共查询到19条相似文献,搜索用时 46 毫秒
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介绍了一种新型连续分离制备性色谱系统——螺旋管连续逆流萃取色谱,可实现分馏萃取、普通逆流萃取、色谱洗脱等分离过程,而且易实现工业化放大,适用于天然产物、蛋白质和多肽、抗生素、精细化工等附加值高且较难分离物质的连续制备性分离.该系统是在逆流色谱分离原理的基础上开发出来的,主要由萃取部分、进样控制部分和样品收集部分组成.本色谱系统采用特殊的双向流动方式使得各组分能够在长度有限的管程内实现分离,可降低生产成本,缩短操作周期.利用自动控制技术对进样和溶剂的流量进行程序控制,其动作程序可根据分离条件和要求进行设定. 相似文献
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以硅胶为基质,用自己研制的并装填的高效铜螯合物,采用醋酸盐缓冲液、磷酸盐缓冲液、硫酸盐、硝酸盐、氯化物等洗脱体系对基本工程α-D型干扰素和注射用人血白细胞干扰素进行了分离。实验表明:铜螯合柱的最佳分离pH为5.0-6.0,用NaCl/HAc、NH4Cl/HAc为洗脱剂时可获得满意的分离效果,收集相应的色谱峰的洗出液,用细胞病变抑制法测定其活性,确定了具有活性的干扰素的色谱峰位置。 相似文献
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开发采用逆流变温色谱分离柠檬酸的新工艺,提出以生产率和洗脱剂耗量作为柠檬酸工业色谱分离系统的性能指标函数。在保证柠檬酸产品纯度>99.5%,分离收率>99%的前提下,采用基于模型仿真的响应面分析法研究操作条件对系统分离效能的影响,以此指导工业分离系统操作条件的选择,实现柠檬酸优化生产。 相似文献
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在羟基磷灰石色谱上施加电场 ,发展了一种新的电色谱分离技术 .对蛋白质电泳和溶液电渗对分离特性的影响进行了实验研究 ,测量了羟基磷灰石电色谱装置中膜、膜与填充介质在不同浓度磷酸缓冲溶液和在不同电流下产生的电渗流 ,分别计算出由膜和羟基磷灰石电渗而产生的推动力 .实验结果表明电渗流量随缓冲溶液离子强度的降低和电流的增加而增加 .在施加电场的情况下 ,羟基磷灰石对牛血清白蛋白的吸附速度加快 ,动态吸附量增加 .分别考察了不同洗脱条件下电场对洗脱效果的影响 .在高浓度的洗脱溶液下 ,电渗的作用很小 ,电场的作用主要是电迁移的作用 ,可以通过选择适宜的电场方向来提高分离精度 ;在低浓度的洗脱溶液下 ,电渗的作用有效地促进了洗脱液与介质颗粒的传质 ,提高了洗脱效果 .在羟基磷灰石色谱上施加电场提高了该色谱分离过程的速率和效率 . 相似文献
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尤新 《精细与专用化学品》2002,10(6):20-21
柠檬酸是世界上生产量和消费量最大和最主要的食用有机酸,世界柠檬酸的总产量约为100万t/a。在传统的“钙盐法”生产工艺中,每生产1t柠檬酸要消耗1t硫酸和1t碳酸钙,同时排放2.5t湿硫酸钙,存在着严重的污染问题。热水洗脱柠檬酸色谱分离技术能割除“钙盐法”繁杂的中和过滤、酸解过滤等工序,不再添加新的化学剂,大量减少了化工材料的消耗,进一步提高了产品纯度和收率,降低了产品成本,同时消除了传统工艺产生的湿石膏排放,是一项具有重大意义的技术创新。如果这一成果在全国范围推广应用,将大大改变柠檬酸行业的生产面貌,产生十分巨大的经济、环境和社会效益。 相似文献
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给出SMB两组份色谱分离过程的一种优化方法。基于非线性等温线下的平衡速率模型 ,利用Matlab对算法进行了大量仿真研究 ;并通过与经典三角形理论方法的比较验证该方法的有效性 相似文献
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连续CACE过程借助流场和逆向电场的共同作用,使目标蛋白质在分离柱富集区内连续富集。本文提出了连续CACE分离柱内浓度分布微分方程和定解条件,并对方程进行了求解。解决了富集区内目标蛋白质浓度的在线检测,用牛血红蛋白和细胞色素C在两套连续CACE装置上进行实验研究,取得了预期效果。 相似文献
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一、概述微反—色谱联用装置是近代催化研究方法的一个重要发展。这种技术可用于研究催化剂的物化性质、催化剂的活性、选择性、催化反应动力学与机理,也可用于研究外加电场、磁场、各种辐射(如X—射线)对催化反应的影响。太原工业大学在过去有关COS的研究 相似文献
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Considering that the on-line measurement and automatic control of element component content (ECC) are dif-ficult to perform in rare earth cascade extraction process, the ECC distribution profile is dyn... 相似文献
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Considering that the on-line measurement and automatic control of element component content (ECC) are dif-ficult to perform in rare earth cascade extraction process, the ECC distribution profile is dynamical y regulated at al stages to assess the effect of product purity control. Focusing on the theory of countercurrent extraction, the technology parameters and pre-setting flow-rates during the extract process are designed. Under varying process parameters, a novel step by step model is also proposed for each stage to analyze the impact on the distribution profile change. Combining the mass balance model and ECC changing trend at the monitoring stage, the ECC dis-tribution profile can be automatical y regulated by dynamical y compensating the related extract or scrubbing liquid flow-rate. To this end, the required product purity at the two outlets is achieved. Based on Wincc and Matlab dynamic simulators, a specific Pr/Nd cascade extraction process is used to illustrate and demonstrate the application of the present approach. 相似文献
