2007年海原县人群流脑抗体水平监测结果分析

目的了解海原县人群流脑免疫抗体水平及带菌状况。方法选择宁夏海原县为监测点,采集调查者的咽拭子和静脉血液,分别进行人群流脑带菌调查及流脑A群和C群免疫抗体水平检测。结果A群流脑IgG抗体总阳性率为53.8%,抗体含量均值为6.64μg/ml,C群流脑IgG抗体总阳性率为30.0%,抗体含量均值为2.10μg/ml,A群和C群抗体含量比较差异有统计学意义(t=5.54,P<0.05)。结论海原县A群流脑抗体阳性率较2006年有所下降,虽未分离到脑膜炎球菌,但A群、C群流脑IgG抗体阳性率均较低,说明人群对流脑普遍易感,应引起重视。     

深圳市外来劳务工人A群、C群流行性脑脊髓膜炎抗体水平检测及分析

目的 利用横断面基线调查深圳市外来劳务工人血清中A群和C群流行性脑脊髓膜炎(流脑)水平,为外来劳务工人流脑防控提供依据.方法 抽取深圳市罗湖区、龙岗区、宝安区3个监测点,每个监测点选择50人份以上,3个监测点共选择1003人,采用间接ELESA法(定量)检测血清中抗A群和C群脑膜炎奈瑟菌抗体效价.结果 共检测1003份血清标本,外来劳务工人A群和C群流脑抗体平均滴度分别为10.78μg/ml、2.71 μg/ml.A群和C群流脑血清抗体保护率分别为93.7%、64.8%,二者差异有统计学意义(P<0.01);不同年龄组、不同籍贯外来劳务工人A群流脑抗体保护率差异均有统计学意义(P<0.05).结论 深圳市外来劳务工人C群流脑抗体保护率明显低于A群,为了预防可能存在的流脑C群流行和暴发,提示应加强外来劳务工C群流脑多糖疫苗免疫接种.     

合川区健康人群流脑抗体水平调查

目的了解合川区0岁~46岁以上人群流脑A群和C群免疫状况.方法采用ELISA法检测健康人群血清中的A群和C群流脑IgG抗体.,结果2010年在检测的210人份样中,A群流脑抗体≥2μg/ml有185人,抗体阳性率为88.10%,C群流脑抗体≥2μg/ml有146人,抗体阳性率为69.52%,阳性率A群>C群2011年在检测的210人份样中,A群流脑抗体≥2μg/ml有180人,抗体阳性率为85.71%,C群流脑抗体≥2μg/ml有180人,抗体阳性率为85.71%.结论合川区健康人群流脑免疫水平偏低,A群和C群抗体水平差异无统计学意义,但应制定相应的免疫对策,避免爆发流行.     

临沂市1988～2007年流行性脑脊髓膜炎流行趋势分析

目的通过分析临沂市流行性脑脊髓膜炎（简称流脑）流行趋势,提供科学防治依据。方法分析流行病学调查结果、人群免疫状况监测及病原学监测结果。结果1988—2007年临沂市流脑疫情除2004、2005年出现小幅反弹外,总体为下降趋势;健康人群流脱脑抗体检测A群阳性率为95．20％,C群阳性率为39．33％。2005年开始监测到C群脑膜炎奈瑟菌引起的流脑病例。结论目前临沂市人群流脑抗体水平较高,不具备A群流脑大规模暴发的条件,C群脑膜炎奈瑟菌引起流脑病例有增多趋势。     

海南省2006年健康人群Nm带菌率及抗体水平调查

目的为了解海南省健康人群中流行性流脑膜炎奈瑟菌（Nm）带菌状况及抗体水平,为制定流脑防治规划和预警提供科学依据。方法采用随机抽样方法抽取海口市、儋州市和东方市,以整群抽样法采集被抽中家庭全部人员健康人群咽拭子和静脉血,进行脑膜炎奈瑟菌（Nm）培养,用间接酶联免疫法监测血清标本中脑膜炎A、C群IgG抗体,含量≥2μg／ml为阳性。结果本次抽样检测744人,脑膜炎奈瑟菌（Nm）培养阳性9人,总带菌率为1．21％,A群和c群带菌都主要集中在儋州地区。共检测676人流脑IgG抗体,其中A群抗体阳性者420人,阳性率为62．13％。C群阳性者195人,阳性率为28．85％。不同年龄组抗体水平差异有非常显著性差异,35-45岁年龄组抗体水平最高（P〈0．01）;A群流脑抗体阳性率62．13％显著高于C群流脑抗体28．25％,差异有统计学意义（P〈0．01）,C群抗体各地区间无差异。结论海南省健康人群中存在流脑奈瑟菌（Nm）带菌者,人群中流脑A、C群保护性抗体较低,应加强流脑的防控工作。     

