有无家族史银屑病环境因素与HLA-DQA1等位基因交互作用的研究

目的　研究银屑病环境危险因素与HLA DQA1等位基因交互作用。方法　采用病例 对照方法调查 176例银屑病患者及 185例健康人环境因素 ,用PCR SSP方法检测HLA DQA1等位基因 ;对环境危险因素与HLA DQA1等位基因交互作用进行研究。结果　①在有及无家族史银屑病中 ,HLA DQA1 0 10 4与受潮存在交互作用 (P <0 .0 5 ,OR>4.0 ) ;在无家族史银屑病中HLA DQA1 0 10 4与饮酒 (P =0 .0 190 ,OR =4.62 )、食鱼虾 (P =0 .0 42 6,OR =2 .82 )存在交互作用。②HLA DQA1 0 2 0 1与食鱼虾 (P =0 .0 0 74,OR =4.72 )仅在无家族史银屑病中存在交互作用。③HLA DQA1 0 5 0 1与受潮 (P =0 .0 0 40 ,OR =10 .5 0 )、食鱼虾 (P =0 .0 3 3 8,OR =5 .41)和精神紧张 (P =0 .0 482 ,OR =8.14 )仅在有家族史银屑病中存在交互作用。结论　HLA DQA1等位基因能增加银屑病环境危险因素发生该病的危险性 ,在有及无家族史银屑病中存在差异。     

关节病型银屑病与HLA-DRB1等位基因相关性研究

目的:探讨HLA-DRB1等位基因与山东汉族关节病型银屑病(PsA)及其临床类型的相关性.方法:应用聚合酶链反应-寡核苷酸探针杂交分型法(PCR-SSOP)对42例山东汉族PsA(病例组)与90例健康献血者(对照组)进行HLA-DRB1等位基因分型.结果:42例PsA患者组中共检测到13对HLA-DRB1等位基因,未发现与PsA及其临床类型相关的HLA-DRB1等位基因,DRB1*12(P=0.036)等位基因出现的频率明显低于对照组,但经校正后无显著性差异.结论:HLA-DRB1等位基因可能与山东汉族PsA及其临床类型无关,对PsA的分型及预后价值有限.     

关节病型银屑病与HLA等位基因关联性Meta分析

目的:了解关节病型银屑病与HLA等位基因的关联性。方法:检索PubMed、ISI、中国期刊全文数据库(CNKI)、维普数据库(VIP)及万方数据资源系统(Wanfang database)1972年1月1日至2019年7月1日期间收录的有关关节病型银屑病与HLA等位基因关联性研究的相关文献,进行质量评估和Meta分析。OR≤0.8的HLA基因记为保护基因,OR≥1.2为风险基因,0.8相似文献   

山东汉族关节病性银屑病与HLA-A、B等位基因相关性研究

目的 探讨HLA-A、B等位基因与山东汉族关节病性银屑病及其临床特征的相关性。方法 PCR-寡核苷酸探针杂交分型法（PCR-SSOP）对42例山东汉族关节病性银屑病患者（患者组）与90例健康献血者（对照组）进行HLA-A、B等位基因分型。结果 两组比较,关节病性银屑病患者组B*27等位基因频率（患者组为11%,对照组为1.8%,Pc < 0.01）、B*57等位基因（分别为4.8%和0.4%,Pc < 0.05）及B*13/B*27杂合体（分别为8.5%和0.5%,Pc < 0.01）的出现频率明显高于对照组,A*33等位基因频率（分别为0.6%和6.7%,Pc < 0.01）明显低于对照组。B*27等位基因频率在关节病性银屑病脊柱受累组为80%,无脊柱受累组为 22%（两组比较,P < 0.01）;外周附着点受累组为63%,无外周附着点受累组为23%（P < 0.05）。7例B*13/27杂合体阳性者中5例（71%）有脊柱炎合并外周关节炎,而36例B*13/27杂合体阴性者中有8例（22%）,两组比较,χ2 = 6.73,P < 0.05。结论 HLA-B*27与山东汉族关节病性银屑病相关。     

