癌痛及其对癌症患者生活质量影响的调查

目的　探讨癌痛及其对癌症患者生活质量的影响。方法　应用简明健康状况调查表(SF 36简表 )及简明疼痛调查表 (briefpaininventoryBPI)对 2 0 0例住院患者的癌痛情况、癌痛对其生活质量的影响及癌痛的处理进行系统的调查。结果　 (1)疼痛的发生率为 6 9 0 % ,其中轻度疼痛占2 1.5 % ,中度疼痛占 19.0 % ,重度疼痛占 2 8.5 %。 (2 )中、重度疼痛患者中消化道肿瘤比例较高。 (3)疼痛与疾病分期无关 (P >0 .0 5 )。 (4)疼痛的发生与骨转移的存在密切相关 (P <0 .0 1)。 (5 )无论是轻度、中度还是重度疼痛 ,均严重影响患者的日常生活、情绪、行走能力、工作、睡眠 ,且随着疼痛程度的加重 ,影响也逐渐加深。但在对生活乐趣和社交两方面的影响上 ,中度疼痛和重度疼痛差异无显著性 (P >0 .0 5 )。 (6 )中度疼痛对患者精神状态的影响要早于重度疼痛 ,因此在癌症患者的疼痛达到中度时 ,就应在止痛治疗的同时密切配合对其心理上的治疗 ,以期达到更好的疼痛缓解。 (7)在疼痛处理上 ,未经适当处理的占 41.3% ;在重度疼痛中 ,强阿片类药物应用仅达 5 2 .1% ,与WHO要求的阶梯止痛治疗原则差距较大。结论　疼痛是影响生活质量的一个重要因素 ,而癌痛的治疗尚存在较大差距。要达到WHO提出的到 2 0 0 0年使全世界癌症患者     

心理健康教育对癌症患者生活质量的影响

癌症是一种严重威胁人类生命健康的难治性疾病,尤其中晚期癌症病人还不能得到彻底治愈。因此,提高癌症患者的生活质量已成为治疗癌症的主要目的之一。生活质量是由病人的精神、社会和身体方面的健康状况决定的。其中精神因素在癌症病人的生活质量中起着非常活跃的作用。本文以癌症病人常出现的抑郁情绪为指标,探讨心理健康教育对病人生活质量的影响。l对象和方法对象接受心理健康教育的癌症病人（每次参加约40多人）均处在临床治疗后的恢复期。在接受健康教育前,按照标准指导语,在一名专业人员指导下,每人完成自评抑郁量表一份,连续…     

疼痛对社区恶性肿瘤患者抑郁情绪及生活质量的影响

[目的]探讨疼痛对社区恶性肿瘤患者抑郁情绪及生活质量的影响。[方法]瑞安市社区1283例恶性肿瘤,采用Zung氏抑郁自评量表评价患者的抑郁情况,采用疼痛程度分级法（NRS）评估患者的疼痛程度。[结果]1283例肿瘤患者抑郁发生率为33.2%,中、重度癌痛发生率为43.6%。疼痛与患者的抑郁发生及生活质量有显著相关性。[结论]癌痛明显影响患者的生活质量和情绪,应积极实施三阶梯止痛原则,降低癌症患者抑郁的发生,提高患者的生活质量。     

我国癌症病情告知对癌症患者及家属焦虑抑郁和生活质量影响Meta分析

目的 采用Meta分析方法探讨癌症病情告知对患者及家属焦虑、抑郁和生活质量的影响.方法 检索PubMed、Cochrane Library、中国知识基础设施工程(CNKI)、万方和维普电子数据库,查找自建库至2020-08-31公开发表的关于我国癌症病情告知对癌症患者及家属焦虑抑郁和生活质量影响的相关文献.中文检索式:...     

癌症患者抑郁治疗的临床研究

目的通过抗抑郁治疗提高癌症患者的生活质量。方法50例抑郁患者中轻度抑郁占52%,中度抑郁占36%,重度抑郁占12%。轻度抑郁患者采取心理治疗和康复指导,中度抑郁患者采用抗抑郁药物和中药治疗。结果治疗后SDS评分下降10分占56%,下降20分占18%,有效率74%。结论通过抗抑郁治疗可缓解癌症患者抑郁和焦虑等情感障碍,促进康复,提高生活质量。     

癌症患者的生活质量研究

本文综述了生活质量概念的提出、研究历史及其定义，阐述了ＱＯＬ研究的必要性、重要性及其在癌症临床研究中的作用及地位，提出了ＱＯＬ研究目前所存在的一些问题并预测其发展趋势。     

