五灵脂对小鼠血液中SOD活性的影响

中药五灵脂具有散瘀、止痛、调经、缓解平滑肌痉挛等功效.本实验证明五灵脂对小鼠体内超氧化物歧化酶(Superoxide Dismutase简称SOD)活力有激活作用.     

Studies on the SOD-like Activity in the Stool of Trogopterus Xanthipes Milne-Edwards

实验表明给小鼠五灵脂提取液，小鼠血液ＳＯＤ活性增强。测定五灵脂有类ＳＯＤ活性，在ｐＨ４５～８５，温度２５～１００℃条件下活性稳定     

防风成分的药理活性研究概况

中药防风为伞形科植物防风[saposhnikovia divaricata (Turca．)schischk)未抽花茎植株的干燥根。防风始载于《神农本草经》,其味辛、甘。性温,归脾、膀胱经,有发汗解表、祛风除湿止痛等功效。     

修饰SOD活性测定方法的改进

修饰SOD已广泛用于化妆品和食品,但其活性测定方法目前国内尚无统一标准。由于酶表面修饰对酶活性测定有影响,本文报道了一种简便、快速的修饰SOD的测定方法。该法不仅准确而且实用。     

大黄十五种化合物的SOD样活性研究

研究中草药中具有SOD样活性的有效成分，可以为进一步开发利用中草药提供科学依据，从我国药材大黄中分离出四类化合物，作者分别测定其中十五种化合物的SOD样活性，用其对超氧负离子自由基的清除率表示，实验结果表明，四类化合物的SOD样活性不同：大黄鞣质的儿茶精类化合物的SOD样活性较强，其中以（－）－表儿茶精的活性最强；芪甙类化合物的活性相对较弱；而大黄酚－8－葡萄糖甙和去氧土大黄甙不但无SOD样活性，还有促进超氧负离子自由基生成的作用。     

SOD—like Activity of Some Cu（Ⅱ）Complexes in Micelles

The SOD-like activity of five Cu(Ⅱ)complexes[Cu(HSal)_2·EtOH,Cu(Gly)_2,Cu(Lys)_2,Cu(His)_2,Cu(Try)_2]have been studied by using cytochrome C method,as well as chemilumine-scence and ESR technique.The four surfactants(CTAB,SDS,Triton X-100 and Tween 20)werepurified and their critical miceile concentration(CMC)in phosphate buffer(pH=7.4)was mea-sured.The effects of four surfactants on O_2~- have been investigated.The co-operative effects of     

中药牛膝化学成分和药理活性的研究进展

本文综述了近年来对传统中药牛膝的研究情况,就其化学成分,药理作用,两者之间的联系及临床应用作以概述.     

商陆属植物皂苷类成分及其药理活性

概述了商陆属植物中皂苷类成分及其药理活性和开发前景。     

蟾蜍灵的药理活性研究进展

蟾蜍灵(bufalin)属强心甙类物质,来源于中华大蟾蜍(Bufo bufo gargarizans Cantor)和黑眶蟾蜍(Bufo melanostictus Schneider)耳后腺及皮肤腺分泌之浆液[1],是中药蟾酥中提取的一种毒性配基,分子式为C24H34O4,相对分子质量为386.5.研究表明,这种成分具有抗癌、强心、毒性、麻醉等作用,它对下丘脑-垂体-睾丸及中枢神经系统功能也有一定影响.现分别综述如下.     

脂质体的电性对水杨酸铜SOD样活性的影响(英文)

采用细胞色素c法研究了水杨酸铜分别在中性、正负电性脂质体中SOD样活性的变化情况。证明中性脂质体包裹的水杨酸铜的SOD样活性比水杨酸铜在水溶液中提高了3倍多。但正负电性脂质体包裹的水杨酸铜的SOD样活性降低。并发现在实验浓度范围内,负电性脂质体包裹的水杨酸铜,活性变化无规则,且荷负电量多的脂质体包裹的水杨酸铜促进超氧自由基的歧化,而荷负电量少的脂质体仅在低浓度区对超氧的歧化表现为促进作用。     

The Effect of Electric Properties of Liposomes on SOD-like Activity ofCopper Salicylate

The SOD-like activities of copper salicylate encapsulated in neutral positively and negativelycharged liposomes were studied with cytochrome c method. The results showed that the SOD-like activity of coppersalicylate encapsulated in neutral liposomes was enhanced over 3 times more than that of copper salicylate in aqueoussolution. However, the activity decreased for copper salicylate encapsulated in positively and negatively chargedliposomes. It was also found that at experimental concentrations there was no regularity for the change of activity ofcopper salicylate encapsulated in negatively charged liposomes, and copper salicylate encapsulated in liposomes withmore negative charges could promote the dismutation of superoxide anion free radicals, however, so could coppersalicylate encapsulated in liposomes with fewer negative charges only in lower concentrations.     

