INCREASED LEVELS OF HELICOBACTER PYLORI IGG ANTIBODIES IN THE AQUE- OUS AND SERUM OF PATIENTS WITH PRIMARY OPEN-ANGLE AND EXFOLIA-TION GLAUCOMA

Objective: We investigated the levels of anti-H. pylori specific IgG antibodies in the aqueous serum of patients with POAG and patients with exfoliation glaucoma (XFG) and compared these with age-matched patients with cataract Design: Prospective, nonrandomized, consecutive comparative study. Participants: 26 patients with POAG, 27 patients with XFG, and 31 age-matched     

Knowledge and awareness of glaucoma in Mexican patients with and without glaucoma diagnosis in an Ophthalmology Referral Center

AIM: To assess and compare knowledge and awareness of glaucoma in subjects with and without glaucoma diagnosis attending an Ophthalmology Referral Center. METHODS: This cross-sectional study was conducted at Asociación Para Evitar la Ceguera in Mexico City, using a questionnaire formulated by a group of experts following the Delphi panel rules, and pre-tested in a pilot study. The questionnaire was applied and compared between: glaucoma patients, relatives of glaucoma patients and patients without glaucoma. Socio-demographic data was collected to assess correlation with the level of knowledge using Logistic regression models, estimating the odds ratios (OR), 95% confidence intervals, and P<0.05. RESULTS: Three hundred and ninety-four subjects were enrolled; with a median age of 61y. One hundred and thirty-four (34%) were patients with glaucoma, 152 (38.6%) patients without glaucoma, and 108 (27.4%) relatives of patients with glaucoma. Two hundred and ninety-one (73.9%) participants were aware of the term “glaucoma”. Regarding knowledge 46.7% had moderate knowledge, 37.8% had poor knowledge, and 15.5% good knowledge. Overall, relatives of glaucoma patients had the highest scores, and patients without glaucoma got the lowest scores. A positive correlation was found between better knowledge and frequent ophthalmological examinations OR 2.24 (P=0.02), higher education level OR 4.17 (P=0.00) and having a family member with glaucoma OR 3.28 (P=0.00). CONCLUSION: Awareness and knowledge of glaucoma in subjects attending an Ophthalmology Referral Center is predominantly moderate or poor. This has important implications regarding attitudes that can result in lack of follow up in ophthalmological care.     

Should mitral valve prolapse be considered as one of the risk factors for open angle glaucoma? A preliminary observation

AIM:To assess the incidence of mitral valve prolapse in patients with newly diagnosed primary open angle glaucoma.METHODS:The study included 12 patients without any other comorbidities or taking any general or local medications.Each patient underwent a full ophthalmological examination with visual field assessment and optical computed tomography of the macula and optic nerve head.Carotid Doppler ultrasound was performed to exclude impaired blood flow in this region and transthoracic echocardiography with assessment of the function and morphology of the heart valves.RESULTS:In the study group,mitral valve prolapse was found in seven patients(58.3%),while mitral valve regurgitation in 11 patients(91.7%).One case of normal pressure glaucoma and four cases of juvenile glaucoma were diagnosed.There were also other risk factors for glaucoma:myopia(58.3%),migraine headaches(41.7%),a positive family history of glaucoma(16.7%).CONCLUSION:Mitral valve prolapse could be indicated as a new risk factor for glaucoma.It seems reasonable to conduct screening tests for glaucoma in patients with mitral valve prolapse in the course of echocardiography.     

INTRAOCULAR PRESSURE (IOP) VARIA-TIONS IN DIFFERENT POSITIONS IN PA-TIENTS WITH GLAUCOMA ASSOCIATED WITH EXFOLIATION SYNDROME (GXFS)

Purpose: To analyze the IOP in different positions in exfoliation syndrome glaucoma (GXFS) and to compare them with primary open-angle glaucoma (POAG) patients and normal subjects without glaucoma (normals). Methods: 3 groups of 10 patients each were evaluated. IOP was measured in a seating position,     

[In Press] Structure-function relationship comparison between retinal nerve fibre layer and Bruch's membrane opening-minimum rim width in glaucoma

