Fullerene Derivatives Attenuate Bronchoconstriction Induced by Xanthine-Xanthine OxidaseX

The intratracheal instillation of xanthine-xanthine oxidase caused a marked decrease in dynamic respiratory compliance, indicating airway constriction. The constriction was significantly attenuated by fullerenol-1, but not by other agents or receptor antagonists.     

Preparation of Fullerene Derivatives by Resistive Heating With Graphite Crucible

We report here the preparation of both endohedral fullerenes (La°C₈₂, La₂°C₈₀) and exohedral fullerenes (C₆₀ (C_mO_n)) by the resistive heating with graphite crucible filled with lanthanum oxide.     

Synthesis of Heterocycle-Containing [60]Fullerene Derivatives

Abstract

Fullerene functionalization with heterocycles is reviewed, focusing attention on cycloaddition methodology and oxidative heterocyclization. ^{1 1}This paper was presented before the Symposium 3 on ‘Expanded Horizons of Fullerene Science and Technology’ organized by L. Y. Chiang, E.Osawa, H. Terrones and M. Saunders at the 4th International Conference on Advanced Materials (ICAM-IV), Aug. 27 to Sept. 1, 1995, Cancun, Mexico.

     

Synthesis of Heterocycle-Containing [60]Fullerene Derivatives

Fullerene functionalization with heterocycles is reviewed, focusing attention on cycloaddition methodology and oxidative heterocyclization.¹     

Fullerene Derivatives, Preparation, Identification and Use

This article is focused on oxidation and halogenation of fullerene, identification of the prepared products and their potential application. The Fourier transform infrared （FTIR） spectrometry was used for analysis of oxidized fullerene derivative and material balance and elemental analysis were used to identify the summary composition of the prepared fullerene halogen derivatives We has conformed yet the radioprotective ability of oxidized fullerene in our recently published work radioprotective properties and toxicity test of C60 fullerene derivative in vivo ＆ in vitro. Since radioprotective properties are associated with the ability to recapture free radicals in the system （formed due to radiolysis of water in the physiological environment）, this property is closely connected also with fire-retarder properties, when the fire is also a radical mechanism. We tested thermal properties of polyvinyl alcohol （hereinafter PVA） nanofibers prepared with C60 and its derivatives as nanocomposites. The TG-DTA and TG-DSC analysis were used for this purpose. We have demonstrated experimentally that a retarder on C600xi basis and C60 halogenderivative has good results in increasing of thermal resistance of PVA-based nanofibers.     

Penetration of Fullerene C60 Derivatives Through Biological Membranes

Penetration of fullerene C₆₀ in hydrated molecular-colloidal form (FMC) and various C₆₀ water-soluble derivatives (FDs) through membranes of human erythrocytes, platelets and symbiosomes (subcellular organelles of plant origin) were tested. The FDs bearing amino acids induced pronounced depolarization of symbiosome membranes energized with Mg-ATP. In erythrocytes and platelets incubated in K⁺-free medium in the presence of FCCP, FDs with malonic acid pendants promoted acidification of the intracellular medium thereby simulating an effect of the K⁺ ionophore valinomycin. Dissipation of ΔpH artificially induced on the plasma membrane of these cells was observed in the presence of C₆₀-γ-aminobutiric acid which, in addition, strongly stimulated Mg-ATP-dependent generation of membrane potential on symbiosome membranes. C₆₀-Arg was shown to dissipate K⁺-diffusion potential on erythrocyte membranes induced by valinomycin. Fullerene C₆₀ used in hydrated molecular-colloidal form (FMC) also entered symbiosomes and platelets as evidenced by the quenching of the fluorescence of the Ca²⁺ indicator chlorotetracycline localized in the interior of these cells. These findings provide evidence for ease of permeation of these fullerene-based compounds through biological membranes from different type cells.     

[60]Fullerene Amino Acids and Related Derivatives

Abstract

This paper is a review of the literature concerning the preparation of [60]fullerene amino acid and peptide derivatives. The structure and applications of these derivatives to the biological and Material sciences is also presented.     

[60]Fullerene Amino Acids and Related Derivatives

This paper is a review of the literature concerning the preparation of [60]fullerene amino acid and peptide derivatives. The structure and applications of these derivatives to the biological and Material sciences is also presented.     

Oxidized Fullerene Derivatives Containing Hydroxyl,Nitro and Fluorine Groups

Abstract

Oxidation of fullerene was performed with fuming nitric acid and a soluble orange compound was synthesized and identified as polyhydroxy-polynitro fullerene. The formation of fullerene derivatives containing oxygen and fluorine were attempted by different methods using F₂, HF aqueous solution and fuming nitric acid. Resulting compounds were generally characterized by X-ray diffraction and IR and NMR spectroscopy.     

Oxidized Fullerene Derivatives Containing Hydroxyl, Nitro and Fluorine Groups

Oxidation of fullerene was performed with fuming nitric acid and a soluble orange compound was synthesized and identified as polyhydroxy-polynitro fullerene. The formation of fullerene derivatives containing oxygen and fluorine were attempted by different methods using F₂, HF aqueous solution and fuming nitric acid. Resulting compounds were generally characterized by X-ray diffraction and IR and NMR spectroscopy.     

