复发与未复发女性尖锐湿疣患者Th_1/Th_2细胞因子检测

目的观察复发与未复发女性生殖器尖锐湿疣(CA)患者外周血Th1/Th2细胞因子水平,探讨CA复发与Th1/Th2细胞因子的相关性。方法选取女性生殖器CA初发患者37例,经电灼治疗后随访3个月(期间不使用任何免疫制剂),再次复发者计入A组(15例),未复发者计入B组(22例)。用ELISA法测定电灼治疗前各组血清标本的细胞因子IL-2、IL-12、IL-4和IL-10的浓度,比较A,B两组血清细胞因子及Th1/Th2比值的差异,分析CA复发与Th1/Th2细胞因子水平的相关性。结果A组治疗前的血清IL-2,IL-12,IL-4,IL-10分别为65.86±20.31,21.09±5.84,98.31±10.95,25.87±9.24,B组分别为82.81±27.24,25.74±10.63,89.02±13.80,25.62±9.84;用Th1/Th2比值来预测CA不复发的敏感性为86.4%,特异性为80.0%,ROC曲线下面积为0.812。结论CA复发与否与患者血清Th1/Th2细胞因子水平呈负相关,以Th1/Th2比值预测CA复发与否有较高的敏感性和特异性,Th/Th比值可作为评价CA复发与否的一个参考指标。     

胸腺肽加阿昔洛韦治疗复发性生殖器疱疹临床观察

生殖器疱疹 (ＧＨ)是由单纯疱疹病毒Ⅱ型 (ＨＳＶ 2 )引起的 1种复发性很高的性传播疾病。我们于1999年 2月～ 2 0 0 0年 11月应用胸腺肽针 (西安长城制药厂 )加服阿昔洛韦片进行治疗 ,在控制其复发方面 ,取得了较好的疗效。现报告如下。1　材料与方法1.1　临床资料　 80例患者均来自焦作市人民医院性病门诊 ,随机分为 2组。治疗组 5 0例 ,男 31例 ,女 19例 ,年龄 35± 14岁 ,病程 15± 10月 ,复发次数 4± 2次/年。对照组 30例 ,男 18例 ,女 12例 ,年龄 34± 12岁 ,病程 16± 11月 ,复发次数 4± 2次 /年。两组病情无明显差异 ,具有可比性…     

活血消疕丸治疗静止期银屑病90例

我院采用自制的活血消丸治疗静止期银屑病 90例 ,并与迪银片治疗的 45例进行对照 ,取得了较为满意的效果。现总结如下 :1　临床资料所有病例均来自本院皮肤科门诊病人 ,且全部为静止期患者 ,共 1 35例 ,随机分为治疗组和对照组。治疗组 90例 ,其中男性 49例 ,女性 41例 ;年龄 1 5～ 6 9岁 ,平均年龄 37.3± 1 1 .6 6岁 ;病程最短 3个月 ,最长 2 0年 ,平均病程 9.0 1± 6 .0 4年。对照组 45例 ,其中男性 2 5例 ,女性 2 0例 ,年龄 1 5～ 6 0岁 ,平均年龄 38.36± 1 1 .2 1岁 ;病程最短 4个月 ,最长 1 9年 ,平均病程 9.3± 5 .80年。2　方药…     

复发性尖锐湿疣患者PBMC中IFN-γ和IL-4的表达

用酶联免疫斑点法 (ELISPOT)检测患者PBMC细胞内细胞因子IFN γ和IL - 4的表达情况。复发性尖锐湿疣患者PBMC中IFN γ及Th1 Th2比值与正常人相比显著降低 (P <0 .0 1)。复发性尖锐湿疣患者PBMC中细胞因子IFN γ降低 ,表达倾向于向Th2偏移 ,Th1 Th2平衡失调在CA的复发中起重要作用     

HPV6感染的尖锐湿疣患者血清抗体反应研究

目的　探讨我国HPV 6感染的尖锐湿疣患者血清抗体反应 ,以评价我国HPV感染的血清学诊断方法 ,并为疫苗研制提供理论依据。方法　采用重组杆状病毒 昆虫细胞系统制备HPV病毒样颗粒 ,通过ELISA法检测 3组共136份标本的血清抗体。结果　尖锐湿疣组血清抗体最高 (阳性率 75 .0 % ,OD平均值为 0 .111± 0 .0 94) ,较健康对照组(阳性率 2 .8% ,OD平均值 0 .0 12± 0 .0 2 4)和宫颈癌组 (阳性率 14 .3 % ,OD平均值 0 .0 2 9± 0 .0 2 2 )差异均有显著性 (P <0 .0 1)。结论　尖锐湿疣患者体内可检测到型特异性抗体 ,尤以女性和复发患者为显著 ,HPV 11感染与HPV 6b血清抗体相关 ,提示HPV病毒样颗粒可用作HPV感染的血清学诊断。     

