新型冠状病毒肺炎病例血清中和抗体动态变化及影响因素

目的:了解新型冠状病毒肺炎(Coronavirus Disease 2019, COVID-19)确诊病例血清抗新型冠状病毒(2019 novel Coronavirus, 2019-nCoV)中和抗体动态变化规律及可能的影响因素。方法:采用微量中和试验检测COVID-19确诊病例血清中和抗体,采用Excel 2007...     

通过与SARS和MERS的比较探索COVID-19远期并发症及防治措施

自2019年12月中国暴发新型冠状病毒肺炎(COVID-19)疫情以来,其病原体新型冠状病毒(SARS-CoV-2)成为人们关注的热点,它与严重急性呼吸综合征冠状病毒(SARS-CoV)、中东呼吸综合征冠状病毒(MERS-CoV)同为冠状病毒β属,均主要影响呼吸系统。本文通过比较严重急性呼吸综合征(SARS)及中东呼吸综合征(MERS)患者远期并发症来探讨COVID-19患者的远期预后,并讨论相应防治措施。     

IFN-λ防治COVID-19的潜力与风险

新型冠状病毒(severe acute respiratory syndrome coronavirus-2,SARS-CoV-2)感染引起的新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)在世界范围内广泛流行,造成了前所未有的公共卫生灾难,找到有效的药物和治疗方案显得尤为迫切。本文综述了干扰素(IFN)与COVID-19相关的最新研究进展,并重点分析了IFN-λ(III型IFN)抗SARS-CoV-2感染的理论基础,提示IFN-λ具有预防和治疗COVID-19的潜力,同时本文也列举了使用IFN-λ治疗COVID-19存在的潜在风险。     

新型冠状病毒病(COVID-19)检测 加拿大安大略省公共卫生局(PHO)实验室的指导文件

正本文提供了2019年底中国湖北省武汉市暴发的呼吸道疾病相关的新型冠状病毒病19(COVID-19,以前称之为2019-nCoV)检测指南。COVID-19的病原体是SARS-CoV-2病毒。为方便交流,PHO统一使用术语COVID-19来指病毒和疾病。谁负责检测:PHO实验室将接受符合卫生部规定的受检对象(person under investigation,PUI)或疑似病例的样本检测COVID-19。     

新型冠状病毒肺炎尸检样本中福尔马林色素的识别与消除

2019年底至今肆虐全球的新型冠状病毒(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)已经造成全球7512万余人感染[1].新型冠状病毒肺炎(coronavirus dis-ease 2019,COVID-19)尸检样本是珍贵并极具价值的诊断和研究...     

新型冠状病毒肺炎患者肺泡灌洗液细胞蜡块制作体会

新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)是2019年新出现的急性呼吸道传染病,临床表现轻重不一.新型冠状病毒(severe acute respiratory syndrome corona-virus 2,SARS-CoV-2)传染性极强,人群普遍易感[1].目前,我国已...     

新型冠状病毒受体ACE2在多种疾病中的作用

自2019冠状病毒病(coronavirus disease 2019, COVID-19)暴发以来,血管紧张素转换酶2(angio?tensin-converting enzyme 2,ACE2)作为新型冠状病毒(severe acute respiratory syndrome coronavirus 2, SAR...     

新冠病毒变异株奥密克戎的变异特点及对免疫学特性的影响

严重急性呼吸综合征冠状病毒2 (severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)新变异株奥密克戎(Omicron)的出现加剧了新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)疫情的传播。奥密克戎变异株首先在非洲发...     

新型冠状病毒核酸检测结果的影响因素

新型冠状病毒肺炎(Coronavirus Disease 2019, COVID-19)是由新型冠状病毒(2019 novel Coronavirus, 2019-nCoV)引起的传染性疾病。目前确诊2019-nCoV使用最多的方法是核酸检测法,疑似病例具备实时荧光RT-PCR检测2019-nCoV核酸阳性者即为确诊病...     

基于量子点免疫层析技术的新型冠状病毒中和抗体检测方法建立

目的:建立简便、快速、低成本的2019新型冠状病毒(2019 novel coronavirus,2019-nCoV)中和抗体检测方法。方法:基于量子点荧光免疫层析原理,建立新冠RBD IgG检测方法,并用新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)患者恢复期血清( ...     

Level of functioning of siblings and parents of probands of varying degrees of retardation

A further analysis of already published data supports the position that retardates of low ability level less frequently have retarded siblings, retarded parents, and parents low in occupational level than do retardates higher in ability level. The analysis supports the position that there are two types of retarded individuals, persons retarded as a result of gene or chromosomal anomalies, brain injury, etc., who more frequently occur in the lower-level retardate group, and persons whose retardation represents polygenic segregation, who more frequently occur in the higher-level group.     

Modes of Inheritance of Errors of Refraction

Eighteen families in which both parents had refractions within the range of +4·0 D to −4·0 D and axial lengths seen in emmetropia (22·3-26·0 mm) showed coefficients of correlation of the order 0·5 indicative of polygenic inheritance. Such coefficients were seen for axial length (0·407) and for the cornea (0·487), but not for the lens (which is known to be yoked to the axial length). No such coefficients were seen in 19 families in which one of the parents had axial length outside the emmetropic range (nine families with long axes and 10 with short axes).

The pattern of polygenic inheritance for emmetropia (completely correlated optical components) and errors of refraction up to 4·0 D (inadequately correlated components: correlation ametropia) follows that seen in stature and other measurable characters. In contrast the high refractive errors with their abnormal axial lengths (component ametropia) are—like the extremes in stature—pathological anomalies with monofactorial inheritance.