Empirical likelihood semiparametric nonlinear regression analysis for longitudinal data with responses missing at random

This paper develops the empirical likelihood (EL) inference on parameters and baseline function in a semiparametric nonlinear regression model for longitudinal data in the presence of missing response variables. We propose two EL-based ratio statistics for regression coefficients by introducing the working covariance matrix and a residual-adjusted EL ratio statistic for baseline function. We establish asymptotic properties of the EL estimators for regression coefficients and baseline function. Simulation studies are used to investigate the finite sample performance of our proposed EL methodologies. An AIDS clinical trial data set is used to illustrate our proposed methodologies.     

Empirical likelihood for semiparametric regression model with missing response data

A bias-corrected technique for constructing the empirical likelihood ratio is used to study a semiparametric regression model with missing response data. We are interested in inference for the regression coefficients, the baseline function and the response mean. A class of empirical likelihood ratio functions for the parameters of interest is defined so that undersmoothing for estimating the baseline function is avoided. The existing data-driven algorithm is also valid for selecting an optimal bandwidth. Our approach is to directly calibrate the empirical log-likelihood ratio so that the resulting ratio is asymptotically chi-squared. Also, a class of estimators for the parameters of interest is constructed, their asymptotic distributions are obtained, and consistent estimators of asymptotic bias and variance are provided. Our results can be used to construct confidence intervals and bands for the parameters of interest. A simulation study is undertaken to compare the empirical likelihood with the normal approximation-based method in terms of coverage accuracies and average lengths of confidence intervals. An example for an AIDS clinical trial data set is used for illustrating our methods.     

Empirical likelihood inference for a partially linear errors-in-variables model with covariate data missing at random

The authors study the empirical likelihood method for partially linear errors-in-variablesmodel with covariate data missing at random. Empirical likelihood ratios for the regression coefficients and the baseline function are investigated, and the corresponding empirical log-likelihood ratios are proved to be asymptotically standard chi-squared, which can be used to construct confidence regions. The finite sample behavior of the proposed methods is evaluated by a simulation study which indicates that the proposed methods are comparable in terms of coverage probabilities and average length of confidence intervals. Finally, the Earthquake Magnitude dataset is used to illustrate our proposed method.     

Empirical likelihood inferences for semiparametric instrumental variable models

This paper studies the empirical likelihood inferences for a class of semiparametric instrumental variable models. We focus on the case that some covariates are endogenous variables, and some auxiliary instrumental variables are available. An instrumental variable based empirical likelihood method is proposed, and it is shown that the proposed empirical log-likelihood ratio is asymptotically chi-squared. Then, the confidence intervals for the regression coefficients are constructed. Some simulation studies are undertaken to assess the finite sample performance of the proposed empirical likelihood procedure.     

协变量随机缺失下线性模型的经验似然推断及其应用

考虑协变量带有缺失的线性模型,提出了加权的经验似然方法和借补的经验似然方法,证明了所提出的经验对数似然比渐近于χ~2分布,由此构造回归系数的置信域。模拟研究了所提出方法的有限样本性质,并进行了实例分析。     

响应变量存在缺失时部分线性模型的经验似然推断

考虑响应变量带有缺失的部分线性模型,采用借补的思想,研究了参数部分和非参数部分的经验似然推断,证明了所提出的经验对数似然比统计量依分布收敛到χ2分布,由此构造参数部分和函数部分的置信域和逐点置信区间.对参数部分,模拟比较了经验似然与正态逼近方法;对函数部分,模拟了函数的逐点置信区间.     

Inference for Cox’s regression models via adjusted empirical likelihood

The Cox’s regression model is one of the most popular tools used in survival analysis. Recently, Qin and Jing (Commun Stat Simul Comput 30:79–90, 2001) applied empirical likelihood to study it with the assumption that baseline hazard function is known. However, in the Cox’s regression model the baseline hazard function is unspecified. Thus, their method suffers from severe defect. In this paper, we apply a variant of plug-in empirical likelihood by estimating the cumulative baseline hazard function. Adjusted empirical likelihood (AEL) confidence regions for the vector of regression parameters are obtained. Furthermore, we conduct a simulation study to evaluate the performance of the proposed AEL method by comparing it with normal approximation (NA) based method. The simulation studies show that both methods produce comparable coverage probabilities. The proposed AEL method outperforms the NA method based on power analysis.     