HLA-A等位基因与白塞病临床表现的相关性研究

目的：探讨HLA- A等位基因与白寒病（BD）临床表现的相关性。方法：应用LABType^TN SSO技术（又称序列微珠综合分析实验系统）对42例BD患者及116人正常对照者的HLA- A等位基因进行检测。结果：与正常对照组相比，有毛睫炎样皮损的BD患者中HLA- A＊02等位基因频率明显降低（P〈0．05），有关节、神经系统受累的BD患者的HLA- A＊29等位基因频率均明显增高（均P〈0．01），有反复口腔溃疡家族史的BD患者中HLA- A＊23等位基因频率明显增高（P〈0．05）。结论：HLA-A等位基因频率与BD的临床表现有一定的相关性。     

山东汉族梅毒患者与HLA-A、B等位基因的相关性研究

目的 探讨山东汉族梅毒患者与HLA-A、B等位基因的相关性.方法 采用PCR-序列特异性寡核苷酸探针杂交(PCR-SSOP)方法对205例山东汉族梅毒患者与5844例山东汉族正常对照的HLA-A、B等位基因表现频率进行检测.结果 梅毒患者组HLA-A*02,B*15、40等位基因频率高于对照组(P值均＜0.01;Pc值均＜0.05),HLA-A*26等位基因频率低于对照组(P=0.003;Pc=0.039),HLA-B*15、40等位基因频率在显性梅毒组高于对照组(P值均＜0.01;Pc值均＜0.05),HLA-A*02、11、29,B*15、40等位基因频率在隐性梅毒组高于对照组(P值均＜0.01;Pc值均＜0.05),HLA-A*30、33等位基因频率在隐性梅毒组低于对照组(P值、Pc值分别为0.002、0.026;0.001、0.013),HLA-A*30等位基因频率在显性梅毒组高于隐性梅毒组(P=0.001;Pc=0.013).结论 HLA-A*02,B*15、40等位基因可能与山东汉族梅毒相关,HLA-A*30可能与山东汉族显性梅毒相关,HLA-A*02、11、29可能与山东汉族隐性梅毒相关.

Abstract：

Objective To investigate the association of HLA-A and -B alleles with syphilis in Shandong Han population. Methods The allele frequencies of HLA-A and -B were detected in 205 patients with syphilis and 5844 normal human controls by PCR-sequence specific oligonucleotide probe (PCR-SSOP)method. Results The patients with syphilis showed a higher frequency of HLA-A*02, B*15, B*40 alleles(all P＜0.01, Pc＜0.05) and a lower frequency of HLA-A*26 allele (P= 0.003, Pc = 0.039) than the normal human controls did. There was an increased frequency of HLA-B*15 and B*40 alleles in patients with symptomatic syphilis (both P＜0.01, Pc＜0.05), as well as an elevated frequency of HLA-A*02, 11, 29, B*15 and 40 alleles (all P＜0.01, Pc＜0.05) and a decreased frequency of HLA-A*30 and 33 in patients with asymptomatic syphilis(P=0.002, 0.026, Pc=0.001, 0.013 respectively), compared with the normal human controls. The frequency of HLA-A*30 allele was significantly higher in patients with symptomatic syphilis than in those with asymptomatic syphilis (P = 0.001, Pc = 0.013). Conclusions There seems to be an association between HLA-A*02, B* 15 and B*40 alleles and syphilis, between HLA-A*30 allele and symptomic syphilis, and between HLA-A*02, 11 and 29 alleles and asymptom1atic syphilis, in Shandong Han population.     

工型及Ⅱ型银屑病发病危险因素分析

目的研究Ⅰ、Ⅱ型银屑病发病危险因素。方法采用病例-对照研究方法,调查了Ⅰ、Ⅱ型银屑病患者分别为581例、117例及同一地区的年龄相匹配正常对照组分别为534例与112例,对Ⅰ、Ⅱ型银屑病的危险因素进行研究。结果①吸烟、嗜酒、食鱼虾、药物、受潮、感染、精神紧张、接种疫苗为Ⅰ型银屑病发病的危险因素。②嗜酒、食鱼虾、受潮、感染、精神紧张为Ⅱ型银屑病发病的危险因素。③吸烟为男性发生Ⅰ型银屑病的危险因素;嗜酒为男性发生Ⅰ型及Ⅱ型银屑病的危险因素;精神紧张在Ⅰ型及Ⅱ型银屑病男女患者中无显著性差异。结论环境因素在Ⅰ、Ⅱ型银屑病发病中起一定作用。     

