复方洗必泰涂膜治疗医用胶布皮肤过敏12例

临床输液和换药中，常可见到患者皮肤对医用胶布过敏，出现皮肤红肿、瘙痒，甚至水泡，增加了患者的痛苦。笔者将我院自制的复方洗必泰涂膜（PB涂膜）用于治疗胶布过敏患者，效果显著，介绍如下。1一般资料本组患者12例，年龄17～75岁，均因胶布过敏引起水泡，     

洗必泰碘络合物毒性测定

经毒性测定，洗必泰碘络合物小鼠口服ＬＤ＿（５０）为３９５６．９９ｍｇ／ｋｇ，蓄积系数大于５。对小鼠骨髓嗜多染红细胞无明显致突变作用；对豚鼠皮肤无刺激作用；刺激豚鼠眼虹膜与结膜，可致暂时性中度充血，４８小时内恢复正常。因而，使用安全。     

洗必泰溶液用于氧气湿化液的研究

采用浓度为０．０１％、０．０２％、０．０５％洗必泰溶液与凉开水作为氧气湿化液，观察溶液带菌情况。洗必泰溶液４日、７日带菌率均小于凉开水１日带菌率，二者比较具有显著性差异（Ｐ〈０．０１）。０．０１％、０．０２％、０．０５％三种浓度洗必泰溶液作为湿化液使用一周，其带菌率无显著性差异（Ｐ〉０．０５）。提示０．０１％洗必泰溶液作为氧气湿化液，既可减少细菌生长，又可延长更换时间，对病人安全无害。     

洗必泰溶液用于氧气湿化液的研究

用０．１－０．５‰洗必泰溶液代替凉开水的作为氧气湿化液，洗必泰溶液４日、７日带菌小于开水１日带菌率，两者相比，Ｐ〈０．０１，差异有显著性，０．１‰、０．２‰、０．５‰三种浓度洗泰溶液一周带菌率相比，Ｐ〉０．０５，差异无显著性，经０．１‰洗必泰溶液湿化的氧化，可减少带菌，延长更换时间，对病人安全无害，无异味，无刺激，配制简单，价廉易保存，具有实用价值。     

洗必泰预防剖宫产术后感染

作者在剖宫产术中采用洗必泰 (Ｃｈｌｏｒｈｅｘｉ ｄｉｎｅ)冲洗宫腔、腹腔及腹壁切口 ,预防术后感染效果显著 ,现介绍如下。1　资料与方法1 996年 1月～ 1 999年 1 2月共行剖宫产术980例 ,产妇平均 2 5岁 ,随机分为 2组 ,试验组采用关腹前洗必泰溶液冲洗宫腔、腹腔及腹壁切口 ,共 360例。对照组为 62 0例 ,对照方法为单纯随机抽样。试验组与对照组孕妇术前感染诱因基本情况一致 ,例Ｈｂ <90 ｇ/Ｌ、阴道炎、羊水性状Ⅱ～Ⅲ度、破膜时间≥ 1 2ｈ、产程时间 ,差异无显著性 ,具有可比性。方法 :试验组剖宫产术中在胎儿、胎盘娩出 ,清理腹腔及…     

洗必泰溶液用于氧气湿化液的研究

用0.1‰～0.5‰洗必泰溶液代替凉开水作为氧气湿化液,洗必泰溶液4日、7日带菌率均小于凉开水1日带菌率,两者相比,P<0.01,具有显著性差异.0.1‰、0.2‰、0.5‰3种浓度洗必泰溶液1周带菌率相比,P>0.05,无显著性差异,经0.1‰洗必泰溶液湿化的氧气,可减少带菌,延长更换时间,对病人安全无害,无异味,无刺激,价廉,配制简单,易保存,具有实用价值.     

