茶苯海明治疗晕动病的安全性和有效性

茶苯海明是一种抗组胺类药,是治疗晕动病的有效药物,具有显著的民用和军事应用价值.本文检索PubMed、the Cochrane Ear,Nose and Throat Disorders Group Trials Register、the Cochrane Central Register of Controlled Trials、EMBASE、CINAHL、Web of Science、BIOSIS Previews等数据库,归纳所有可获得的文献,综合分析茶苯海明治疗晕动病的安全性和有效性.结果显示,尽管治疗晕动病的首选药物是东莨菪碱,但茶苯海明是治疗晕动病伴发恶心和呕吐时的首选药物.这可能与茶苯海明能减少晕动刺激过程中胃的运动有关.因此在治疗伴有恶心和呕吐症状的晕动病时,应首选茶苯海明.     

生姜治疗晕动病的研究

本文查阅大量中外文献,对生姜治疗晕动病进行了研究。通过我国古本草、现代中医及民间对生姜治疗晕动病的应用研究,且与西医药物的疗法比较,得出了生姜是目前较为理想的抗晕动病药物。     

晕动病前庭生理机制研究进展

晕动病是在航空、航天、航海旅行及作业过程中,由异常加速度刺激引起的生理功能紊乱.已证实前庭系统作为运动感受和加速度信息加工的核心,对晕动病的诱发及自主神经症状的产生起重要作用.虽然晕动病的发生机制尚未完全阐明,但近年来在感觉冲突理论的生理基础、自主神经反射的神经机制等方面有了新的突破.本文综述了前庭-视觉-本体感觉信息整合、前庭-海马及前庭-皮质通路与运动信息加工、前庭-内脏反射通路及前庭递质系统与抗晕动病药物靶点等的研究进展,为促进新型晕动病防治手段的开发和应用提供借鉴.     

晕车灵配伍吗丁啉治疗晕动病临床观察

晕动病(Matiom Sickness)是晕船、晕车、晕机和由于摇摆、旋转、加速运动引起的一种疾病 [1].它严重影响人们出行和身心健康.为寻求安全、方便、有效的防治方法,我们用晕海灵配伍吗丁啉防治晕动病,获得良好的效果,现将结果报告如下.     

陆军渡海训练航海晕动病的防治

航海晕动病(简称晕船)是降低军事人员作战效能的重要原因之一。防治晕动病是航海医学研究的一个重要课题。我们对参加海上军事训练的4911名官兵进行航海晕动病病因学调查,探讨预防、治疗晕动病的有效方法。研究在陆军系统如何防治晕船。     

晕动病和抗晕动病药对胃功能的影响

晕动病和抗晕动病药对胃功能的影响〔ＴｈｅＪｏｕｒｎａｌｏｆＣｌｉｎｉｃａｌＰｈａｒｍａｃｏｌｏｇｙ１９９４，３４（６）：６３５－６４３（英文）〕研究观察晕动病和抗晕动病药对胃诽空功能的影响。正常人和晕动病者用药后实验，受试者坐在转椅上，头保持运动以引...     

晕动病的良药——吗丁啉

目的 探讨吗丁啉对晕动病中的疗效. 方法日常生活中晕动病较多,严重困扰着人们生活,本人在临床工作中对其病因及治疗方法的分析. 结果 实例124例,治愈116例,无效8例.有效率为98.54%,无效率为6.45%.吗丁啉应用在晕动病有较好的治疗效果.结论 吗丁啉在晕动病中的应用有发展前途.     

平晕饮对出海舰员抗晕效果的初步观察

运动病是由于异常运动刺激而引起的神经系统功能失调,主要发生在人们乘坐车、船、飞机、游乐设施或航海、航空、航天模拟和实际作业中。运动病发病率较高,迄今尚无理想的防治措施。传统的抗晕药虽有一定效果,但其中枢神经抑制作用严重影响了军事作业。中草药抗晕在我国自古就有应用,     

湿热环境下晕动病发病率、预防训练及退化再适应的综合研究

目的研究湿热环境下晕动病的发病率、防治、退化再习服规律,以为后续实验积累经验.方法首先在常温、单纯高温、湿热环境下测试人员的晕动病发病率及发病等级,然后通过两阶段训练评估晕动病的防治训练效果,对已适应的人群进行退化再适应的研究.结果 (1)常温和单纯高温下的晕动病评分、等级相比差异有统计学意义(P<0.05);常温、高温、湿热环境下的晕动病评分、等级相比差异有统计学意义(P<0.01);(2)单纯湿热环境习服训练前后,受试者的晕动病评分、等级相比差异无统计学意义(P>0.05);针对性的抗眩晕训练后,晕动病评分、等级相比差异有统计学意义(P<0.05);(3)对已习服的受试者,3个月后进行的再习服训练,与训练期相比差异无统计学意义(P>0.05),且两曲线趋势、形态并无明显差异.结论晕动病在常温、单纯高温、湿热环境下的发病率和发病等级呈逐步加重的趋势;针对湿热环境下的晕动病,单纯的湿热环境习服训练意义不大,针对性的专项抗眩晕训练则效果明显;对已习服的群体,再习服训练的间隔期至少应小于3个月.     

家庭药箱应当如何配备

内服药物的配备安定具有镇静、催眠等作用。失眠者可于睡前服用,但久服易成瘾;男病人易导致阳痿。对孕妇、婴儿、青光眼病人及重症肌无力患者禁用。乘晕宁患晕动病者,乘车、船、飞机前半小时服用,能避免眩晕、呕吐等反应。阿司匹林能退热、止痛、抗炎、抗风     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.