Ⅰ型及Ⅱ型银屑病发病危险因素分析

目的研究Ⅰ、Ⅱ型银屑病发病危险因素。方法采用病例－对照研究方法,调查了Ⅰ、Ⅱ型银屑病患者分别为５８１例、１１７例及同一地区的年龄相匹配正常对照组分别为５３４例与１１２例,对Ⅰ、Ⅱ型银屑病的危险因素进行研究。结果①吸烟、嗜酒、食鱼虾、药物、受潮、感染、精神紧张、接种疫苗为Ⅰ型银屑病发病的危险因素。②嗜酒、食鱼虾、受潮、感染、精神紧张为Ⅱ型银屑病发病的危险因素。③吸烟为男性发生Ⅰ型银屑病的危险因素;嗜酒为男性发生Ⅰ型及Ⅱ型银屑病的危险因素;精神紧张在Ⅰ型及Ⅱ型银屑病男女患者中无显著性差异。结论环境因素在Ⅰ、Ⅱ型银屑病发病中起一定作用。     

国内银屑病发病危险因素的Meta分析

目的：综合评价国内银屑病患者发病的危险因素,为其防治提供参考依据。方法：通过Meta分析对国内9篇公开发表的有关银屑病发病危险因素的病例对照研究进行定量综合分析,共对16个因素进行评价,计算每个因素的合并OR值。结果：感染、外伤、日光暴晒、居住潮湿、饮酒、吸烟、新鲜蔬菜水果、饮茶、喜食辛辣、常食鱼虾、服药、精神紧张、伴发疾病、接触油漆、失眠、家族史等16个因素的合并OR值分别为：2．28（1．39～4．30）、2．07（1．53～4．08）、0．97（0．27～2．95）、4．94（2．84～7．81）、2．79（1．35～6．12）、3．11（1．40～7．91）、0．67（0．51～0．80）、0．93（0．47～3．15）、1．98（1．21～6．10）、2．92（1．39～5．65）、1．80（1．37～4．11）、2．58（1．60～6．83）、1．69（1．07～3．41）、1．77（1．03～2．95）、1．28（0．87～3．31）、7．21（3．94～12．07）。结论：家族史、居住潮湿、吸烟、常食鱼虾、饮酒、精神紧张、感染、外伤为银屑病发病的危险因素,喜食辛辣、服药、伴发疾病、接触油漆处于临界状态,日光暴晒、新鲜蔬菜水果、饮茶、失眠对银屑病发病的作用尚不能确定。     

寻常型银屑病诱因流行病学研究

目的：研究寻常型银屑病的诱因。方法：采用病例对照研究方法,调查了１８２例寻常型银屑病首发患者、６０９例复发患者及同一地区的健康对照６４７例,对建党型银病的诱发因素进行了研究。结果：（１）建党银屑病首发诱因为：服药、感染、精神紧张、受潮、嗜酒、吸烟、食鱼虾、接种疫苗及外伤（Ｐ〈０．０５）;（２）建党银屑病复发诱因为：精神紧张、受潮、嗜酒、吸烟、食鱼虾、服药、接种疫苗、感染（Ｐ〈０．０５）;（３）诱发     

Risk factors for psoriasis: A case–control study

A case–control study of 110 consecutive psoriatic outpatients and 200 unmatched controls was carried out in order to analyze the association of psoriasis with smoking habits, alcohol consumption, family history of psoriasis and stressful life events. Stressful life events were assessed with Paykel's Interview for Recent Life Events, a semi-structured interview covering 63 life events. According to our results, the risk of psoriasis is higher in urban dwellers (odds ratio [OR] = 3.61; 95% confidence interval [CI] = 0.99–13.18), patients who were divorced (OR = 5.69; 95% CI = 2.26–14.34) and those exposed to environmental tobacco smoke at home (OR = 2.29; 95% CI = 1.12–4.67). Alcohol consumption (OR = 2.55; 95% CI = 1.26–5.17), family history of psoriasis (OR = 33.96; 95% CI = 14.14–81.57) and change in work conditions (OR = 8.34; 95% CI = 1.86–37.43) are also risk factors for psoriasis. Separate analyses for men and women showed that the risk of developing psoriasis was stronger in men with a family history of psoriasis (OR = 30.39; 95% CI = 6.72–137.42) than in women (OR = 16.99; 95% CI = 7.21–40.07). The effect of environmental tobacco smoke at home was found only in women (OR = 2.44; 95% CI = 1.26–4.73). Future well-designed epidemiological studies need to be performed in order to determine whether lifestyle factors and stress could be risk factors triggering or aggravating psoriasis.     