AIM: To evaluate and compare structural OCT-based parameters, such as Bruch′s membrane opening-minimum rim width (BMO-MRW), and retinal nerve fiber layer (RNFL) thickness in glaucoma patients with visual field (VF) defects, and to correlate both to mean deviation (MD) values of obtained standard achromatic perimetry (SAP) examinations. METHODS: Patients with glaucoma and glaucomatous VF defects were enrolled in this prospective study and compared to age-matched healthy individuals. All study participants underwent a full ophthalmic examination and visual field (VF) testing with SAP. Peripapillary RNFL thickness and BMO-MRW were acquired with SD-OCT. Correlation analyses between obtained global functional and global as well as sectorial structural parameters were calculated. RESULTS: A consecutive series of 30 glaucomatous right eyes of 30 patients were included and compared to 36 healthy right eyes of 36 patients in the control group. Global MD of values correlated significantly with global RNFL (Pearson corr. coeff: 0.632, P=0.001) and global BMO-MRW (Pearson corr. coeff: 0.746, P<0.001) values in the glaucoma group. Global MD and sectorial RNFL or BMO-MRW values correlated less significantly. In the control group, MD values did not correlate with RNFL or BMO-MRW measurements. A subgroup analysis of myopic patients (>4dpt) within the glaucoma group (n=6) revealed a tendency for higher correlations between MD and BMO-MRW than MD and RNFL measurements. CONCLUSION: In a clinical setting, RNFL thickness and BMO-MRW correlate similarly with global VF sensitivity in glaucoma patients with BMO-MRW showing higher correlations in myopic glaucoma patients.     

Structure-function relationship comparison between retinal nerve fibre layer and Bruch’s membrane opening-minimum rim width in glaucoma

AIM: To evaluate and compare structural optical coherence tomography (OCT)-based parameters, such as Bruch’s membrane opening-minimum rim width (BMO-MRW), and retinal nerve fiber layer (RNFL) thickness in glaucoma patients with visual field (VF) defects, and to correlate both to mean deviation (MD) values of obtained standard achromatic perimetry (SAP) examinations. METHODS: Patients with glaucoma and glaucomatous VF defects were enrolled in this prospective study and compared to age-matched healthy individuals. All study participants underwent a full ophthalmic examination and VF testing with SAP. Peripapillary RNFL thickness and BMO-MRW were acquired with SD-OCT. Correlation analyses between obtained global functional and global as well as sectorial structural parameters were calculated. RESULTS: A consecutive series of 30 glaucomatous right eyes of 30 patients were included and compared to 36 healthy right eyes of 36 individuals in the control group. Global MD of values correlated significantly with global RNFL (Pearson corr. coeff: 0.632, P=0.001) and global BMO-MRW (Pearson corr. coeff: 0.746, P<0.001) values in the glaucoma group. Global MD and sectorial RNFL or BMO-MRW values correlated less significantly. In the control group, MD values did not correlate with RNFL or BMO-MRW measurements. A subgroup analysis of myopic patients (>4 diopters) within the glaucoma group (n=6) revealed a tendency for higher correlations between MD and BMO-MRW than MD and RNFL measurements. CONCLUSION: In a clinical setting, RNFL thickness and BMO-MRW correlate similarly with global VF sensitivity in glaucoma patients with BMO-MRW showing higher correlations in myopic glaucoma patients.     

RESULTS OF COMBINED TRABECULEC-TOMY AND PHACOEMULSIFICATION IN PSEUDOEXFOLIATION VERSUS NON -PSEUDOEXFOLIATION GLAUCOMA PA-TIENTS

Purpose: To evaluate the outcome of intraoperative and postoperative complications of combined phacoemulsification and tra-beculectomy in patients with pseudoexfoliation (PSX) versus non-pseudoexfoliation (non-PSX) glaucoma. Methods: The records of patients with coexisting glaucoma and cataract who underwent combined phacoemulsification, posterior chamber in-     

EFFECT OF LATANOPROST MONOTHER- APY ON PRIMARY OPEN ANGLE GLAU-COMA AND PSEUDOEXFOLIATION

Purpose: To evaluate the hypotensive effect of latanoprost when applied as monotherapy, on primary open angle glaucoma (POAG) and pseudoexfoliation glaucoma (PSXG). Methods: Twenty-six eyes of 14 patients with POAG and 14 eyes of 10 patients with PSXG were included in the study. Mean age was 62 /-10 years in POAG group and 67.7 years in PSXG group.     