自我效能干预对门诊癌痛患者疼痛程度及生活质量的影响

目的：探讨自我效能干预对门诊癌痛患者疼痛程度及生活质量的影响。方法以门诊收治的118例中重度癌痛患者作为研究对象,采用随机数字表法分为观察组和对照组,每组各59例。两组患者均给予规范的癌痛治疗与常规护理,观察组患者在此基础上实施自我效能干预。两组患者均于干预前后分别采用数字评定量表及生活质量评价量表对患者的自我疼痛强度及生活质量进行评估和比较分析。结果干预后观察组NRS评分为（3.54±1.02）分,对照组NRS评分为（5.11±1.31）分,组间比较,观察组明显低于对照组,差异有统计学意义（P＜0.05）,其中观察组轻度疼痛患者明显增加,而重度疼痛患者明显减少,差异有统计学意义（P＜0.05）;干预后观察组疼痛缓解达CR的多于对照组患者,而NR人数则少于对照组,差异有统计学意义（P＜0.05）;干预后观察组和对照组患者的生活质量评分分别为（38.22±1.34）分和（36.88±1.07）分,相比干预前均有明显增长,且组间比较观察组生活质量评分高于对照组,差异均有统计学意义（P＜0.05）。结论采用自我效能干预能有效缓解癌痛患者的疼痛程度,提高患者的生活质量。     

晚期恶性肿瘤患者抑郁状态对生活质量的影响

 目的　调查恶性肿瘤患者抑郁的发生情况及其生活质量状况。方法　选用Beck抑郁问卷、生活质量问卷对住院的晚期恶性肿瘤患者进行调查,分析Beck抑郁得分与生活质量各因子之间的相关性。结果　共调查230例患者,回收有效问卷213份,95.3 %（203／213）患者存在明显的抑郁症状。Beck抑郁状态评估得分与生活质量问卷的躯体、角色、情绪、认知、社会、恶心呕吐、疼痛、呼吸困难、失眠和厌食因子呈正相关（均P＜0.05）,与总健康因子呈负相关（r＝-0.296,P＜0.01）。结论　晚期恶性肿瘤患者存在普遍的抑郁状态,且与生活质量间存在相关性。因此有针对性的给予心理干预,利于减轻患者的抑郁,提高生活质量。     

上海市社区癌症患者抑郁状况初步研究

目的探讨社区癌症患者发生抑郁的相关因素,以提高临床工作者对癌症患者抑郁的认识,为在社区中开展癌症患者抑郁的防治提供理论依据.方法选择上海市社区癌症患者共计2525例,调查方法包括自评和访谈,采用国内外通用的癌症患者生活质量自评量表FACT-G,抑郁自评量表Zung以及有关癌症患者疾病和社会信息的一般状况登记表.采用多元Logistic回归分析方法处理数据.结果本组患者抑郁发生率为23.3%,有5种因素与社区中的癌症患者抑郁发生密切相关,依次为:KPS评分、受教育程度、疼痛状况、收入和年龄,其相关系数和显著性检验分别为-0.044、0.000;0.189、0.000;0.720、0.000;0.217、0.000;0.012、0.003.结论KPS评分下降、受教育程度低、出现癌痛症状、收入状况差和年龄大的患者,其抑郁的发生率也相应高.     

The impact of optimism on anxiety,depression and quality of life in urogenital cancer patients

Objective: The purpose of the present study was to examine the relationship between optimism and anxiety, depression and health‐related quality of life (HRQOL). A further aim was to investigate the predictive value of optimism for anxiety, depression and HRQOL, quantified with and without controlling the corresponding base level. Methods: A total of 427 urogenital cancer patients were asked to complete the Life Orientation Test (LOT), the Hospital Anxiety and Depression Scale (HADS) and the health survey SF‐8 during their stay in the hospital (T1), two weeks later (T2) and three months later. Results: Finally, 275 patients (64.4%) completed all questionnaires. Optimism at T1 was significantly associated with anxiety (r=?0.35), depression (r=?0.41) and HRQOL (physical: r=0.29; mental: r=0.27) and can predict outcome variables three months later. After controlling for the base levels of anxiety, depression and HRQOL, the predictive value of optimism remained significant but small. The incrementally variance explained by the LOT varied between 2.1% in anxiety and 8.2% in physical HRQOL. Conclusion: Especially patients with a low level of optimism and a high level of pessimism are at risk for higher levels of anxiety and depression in addition to lowered HRQOL. Copyright © 2009 John Wiley & Sons, Ltd.     

