Smoking and ulcerative colitis

In a case-control study of smoking and ulcerative colitis patients with the disease were much less likely to smoke than community controls matched for age and sex. The difference was substantial, with an estimated relative risk of 3.8 for non-smoking on current habits, was even larger (6.2) when habits at onset of the disease were examined, and was mainly accounted for by 42 of 55 patients who had given up smoking a mean of eight years before onset. The association could not be explained by confounding by social class. These findings suggest that smoking directly or indirectly confers protection against ulcerative colitis.     

溃疡性结肠炎患者心身状态调查及应对措施

目的调查溃疡性结肠炎患者心身状态并提出应对措施。方法应用症状自评量表(SCL-90)对200例患者进行问卷调查,调查表包括躯体化症状、强迫症状、人际关系、抑郁等12个项目,将所有项目与国内常模比较。结果溃疡性结肠炎患者的各项因子得分与国内常模分数比较,差异均有统计学意义(P0.05)。结论溃疡性结肠炎患者的心理健康水平低于正常人群,在药物治疗的同时要加入心理治疗,只有使患者的身心同时进入放松状态,疾病的转归才能走向良性循环的过程。     

IL-27在溃疡性结肠炎患者血液中的表达及意义

目的检测溃疡性结肠炎（UC）患者血液中IL-27mRNA的表达,探讨其在UC发病中的作用。方法收集我院2008年1月～2010年12月消化内科诊治的UC患者34例,另取健康对照34例,Trizol提取血液细胞总RNA,Real—time荧光定量PCR检测IL-27基因的表达。结果健康对照与UC患者血液中均能检测到IL-27基因的表达．UC患者和健康对照IL-27基因的△Ct值分别为（6．22±1．38）和（11．35±2．46）,差异有高度统计学意义（P〈0．01）。不同病变程度UC患者之间IL-27mRNA的表达差异有统计学意义（P〈0．05）,Pearson相关性分析显示血液中IL-27基因的表达与UC患者的病变程度成正相关（r=0．49,P〈0．01）。结论溃疡性结肠炎血清中IL-27高表达,且其水平的高低与临床的病变程度相关,IL-27可能参与UC的发病并在UC患者肠道的损伤中发挥着重要的调节作用。     

己酮可可碱对大鼠溃疡性结肠炎治疗作用及其机制

目的:观察己酮可可碱(PTX)对大鼠溃疡性结肠炎(UC)模型的治疗作用,探讨血栓及血栓前状态(PTS)在溃疡性结肠炎发病中的作用和己酮可可碱作用机制.方法:用2,4,6-三硝基苯磺酸(TNBS)造大鼠溃疡性结肠炎模型,将大鼠模型随机分为模型组,模型 生理盐水组,模型 己酮可可碱组,另设空白对照组,共4组.观察各组大鼠肠道大体形态和组织学改变;采用血小板黏附仪检测血小板黏附功能( PAdT),智能血液凝聚仪检测血小板的聚集功能(PAgT);ELISA法测定血清中的血栓烷B2( TXB2);单克隆酶联吸附法检测血管性假血友病因子相关抗原(vWF∶Ag);酶联免疫吸附法检测细胞内粘附因子1(ICAM-1).结果:与模型 生理盐水组比较,模型 己酮可可碱组损伤指数下降(6.02±0.74 vs 0.85±0.50,P＜0.01; 5.68±0.60 vs 1.08±0.45,P＜0.01);模型组血小板黏附率和聚集率与空白对照组无明显增加(P＞0.05); 模型组TXB2,vWF∶Ag,ICAM-1均较空白对照组的差异无统计学意义(P＜0.01),经己酮可可碱治疗后,均较模型 生理盐水组降低(P＜0.05).结论:TNBS所诱导大鼠溃疡性结肠炎模型与PTS有一定关系.PTX通过抗凝、抗炎症介质、抗细胞因子而发挥治疗UC作用.     

Coexistent ulcerative colitis and Crohn's disease

This case report describes a patient with chronic ulcerative colitis and epithelial dysplasia of 17 y duration ultimately complicated by colonic carcinoma. At laparotomy, clinically unsuspected but typical Crohn's disease of the terminal ileum was also found. The macroscopic and histological features of the resected terminal ileum were characteristic of Crohn's disease.     

Autoimmune haemolytic anaemia and ulcerative colitis

Two cases of ulcerative colitis are described in which there was associated severe auto-immune haemolytic anaemia. The colitis in both patients responded to conventional therapy and one patient underwent splenectomy for her anaemia. Possible aetiological links are discussed.     

Course and prognosis of ulcerative colitis

A study of 50 patients (23 males and 27 females) of ulcerative colitis, who were on follow-up showed that maximum number of patients had the disease before the age of 50 years. At the onset, the activity of the disease was severe in 44%, moderate in 32% and mild in 24% of cases. The commonest clinical course of the disease was chronic intermittent type (48%), followed by single attack with subsequent remission (42%). Chronic continuous type was seen in 10% patients only. There was no correlation of the extent of the bowel involvement with the clinical course. The precipitating factors for the onset or reactivation of the disease appeared to be emotional disturbances in 18% and pregnancy in 8%. The complications, both local and systemic, were not frequent. Serious complications like massive haemorrhage, perforation, toxic megacolon and carcinoma colon were not seen at all.     

溃疡性结肠炎患者小肠细菌过度生长情况分析及意义

目的 分析不同疾病程度溃疡性结肠炎(UC)患者的肠道屏障功能及小肠细菌过度生长(SIBO)情况.方法 选取2016年5月至2018年10月就诊于该院的确诊UC患者126例,按照Southerland疾病活动指数分为症状缓解期组(n=20)、轻度活动组(n=42)、中度活动组(n=46)及重度活动组(n=18),采用乳果...     

Cytomegalovirus colitis with a new diagnosis of ulcerative colitis in an elderly woman

Objectives: Cytomegalovirus (CMV) colitis is generally diagnosed in immunocompromised patients. It is rare for patients who are not immunocompromised to develop CMV colitis. Cases of CMV colitis in patients with inflammatory bowel disease have also been reported. We encountered a case of CMV colitis with a new diagnosis of severe ulcerative colitis and demonstrated the importance of suspecting ulcerative colitis in immunocompetent patients with CMV colitis.Patient: A 78-year-old woman was hospitalized with fever and diarrhea that had lasted for a month. Colonoscopy revealed continuous diffuse edema, mucosal redness, and multiple punched-out ulcers with bleeding, suggesting cytomegalovirus (CMV) colitis, although she was not immunocompromised. Immunohistochemical staining revealed CMV-positive cells, and CMV colitis was diagnosed. One month later, a colonoscopy was conducted owing to persistent symptoms despite initiating the prescribed antiviral drug. A complete loss of vascular pattern, easy bleeding of the crude mucosa, and exacerbation of multiple punched-out ulcers were observed. She was diagnosed with severe ulcerative colitis. The symptoms of ulcerative colitis disappeared with prednisolone and 5-amino salicylic acid treatment.Conclusion: Ulcerative colitis should be suspected in immunocompetent patients with CMV colitis.