MARS: selecting basis functions and knots with an empirical Bayes method

An empirical Bayes method to select basis functions and knots in multivariate adaptive regression spline (MARS) is proposed, which takes both advantages of frequentist model selection approaches and Bayesian approaches. A penalized likelihood is maximized to estimate regression coefficients for selected basis functions, and an approximated marginal likelihood is maximized to select knots and variables involved in basis functions. Moreover, the Akaike Bayes information criterion (ABIC) is used to determine the number of basis functions. It is shown that the proposed method gives estimation of regression structure that is relatively parsimonious and more stable for some example data sets.     

核实数据下响应变量缺失的线性EV模型经验似然推断

考虑响应变量随机缺失而协变量带有误差的线性模型,借助于核实数据和借补方法,构造了回归系数的两种经验似然比,证明了所提出的估计的经验对数似然比渐近于一个自由度为1的独立χ2变量的加权和;而经调整后所得的调整经验对数似然比渐近于自由度为p的χ2分布,该结果可以用来构造未知参数的置信域.此外,我们也构造了响应均值的调整经验对数似然比统计量,并证明了所提出的统计量渐近于x2分布,可用此结果构造响应均值的置信域.通过模拟研究比较了置信域的精度及其平均区间长度.     

Partial penalized empirical likelihood ratio test under sparse case

A consistent test via the partial penalized empirical likelihood approach for the parametric hypothesis testing under the sparse case, called the partial penalized empirical likelihood ratio (PPELR) test, is proposed in this paper. Our results are demonstrated for the mean vector in multivariate analysis and regression coefficients in linear models, respectively. And we establish its asymptotic distributions under the null hypothesis and the local alternatives of order n^?1/2 under regularity conditions. Meanwhile, the oracle property of the partial penalized empirical likelihood estimator also holds. The proposed PPELR test statistic performs as well as the ordinary empirical likelihood ratio test statistic and outperforms the full penalized empirical likelihood ratio test statistic in term of size and power when the null parameter is zero. Moreover, the proposed method obtains the variable selection as well as the p-values of testing. Numerical simulations and an analysis of Prostate Cancer data confirm our theoretical findings and demonstrate the promising performance of the proposed method in hypothesis testing and variable selection.     

非线性回归模型的经验似然诊断

经验似然方法已经被广泛用于线性模型和广义线性模型.本文基于经验似然方法对非线性回归模型进行统计诊断.首先得到模型参数的极大经验似然估计;其次基于经验似然研究了三种不同的影响曲率度量;最后通过一个实际例子,说明了诊断方法的有效性.     

半参数变系数部分线性模型的统计推断

本文在多种复杂数据下, 研究一类半参数变系数部分线性模型的统计推断理论和方法. 首先在纵向数据和测量误差数据等复杂数据下, 研究半参数变系数部分线性模型的经验似然推断问题, 分别提出分组的和纠偏的经验似然方法. 该方法可以有效地处理纵向数据的组内相关性给构造经验似然比函数所带来的困难. 其次在测量误差数据和缺失数据等复杂数据下, 研究模型的变量选择问题, 分别提出一个“纠偏” 的和基于借补值的变量选择方法. 该变量选择方法可以同时选择参数分量及非参数分量中的重要变量, 并且变量选择与回归系数的估计同时进行. 通过选择适当的惩罚参数, 证明该变量选择方法可以相合地识别出真实模型, 并且所得的正则估计具有oracle 性质.     

Empirical likelihood for single-index models with responses missing at random

The missing response problem in single-index models is studied, and a bias-correction method to infer the index coefficients is developed. Two weighted empirical log-likelihood ratios with asymptotic chisquare are derived, and the corresponding empirical likelihood confidence regions for the index coefficients are constructed. In addition, the estimators of the index coefficients and the link function are defined, and their asymptotic normalities are proved. A simulation study is conducted to compare the empirical likelihood and the normal approximation based method in terms of coverage probabilities and average lengths of confidence intervals. A real example illustrates our methods.     

