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Vitamin D deficiency is associated with increased human sinonasal fibroblast proliferation in chronic rhinosinusitis with nasal polyps 
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下载免费PDF全文 William W. Carroll MD Rodney J. Schlosser MD Brendan P. O'Connell MD Zachary M. Soler MD MSc Jennifer K. Mulligan PhD 《International forum of allergy & rhinology》2016,6(6):605-610
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Quality of life improvement from sinus surgery in chronic rhinosinusitis patients with asthma and nasal polyps 下载免费PDF全文
下载免费PDF全文 Zi Zhang MD MSCE Nithin D. Adappa MD Laurel J. Doghramji RN BSN Alexander G. Chiu MD Ebbing Lautenbach MD MPH MSCE Noam A. Cohen MD PhD James N. Palmer MD 《International forum of allergy & rhinology》2014,4(11):885-892
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Distinct gene expression profiles and regulation networks of nasal polyps in eosinophilic and non‐eosinophilic chronic rhinosinusitis 下载免费PDF全文
下载免费PDF全文 Naoko Okada PhD Tsuguhisa Nakayama MD PhD Daiya Asaka MD PhD Natsuki Inoue MD Tadao Tsurumoto MD Shinya Takaishi MD Nobuyoshi Otori MD PhD Hiromi Kojima MD PhD Akio Matsuda PhD Keisuke Oboki PhD Hirohisa Saito MD PhD Kenji Matsumoto MD PhD Mamoru Yoshikawa MD PhD 《International forum of allergy & rhinology》2018,8(5):592-604
Background
Chronic rhinosinusitis with nasal polyps (CRSwNP) is known to have 2 phenotypes in East Asia. Eosinophilic CRSwNP (ECRSwNP), defined as tissue eosinophilia and easily recurrent, is distinguished from other non‐eosinophilic CRSwNP (NECRSwNP) types. However, the pathogenesis of each remains unclear.Methods
Nasal polyp tissues from ECRS (ECRSwNP) and NECRS (NECRSwNP) patients were obtained, and their comprehensive gene expression profiles were investigated by microarray analysis. Bioinformatics approaches (eg, Ingenuity Pathway Analysis [IPA]) were used to interrogate the data sets.Results
Hierarchical clustering and principal component analysis (PCA) collectively showed that ECRSwNP and NECRSwNP had distinct gene expression patterns. Of note, these genes could be divided into 8 distinctive clusters having different expression patterns and functions. Upstream Regulator Analysis revealed that not only T‐helper 2 (Th2) and the eosinophilia–related molecules (interleukin 4 [IL4], IL5, and colony stimulating factor 2 [CSF2]) reported so far, but also cell cycle regulators (cyclin dependent kinase inhibitor 1A [CDKNA1] and cyclin D1 [CCND1]) and a tissue fibrosis–related molecule (transforming growth factor β [TGFβ]) were identified in ECRSwNP. On the other hand, mainly interferons (IFNs) and acute inflammatory cytokines (IL1 and IL6) were predicted as upstream regulators in NECRSwNP.Conclusion
These results are useful for understanding the molecular basis of the mechanisms of CRSwNP and point to new targets for developing specific biomarkers and personalized therapeutic strategies for CRSwNP.16.
Yasuyuki Noyama Mitsuhiro Okano Tazuko Fujiwara Shin Kariya Takaya Higaki Takenori Haruna Sei-ichiro Makihara Kengo Kanai Takahisa Koyama Masami Taniguchi Jun-ichi Ishitoya Akira Kanda Yoshiki Kobayashi Mikiya Asako Koichi Tomoda Kazunori Nishizaki 《Allergology international》2017,66(1):42-51
Background
IL-22 is an IL-10-family cytokine that regulates chronic inflammation. We investigated the role of IL-22 and its receptor, IL-22R1, in the pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNP).Methods
IL-22 and IL-22R1 protein and mRNA expression in NP and in uncinate tissues (UT) from CRS and non-CRS patients was examined using immunohistochemistry and real-time PCR, respectively. Dispersed NP and UT cells were cultured with the Staphylococcus aureus exotoxins, staphylococcal enterotoxin B and alpha-toxin, following which exotoxin-induced IL-22 levels and their association with clinicopathological factors were analyzed. Effects of IL-22 on MUC1 expression and cytokine release in NP cells were also determined.Results
IL-22 and IL-22R1 in NP were mainly expressed in infiltrating inflammatory cells and in epithelial cells, respectively. IL-22 mRNA levels in NP were significantly higher than those in UTs from non-CRS patients whereas IL-22R1 levels were conversely lower in NPs. NP cells produced substantial amounts of IL-22 in response to exotoxins. Exotoxin-induced IL-22 production by NP cells significantly and negatively correlated with the degree of local eosinophilia and postoperative computed tomography (CT) score, whereas conversely it positively correlated with the forced expiratory volume in 1s (FEV1)/forced vital capacity (FVC) ratio. IL-22 significantly enhanced MUC1 mRNA expression in NP cells. IL-22-induced MUC1 mRNA levels were significantly and positively correlated with IL-22R1 mRNA levels in NPs.Conclusions
These data suggest that imbalance of IL-22/IL-22R1 signaling regulates the pathogenesis of CRSwNP, including local eosinophilia, via alteration of MUC1 expression. 相似文献17.
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