The association of depression and anxiety with health‐related quality of life in cancer patients with depression and/or pain

Objectives: Depression is known to be a major problem in cancer patients, and evidence is emerging about the importance of anxiety. Because the disorders are highly comorbid, we examined the relationship of anxiety and depression with health‐related quality of life (HRQL) in cancer patients. Methods: Sample included 405 adult oncology patients participating in a randomized controlled trial of telecare management for pain and depression. This secondary cross‐sectional analysis of baseline data examined independent and additive effects of anxiety and depression on HRQL, disability, and somatic symptom severity. Results: In 397 patients who screened positive for either pain or depression or both, 135 had comorbid anxiety and depression, 174 had depression but not anxiety, and 88 had neither. Differences existed across all nonphysical HRQL domains and were more pronounced incrementally across the three groups in the expected direction. In GLM modeling, anxiety and depression were each associated with all the domains when modeled separately (p<0.0001). When modeled together, anxiety and depression had independent and additive effects on the mental health domains of HRQL and on somatic symptom burden. In other domains (vitality, perceived disability, overall quality of life, and general health perceptions), only depression had an effect. Conclusion: Anxiety and depression have strong and independent associations with mental health domains and somatic symptom burden in cancer patients. However, depression has a more pervasive association with multiple other domains of HRQL. Paying attention to both anxiety and depression may be particularly important when addressing mental health needs and somatic symptom distress. Copyright © 2009 John Wiley & Sons, Ltd.     

癌痛治疗与癌痛患者生活质量的关系研究

目的探讨恶性肿瘤生存者癌痛治疗与生存质量的关系。方法对入选患者给予三阶梯止痛治疗,应用数字评分疼痛分级法及EORTC QLQ-C30问卷调查表分别对止痛治疗前后患者进行疼痛测定及生活质量测定,对结果进行比较分析。结果 （1）使用三阶梯止痛治疗后,中度疼痛缓解率为95.3%,重度疼痛缓解率为85.3%,疼痛总缓解率为88.4%;不良反应主要表现为恶心、呕吐、便秘等。（2）按照三阶梯止痛疗法疼痛治疗后患者生活质量较好,中、重度癌痛患者社会功能、情绪功能、躯体功能、失眠、整体质量均明显改善（P〈0.01）;中度疼痛患者生活质量得分为65.49±8.54,重度疼痛患者生活质量得分33.38±10.67,与治疗前比较差异均有统计学意义（P〈0.01）。结论三阶梯止痛疗法能明显缓解癌性疼痛,有效地提高恶性肿瘤生存者的生活质量。     

放疗前患者癌痛和生活质量状况调查

目的：了解放疗前患者癌痛的发生率及其对生活质量的影响。方法采用欧洲癌症研究和治疗组织的生命质量核心问卷（the Europe Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30,EORTC QLQ-C30）对门诊行CT定位的100例患者进行问卷调查。结果100例准备行放疗的患者中,疼痛患者42例,其中轻度疼痛33例,中度疼痛7例,重度疼痛2例。与无疼痛患者比较,疼痛患者在躯体功能、角色功能、情绪功能和认知功能方面得分均较低,差异均具有统计学意义（均P＜0．05）,而在总体健康状况方面得分高于无疼痛患者,差异具有统计学意义（P＜0．01）。多元线性回归分析显示,24 h最重的以及平均疼痛对生活质量的影响比较明显,需要药物止痛的患者认知功能得分较低,女性及文化程度高的患者社会功能得分较低（均P＜0．05）。结论疼痛在多个方面影响癌症患者的生活质量,尤其对躯体功能、角色功能及社会功能的影响较为突出。     

An open-label study of the effects of bupropion SR on fatigue, depression and quality of life of mixed-site cancer patients and their partners

This preliminary study investigated whether bupropion sustained release (SR) improved symptomatic fatigue, depression and quality of life in cancer patients and caregiver quality of life. The sample consisted of a prospective open case series of 21 cancer patients, with fatigue and with or without depression at moderate to severe levels, referred for psychiatric assessment from a tertiary care cancer centre. Both patient symptom ratings and caregiver ratings were measured before and after 4 weeks of treatment with the maximally tolerated dose of bupropion in the range of 100-300 mg per day. At trial completion, significant improvement was found for symptoms of fatigue and depression. Subjects were divided into two groups: depressed and non-depressed (based on a cut-off score of 17 on the Hamilton Depression Rating Scale). Both groups reported improvement for fatigue and depressive symptoms. Depressed subjects and their caregivers did not experience any change in quality of life, while the non-depressed subjects and their caregivers reported improvements. Results from this small group of patients suggest that bupropion may have potential as an effective pharmaceutical agent for treating cancer-related fatigue. A randomized, placebo-controlled trial with this medication is indicated.