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Kostanyan A. E. Voshkin A. A. Kodin N. V. 《Theoretical Foundations of Chemical Engineering》2011,45(5):779-785
Theoretical Foundations of Chemical Engineering - A new apparatus for the chromatographic separation of liquid mixtures is investigated. The apparatus contains a number of vertical columns... 相似文献
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The kinetics of extraction processes with chemical reaction was studied experimentally on the system copper/Acorga PT 5050 and quantified according to meaningful kinetic models. These were coupled with other models describing the behaviour of dispersions in columns in order to permit a computer aided simultation of reactive extraction. Thus, a better prediction of column performance is achieved. 相似文献
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A. E. Kostanyan 《Theoretical Foundations of Chemical Engineering》2006,40(6):587-593
Some general regularities of liquid chromatography with a free stationary phase and countercurrent extraction are considered. An analytical solution to the linear model of nonequilibrium chromatography is presented. 相似文献
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H. K. Latourette H. M. Castrantas R. J. Gall L. H. Dierdorff 《Journal of the American Oil Chemists' Society》1960,37(11):559-563
Conclusion and Summary A laboratory process has been developed for the continuous countercurrent preparation of epoxidized oils. This consists of
introducing continuously, to a packed column, an unsaturated oil, hydrogen peroxide, and acetic acid, and withdrawing the
epoxidized product. Operating variables have been investigated and optimum conditions predicted. Obtainment of maximum yields
must await construction of a longer column.
Presented at the fall meeting, American Oil Chemists' Society, September 28–30, 1959, Los Angeles, Calif.
Research performed for and under the direction of the Becco Chemical Division. 相似文献
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Experimental data obtained in a pilot plant rotating disc contactor were used to obtain values of parameters for the hydrodynamic and mass transfer models representing column operation. The unique feature of the data was that drop size within the column did not vary appreciably with vertical position. Column performance measurements were therefore truly representative of the particular drop size generated. The models, with the resulting parameter values, were then used in design mode to determine column dimensions as a function of drop size. An optimum drop diameter of 0.20–0.25 cm is indicated for the toluene-acetone-water system. 相似文献