Negative Ions of Trifluoromethyl Fullerene Derivatives: First Thermodynamic Data

Abstract

The mixtures of trifluoromethyl derivatives of C₆₀ were studied by Knudsen cell mass‐spectrometry. Ion–ion and electron exchange equilibria between charged and neutral species in the gas phase were investigated and the electron affinity (EA) values for C₆₀(CF₃)₆, C₆₀(CF₃)₈, and C₆₀(CF₃)₁₀ were estimated.     

富勒烯及其衍生物生物学效应的研究进展

富勒烯及其衍生物的生物学效应成为富勒烯研究非常有潜力的领域和方向.介绍了富勒烯及其衍生物的5种生物学效应,即与蛋白和酶的相互作用、自由基清除作用、光敏化作用、抗菌作用和对生物膜的双重作用,提出了富勒烯及其衍生物可能被开发为一类新型药物.     

Polyfunctional Fullerene Derivatives as UV-MALDI Matrices to Detect Peptides and Proteins

Abstract

Fullerene derivatives with polyfunctional groups were synthesized and used as matrices in UV matrix-assisted laser desorption ionization (UV-MALDI) to detect polar biomolecules such as peptides and proteins. The fullerene derivatives are N,N-dimethylformamide (DMF) or water soluble. The matrix solutions (in DMF or water) can mix well with the aqueous solution containing the analyte. Visual observation with the assistance of magnifying glasses indicated that after drying, a homogenous sample solution was produced on the sample probe. MALDI/time-of-flight (MALDI/TOF) analyses results demonstrate that strong signals from peptides and proteins can be obtained. The fact that a homogenous sample solution was produced on the sample probe accounts for why the analyte's signals were detected everywhere on the probe.     

Polyfunctional Fullerene Derivatives as UV-MALDI Matrices to Detect Peptides and Proteins

Fullerene derivatives with polyfunctional groups were synthesized and used as matrices in UV matrix-assisted laser desorption ionization (UV-MALDI) to detect polar biomolecules such as peptides and proteins. The fullerene derivatives are N,N-dimethylformamide (DMF) or water soluble. The matrix solutions (in DMF or water) can mix well with the aqueous solution containing the analyte. Visual observation with the assistance of magnifying glasses indicated that after drying, a homogenous sample solution was produced on the sample probe. MALDI/time-of-flight (MALDI/TOF) analyses results demonstrate that strong signals from peptides and proteins can be obtained. The fact that a homogenous sample solution was produced on the sample probe accounts for why the analyte's signals were detected everywhere on the probe.     

Preparation of Two Novel C60 and C70 Fullerene Pyrrolidine Derivatives

Abstract

C₆₀ reacted with paraformaldehyde and DL-valine in dry toluene under nitrogen to give a monoadduct. Under the similar conditions,C₇₀ gave a bisadduct. Both products were characterized by FT-IR,UV-Vis,EI-MS and NMR.The studies of the cyclic voltammetry showed that the abilities of donating electron of the products were increased compared to C₆₀ and C₇₀ respectively.     

Preparation of Two Novel C60 and C70 Fullerene Pyrrolidine Derivatives

C₆₀ reacted with paraformaldehyde and DL-valine in dry toluene under nitrogen to give a monoadduct. Under the similar conditions,C₇₀ gave a bisadduct. Both products were characterized by FT-IR,UV-Vis,EI-MS and NMR.The studies of the cyclic voltammetry showed that the abilities of donating electron of the products were increased compared to C₆₀ and C₇₀ respectively.     

Highly Efficient Planar Perovskite Solar Cells Via Interfacial Modification with Fullerene Derivatives

Planar heterojunction perovskite solar cells with a high efficiency up to 17.76% are fabricated by modifying the compact TiO₂ (c‐TiO₂) with a [6,6]‐phenyl‐C₆₁‐butyric acid (PCBA) monolayer. High quality CH₃NH₃PbI₃ films can be easily fabricated on PCBA‐modified c‐TiO₂ substrates by a one‐step solution processing method. Significant improvements of the device parameters are observed after PCBA modification. A high open‐circuit voltage (V_oc) of 1.16 V has been achieved, indicating that the PCBA monolayer can act as a hole blocking layer to reduce the trap site density atop the c‐TiO₂ and the hole recombination at the c‐TiO₂/perovskite interface. The enhancement of the fill factor, as well as the partial quenching of the fluorescence of perovskite after modification with PCBA, reveals that the charge extraction is improved.     

Evaluation of Effects of C60 Fullerene and Its Derivatives on Selected Microorganisms

The contribution deals with preparation of C50 fullerene derivatives （oxo derivative, bromo derivative, hydrolyzed bromoderivative, bromo-chloro derivative）, their identification and pilot testing of their biological effects on unicellular organisms. The contribution describes effects of C60 fullerene derivatives, both on prokaryotic organisms （bacteria, cyanobacteria） and eukaryotic organisms （algae） and assesses their potential use as biocides.