五灵脂无机成分的分析研究

15g五灵脂内含人体必需微量元素和常量元素比其它中草药更接近人体日需要量。服用少量五灵脂可使体内某些微量元素达到平衡,从而调节新陈代谢达到治病目的。尤其含钼、镁等防癌元素,含锶、锰、锌、铁等人体必需微量元素及适量钙等,可作为人体防癌保健食品添加剂开发利用。     

Comparing the functional components,SOD-like activities,antimutagenicity, and nutrient compositions of Phellinus igniarius and Phellinus linteus mushrooms

Many species of the genus Phellinus possess beneficial properties, including antioxidant, immune-enhancing, and antimutagenic effects. Phenolic compounds and polysaccharides are two kinds of bioactive compounds; however, few studies have compared the differences between Phellinus igniarius and Phellinus linteus in their functional components, functional activities, and nutrient compositions. Herein, the proximate compositions and microelements of the fruiting body of P. igniarius and P. linteus were determined. The fruiting body of P. igniarius and P. linteus were extracted by boiling water [water extract of P. igniarius (WEPI) and P. linteus (WEPL)]. The contents of total phenolics and polysaccharides, as well as superoxide dismutase (SOD)-like and antimutagenic activities of WEPI and WEPL, were compared. We found that WEPI was rich in phenolics and polysaccharides and had higher SOD-like activity than WEPL. Nutrient compositions were mainly different in minerals, whereas anitmutagenicity was similar. All of these results suggested that P. igniarius has greater potential for the development of antioxidant and immunomodulating food products than P. linteus.     

玉米功能短肽的制备及其类超氧化物歧化酶活性研究

目的制备具有类超氧化物歧化酶 (SOD)活性的玉米功能短肽 ,并与SOD进行活性比较。方法以玉米蛋白粉为原料 ,采用酶水解的方法 ,经SephadexG 2 5分离 ,以TNBS法测定各组分的平均链长 ,用邻苯三酚自氧化法测定各组分的抗氧化活性 ,同时与SOD进行活性比较。结果含有 2～ 6个氨基酸残基的玉米功能短肽 ,对邻苯三酚自氧化具有较好的抑制作用 ,玉米功能短肽 (浓度 10mg ml)的抑制率为 2 1.78%。结论玉米功能短肽具有较好的类超氧化物歧化酶活性     

蜂胶的药理活性

近年来对蜂胶的药理活性研究较为广泛，主要以直接或处理后的单味蜂胶和复方蜂胶制剂为对象进行研究。这两种研究方式都很好地证明了蜂胶具有广泛的药理活性，如抗菌、抗氧化、抗肿瘤、抗辐射、抗炎等作用，且毒性很小，为今后蜂胶的临床应用提供了参考依据。     

扇贝裙边糖胺聚糖的体外抗肿瘤活性及对荷瘤小鼠抗氧化作用的研究

目的:研究扇贝裙边糖胺聚糖(SS-GAG)的体外抗肿瘤活性及对荷瘤小鼠的抗氧化功能的影响。方法:用MTT法观察不同浓度的SS-GAG对体外培养的宫颈癌HeLa、人大肠癌LOVO、肺癌A549、神经胶质瘤U251等肿瘤细胞株增殖活性的影响;观察SS-GAG对小鼠接种S180后30d内的存活时间;通过黄嘌呤氧化酶法、硫代巴比妥酸显色法等多种生化方法观察SS-GAG对荷瘤小鼠血清总抗氧化能力(T-AOC)、超氧化物岐化酶(SOD)活性和丙二醛(MDA)含量的影响,并与对照比较。结果:与对照比较,SS-GAG可明显抑制HeLa、U251细胞生长,对LOVO、A549细胞生长也有一定的抑制作用;SS-GAG能显著延长S180腹水瘤小鼠的生存时间,提高荷瘤小鼠的T-AOC、SOD水平,降低MDA含量(P<0.01或P<0.05)。结论:SS-GAG可抑制肿瘤生长,并有一定的抗氧化作用。     

云南茶叶和甜茶的抗过敏活性

采用透明质酸酶体外抑制试验 ,测定了 1 1种云南大叶茶种市售茶叶的抽提物 ,结果表明 ,1 1种茶叶均具有强抗过敏活性 ,其抗过敏活性高于福建乌龙茶和广西甜茶。云南甜茶成分预试验和溶剂系统提取结果表明 ,抗过敏成分为酚类物质 ,乙酸乙酯组分具有强抗过敏作用。云南大叶茶和甜茶具有极大的开发价值。