自体疣免疫法治疗顽固性尖锐湿疣5例

作者 1996年— 1997年间对所遇 5例顽固性尖锐湿疣患者 ,作自体疣置入人工免疫法治疗 ,效果满意现报告如下 :1　临床资料　 5例患者均为男性 ,年龄 2 6— 47岁 ,平均32 8岁 ,病程 6 2天— 1年余 ,平均 5 8个月 ;其中 :包皮 ,龟头多发性尖锐湿疣 3例 ,肛周 1例 ,尿道口尖锐湿疣 1例 ,疣体大者 1 2ｃｍ× 0 7ｃｍ ,小者呈粟粒样。形态呈菜花样 3例 ,乳头样 2例。复发 2次 :2例 ,复发 3次 :1例 ,复发 4次 ,1例 ,均为ＣＯ2 激光加抗病毒药物治疗后复发。2　方法与结果　2 1　方法　切取自身最新出现疣组织 1个 ,先用 0 2 5 %氯霉素生理盐水…     

CO2激光联合干扰素局部注射治疗尖锐湿疣的临床观察

尖锐湿疣 (ＣＡ)是由人类乳头瘤病毒感染引起的一种常见的病毒性性传播疾病。目前临床治疗方法很多 ,但容易复发。我们用二氧化碳激光联合干扰素 (ＩＦＮ)局部注射治疗ＣＡ ,收到较好疗效 ,现将观察结果报告如下 :1　资料与方法1 .1　一般资料　 1 1 3例ＣＡ患者均系 1 999年 6月～ 2 0 0 0年 1 2月我院宁化皮肤性病科门诊初诊者 ,入选病例均具有典型的临床症状 ,醋酸白试验 ( +) ,符合卫生部防疫司 1 991年制定的ＣＡ诊断标准。其中男性 74例 ,女性 3 9例。年龄 1 8～ 5 8岁 ,平均年龄 3 2 8± 3 8岁。病程 1个月～ 8个月 ,平均 2 2± 1…     

NK细胞与尖锐湿疣转归关系研究

目的 :　研究尖锐湿疣患者外周血NK细胞数 ,探讨NK细胞数在尖锐湿疣转归中的作用。方法 :　用流式细胞仪检测尖锐湿疣患者外周血NK细胞数目 ,皮损给予液氮冷冻、上臂内侧皮下注射转移因子、皮损局部注射干扰素治疗 ,疗程结束后随访 3个月 ,观察尖锐湿疣复发情况。结果 :　 74例患者 47例临床治愈 ,2 7例复发。 74例患者外周血NK细胞数明显高于对照组 (P <0 .0 1) ,病程小于 3个月组高于病程大于 3个月组 (P <0 .0 5 ) ,未复发组高于复发组 (P <0 .0 5 ) ,未复发组 15例复查了NK细胞 ,基本恢复正常。结论 :　尖锐湿疣患者外周血NK细胞数增高 ,增高的程度与病程有关 ,短病程者高于长者 ,NK细胞增高的程度与复发有一定关系 ,明显增高者不易复发。     

5%咪喹莫特预防宫颈和肛管尖锐湿疣复发的临床观察

目的:观察5%咪喹莫特预防宫颈和肛管尖锐湿疣复发的临床效果.方法:经临床和病理诊断宫颈尖锐湿疣患者5例纳入A组,经临床诊断肛管尖锐湿疣的患者6例纳入B组.所有患者既往经物理治疗复发2次以上,先用高频电刀清除可见疣体,一周后创面愈合.两组患者均每周外用5%咪喹莫特1次,每次250 mg,连续12周.结果:5例宫颈尖锐湿疣患者治疗过程中,1例患者出现宫颈中度糜烂,后延期1周继续治疗;2例患者轻度糜烂,2例患者宫颈轻度充血.6例肛管直肠尖锐湿疣患者有肛门灼痛感,无其他不适.11例患者疗程结束后均无可见尖锐湿疣疣体复发.随诊6～10个月,均无复发.结论:对于宫颈和肛管复发性尖锐湿疣,经物理治疗清除可见疣体后,外用5%咪喹莫特可有效预防复发,且无创伤,痛苦小.     

