华蟾素辅助治疗中晚期非小细胞肺癌临床观察

目的 观察华蟾素注射液配合化疗治疗中晚期非小细胞肺癌的疗效.方法 将60例中晚期非小细胞肺癌患者随机分组,分别施以单纯化疗(对照组,n=30)和华蟾素注射液配合化疗(治疗组,n=30),对多个临床指标进行比较观察.结果 观察发现治疗组在临床症状缓解、病灶缩小、生存期延长及生活质量提高等方面均优于单纯化疗对照组,疗效显著.结论 华蟾素注射液用于配合化疗治疗中晚期非小细胞肺癌有一定疗效.     

参麦注射液联合华蟾素治疗中晚期肺癌的疗效观察

目的:观察参麦注射液联合华蟾素注射液治疗中晚期癌证属气阴两虚的临床疗效。方法:将60例中晚期肿瘤患者随机分为治疗组和对照组,每组30例,两组均以华蟾素治疗。治疗组同时与参麦注射液治疗。观察比较两组中医证侯、KPS评分、的变化。结果:与对照组相比,治疗组的体质状况,KPS评分明显增高(P0.05),疼痛NRS评分下降(P0.05)。结论:参麦注射液联合华蟾素注射液治疗中晚期癌症有确切疗效,可改善患者症状、提高患者生存治疗,减轻疼痛。     

艾迪注射液和华蟾素注射液治疗晚期肺癌的对比临床观察

目的：比较艾迪注射液和华蟾素注射液对中晚期肺癌的疗效与毒性。方法：观察组用艾迪注射液加基础治疗,对照组用华蟾素注射液加基础治疗,分别观察临床综合疗效、主要症状积分、Karnofsky评分、以及肿瘤标志物（CEA、CA125）的变化,观察治疗3个月。结果：治疗后临床症状改善方面,2组比较差异有显著性。Karnofsky评分,以及肿瘤标志物水平改善方面,艾迪组优于华蟾素组（P〈0.05）。结论：对于晚期肺癌患者,艾迪注射液和华蟾素注射液都有较好疗效。由于艾迪注射液是多种成分的复方制剂,其治疗效果优于华蟾素注射液。     

不同护理方法防治华蟾素所致静脉炎的效果观察

中晚期原发性肝癌常因无法手术或行肝动脉化疗栓塞而得不到有效治疗。目前临床采用中西医结合治疗中晚期原发性肝癌,取得了一定疗效。华蟾素注射液是常用的中药抗肿瘤制剂。临床研究表明,其不仅能抗癌祛邪,且能减毒扶正,从而起到抑制肿瘤生长、提高生存质量和延长生存期的作用,被广泛应用于中晚期原发性肝癌的治疗。但应用过程中,常因出现静脉滴注局部红、肿、疼痛等静脉炎症状,使患者不愿接受或不能坚持长期治疗,从而影响治疗效果。我们对88例中晚期原发性肝癌患者,在静滴华蟾素过程中采用不同护理方法防治华蟾素所致的静脉炎。现将观察结果报告如下。     

参麦注射液联合化疗治疗晚期恶性肿瘤的疗效分析

目的 探讨参麦注射液联合化疗治疗中晚期恶性肿瘤的临床疗效.方法 选取我院收治的62例中晚期恶性肿瘤患者,以患者住院顺序为依据将其分为观察组和对照组,每组各31例,观察组患者行参麦注射液联合化疗治疗,对照组患者仅行化疗治疗,比较两组患者的临床疗效.结果 观察组患者经参麦注射液联合化疗治疗后总有效率为61.3％,对照组患者经单纯化疗治疗后其总有效率为29.0％,两组比较有显著性差异(P＜0.05).治疗后观察组患者的体力情况明显优于对照组(P＜0.05).结论 给予中晚期恶性肿瘤患者参麦注射液联合化疗治疗可取得显著疗效,且可促进患者体力恢复,值得推广和应用.     