氟保护漆对覆盖义齿基牙抗龋作用的体外研究

目的本实验评估体外脱矿环境中氟保护漆对覆盖义齿基牙的防龋作用,为临床预防覆盖义齿基牙龋坏提供参考。方法选择因正畸需要拔除的无龋前磨牙8颗,从釉牙本质界处横切开,取牙本质模拟覆盖义齿的基牙预备后,将牙齿按颊舌向纵剖为二,在标本牙合面上预备出面积为1mm×4mm的牙本质块作为实验区,其余部分涂布无色透明指甲油。标本随机分成4组0.1%氟保护漆组,0.60%氟化泡沫组,1.23%氟化泡沫组,空白对照组。氟保护漆组用对应浓度的氟漆涂布两层,氟化泡沫组用对应浓度的氟化泡沫处理4min,空白对照组用去离子水处理4min。将已处理的牙齿标本分别浸泡于8mL0.1mol/L的人工龋蚀液中,分别在第1、3、6、12、24、48、72、168h各吸取1mL液体,检测龋蚀液中Ca2+浓度值,计算出每组在各时间点牙本质钙溶出的总量。结果氟制剂组抑制钙溶出效果明显优于空白对照组,氟保护漆组优于氟化泡沫组,氟化泡沫组之间无显著性差异。结论0.1%氟保护漆抑制牙本质脱钙作用显著。     

局部运用氟制剂抑制牙骨质脱矿的研究

目的 评估体外脱矿环境中几种氟制剂对牙骨质的脱钙作用.方法 将15颗因正畸拔出的前磨牙在牙根颈1/3预备出面积为3 mm×4 mm的牙骨质块作为实验区,其余部分涂两层指甲油后,按随机数字表法分为3组,每组5颗.0.1%氟保护漆组用0.1%氟保护漆于实验区涂布两层;0.6%氟化泡沫组用0.6%的氟化泡沫处理4 min;空白对照组用去离子水处理4 min.将已处理的标本牙分别浸泡于8 Ml 0.1 mol·L-1的人工龋蚀液中,分别在第1、3、6、12、24、48、72、168小时各吸取1 Ml液体,检测龋蚀液中Ca2+浓度值,计算出每组在各时间点牙本质钙溶出的总量.结果 0.1%氟保护漆能有效抑制牙骨质脱钙,而0.6%氟化泡沫对防止牙骨质脱钙无明显效果.结论 氟保护漆抑制牙骨质脱钙作用显著.     

抗小叶增生合剂的质量标准研究

目的建立抗小叶增生合剂的质量控制方法。方法采用薄层色谱法对白芍、丹参进行定性鉴别;采用高效液相色谱法测定当归中的阿魏酸的含量。结果在薄层色谱中能同时检出白芍、丹参;阿魏酸在24．8-248 μg／L范围内线性关系良好,相关系数（r）=0．9995,平均回收率为100．11％,RSD为0．86％（n=5）。结论方法简便、准确、重现性好,可有效控制制剂质量。     

The effect of triclosan, stannous fluoride and chlorhexidine products on: (II) Salivary bacterial counts

Abstract. A previous study demonstrated that triclosan and stannous fluoride containing oral hygiene products reduced plaque regrowth compared to saline but were not more effective than a conventional commercial fluoride/anionic detergent toothpaste. To further understand these results, this study measured the persistance of antimicrobial activity of the same products by recording the duration of salivary bacterial count reductions following a single exposure to each product. Comparison was also made with a chlorhexidine rinse as the positive control. From a panel of 16 volunteers, in an 8-cell randomised cross-over designed study, salivary bacterial counts were recorded at baseline and to 420 min. All test and control products were significantly more effective than saline and significantly less effective than chlorhexidine at suppressing bacterial counts. Unlike chlorhexidine, evidence of bacterial recovery was apparent after the 30-min sampling time. There were essentially no significant differences between the test and control products, although the stannous fluoride toothpaste performed marginally better than other products. The findings are consistent with the plaque regrowth results previously obtained and again demonstrate to date that it is difficult to surpass the antimicrobial and plaque inhibitory properties of conventional commercially available toothpastes by the addition of antimicrobial agents such as triclosan and metal salts.     

