常规矫正与微型种植体支抗在口腔正畸中的应用效果比较

目的对比分析常规矫正与微型种植体支抗在错颌畸形患者口腔正畸治疗中的效果。方法通过不记名随机筛选与患者详细沟通为原则,选取2015年2月15日至2016年7月15日在南阳市中心医院口腔科进行畸形牙矫正的66例患者,随机分为观察组和对照组,各33例,分别进行微型种植体支抗治疗与常规矫正治疗。对患者矫正后的治疗有效率进行对比。结果微型种植体支抗治疗与常规矫正治疗的有效率分别为93.94%、72.73%,差异有统计学意义(P<0.05)。结论在错颌畸形患者口腔正畸治疗中采用微型种植体支抗的临床治疗效果优于常规矫正治疗,值得各地医院推广应用。     

微型种植体支抗在青少年口腔正畸治疗中的运用效果观察

目的研究微型种植体支抗治疗青少年口腔正畸的疗效。方法选取2008年1月至2012年1月就诊于广西壮族自治区民族医院口腔科608例存在错颌畸形的青少年患者作为研究对象,根据患者不同的治疗方式分组:治疗组306例患者进行微型种植体支抗治疗;对照组302例患者进行非种植体支抗治疗。对两组患者治疗后不良反应及治疗情况进行分析比较。结果两组患者错颌畸形术后轻度水肿、感染、明显不适感的发生率相比,均无统计学意义;治疗组治疗后上中切牙凸距差和上中切牙倾角差均显著大于和高于对照组[(4.01±2.27)mm vs(2.68±2.62)mm](P<0.05)和[(28.02±1.47)°vs(13.01±1.37)°](P<0.05);磨牙位移治疗组显著少于对照组[(3.62±1.27)mm vs(6.02±1.86)mm](P<0.05)。结论微型种植体支抗用于青少年口腔正畸治疗综合效价优于非种植体强支抗治疗。     

微型种植体支抗对青少年口腔正畸患者口腔功能及预后的影响

目的 青少年口腔正畸患者应用微型种植体支抗治疗对其口腔功能及预后的影响。方法 选取2019年4月—2020年1月抚州市东乡区中医院收治的74例青少年口腔畸形患者,根据治疗方式分为2组,其中37例实施传统支抗治疗的患者归为常规组,37例实施微型种植体支抗治疗的患者归为观察组,对2组治疗效果进行比较。结果 观察组治疗优良率高于常规组（P<0.05）。治疗后观察组磨牙位移、上齿槽座角小于常规组（P<0.05）,观察组上中切牙凸距差、上中切牙倾角、尖牙间宽度和下齿槽座角大于常规组（P<0.05）。治疗后观察组咀嚼功能（咬合力、咀嚼效率）优于常规组（P<0.05）。观察组不良反应发生率低于常规组（P<0.05）。结论 对青少年口腔正畸患者予以微型种植体支抗治疗效果佳,有利于改善患者口腔功能,减少不良反应的发生,改善患者预后。     

微型种植体支抗在错牙合畸形口腔正畸治疗患者中的应用效果

目的：观察微型种植体支抗在错牙合畸形口腔正畸治疗患者中的应用效果。方法：选取2020年7月至2022年7月该院收治的84例错牙合畸形口腔正畸治疗患者进行前瞻性研究,按随机数字表法将其分为对照组与观察组各42例。对照组给予传统支抗治疗,观察组给予微型种植体支抗治疗。比较两组牙齿结构相关指标水平、舒适度评分、临床疗效和不良事件发生率。结果：观察组磨牙位移小于对照组,上中切牙凸距差、上中切牙倾角差均大于对照组,差异有统计学意义（P<0.05）;观察组舒适度评分高于对照组,差异有统计学意义（P<0.05）;观察组治疗总有效率为95.24%(40/42),高于对照组的76.19%(32/42),差异有统计学意义（P<0.05）;两组不良事件发生率比较,差异无统计学意义（P>0.05）。结论：微型种植体支抗应用于错牙合畸形口腔正畸治疗患者可提高治疗总有效率和舒适度评分,改善牙齿结构相关指标水平,其效果优于传统支抗治疗。     

微螺钉支抗种植体和口外弓强支抗正畸法用于口腔正畸的效果对比

目的：对比研究微螺钉支抗种植体和口外弓强支抗正畸法用于口腔正畸的临床效果。方法选择2011年1月—2013年6月该院收治的70例错颌畸形患者进行研究。按随机数表法分为试验组与对照组,试验组36例患者采用微螺钉支抗种植体方法进行矫治,对照组34例患者采用口外弓强支抗正畸法进行矫治,治疗后,对两组患者疗效及不良反应发生情况进行对比分析。结果经不同治疗后,试验组上中切牙倾角改变量、上中切牙凸距改变量均显著大于对照组;第一磨牙位移明显小于对照组（P<0.05）;试验组不良反应发生率为13.9%;对照组不良反应发生率为14.7%。两组不良反应发生率比较差异无统计学意义（χ2=0.0095,P=0.9222）,所有发生不良反应的患者经对症处理后,均未造成严重影响,仍继续接受矫治。结论微螺钉支抗种植体用于口腔正畸,临床效果良好,不良反应轻微,值得临床推广应用。     

