭反应。 相似文献
10.
该文基于Perkin反应合成了具有血管阻断及抗肿瘤活性的天然产物Combretastatin B-1(CB1)。以异香兰素为起始原料,用二溴海因对其进行选择性溴代得到2-溴-3-羟基-4-甲氧基苯甲醛(Ⅱ),该化合物与3,4,5-三甲氧基苯乙酸(Ⅲ)发生Perkin反应得到(Z/E)-2-(3,4,5-三甲氧基苯基)-3-(2'-溴-3'-乙酰氧基-4'-甲氧基)丙烯酸(Z-4、E-4),再经羟化反应及脱羧-异构化反应制备得到E-Combretastatin A-1(E-CA1),最后经催化氢化反应得到CB1,总收率为53.4%。 相似文献
11.
The phospholipids of the spongeStrongylophora durissima were analyzed. The major phospholipids present were phosphatidylethanolamine (PE), phosphatidylcholine (PC), phosphatidylserine
(PS), phosphatidylglycerol (PG) and phosphatidylinositol (PI). The major fatty acid components of the phospholipids consisted
of short chain (C14−C19) and very long chain (C25−C30) “Demospongic” acids. Three novel branched Δ5 monounsaturated acids,Z-19-methyl-5-pentacosenoic,Z-19-methyl-5-hexacosenoic andZ-19-methyl-5-heptacosenoic acids were encountered in the sponge. The 3-saturated counterparts of these compounds, 19-methylpentacosanoic,
19-methylhexacosanoic and 19-methylheptacosanoic acids, as well as 19-methylpentacosanoic and 20-methyloctacosanoic acids
also are hitherto undescribed acids present in the sponge. Trace amounts of 2 very long chain acids also were detected and
their structures tentatively assigned as 19,21-dimethylheptacosanoic and 20,22-dimethyloctacosanoic acids. The distribution
of these fatty acids according to phospholipid head groups also was described. 相似文献
12.
13.
14.
The reaction of hydrogen bromide (HBr) with long chain triol acids has been investigated in some detail. The 9, 10, 12-trihydroxy
stearic acid (I) on treatment with HBr yielded three products, namely 9(10)-bromo-10(9)-hydroxy-12-bromo (III), 9(10)-bromo-10(9)acetoxy-12-bromo
(IV) and 9,10-dibromo-12-hydroxy (V) stearic acids. When 9,12,13-trihydroxy stearic acid (II) was subjected to the same reaction
under similar conditions, 12,13-dibromo-9-hydroxy (VI), 12(13)-bromo-13(12) acetoxy-9-bromo (VII) stearic acids were obtained.
The structure of these products were established on the basis of their elemental values, spectral data and chemical evidence. 相似文献
15.
Marcel S. F. Lie Ken Jie M. S. K. Syed Rahmatullah 《Journal of the American Oil Chemists' Society》1995,72(2):245-249
Enrichment ofcis-5 polyunsaturated fatty acids [20:3(5c,11c,14c), 4.3% and 20:4(5c,11c,14c,17c), 11.3%] fromBiota orientalis seed oil was carried out by lipase-catalyzed selective esterification and hydrolysis reactions. Lipases fromRhizomucor miehei (Lipozyme),Candida cylindracea and porcine pancreas were used. Lipozyme-catalyzed esterification ofBiota fatty acids withn-butanol inn-hexane allowed 20:3 and 20:4 (as fatty acids) to be enriched to a maximum level of 52.9%, and in the presence ofC. cylindracea lipase 61.5% enrichment was achieved. Esterification with pancreatic lipase was poor with low levels of enrichment of 20:3
and 20:4 (22%). A multigram scale esterification of the free fatty acids fromBiota seed oil by repeated treatment of the isolated fatty acid fraction withn-butanol inn-hexane in the presence ofC. cylindracea lipase furnished an enrichment yield of 72.5% of a mixture of 20:3 and 20:4 fatty acids. Urea fractionation of the free fatty
acids ofBiota oil gave an initial enriched fraction of 20:3 (9.5%) and 20:4 (25.2%) which, upon treatment withC. cylindracea lipase inn-butanol andn-hexane, gave an enriched fraction of 85.3% of 20:3 and 20:4 fatty acids. Partial hydrolysis of the triglycerides ofBiota oil byC. cylindracea lipase in potassium phosphate buffer at 25°C resulted in a 2.8-fold enrichment ofcis-5 polyunsaturated fatty acids (40.8% of 20:3 and 20:4) as contained in the unhydrolyzed acylglycerol fractions. 相似文献
16.
