重度子痫前期患者尿钙与血清尿酸测定的临床意义

目的 研究重度子痫前期患者中尿钙排泄量和尿酸的临床意义.方法 选择重度子痫前期患者47例为实验组,正常晚孕妇女50例为对照组,测定尿钙与尿酸水平.结果 重度子痫前期组与对照组相比,尿钙总量明显降低(1.6 mmol/24 h±1.1 vs 6.1 mmol/24 h±4.2),差异具有统计学意义(P<0.05),而重度...     

新生儿缺氧缺血性脑病血清尿酸水平及临床意义

目的探讨不同程度新生儿缺氧缺血性脑病患儿血清尿酸水平的变化,指导临床治疗及评估预后。方法检测60例患儿血清UA水平,并与60例正常新生儿作为对照。结果 HIE组血清尿酸明显高于对照组（P〈0.01）,且病情越重,尿酸越高,两者比较差异有统计学意义（P〈0.01）;中、重度HIE组血清UA与对照组和轻度HIE组比较差异有统计学意义（P〈0.01）,轻度HIE与对照比较无统计学意义（P〉0.05）。结论新生儿HIE患儿血清UA水平与病情有较好的平行关系,脑损伤程度越重,其水平越高。监测血清UA水平可帮助判断病情,在一定程度上可反映缺氧后脑损伤的程度,能为临床判断病情,评估预后及指导治疗提供一个有价值的生化指标。     

妊娠期高血压疾病患者血清肌酐、尿素氮、尿酸联合检测的临床意义

目的探讨妊娠期高血压疾病患者血清肌酐（Cr）、尿素氮（BUN）和尿酸（UA）联合检测的临床意义。方法选择2010年1月至2012年12月本院诊治的82例妊娠期高血压疾病患者作为观察组,其中妊娠期高血压34例（A组）,轻度子痫前期27例（B组）,重度子痫前期21例（C组）;选择同期正常妊娠孕晚期妇女作为对照组（55例）。测定血清UA、Cr和BUN三项肾功能指标水平,并比较围产儿结局。结果妊娠期高血压疾病患者血UA水平明显高于正常对照组孕妇,且随着病情发展呈现明显上升趋势,与妊娠期高血压疾病的严重程度呈正相关性,并有统计学意义（P〈0．01）。血清UA值增高与胎儿生长受限、胎儿宫内窘迫、新生儿窒息及围产儿死亡的发生率呈正相关性,并有统计学意义（P〈0．05）。结论妊娠期高血压疾病病情严重程度及围产儿预后与血清uA密切相关,动态联合监测UA、Cr和BUN对预测妊娠期高血压疾病病情变化和判断围产儿预后具有重要临床意义。     

2型糖尿病患者血清胆红素和尿酸水平变化及意义

目的探讨2型糖尿病（T2DM）患者血清胆红素、尿酸（UA）和血脂水平变化及意义。方法采用全自动生化分析仪，检测46例T2DM血管病变患者血清胆红素、UA及血脂水平，并与50例对照组比较分析。结果T2DM伴血管病变患者血清总胆红素（TBIL）和间接胆红素（NDBIL）含量明显低于无并发症组（P〈0．01），血清UA含量显著高于对照组（P〈0．01），大、微血管组TBIL、UA比较均无统计学意义；血管病变组总胆固醇（TC）、低密度脂蛋白胆固醇（LDL—C）含量与无并发症组和对照组比较显著升高，而高密度脂蛋白胆固醇（HDL—C）则降低（P〈0．01）。结论低胆红素血症、UA升高及血脂异常与T2DM血管病变密切相关，检测三者含量对判断T2DM伴发血管病变具有重要意义。     

血清尿酸水平与过敏紫癜性肾炎的相互关系探讨

过敏紫癜肾炎(HSPN)是儿科常见的继发性肾小球疾病，其机制尚未完全明确。近年发现，血清尿酸(BUA)升高与许多疾病相伴随。我们探讨了BUA升高与HSPN之间的相关性。     