Impact of binocular visual field loss on driving performance in glaucoma patients

AIM:To evaluate the driving performance in young and middle-aged Chinese glaucoma patients with mild to severe visual field loss compared to those without glaucoma by using a driving simulation test.METHODS:Twenty-nine participants were included in this study:nine patients with glaucoma but pass the binocular Esterman visual field test,ten patients with glaucoma and fail the binocular Esterman visual field test,and ten age-matched healthy controls.A driving simulation test was designed as a frequency-based analysis of a lanekeeping task.The total performance error,the controlresponse amplitude and delay were calculated.RESULTS:Esterman visual field test fail group showed the longest delay of control-response among three groups(P=0.02).And the delay in lane-keeping task was significantly associated with inferior field of better-eye(r=0.51,P=0.004)and integrated visual field(r=0.55,P=0.002).CONCLUSION:Young and middle-aged glaucoma patients with binocular visual field loss suffered from a longer delay of response in driving simulation test,while inferior visual field having more impact than superior visual field.     

Sturge-Weber综合征继发青光眼的手术治疗

Objective To evaluate the efficacy and complications of anti-glaucoma surgery in child-hood with Sturge Weber syndrome (SWS) and secondary glaucoma. Methods We have performed glaucoma filtering surgery in 6 patients (10 eyes) with SWS and secondary glaucoma. Results The mean intraocular pressure (IOP) was 34.3mmHg (25.81～50.62 mmHg) preoperatively. ARe, surgery, the mean lOP in all cases was 22.22mmHg ( 14.75～30.82 mmHg) and in the end of follow-up,IOP of 5 patients were controlled to nor-real. We have not observed any intraopemtive or postoperative complications. Conclusion The better safety and efficacy of glaucoma filtering surgery could be obtained in patients with SWS.     

Sturge-Weber综合征继发青光眼的手术治疗

Objective To evaluate the efficacy and complications of anti-glaucoma surgery in child-hood with Sturge Weber syndrome (SWS) and secondary glaucoma. Methods We have performed glaucoma filtering surgery in 6 patients (10 eyes) with SWS and secondary glaucoma. Results The mean intraocular pressure (IOP) was 34.3mmHg (25.81～50.62 mmHg) preoperatively. ARe, surgery, the mean lOP in all cases was 22.22mmHg ( 14.75～30.82 mmHg) and in the end of follow-up,IOP of 5 patients were controlled to nor-real. We have not observed any intraopemtive or postoperative complications. Conclusion The better safety and efficacy of glaucoma filtering surgery could be obtained in patients with SWS.     

Sturge-Weber综合征继发青光眼的手术治疗

Objective To evaluate the efficacy and complications of anti-glaucoma surgery in child-hood with Sturge Weber syndrome (SWS) and secondary glaucoma. Methods We have performed glaucoma filtering surgery in 6 patients (10 eyes) with SWS and secondary glaucoma. Results The mean intraocular pressure (IOP) was 34.3mmHg (25.81～50.62 mmHg) preoperatively. ARe, surgery, the mean lOP in all cases was 22.22mmHg ( 14.75～30.82 mmHg) and in the end of follow-up,IOP of 5 patients were controlled to nor-real. We have not observed any intraopemtive or postoperative complications. Conclusion The better safety and efficacy of glaucoma filtering surgery could be obtained in patients with SWS.     

LONG -TERM REDUCTION IN THE IN- TRAOCULAR PRESSURE BY LA- TANOPROST

We conducted a retrospective analysis of the intraocular pressure (IOP) in 331 patients treated with latanoprost We studied 299 eyes in 177 patients with primary open angle glaucoma (POAG), 185 eyes in 106 patients with normal tension glaucoma (NTG), 48 eyes in 32 patients with secondary glaucoma (SG), and 23 eyes in 16 patients with primary angle closure     

INFLUENCE OF MEDICAL THERAPY ON VISUAL FUNCTIONS HYDRODYNAMICS AND BLOOD-FLOW IN THE OPTIC NERVE IN PATIENTS WITH GLAUCOMA IN COMBINATION WITH MYOPIA

Purpose: to study influence of medical treatment on visual functions, hydrodynamics and a blood-flow in the optic nerve in patients with glaucoma in combination with myopia. Methods: Two groups of patients with glaucoma with the normalized intraocular pressure in combination with myopia were examined. The first group has consisted of 57 patients receiving rates of medical     

Sturge-Weber综合征继发青光眼的手术治疗

Objective To evaluate the efficacy and complications of anti-glaucoma surgery in child-hood with Sturge Weber syndrome (SWS) and secondary glaucoma. Methods We have performed glaucoma filtering surgery in 6 patients (10 eyes) with SWS and secondary glaucoma. Results The mean intraocular pressure (IOP) was 34.3mmHg (25.81～50.62 mmHg) preoperatively. ARe, surgery, the mean lOP in all cases was 22.22mmHg ( 14.75～30.82 mmHg) and in the end of follow-up,IOP of 5 patients were controlled to nor-real. We have not observed any intraopemtive or postoperative complications. Conclusion The better safety and efficacy of glaucoma filtering surgery could be obtained in patients with SWS.     

