螺旋管连续逆流萃取色谱系统

介绍了一种新型连续分离制备性色谱系统——螺旋管连续逆流萃取色谱,可实现分馏萃取、普通逆流萃取、色谱洗脱等分离过程,而且易实现工业化放大,适用于天然产物、蛋白质和多肽、抗生素、精细化工等附加值高且较难分离物质的连续制备性分离.该系统是在逆流色谱分离原理的基础上开发出来的,主要由萃取部分、进样控制部分和样品收集部分组成.本色谱系统采用特殊的双向流动方式使得各组分能够在长度有限的管程内实现分离,可降低生产成本,缩短操作周期.利用自动控制技术对进样和溶剂的流量进行程序控制,其动作程序可根据分离条件和要求进行设定.     

凝胶色谱电泳分离装置及过程理论的研究

研制成功凝胶色谱电泳(CACE)分离装置,采用标准蛋白质模式混合物进行实验研究。通过理论分析,用体积平均方法建立了过程数学模型,计算并比较了不同条件下目标蛋白质的聚焦过程及分离操作的动态特性,说明了流场与电场强度对分离过程的重要影响。模拟结果与实验数据充分吻合。该模型对CACE分离过程及装置的设计和优化提供了理论依据。     

在高效液相（铜）螯合色谱中数种洗脱体系对分离干扰素的研究

以硅胶为基质，用自己研制的并装填的高效铜螯合物，采用醋酸盐缓冲液、磷酸盐缓冲液、硫酸盐、硝酸盐、氯化物等洗脱体系对基本工程α－Ｄ型干扰素和注射用人血白细胞干扰素进行了分离。实验表明：铜螯合柱的最佳分离ｐＨ为５．０－６．０，用ＮａＣｌ／ＨＡｃ、ＮＨ４Ｃｌ／ＨＡｃ为洗脱剂时可获得满意的分离效果，收集相应的色谱峰的洗出液，用细胞病变抑制法测定其活性，确定了具有活性的干扰素的色谱峰位置。     

柠檬酸色谱分离过程分离效能优化研究

开发采用逆流变温色谱分离柠檬酸的新工艺,提出以生产率和洗脱剂耗量作为柠檬酸工业色谱分离系统的性能指标函数。在保证柠檬酸产品纯度＞99．5％,分离收率＞99％的前提下,采用基于模型仿真的响应面分析法研究操作条件对系统分离效能的影响,以此指导工业分离系统操作条件的选择,实现柠檬酸优化生产。     

柠檬酸色谱分离技术的新突破

柠檬酸是世界上生产量和消费量最大和最主要的食用有机酸,世界柠檬酸的总产量约为100万t/a。在传统的“钙盐法”生产工艺中,每生产1t柠檬酸要消耗1t硫酸和1t碳酸钙,同时排放2.5t湿硫酸钙,存在着严重的污染问题。热水洗脱柠檬酸色谱分离技术能割除“钙盐法”繁杂的中和过滤、酸解过滤等工序,不再添加新的化学剂,大量减少了化工材料的消耗,进一步提高了产品纯度和收率,降低了产品成本,同时消除了传统工艺产生的湿石膏排放,是一项具有重大意义的技术创新。如果这一成果在全国范围推广应用,将大大改变柠檬酸行业的生产面貌,产生十分巨大的经济、环境和社会效益。     

生化反应──色谱分离耦合过程模型研究

建立了描述生化反应─色谱分离耦合过程的一般数学模型,以蔗糖酶促水解制果糖、葡萄糖为模型反应,研究了底物转化率和产物分离度与操作条件的关系.理论计算值与实验结果在低浓度下符合较好．     

COS水解反应研究中微反—色谱联用装置的改进

一、概述微反—色谱联用装置是近代催化研究方法的一个重要发展。这种技术可用于研究催化剂的物化性质、催化剂的活性、选择性、催化反应动力学与机理,也可用于研究外加电场、磁场、各种辐射(如X—射线)对催化反应的影响。太原工业大学在过去有关COS的研究     

SMB色谱分离过程优化设计研究

给出SMB两组份色谱分离过程的一种优化方法。基于非线性等温线下的平衡速率模型 ,利用Matlab对算法进行了大量仿真研究 ;并通过与经典三角形理论方法的比较验证该方法的有效性     

工业色谱分析仪在大型乙烯装置生产中的应用研究

随着我国乙烯工业的快速发展,色谱技术作为一种先进的分析技术,目前被广泛地应用于乙烯装置的生产中。由于工业色谱分析仪具有稳定性高、分析数据准确等优点,因此,在一些大型乙烯装置的生产中得到了广泛地应用。但是工业色谱分析仪的系统相比普通仪表要复杂的多,其运行情况直接影响着乙烯装置生产稳定运行,因此,我们必须正确的设计、使用和维护工业色谱分析仪,从而确保乙烯装置的正常生产。本文分析了工业色谱分析仪的构成及其在乙烯装置生产中的作用,并重点叙述了工业色谱分析仪在乙烯装置生产中的应用,旨在为乙烯工业的发展提供一些借鉴。     