血液透析患者血清尿酸与C反应蛋白水平的相关研究

目的：验证血清尿酸（SUA）与C反应蛋白（CRP）的关系及两者在血液透析患者心血管事件发生中是否存在协同作用。方法：本研究入组的67例患者均为在我院血净中心进行常规血液透析（透析龄≥3个月）的患者。所有患者均无明显感染和传染性疾病病史。检测患者的基线SUA、CRP、KT/V及其他临床指标。并对患者进行了6个月的随访,以观察高尿酸血症合并CRP升高对血液透析患者心血管并发症的影响。结果：67例患者均完成了6个月的随访,未出现死亡病例。入组时平均SUA水平为（459.6±128.9）μmol/L,其中高尿酸血症患者38例（56.7%）;CRP升高者35例（52.2%）。高尿酸血症伴CRP升高者24例（35.8%）。多元回归分析显示,在进行年龄、性别、体重、Kt/V、三酰甘油、吸烟史、糖尿病病史、高血压等校正后,血清尿酸仍与CRP-log明显相关关系（OR：2.24,Z=2.24,P=0.001）。随访6个月,67例血液透析患者中共有26例（38.8%）患者发生心血管事件,其中高尿酸血症伴CRP升高组心血管事件发生率70.8%（17/24）;单纯高尿酸血症组27.3%（3/11）;单纯CRP升高组28.6%（4/14）血清尿酸及CRP水平均正常组11.1%（2/18）。结论：血液透析患者的血清尿酸水平与C反应蛋白水平可能相关。高尿酸血症与CRP共同作用可增加血液透析患者心血管事件的发生率。     

子痫前期孕妇血清CCL20及IL-17表达及其临床意义

目的 探讨血清CC趋化因子配体20(CCL20)及白介素-17(IL-17)水平与子痫前期的相关性及其对子痫前期的诊断效能。方法 选择2021年1月至2022年12月陕西省人民医院产科收治的150例子痫前期孕妇为子痫前期组,另选取同期90例健康妊娠妇女为对照组。采用酶联免疫吸附法(ELISA)检测血清CCL20及IL-17的表达水平,采用Pearson相关法分析血清CCL20及IL-17与子痫前期患者临床参数的相关性;采用受试者工作特征曲线(ROC)分析血清CCL20及IL-17对子痫前期的诊断价值。结果 子痫前期组孕妇血清CCL20及IL-17水平均显著高于对照组(P<0.001)。子痫前期组孕妇血清CCL20及IL-17的表达均与收缩压(分别为r=0.463、r=0.545)、舒张压(分别为r=0.475、r=0.467)及尿蛋白(分别为r=0.302、r=0.342)呈显著正相关(P<0.001),而与终止妊娠孕周(分别为r=-0.281、r=-0.188)、新生儿出生体重(分别为r=-0.299、r=-0.200)及1 min Apgar评分(分别为r=-0.215...     

血清骨钙素在不同年龄段的水平变化及临床意义

目的：探讨不同年龄段血清骨钙素水平的变化。方法：采用放射免疫分析法(RIA)对316例健康人血清骨钙素(BGP)水平进行测定。结果：少年组与青年组、中年组、老年组比较差异非常显著(P＜0．001),青年组与中年组比较差异有显著性(P＜0．05),青年组与老年组比较有明显差异(P＜0．001),中年组与老年组比较有明显差异(P＜0．001)。少年组、中年组男女之间比较无明显差异,青年组男女之间比较差异有显著性(P＜0．05),老年组男、女比较有明显差异(P＜0．001)。结论：血清骨钙素水平随年龄变化而变化。     