Sturge-Weber综合征继发青光眼的手术治疗

Objective To evaluate the efficacy and complications of anti-glaucoma surgery in child-hood with Sturge Weber syndrome (SWS) and secondary glaucoma. Methods We have performed glaucoma filtering surgery in 6 patients (10 eyes) with SWS and secondary glaucoma. Results The mean intraocular pressure (IOP) was 34.3mmHg (25.81～50.62 mmHg) preoperatively. ARe, surgery, the mean lOP in all cases was 22.22mmHg ( 14.75～30.82 mmHg) and in the end of follow-up,IOP of 5 patients were controlled to nor-real. We have not observed any intraopemtive or postoperative complications. Conclusion The better safety and efficacy of glaucoma filtering surgery could be obtained in patients with SWS.     

Sturge-Weber综合征继发青光眼的手术治疗

Objective To evaluate the efficacy and complications of anti-glaucoma surgery in child-hood with Sturge Weber syndrome (SWS) and secondary glaucoma. Methods We have performed glaucoma filtering surgery in 6 patients (10 eyes) with SWS and secondary glaucoma. Results The mean intraocular pressure (IOP) was 34.3mmHg (25.81～50.62 mmHg) preoperatively. ARe, surgery, the mean lOP in all cases was 22.22mmHg ( 14.75～30.82 mmHg) and in the end of follow-up,IOP of 5 patients were controlled to nor-real. We have not observed any intraopemtive or postoperative complications. Conclusion The better safety and efficacy of glaucoma filtering surgery could be obtained in patients with SWS.     

Sturge-Weber综合征继发青光眼的手术治疗

Objective To evaluate the efficacy and complications of anti-glaucoma surgery in child-hood with Sturge Weber syndrome (SWS) and secondary glaucoma. Methods We have performed glaucoma filtering surgery in 6 patients (10 eyes) with SWS and secondary glaucoma. Results The mean intraocular pressure (IOP) was 34.3mmHg (25.81～50.62 mmHg) preoperatively. ARe, surgery, the mean lOP in all cases was 22.22mmHg ( 14.75～30.82 mmHg) and in the end of follow-up,IOP of 5 patients were controlled to nor-real. We have not observed any intraopemtive or postoperative complications. Conclusion The better safety and efficacy of glaucoma filtering surgery could be obtained in patients with SWS.     

Sturge-Weber综合征继发青光眼的手术治疗

Objective To evaluate the efficacy and complications of anti-glaucoma surgery in child-hood with Sturge Weber syndrome (SWS) and secondary glaucoma. Methods We have performed glaucoma filtering surgery in 6 patients (10 eyes) with SWS and secondary glaucoma. Results The mean intraocular pressure (IOP) was 34.3mmHg (25.81～50.62 mmHg) preoperatively. ARe, surgery, the mean lOP in all cases was 22.22mmHg ( 14.75～30.82 mmHg) and in the end of follow-up,IOP of 5 patients were controlled to nor-real. We have not observed any intraopemtive or postoperative complications. Conclusion The better safety and efficacy of glaucoma filtering surgery could be obtained in patients with SWS.     

Sturge-Weber综合征继发青光眼的手术治疗

Objective To evaluate the efficacy and complications of anti-glaucoma surgery in child-hood with Sturge Weber syndrome (SWS) and secondary glaucoma. Methods We have performed glaucoma filtering surgery in 6 patients (10 eyes) with SWS and secondary glaucoma. Results The mean intraocular pressure (IOP) was 34.3mmHg (25.81～50.62 mmHg) preoperatively. ARe, surgery, the mean lOP in all cases was 22.22mmHg ( 14.75～30.82 mmHg) and in the end of follow-up,IOP of 5 patients were controlled to nor-real. We have not observed any intraopemtive or postoperative complications. Conclusion The better safety and efficacy of glaucoma filtering surgery could be obtained in patients with SWS.