Fritz Thell Mechthild Henning Hans Schick Sigfrid Schwarz 《Advanced Synthesis \u0026amp; Catalysis》1985,327(6):917-922
Methyl 7-bromo-5-heptynoate ( 11 ) was synthesized in 8 steps using the alkylation of 1-(2H-tetrahydropyran-2-yloxy)-2-propyne with 1-bromo-4-chloro-butane as a key reaction step. Furthermore it was shown, that also the unprotected propargyl alcohol ( 12 ) can be C-alkylated with high chemoselectivity using 1-bromo-4-chloro-butane. In this way the number of necessary reaction steps could be reduced without decrease in the total yield. Attempts failed to use trimethylsilyl 4-bromo-butanoate or 4-bromo-butyl acetate as alkylating reagent in this synthesis. 相似文献
17.
A new method for the synthesis ofcis-3,cis-5- andtrans-3,cis-5-tetradecadienoic acids, pheromone constituents of the dermestid beetlesAttagenus elongatulus andA. megatoma, was developed. The syntheses are based upon the formation oftrans-2-tetradecen-5-ynoic acid by reaction of 4-bromo-2-butenoic acid with 1-decynylmagnesium bromide. The enynoic acid undergoes
alkali-induced isomerization to yield a mixture of acids from whichcis-3- andtrans-3-tetradecen-5-ynoic acids were separated in 31% and 34% yields, respectively. Methyltrans-2-tetradecen-5-ynoate was similarly prepared and isomerized to furnish methylcis-3-tetradecen-5-ynoate in 8% yield. Reduction of the tetradecenynoic acids with dicyclohexylborane gavecis-3,cis-5-andtrans-3,cis-5-tetradecadienoic acids in 4% and 39% yields, respectively. A better yield (49%) in the reduction ofcis-3-tetradecen-5-ynoic acid tocis-3,cis-5-tetradecadienoic acid was obtained by hydrogenation over Lindlar's catalyst. Similarly, reduction of methylcis-3-tetradecen-5-ynoate with disiamylborane gave 22% methylcis-3,cis-5-tetradecadienoate. 相似文献
18.
Masaki Kaneniwa Kazuo Miyashila Toru Takagi 《Journal of the American Oil Chemists' Society》1988,65(9):1470-1474
Autoxidation rates of the 5-olefinic monoenoic and dienoic fatty acids from sea urchin lipids and meadow-foam oils were compared
with those of normal monoenoic and dienoic fatty acids by gas-liquid Chromatographic determination of the unoxidized fatty
acid methyl esters remaining through the autoxidation period. The fatty acids are classified into five groups shown below
according to the oxidation rate of their methyl esters: I 5-olefinic monoenoic acids (c5-18:l, c5-20:l and c5-22:1), II normal
monoenoic acids (c9-18:l, cll-18:l, c9-20:1, cl3-20:l and cl3-22:l), III 5-olefinic dienoic acids (c5,cll-20:2, c5,cl3-20:2
and c5,cl3-22:2), IV 7-olefinic dienoic acids (c7,cl3-22:2 and c7,cl5-22:2) and V normal dienoic acids (c6,c9-18:2, c9,cl2-18:2
and cll,cl4-20:2). The oxidation rates of these groups increased during autoxidation in order from I to V. These results show
that the 5-olefinic monoenoic and dienoic acids are more stable to autoxidation than the normal monoenoic and dienoic acids,
respectively. The higher stabilities of the 5-olefinic monoenoic and dienoic acids in organisms are shown from these results. 相似文献
19.
Transannular Reactions of Cycloalkenes, Cycloalkadienes and Cycloalkatrienes. VIII. The Electrophilic Addition of Pseudohalogenes to Cycloocta-1(Z), 5(Z)-diene The reaction of cycloocta-1(Z), 5(Z)-diene 5 with chlorothiocyanate is described. The main process is the normal anti-addition to produce trans-5-chloro-6-thiocyanato-(Z)-cyclooctene 6 . In addition 2,6-dichloro-9-thiabicyclo [3.3.1] nonane 7 and 2,6-dithiocyanato-9-thiabicyclo[3.3.1] nonane 8 are obtained as products of a transannular reaction. 相似文献
20.
Philip E. Sonnet Thomas A. Foglia Mary Welch Baillargeon 《Journal of the American Oil Chemists' Society》1993,70(10):1043-1045
The relative reactivities of several long-chain fatty acids in esterifications with 1-butanol catalyzed by lipases ofGeotrichum candidum were evaluated. As has been noted previously, these lipases are not uniformly highly selective forcis-9 unsaturated fatty acids. However, the lipase preparations examined do uniformly discriminate against fatty acids having
a chainlength greater than C-18 such as erucic acid. The reactivities of γ-linolenic and ricinoleic acid were also low compared
to that of oleic. An examination of the effect of the alcohol upon the relative reactivities of acids showed that one could
enhance fatty acid selectivity by proper choices of alcohol. For example, oleic acid esterifies 2.5 times faster than palmitic
acid with 1-butanol catalyzed by Amano GC-4 lipase, but esterifies over 50 times faster with 2-methyl-1-propanol or cyclopentanol. 相似文献