妊娠期高血压疾病尿酸含量对围产结局的影响

妊娠期高血压疾病是一种常见的产科并发症．是导致胎儿生长受限、胎儿宫内窘迫及围产儿死亡的重要原因之一．血清尿酸含量的升高．在妊娠期高血压疾病治疗中．常被认为只提示。肾脏的早期损害．而近年研究证明尿酸含量与围产儿的结局密切相关。为进一步探讨妊娠期高血压疾病尿酸增高程度与围产结局的关系．本对本院145例妊娠期高血压疾病孕妇及同期36例正常孕妇进行血清尿酸的测定．现分析如下。     

卵巢癌患者手术前后血清糖类抗原125的水平变化及临床意义

本文用放射免疫分析（RIA）对40例卵巢癌患者手术前后血清糖类抗原125（CA125）进行检测，并与正常健康对照组比较，以了解其在卵巢癌的诊断、疗效评价及预后观察中的价值，现报告如下。     

血尿酸与骨密度相关性的研究进展

尿酸是嘌呤代谢的最终产物,是人体内一种重要的内源性抗氧化剂,在氧化应激方面发挥重要作用,而氧化应激是骨质疏松形成的一个独立的危险因素,因此,血尿酸与骨量丢失可能存在某种相关性。近年来,国内外对血尿酸与骨密度相关性的研究较多,但其确切关系仍存在争议。本文主要从不同人群血尿酸与骨密度相关性、二者相关性的可能机制、及其存在的争议等问题进行阐述,以期能进一步加深对二者的认识,为临床治疗研究提供新的思路。     

血尿酸与骨质疏松性骨折的相关性

目的系统评价血尿酸与骨质疏松性骨折之间的关系。方法通过PubMed数据库、Cochrane Collaboration数据库、中国知识资源总库(CNKI)、万方数据知识服务平台和Sino Med数据库进行检索,查找关于高血尿酸与骨质疏松性骨折发生风险的相关文献。结果依纳入标准,共纳入7个研究,含30 855例患者。Meta分析结果显示:高血尿酸水平患者发生骨质疏松性骨折风险明显下降(HR=0.88,95%CI为0.83～0.93,P0.001)。发表偏倚及敏感性分析显示:漏斗图及Egg检验未见明显发表偏倚,敏感性分析提示结果较稳定。结论高血尿酸可降低骨质疏松性骨折发生风险。     

老年股骨颈与粗隆间骨折患者血尿酸水平的比较研究

目的通过比较老年股骨颈与股骨粗隆间骨折患者的血尿酸(SUA)水平,研究尿酸与骨代谢的相关性。方法笔者收集自2014-01—2016-06诊治的437例股骨颈或股骨粗隆间骨折,其中股骨颈骨折264例,股骨粗隆间骨折173例,空腹血检测SUA水平。结果股骨颈骨折患者的年龄为(75.6±9.1)岁,股骨粗隆间骨折患者的年龄为(80.5±7.3)岁,股骨颈骨折患者年龄小于股骨粗隆间骨折,差异有统计学意义(P0.001)。男性患者的SUA水平为(298.6±93.4)μmol/L,女性患者的SUA水平为(261.7±85.2)μmol/L,男性患者SUA水平高于女性,差异有统计学意义(P0.001),各年龄段男女患者的SUA水平与该结果保持一致。股骨颈与粗隆间骨折患者的SUA水平较高,两者间比较差异无统计学意义(P=0.063),且各年龄段中男(女)性股骨颈与粗隆间骨折患者的SUA水平差异无统计学意义。结论年龄是骨质疏松独立的危险因素,股骨粗隆间骨折患者的年龄明显高于股骨颈骨折患者,提示其骨质疏松程度更高。但SUA水平在2组患者间差异无统计学意义,初步说明尿酸与骨代谢无关。在临床中仍应积极控制尿酸水平,避免高尿酸血症引起的相关并发症。     

Impact of serum uric acid on renal function after bariatric surgery: a retrospective study