Potentially modifiable risk factors for adverse pregnancy outcomes in women with psoriasis

Background Data on pregnancy outcomes among women with psoriasis are lacking. However, there are several known comorbidities of psoriasis, including obesity, smoking and depression, each of which increases the risk for negative birth outcomes. Objectives To determine if pregnant women with psoriasis have an excess of potentially modifiable risk factors for adverse pregnancy outcomes. Methods Prospectively collected data from the Organization of Teratology Information Specialists (OTIS) Autoimmune Diseases in Pregnancy Project were analysed to compare the prevalence of selected risk factors between 170 pregnant women with psoriasis and 158 nondiseased controls. Results Women with psoriasis were more likely to be overweight/obese prior to pregnancy (P < 0·0001), to smoke (P < 0·0001), or to have a diagnosis of depression (P = 0·03), and were less likely to have been taking preconceptional vitamin supplements (P = 0·004). After controlling for race/ethnicity and socioeconomic status, women with psoriasis were 2·37 (95% confidence interval 1·45–3·87) times more likely to be overweight/obese as women without psoriasis. Duration of disease, age at onset, measures of disease impact during pregnancy, or use of biologics in pregnancy were not significant predictors of overweight/obesity in the subset of psoriatic women. Conclusions Pregnant women with psoriasis may be at increased risk for adverse pregnancy outcomes due to comorbidities or other health behaviours associated with the disease. These should be taken into consideration during clinical treatment of women with psoriasis who are in their childbearing years.     

110例银屑病患者心理状态与个性特征的研究

目的探讨银屑病患者的心理状态与个性特征,为疾病的治疗提供新思路。方法采用症状自评量表(SCL-90)及艾森克个性问卷(EPQ),对110例银屑病患者进行心理状态及个性特征的分析。结果(1)银屑病组的SCL-90各因子分及总分均明显高于正常对照组(P<0.01)。(2)银屑病组的N分及P分明显高于正常对照组(P<0.01)。结论银屑病患者存在有心理问题及个性改变,应采取积极的社会心理干预措施。     

Incidence of risk factors for myocardial infarction and other vascular diseases in patients with psoriasis

Background Recent cross‐sectional studies reported a higher prevalence of diabetes and other risk factors for cardiovascular disease in patients with psoriasis than in the general population. Objectives To estimate the cumulative incidences of risk factors for myocardial infarction and other vascular diseases after a first recorded diagnosis of psoriasis and the hazard ratio (HR) for these conditions in patients with psoriasis compared with the general population. Methods We used the General Practice Research Database to conduct a cohort study of 44 164 patients with a first‐time diagnosis of psoriasis and 219 784 nonpsoriasis comparison subjects psoriasis‐matched on age, sex and index date. Results HRs were increased among patients with psoriasis vs. the comparison cohort for incident diabetes [HR 1·33; 95% confidence interval (CI) 1·25–1·42], hypertension (HR 1·09; 95% CI 1·05–1·14), obesity (HR 1·18; 95% CI 1·14–1·23) and hyperlipidaemia (HR 1·17; 95% CI 1·11–1·23). Patients with psoriasis also had higher risks of incident myocardial infarction (HR 1·21; 95% CI 1·10–1·32), angina (HR 1·20; 95% CI 1·12–1·29), atherosclerosis (HR 1·28; 95% CI 1·10–1·48), peripheral vascular disease (HR 1·29; 95% CI 1·13–1·47) and stroke (HR 1·12; 95% CI 1·00–1·25). Conclusions Risk factors for cardiovascular disease as well as myocardial infarction and other vascular diseases occur with higher incidence in patients with psoriasis than in the general population. Further work is needed to investigate whether these associations involve causal factors related to psoriasis or its treatment.     