化州市2005年健康人群流脑抗体水平调查

目的了解化州市健康人群流行性脑脊髓膜炎（简称流脑）抗体水平状况。方法采用分层随机抽样的方法，将调查对象分成7个年龄组，每人采集3ml静脉血进行A和C群流脑抗体检测，并做统计分析。结果化州健康人群A和C群流脑抗体阳性率分别为85．86％和13．61％；A群和C群抗体几何平均滴度（GMT）分别为1：7．12和1：1．13。结论A群为当地优势流脑菌群，当地近期出现A群流脑爆发流行的可能性较小；应加强A＋C流脑疫苗的推广接种工作。     

2006年宁夏三市健康人群血清流脑抗体含量分析

目的通过开展健康人群(无流行性脑脊髓膜炎临床症状和体征的人群)流脑抗体含量测定,评价流脑多糖菌苗的接种现状,促进和加强计免工作,保证接种质量和接种效果。方法严格按照《全国流行性脑脊髓膜炎防控工作方案》要求分组采样,统一采用ELISA方法测定健康人群血清中A群、C群流脑IgG抗体含量。结果全区三市(银川、中卫、固原市)7个年龄组共检测632人,流脑A群抗体平均含量4.325μg/ml,A群阳性率69.30%(438/632),阳性抗体含量中位数为4.91μg/ml,各年龄组之间抗体阳性率有统计学意义(χ2=15.38,P<0.05);流脑C群抗体平均含量3.243μg/ml,C群阳性率39.08%(247/632),阳性抗体含量中位数为3.92μg/ml,各年龄组之间抗体阳性率有统计学意义(χ2=40.506,P<0.05)。结论宁夏三市健康人群流脑抗体水平普遍较低,应提高流脑疫苗预防接种质量,加强流脑抗体水平监测。     

哈尔滨市2007年健康人群流脑免疫水平和带菌状况

目的了解哈尔滨市健康人群流行性脑脊髓膜炎（以下简称流脑）带菌状况和免疫水平,预测流脑发病的趋势,为流脑的防控提供科学依据。方法选择宾县作为哈尔滨市流脑监测点。监测点按《全国流脑监测方案》要求,采集3个乡的〈1岁、1也岁、34岁、5-6岁、7～14岁、15～19岁及20岁以上共7个年龄组人群的咽拭子及静脉血分剐进行健康人群带菌调查及人群抗体水平检测。结果哈尔滨市健康人群A群流脑IgG抗体的总阳性率为82．86％（174／2101,C群流脑IgG抗体的总阳性率为62．38％（131／2101;健康人群脑膜炎奈瑟氏菌（以下简称Nm）的带菌率为3．33％（7,210）。结论哈尔滨市健康人群Nm带菌率较低,健康人群A群流脑IgG抗体阳性率维持在较高水平,C群流脑IgG抗体阳性率相对较低,表明大部分人对A群有免疫力,但C群感染率较高。     

海南省流行性脑脊髓膜炎菌群分布和人群免疫水平调查

目的 了解海南省健康人群流脑菌群分布及免疫水平，为防治流脑提供科学依据。方法 采取分层随机抽样的方法采集海口市、屯昌县、陵水县和儋州市0～59岁健康人群静脉血和咽拭子，检测A群和C群血清抗体水平同时进行咽拭子脑膜炎奈瑟氏菌阳性菌株分离。结果 全省共调查693人，采集静脉血693份，捡出A群抗体阳性率40．32％，平均滴度1：5．7；C群血清抗体阳性率19．22％，平均滴度l：2．0。最低血清抗体滴度l：2。最高血清抗体滴度〉1：256；采集健康人群咽拭子617份，检出率0．02％。5岁以下少儿童A群和c群血清抗体阳性率均低于20％；20～40岁青壮年血清抗体阳性率和脑膜炎奈瑟氏菌阳性菌株检出率最高。结论 海南省流脑疫情趋势属于低流行区，15岁以下少年儿童A群和C群血清抗体阳性率水平偏低，不能形成免疫屏障．建议加强流脑疫情监测和15岁以下少年儿童流脑疫苗免疫接种。防止流脑瘦情暴发流行。     

2007年广西居民流脑带菌率和抗体水平监测结果

目的了解广西居民流脑带菌和抗体水平，为科学防制流脑提供依据。方法选择柳州市、百色市和贵港市作为监测点，在流脑流行前期，抽取一定数量的居民采集咽拭子和血液标本，进行咽拭子培养和血液抗体水平检测。结果监测点部分人群带菌率8．1％，A群抗体阳性率为82．63％，C群抗体阳性率为66．72％。结论监测点人群对A群流脑有一定抵抗力，对C群流脑的免疫力相对较低。婴幼儿和成年人抗体水平不高，应采取疫苗接种为主的综合性防制措施，大力加强散居儿童、流动人口等重点人群的免疫接种工作。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.