90例尖锐湿疣复发原因分析

本文收集了复发性尖锐湿疣病人 90例 ,其中男性 72例 ,女性 1 8例。年龄 1 9～ 62岁 ,平均 3 4岁。复发期 1 5天～ 6个月 ,平均 3 3个月 ,皮损 1～ 4 2个 ,平均 7个。对上述病例进行分析 ,以期找出复发因素 ,指导治疗。1　包皮过长 . 66例 ,占男性湿疣的 92 % ,为男性病人复发的主要因素。男性性病合并包皮过长者占 89%。包皮过长产生污垢 ,发生潮湿环境病原微生物滋生 ,引起包皮龟头炎 ,损伤皮肤粘膜 ,利于ＨＰＶ的侵入、复制和扩散。对上述病例去除疣体后行包皮环切术 ,复发仅 2例 ,复发率为 3 % ,大大低于通常 2 0～ 3 3 %的复发率。2　…     

Outcomes and adverse effects of ablative vs nonablative lasers for skin resurfacing: A systematic review of 1093 patients

It is generally believed that ablative laser therapies result in prolonged healing and greater adverse events when compared with nonablative lasers for skin resurfacing. To evaluate the efficacy of ablative laser use for skin resurfacing and adverse events as a consequence of treatment in comparison to other modalities, a PRISMA‐compliant systematic review (Systematic Review Registration Number: 204016) of twelve electronic databases was conducted for the terms “ablative laser” and “skin resurfacing” from March 2002 until July 2020. Studies included meta‐analyses, randomized control trials, cohort studies, and case reports to facilitate evaluation of the data. All articles were evaluated for bias. The search strategy produced 34 studies. Of 1093 patients included in the studies of interest, adverse events were reported in a total of 106 patients (9.7%). Higher rates of adverse events were described in nonablative therapies (12.2% ± 2.19%, 31 events) when compared with ablative therapy (8.28% ± 2.46%, 81 events). 147 patients (13.4%) reported no side effects, 68 (6.22%) reported expected, transient self‐resolving events, and five (0.046%) presented with hypertrophic scarring. Excluding transient events, ablative lasers had fewer complications overall when compared with nonablative lasers (2.56% ± 2.19% vs 7.48% ± 3.29%). This systematic review suggests ablative laser use for skin resurfacing is a safe and effective modality to treat a range of pathologies from photodamage and acne scars to hidradenitis suppurativa and posttraumatic scarring from basal cell carcinoma excision. Further studies are needed, but these results suggest that ablative lasers are a superior, safe, and effective modality to treat damaged skin.     

New fillers for the new man

ABSTRACT:  Two new collagen-based lidocaine-containing dermal fillers, ArteSense™/ArteFill™ (Artes Medical, San Diego, CA) and Evolence® (Colbar LifeScience Ltd., Herzliya, Israel), have proved to be of particular interest to men, many of whom seek a long-lasting or permanent correction. ArteFill™ has been available in the United States since 2006, and it is expected that Evolence® will reach the American market in 2008. The properties of the two products will be described, and experience based on the administration of many hundreds of syringes of both products by a Canadian dermatologist will be detailed here, with tips and precautions to optimize patient outcomes.     

Multiple New-Onset Subcutaneous Nodules of the Upper Extremity Digits: Giant Cell Tumor of Tendon Sheath and Lipoma

A black woman with the concurrent onset of two subcutaneous nodules located on the digits of her upper extremities is described. Initially, a single systemic disorder was considered; yet, the lesions differed in morphology and consistency. Microscopic examination of the nodules showed a giant cell tumor of tendon sheath and a lipoma. Although Occam's “razor” suggests that multiple lesions in the same person are more likely to represent variable manifestations of a single disorder than several different diseases in that individual, the simultaneously appearing lesions in this patient represented two different conditions.     

Genetic alterations in RAS‐regulated pathway in acral lentiginous melanoma

Studies integrating clinicopathological and genetic features have revealed distinct patterns of genomic aberrations in Melanoma. Distributions of BRAF or NRAS mutations and gains of several oncogenes differ among melanoma subgroups, while 9p21 deletions are found in all melanoma subtypes. In the study, status of genes involved in cell cycle progression and apoptosis was evaluated in a panel of 17 frozen primary acral melanomas. NRAS mutations were found in 17% of the tumors. In contrast, BRAF mutations were not found. Gains of AURKA gene (20q13.3) were detected in 37.5% of samples, gains of CCND1 gene (11q13) or TERT gene (5p15.33) in 31.2% and gains of NRAS gene (1p13.2) in 25%. Alterations in 9p21 were identified in 69% of tumors. Gains of 11q13 and 20q13 were mutually exclusive, and 1p13.2 gain was associated with 5p15.33. Our findings showed that alterations in RAS‐related pathways are present in 87.5% of acral lentiginous melanomas.     

Medición del impacto psicológico en pacientes con psoriasis en tratamiento sistémico

Background and objectives

The negative impact of psoriasis on patient quality of life can be as important as the physical consequences of the disease. We could assume that clearance of the disease would also lead to an improvement in its psychosocial impact. The present study assesses the psychological state of patients with psoriasis receiving systemic treatment in a psoriasis unit, especially those with mild or no disease involvement.