华蟾素注射液治疗晚期恶性肿瘤临床疗效观察

观察华蟾素注射液治疗晚期恶性肿瘤临床疗效。选取我院2013年1月至2015年12月接受治疗的100例晚期消化系统恶性肿瘤患者,按是否给予华蟾素注射液治疗分治疗组和对照组,各50例。治疗组给予华蟾素注射液治疗1个疗程,辅以对症支持治疗,对照组只给予对症支持治疗。观察患者肿瘤大小,体力状况,癌症疼痛,不良反应的变化。对瘤体疗效方面:治疗组临床获益率为40.00%,高于对照组的36.0%,但两组比较无显著性差异(P0.05);体力状况疗效方面:治疗组提高+稳定例数占72.0%,高于对照组的42.0%,两组比较有显著性差异(P0.05);癌症疼痛疗效方面:治疗组缓解+部分缓解例数占80.0%,高于对照组的52.0%,两组比较有显著性差异(P0.05)。华蟾素注射液在一定程度上抑制肿瘤的生长,改善体力状况,缓解癌症疼痛,在姑息性治疗晚期消化系统恶性肿瘤方面,具有一定疗效。     

华蟾素联合介入疗法治疗110例中晚期肝癌的临床分析

肝癌在我国发病率较高,由于初期症状不易察觉,易导致病情贻误.因此中晚期肝癌患者占绝大多数[1].针对中晚期肝癌患者不能手术的特点,介入疗法成为治疗的首选方案.但是从多年的临床实践经验来看,介入疗法存在肿瘤复发转移的现象,因而进行联合治疗成为一种趋势.华蟾素是经我国传统中医学验证的一种抗炎、抗病毒药物,对恶性肿瘤也有一定疗效,应用前景甚广[2].我们联合应用华蟾素和介入疗法对中晚期肝癌患者进行治疗,现报告如下.     

华蟾素注射液治疗中晚期原发性肝癌临床疗效观察

目的　观察华蟾素注射液治疗中晚期原发性肝癌的临床疗效。方法　 10 0例中晚期原发性肝癌患者随机分成华蟾素治疗组与一般治疗组 ,各 50例。分别观察两组患者治疗前后的生存质量、肿瘤大小、部分实验室指标的变化 ,并随访生存期。结果　在控制肿瘤方面 ,华蟾素治疗组的恶化率 (18% )低于一般治疗组 (3 2 % ) ;在生存质量方面 ,华蟾素治疗组的总有效率(80 % )高于一般治疗组 (72 % ) ,但两组比较无显著性差异 ;在生存期方面 ,华蟾素治疗组 >12个月的生存率 (3 0 % )显著高于一般治疗组 (18% ) ,两组比较有显著性差异 ;在肝功能方面 ,华蟾素治疗组的血清总胆红素、丙氨酸氨基转移酶等指标在治疗后有明显下降 ,而在一般治疗组则呈不同程度的升高 ;在甲胎蛋白 (AFP)方面 ,一般治疗组的AFP在治疗后较治疗前有明显上升 ,而华蟾素治疗组则略有上升 ,但与治疗前相比无显著性差异。结论　华蟾素注射液能在一定程度上抑制癌瘤的生长 ,并且具有保护肝功能、提高生存质量、延长生存期的作用 ,在治疗中晚期原发性肝癌方面 ,具有“攻邪不伤正”的特点     

华蟾素与酚妥拉明合用在恶性肿瘤应用中的不良反应观察

目的:观察华蟾素注射液与酚妥拉明注射液合用治疗各种类型恶性肿瘤出现的不良反应。方法:对合用华蟾素注射液与酚妥拉明注射液的患者出现的症状、体征进行观察分析。结果:两药合用不良反应发生率为6.03%,主要是心血管系统如静脉炎、头昏及消化系统中的恶心、呕吐、腹痛。结论:引起不良反应的原因为华蟾素中某些成分引起Ⅰ型变态反应及酚妥拉明的副作用。     

爱迪注射液治疗中晚期恶性肿瘤39例

观察爱迪注射液治疗中晚期恶性肿瘤的临床疗效。对 3 9例中晚期恶性肿瘤采用爱迪注射液治疗 ,并在治疗前后检测LBT、NK细胞活性和IL -Ⅱ。结果 ,PR为 2 3 .1 % ,NC为 4 8.7% ,治疗后免疫指标均有明显提高(P <0 .0 1) 。观察结果表明 ,爱迪注射液是治疗中晚期恶性肿瘤的有效药物     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.