缺失数据下线性模型中回归参数的经验似然置信区域

在缺失样本下,构造了线性模型中参数的调整的经验似然置信域,数值模拟表明调整的经验似然置信域有较好的覆盖率和精度.     

Markov regime-switching quantile regression models and financial contagion detection

In this paper, we propose a Markov regime-switching quantile regression model, which considers the case where there may exist equilibria jumps in quantile regression. The parameters are estimated by the maximum likelihood estimation (MLE) method. A simulation study of this new model is conducted covering many scenarios. The simulation results show that the MLE method is efficient in estimating the model parameters. An empirical analysis is also provided, which focuses on the detection of financial crisis contagion between United States and some European Union countries during the period of sub-prime crisis from the angle of financial risk. The degree of financial contagion between markets is subsequently measured by utilizing the quantile regression coefficients. The empirical results show that in a crisis situation, the interdependence between United States and European Union countries dramatically increases.     

EMPIRICAL LIKELIHOOD FOR LINEAR MODELS UNDER m-DEPENDENT ERRORS

In this paper，the empirical likelihood confidence regions for the regression coefficient in a linear model are constructed under m-dependent errors. It is shown that the blockwise empirical likelihood is a good way to deal with dependent samples.     

Minimax Hierarchical Empirical Bayes Estimation in Multivariate Regression

The multivariate normal regression model, in which a vector y of responses is to be predicted by a vector x of explanatory variables, is considered. A hierarchical framework is used to express prior information on both x and y. An empirical Bayes estimator is developed which shrinks the maximum likelihood estimator of the matrix of regression coefficients across rows and columns to nontrivial subspaces which reflect both types of prior information. The estimator is shown to be minimax and is applied to a set of chemometrics data for which it reduces the cross-validated predicted mean squared error of the maximum likelihood estimator by 38%.     

Inference on Clustered Survival Data Using Imputed Frailties

This article proposes a new method for fitting frailty models to clustered survival data that is intermediate between the fully parametric and nonparametric maximum likelihood estimation approaches. A parametric form is assumed for the baseline hazard, but only for the purpose of imputing the unobserved frailties. The regression coefficients are then estimated by solving an estimating equation that is the average of the partial likelihood score with respect to the conditional distribution of frailties given the observed data. We prove consistency and asymptotic normality of the resulting estimators and give associated closedform estimators of their variance. The algorithm is easy to implement and reduces to the ordinary Cox partial likelihood approach when the frailties have a degenerate distribution. Simulations indicate high efficiency and robustness of the resulting estimates. We apply our new approach to a study with clustered survival data on asthma in children in east Boston.     

Empirical likelihood for single-index models

The empirical likelihood method is especially useful for constructing confidence intervals or regions of the parameter of interest. This method has been extensively applied to linear regression and generalized linear regression models. In this paper, the empirical likelihood method for single-index regression models is studied. An estimated empirical log-likelihood approach to construct the confidence region of the regression parameter is developed. An adjusted empirical log-likelihood ratio is proved to be asymptotically standard chi-square. A simulation study indicates that compared with a normal approximation-based approach, the proposed method described herein works better in terms of coverage probabilities and areas (lengths) of confidence regions (intervals).     

区间数据情形下线性模型的经验似然推断

§1Introduction Instatisticalapplications,weoftenencounterintervalcensoreddatawhenafailure timeYcannotbeobserved,butcanonlybedeterminedtolieinanintervalobtainedfroma sequenceofexaminationtimes.Forinstance,themaximumdosagewhichpatientscan endureisconcerned.LetYibethemaximumdosagewhichtheithpatientcanendure,Ui,j(j=1,2,...,k)bethedosagewhichthepatienthasbeentested.ItisobviousthatYiis unobservable.SupposetheithpatientisnormalwhenthedosageisUi,j,andhe(orshe)is abnormalwhenthedosageisUi,j+1.Then…