The effect of triclosan, stannous fluoride and chlorhexidine products on: (I) Plaque regrowth over a 4-day period

Abstract. A number of substances have been incorporated into toothpastes or gels to inhibit plaque regrowth. The aim of this study was to evaluate triclosan and stannous fluoride products for plaque inhibitory properties by comparison with a chlorhexidine or saline rinse and a control product which was a conventional commercially available toothpaste. In a blind 8 cell cross-over study, 15 volunteers rinsed 2 × a day for 4 days with slurries of the products or the saline and chlorhexidine solutions. No other form of oral hygiene was performed and plaque regrowth from a zero baseline was recorded by plaque score and plaque area. Plaque regrowth was significantly less with the chlorhexidine rinse and significantly greater with the saline rinse compared to the toothpaste and gel products. No significant differences were found between the test and control products. The results again demonstrate that commercially available toothpastes have plaque inhibitory effects which so far appear difficult to improve upon by the addition of specific ingredients, in this case stannous fluoride or triclosan. Commercially available products of known activity would appear useful benchmarks for comparison of experimental formulations.     

Assessment, management, and prevention of early childhood caries

Purpose: To discuss the role of primary care health providers in identifying infants and young children at risk for dental caries during well-child visits, in providing anticipatory guidance to parents and primary care givers of at-risk children, and in providing appropriate referrals for the timely establishment of a dental home.
Data sources: The search included the following: Ovid MEDLINE, PubMed, American Academy of Pediatrics Web site, American Academy of Pediatric Dentistry Web site, and the American Dental Association Web site. The following search terms were used: dental caries prevention, caries process, caries balance, dental home, early childhood caries, oral health disparities, dental caries risk assessment, fluoride varnish, oral health anticipatory guidance. Search was limited to English language sources from 1990 through 2007.
Conclusions: Dental caries is a preventable and reversible infectious disease process, yet it continues to be the single most common chronic disease of childhood. Despite a decrease in caries prevalence and a decrease in untreated tooth decay in 6–19-year-olds in the United States, a 15.2% increase in disease was noted among the nation's youngest children aged 2–5 years. Primary care health providers are uniquely positioned to play a significant role in the prevention of dental caries and are encouraged to complete certification courses in caries risk assessment, intervention, education, and referral.
Implications for practice: Clinicians need to understand the dental caries process, including the process of enamel demineralization and remineralization, and the factors contributing to caries balance. The importance of early identification and intervention for infants and toddlers at high risk for dental caries and primary care health provider-delivered anticipatory guidance during well-child care visits cannot be overestimated.     

钛表面单宁酸络合氯化钙涂层接枝氯己定功能及稳定性探究

目的 探究钛表面单宁酸和氯化钙络合后接枝氯己定的生物相容性、抗菌性以及稳定性.以期在种植体表面构建持久抗菌涂层.方法 商业钛片经打磨后,以光滑钛片为对照组,接枝不同浓度的氯己定.通过X射线光电子能谱分析元素组成.接触角测量仪分析其亲水性,Zeta电位实验分析其反应稳定性,金黄色葡萄球菌的涂板计数法,抑菌环法以及增值法分...     

携带抗药基因的CNS对醋酸氯己定的抗力研究

目的研究凝固酶阴性葡萄球菌(CNS)抗药基因携带及其对氯己定类消毒剂抗力变化情况。方法采用细菌分离鉴定方法和基因扩增技术,对医院环境和医务人员手上采样标本进行了分离培养和检测。结果在841份标本中,检出63株CNS,检出率为7.49%。63株CNS中,有12株检出qacA基因,检出率为19.05%。醋酸氯己定对12株CNS最小抑菌浓度范围在0.24 mg/L～1.96 mg/L,其中有7株CNS的最小抑菌浓度高于标准菌株者;最小杀菌浓度范围在7.81 mg/L～500 mg/L,其中有9株CNS的最小杀菌浓度明显高于标准菌株。结论医院环境表面和医务人员手上CNS检出率较高,多数携带qacA基因的菌株对醋酸氯己定消毒剂抗力有增加的趋势。     

某碘伏与胍类复合消毒剂消毒相关性能研究

目的 研究一种聚维酮碘和醋酸氯己定复方消毒剂的消毒相关性能,为实际应用提供科学依据.方法 采用悬液定量杀菌试验和毒理学试验方法,对该消毒液的杀菌效果和毒性进行观察.结果 该消毒剂含聚维酮碘5090 mg/L和醋酸氯己定320 mg/L.用该消毒剂原液作用1 min,对悬液内大肠埃希菌、金黄色葡萄球菌、铜绿假单胞菌和白色...