微型种植体支抗和非种植体支抗在青少年口腔正畸治疗中的效果对比

目的 比较微型种植体支抗和非种植体支抗在青少年口腔正畸治疗中的效果.方法 选取该院于2012年9月—2015年8月收治的青少年错牙合畸形患者260例,将其随机分成观察组与对照组,每组130例,观察组患者采用微型种植体支抗治疗,对照组患者采用非种植体支抗治疗.治疗后,对两组的治疗效果与不良反应进行对比分析.结果 治疗后,观察组上中切牙凸距差为(4.1±1.3)mm,对照组上中切牙凸距差为(2.2±0.9)mm,观察组的磨牙位移(3.7±0.3)mm,观察组的磨牙位移(6.1±0.6)mm,两组结果比较其差异有统计学意义(P<0.05);观察组与对照组错牙合畸形正畸治疗术后的不良反应相比较,其差异有统计学意义(P<0.05).结论 对于青少年口腔正畸治疗采用微型种植体支抗的效果显著好于非种植体支抗,且不会增加不良反应,值得临床应用与推广.     

正畸微种植体支抗对错(牙合)畸形患者口腔炎症反应的影响

目的探究正畸微种植体支抗对错(牙合)畸形患者牙齿结构与口腔炎症反应的影响。方法选取该院2017年1月至2019年1月收治的78例错(牙合)畸形患者,按随机数表法分为对照组与观察组各39例,对照组采取传统正畸治疗,观察组采取正畸微种植体支抗治疗,比较两组牙齿结构变化、口腔炎症反应。结果相比对照组,观察组磨牙移位较小,上中切牙倾角差、上中切牙凸距离差较大(P0.05);治疗后,两组白细胞介素-6、白细胞介素-1β、白细胞介素-8水平均较治疗前高(P0.05),但观察组各指标水平均低于对照组(P0.05)。结论错(牙合)畸形患者采取正畸微种植体支抗可改善牙齿结构,减轻炎症反应。     

微种植体支抗在口腔正畸中的临床应用效果观察

目的观察在口腔正畸中使用微种植体支抗的临床效果,并分析微螺钉种植体支抗的作用及意义。方法选取邵东县中医医院进行口腔正畸的安氏Ⅱ类错颌畸形患者47例,按照常规正畸方案进行矫治,在正畸过程中使用微螺钉种植体支抗,对比患者治疗前、后头影测量差别,并评估临床效果。结果头影测量结果显示患者治疗后上下唇缘点与审美平面距离明显降低,U 1-SN、L 1-MP角度治疗后明显减少,而U 1-L 1角度治疗后明显增加,相比治疗前,差异有统计学意义（P〈0.05）。结论在口腔正畸中使用微种植体支抗,对患者牙齿具有理想的移动能力,能够使患者侧貌更贴近审美平面,达到更好的矫治效果。     

微型种植体支抗在口腔正畸治疗中的应用价值

目的探讨微型种植体支抗在口腔正畸治疗中的应用价值。方法回顾性分析2009年8月-2012年8月广饶县人民医院收治的100例采用微型种植体进行口腔正畸治疗患者的临床资料,评估其可行性及疗效。结果 100例患者均能够较好耐受微型种植体,矫治结束后患者面形良好,牙齿排列整齐,治疗前后X线头影测量值变化差异有统计学意义(P<0.05)。结论微型种植体可为口腔正畸治疗提供稳定可靠的骨性支抗。     

基于常规矫正与微型种植体支抗用于口腔正畸临床的安全性与有效性比较分析

目的探讨在口腔正畸治疗时使用常规矫正与微型种植体支抗的治疗效果。方法选取2020年1—12月本院收治的52例口腔正畸患者,随机分为两组,各26例。对照组采用常规矫正,研究组采用微型种植体支抗,比较两组临床疗效、不良反应发生率、临床指标、治疗时间、成功率及患者满意度。结果研究组治疗总有效率高于对照组,不良反应发生率低于对照组,临床指标优于对照组,成功率高于对照组,治疗时间短于对照组,患者满意度高于对照组,差异均有统计学意义(P<0.05)。结论在口腔正畸治疗时使用微型种植体支抗,磨牙位移较小,临床指标恢复,成功率较高,且治疗时间较短,临床治疗效果显著,且不良反应少,更为安全可靠,值得临床推广应用。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.