连续逆向色谱电泳过程

连续CACE过程借助流场和逆向电场的共同作用,使目标蛋白质在分离柱富集区内连续富集。本文提出了连续CACE分离柱内浓度分布微分方程和定解条件,并对方程进行了求解。解决了富集区内目标蛋白质浓度的在线检测,用牛血红蛋白和细胞色素C在两套连续CACE装置上进行实验研究,取得了预期效果。     

多级逆流萃取的数学模型

从物料衡算、热量衡算和相平衡出发，提出了适合溶剂部分互溶体系的多级逆流萃取模型。     

Calculation of reactive extraction in countercurrent columns

The kinetics of extraction processes with chemical reaction was studied experimentally on the system copper/Acorga PT 5050 and quantified according to meaningful kinetic models. These were coupled with other models describing the behaviour of dispersions in columns in order to permit a computer aided simultation of reactive extraction. Thus, a better prediction of column performance is achieved.     

Pulsed cyclic device for liquid countercurrent chromatography

Theoretical Foundations of Chemical Engineering - A new apparatus for the chromatographic separation of liquid mixtures is investigated. The apparatus contains a number of vertical columns...     

A novel continuous countercurrent epoxidation process

Conclusion and Summary A laboratory process has been developed for the continuous countercurrent preparation of epoxidized oils. This consists of introducing continuously, to a packed column, an unsaturated oil, hydrogen peroxide, and acetic acid, and withdrawing the epoxidized product. Operating variables have been investigated and optimum conditions predicted. Obtainment of maximum yields must await construction of a longer column. Presented at the fall meeting, American Oil Chemists' Society, September 28–30, 1959, Los Angeles, Calif. Research performed for and under the direction of the Becco Chemical Division.     

General regularities of liquid chromatography and countercurrent extraction

Some general regularities of liquid chromatography with a free stationary phase and countercurrent extraction are considered. An analytical solution to the linear model of nonequilibrium chromatography is presented.     

多级逆流液液萃取法浓缩糠醛的研究

分别选择1,1,1-三氯乙烷和四氯化碳为萃取溶剂,研究液液萃取法浓缩糠醛过程,以UNIQUAC方程为平衡模型,建立逆流模拟计算框图,计算结果表明1,1,1-三氯乙烷和四氯化碳是糠醛浓缩的有效溶剂,在N=4时,分离后糠醛质量分数达99.3%以上,萃余液中糠醛质量分数可降至0.07%以下,以1,1,1-三氯乙烷为萃取剂,分离后糠醛质量分数达99.9%以上,收率达到98.5%以上;在模拟计算的基础上,建立液液萃取装置并进行试验,试验和模拟结果基本一致,研究结果为进一步放大试验研究提供了有效的依据。     

Optimisation of drop size in countercurrent flow liquid-liquid extraction columns

Experimental data obtained in a pilot plant rotating disc contactor were used to obtain values of parameters for the hydrodynamic and mass transfer models representing column operation. The unique feature of the data was that drop size within the column did not vary appreciably with vertical position. Column performance measurements were therefore truly representative of the particular drop size generated. The models, with the resulting parameter values, were then used in design mode to determine column dimensions as a function of drop size. An optimum drop diameter of 0.20–0.25 cm is indicated for the toluene-acetone-water system.     

Analysis of the process of the countercurrent cyclic chromatography

Cyclic countercurrent chromatography, a new method of liquid chromatography, has been considered. A mathematical model of a cyclic process has been developed. Each cycle consists of two half-periods, i.e., a half-period of the motion of a light phase (a heavy phase plays a role of an immobile phase) and a half-period of the motion of a heavy phase (a light phase plays a role of an immobile phase). Sampling is introduced in the form of a pulse into the average zone of a system of sequentially connected equilibrium steps into the half-period of the motion of the light phase of the initial process cycle. Analytical dependences for calculating the cyclic processes of the countercurrent chromatography have been derived. The experiment and the theory are correlated, and satisfactory agreement between the experimental results and computational investigations has been established.     

Analysis of countercurrent membrane vapor extraction of a dilute aqueous biosolute

Removal of dilute bioproducts from fermenter broths is a major challenge both to avoid microbe inhibition and to recover solutes economically without water loss. We analyze a proposed new process, membrane vapor extraction (MVE), where semi‐volatile dilute aqueous solutes vaporize at the upstream side of an omniphobic, microporous membrane and dissolve into a nonpolar solvent highly favorable to the solutes but not to water. A new membrane‐process analysis is outlined and applied to the countercurrent recovery of 2 wt % aqueous butanol by a prototype solvent (dodecane) at 40°C. Thermodynamic phase equilibria, pioneered by the Prausnitz school, are crucial to MVE process design. Over 90% of the feed butanol is recovered with essentially no water loss giving a separation factor of over 1000. Energy requirements in MVE are low. Our design calculations demonstrate that MVE is a viable separation process to remove and recover dilute aqueous biosolutes. © 2015 American Institute of Chemical Engineers AIChE J, 61: 2795–2809, 2015