BackgroundDespite a known negative association between serum uric acid level (SUA) and renal function, this correlation in patients after bariatric surgery remains unknown.ObjectiveTo assess correlation between postoperative SUA and estimated glomerular filtration rate (eGFR) at 12 months after bariatric surgery.SettingA single tertiary referral center.MethodsA total of 252 patients (age = 40.5 ± 11.2; body mass index = 39.0 ± 5.5 kg/m²) undergoing bariatric surgery divided into 2 groups (i.e., normal renal function [90 ≤ eGFR < 125 mL/min/1.73 m², n = 176] versus renal function impairment [eGFR < 90 mL/min/1.73 m², n = 76]) were assessed for relationships between SUA and eGFR in both groups (primary endpoint) and associations of percentage weight loss with changes in SUA (△SUA) and eGFR (△eGFR) for all patients (secondary endpoint) at 12 months.ResultsOverall, prevalence of hyperuricemia was 40.4% and 22.2% (baseline and postoperative 12 mo, respectively). Reverse relationship was observed between SUA and eGFR (r = −.152, P = .007) for all patients with no association noted between baseline SUA and eGFR in each group as well as between SUA and eGFR at 12 months in the normal group (r = −.076, P = .437). The reverse relationship was found (r = −.417, P = .005) in renal function impairment group for whom SUA was identified as a predictor of eGFR at 12 months. There was no association of percentage weight loss with △SUA (r = .089, P = .601) and △eGFR (r = −.046, P = .785).ConclusionThe results demonstrated a negative relationship between postoperative SUA and renal function in patients with preexisting renal dysfunction undergoing bariatric surgery. Clinical significance of our findings warrants further investigation.     

Exploration of the association between serum uric acid and testosterone in adult males: NHANES 2011–2016

BackgroundPrevious studies have suggested that the possible relationship between serum uric acid (SUA) and testosterone. However, the results of previous studies are controversial and there is limited evidence examining the relationship between SUA and testosterone in a general US population of men. The objective of this study is to explore the correlation of SUA and testosterone among adult males from the US.MethodsData from the National Health and Nutrition Examination Survey 2011–2016 were used, including a total of 7,796 male participants aged 18 years or older and excluding those lacking serum testosterone and uric acid data. Clinical characteristics of the participants among different SUA groups and testosterone groups are compared. Univariate and multivariate linear regression analyses were applied to evaluate the association between SUA and testosterone.ResultsWe found an inverse association between SUA and testosterone after fully adjusted the potential confounding factors in general US adult males. In the multivariate linear regression analysis, we found that increasing age (estimate testosterone percent difference: −0.20% per year, P<0.01), uric acid (estimate testosterone percent difference: −4.40% per md/dL, P<0.01) and BMI (estimate testosterone percent difference: −2.86% per kg/m2, P<0.01) were associated with declining serum testosterone. This association remained significant in sensitivity analysis, while in the stratified analysis, above association was not significant in men with diabetes or aged 65 and over.ConclusionsSUA levels might be negatively associated with serum testosterone in adult males.     

Serum uric acid and cardiovascular risk: State of the art and perspectives

Hyperuricaemia is commonly found in subjects with cardiovascular disease, but its role as risk factor is very controversial. Although several studies reported serum uric acid as a marker of an underlying pathophysiological process, other studies hypothesis a potential causal link between serum uric acid and cardiovascular diseases. Some studies suggest that uric acid is biologically active and may have an atherogenesis role in development of cardiovascular diseases, although the mechanisms are not fully understood. Other studies have shown that uric acid can independently predict the development of some cardiovascular risk factors such as hypertension and metabolic syndrome, as well as myocardial infarction and stroke. The relations between serum uric acid and established cardiovascular risk factors are complex, and these latter could be considered as confounding factors. In this report, we review the inextricably link of serum uric acid to known cardiovascular risk factors, and we describe the possible mechanisms and potential causative role between serum uric acid and cardiovascular events in the general population, in subjects with cardiovascular risk factors and in those with pre-existing cardiovascular diseases. Limited information however is available concerning the impact of urate-lowering treatments on cardiovascular events, whereas only a positive therapeutic trial could give definite answers to the difficult problem of causality of uric acid in relation to cardiovascular risk. Thus, it is time to propose the design of a therapeutic trial, integrating cardiologists and rheumatologists, in order to further decrease cardiovascular risk.     