嗜脂性马拉色菌与银屑病发病相关关系初探

目的：探讨嗜脂性马拉色菌与银屑病发病相关关系。方法：采用病例对照设计,以嗜脂性马拉色菌（原卵形糠秕孢子菌P.ovale)整菌（WPO）、胞外提取物（ECE）、胞壁提取物（CWE）、胞浆提取物（CPE）为抗原,用间接酶联免疫吸附试验（ELISA）方法检测67例点滴状、35例斑块状寻常型银屑病患者和等量正常人血清中的抗P.avale抗体。结果：点滴状寻常型银屑病患者血清中除抗WPO IgG、IgM、IgA抗体高于正常外（P＜0．01,P＜0．05）,其余与正常对照组均相同;与点滴状相比,斑块状寻常型银屑病患者血清中抗ECE IgM、IgA抗体显著高于正常对照组（P＜0．01）,其检测O.D．值是正常对照组的2倍以上。结论：寻常型银屑病患者对人体皮肤正常菌群的嗜脂性马拉色菌存在免疫应答异常,斑块状寻常型银屑病的发病和（或）病情加重可能与嗜脂性马拉色菌有关。     

特殊类型银屑病伴发高尿酸血症相关因素分析

目的:探讨特殊型银屑病伴发高尿酸血症的相关因素。方法:对117例红皮病型、泛发性脓疱型或/及关节病型银屑病患者的临床资料进行回顾性分析;根据尿酸代谢过程、影响因素、银屑病的临床表现等确定分析指标15项,对高尿酸血症组、正常组间各指标先后进行单因素分析及多因素Logistic回归分析;同时分析特殊用药、病情演变与患者血尿酸水平变化间的关系。结果:特殊类型银屑病伴高尿酸血症发生率为31.62%;高尿酸血症组与正常组比较,性别、红皮病型损害、泛发性脓疱型损害及血甘油三酯增高间的差异均有统计学意义(P<0.05);红皮病型损害、男性、甘油三酯增高、泛发性脓疱型损害是影响高尿酸血症发生的重要因素,其相对危险度(RR)依次为8.93、6.83、2.86、0.31。结论:特殊型银屑病伴发高尿酸血症可能与性别、红皮病型损害、泛发性脓疱型损害、甘油三酯增高及特殊用药有关。     

Predicting risk for early infantile atopic dermatitis by hereditary and environmental factors

Background Hereditary and environmental factors contribute to the occurrence of atopic dermatitis (AD). However, the interaction of these two factors is not totally understood. Objectives To evaluate the early risk factors for infantile AD at the age of 6 months and to develop a predictive model for the development of AD. Methods In 2005, a representative sample of mother and newborn pairs was obtained by multistage, stratified systematic sampling from the Taiwan national birth register. Information on hereditary and environmental risk factors was collected by home interview when babies were 6 months old. Multivariate regression analysis was applied to determine the risk factors for AD in the infants. Results A total of 20 687 pairs completed the study satisfactorily. AD was diagnosed in 7·0% of 6‐month‐old infants by physicians. Parental asthma, atopic dermatitis and allergic rhinitis, and maternal education levels were risk factors for AD in infants. Among environmental factors, fungus on walls at home and renovation/painting in the house during pregnancy were significantly associated with early infantile AD. Using these factors, the probability of having infantile AD was estimated and grouped into low, high and very high. With five runs of tests in mutually exclusive subsets of this population, the likelihood of AD for 6‐month‐old infants was consistent in all the groups with the predictive model. The highest predicted probability of AD was 70·1%, among boys with maternal education levels > 12 years, both parents with AD, renovation and painting of the house during pregnancy and fungus on walls at home. The lowest probability was 3·1%, among girls with none of the above factors. Conclusions This investigation provides a technique for predicting the risk of infantile AD based on hereditary and environmental factors, which could be used for developing a preventive strategy against AD, especially among those children with a family history of atopy.