Effects of two diphosphonates (EHDP and Cl2MDP) on serum uric acid in pagetic patients

Summary The effects on serum uric acid (SUA) of two diphosphonates (EHDP at 5 and 20 mg/kg/day and Cl₂MDP at 400 and 1600 mg/day) were studied in 49 pagetic patients treated for 6 months. Patients were divided into two groups: group I, initially normouricemic (SUA <385μmol/l); group II, initially hyperuricemic (SUA ⩾385μmol/l). SUA was significantly decreased (P<0.01) after 6 months of diphosphonate therapy in all group II patients. However, 3 months after withdrawal of therapy, SUA returned to values not significantly different from those initially recorded in this group. SUA did not change during or after treatment in the group I patients. Groups I and II could not be differentiated on the basis of initial serum alkaline phosphatase or urinary hydroxyproline values. In response to therapy, both groups showed the same reduction in these parameters. These results suggest that diphosphonates have no effect at a single level in uric acid metabolism. They certainly reduce the part of the urate pool coming from the nucleic acids of the increased bone cell population by reducing the number of osteoclasts and osteoblasts, which is extremely high in pagetic bone. They also must act on uric acid metabolism through other mechanisms which need to be investigated in further studies.     

血清和糖皮质激素诱导的蛋白激酶1在高血压肾损害大鼠模型中的表达

目的探讨血清和糖皮质激素诱导的蛋白激酶1（SGK1）在高血压肾损害大鼠模型中的表达及其意义。方法采用NG-硝基-L-精氨酸甲酯（L-NAME）诱导大鼠高血压模型,观察肾脏组织病理学改变;检测尿微量白蛋白（mAlb）、β2微球蛋白（β2-MG）和血肌酐（SCr）浓度;实时PCR法检测肾皮质sGK1 mRNA的表达;Western blot法检测肾皮质SGK1蛋白的表达。结果8周时高血压组大鼠肾脏组织可见小动脉中膜增厚,管腔缩小,肾小球和肾小管缺血样改变,伴有问质基质增生和炎症细胞浸润。尿mALB和β2-MG显著增加,SCr改变不明显。肾皮质SGK1 mRNA和蛋白表达显著上调,与对照组比较有统计学差异（P〈0．01）。结论高血压组大鼠肾皮质SGK1基因表达明显增加,提示SGK1可能在高血压肾损害的发病机制中发挥了重要作用。     

男性强直性脊柱炎患者骨密度与血尿酸水平相关性研究

目的分析强直性脊柱炎(ankylosing spondylitis,AS)男性患者骨密度(bone mineral density,BMD)与血尿酸(serum uric acid,SUA)的相关关系。方法回顾性分析2013年9月到2018年9月在中日友好医院确诊的143名男性AS患者,按腰椎、股骨颈、股骨粗隆BMD水平各分为正常骨量组和骨量减少组。比较两组间患者临床基本资料、疾病活动程度指标等的差异;使用多元回归分析评估SUA水平与男性AS患者各部位BMD的关系;使用Logistic回归模型预测SUA与各部位BMD之间的风险概率;构建列线图预测男性AS患者腰椎及股骨粗隆发生骨量减少的风险。结果两组间比较结果显示,身高、腰椎、股骨颈、股骨粗隆BMD比较差异均有统计学意义(均P<0.05)。多元线性回归分析提示SUA水平与腰椎、股骨粗隆的BMD呈正相关。Logistic回归分析结果提示,SUA每降低78 mmol/L发生腰椎和股骨粗隆骨量减少的风险分别升高18%和17%。通过构建的列线图可预测男性AS患者发生腰椎及股骨粗隆骨量减少的风险。结论SUA水平低可能会增加男性AS患者腰椎和股骨粗隆骨量减少的风险,SUA具有反映男性AS患者骨量减少风险的潜力。