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肿瘤微环境——肿瘤转移的关键因素 总被引:1,自引:0,他引:1
肿瘤转移是癌症治疗失败和患者死亡的主要原因,其分子机制复杂,涉及多步骤、多阶段、多基因的变化。作为肿瘤细胞赖以生存的场所,肿瘤微环境在肿瘤转移过程中起到至关重要的作用。因此,研究肿瘤微环境与肿瘤转移的动态关系,阐明微环境中不同因子在转移过程中的分子机制是抑制肿瘤转移的关键。 相似文献
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转移是肿瘤患者死亡的主要原因之一,其基因及分子调控机制仍不清楚。肿瘤转移抑制基因在体内能直接抑制肿瘤转移潜能而对原发肿瘤生长没有影响,其发现与分离对于转移机制调节的研究具有重要意义,并具有广阔的应用前景。现综述肿瘤转移抑制基因的研究现状、临床意义及应用。 相似文献
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肿瘤转移与肿瘤微环境中成纤维细胞、转化生长因子、肿瘤相关巨噬细胞、趋化因子及其受体、凝血酶等多种因素密切相关。成纤维细胞通过促进肿瘤血管生成、促进癌细胞与细胞外基质黏附、促进细胞外基质降解等环节参与肿瘤的转移。TGF-β是由巨噬细胞、间质细胞和肿瘤细胞产生,它能对抗血管内皮的紧密连接和黏附连接,使毛细血管壁完整性受到破坏,从而导致毛细血管通透性增加,使肿瘤细胞从血管中游出进入器官组织中形成种植转移。肿瘤相关性巨噬细胞可合成和分泌EGF等细胞因子,引导肿瘤细胞穿越血管壁,促进肿瘤的转移。趋化因子及其受体对肿瘤细胞的迁移起着决定性的作用。凝血酶能通过影响微环境中其他细胞的行为而为肿瘤转移提供一个相容的环境。明晰肿瘤转移与肿瘤微环境的关系,进而明确在肿瘤发生、发展、转移过程中发挥重要作用的关键分子,寻找其相对应的靶点,对于肿瘤的诊断及治疗具有重要的作用。 相似文献
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肿瘤的转移是导致癌症病人死亡最主要原因,占癌症患者死亡人数90%以上。目前我们对肿瘤转移的分子和细胞学机制尚不明确,对肿瘤的预防和治疗产生了很大的障碍。肿瘤的转移是一个多步骤过程,组织学上转移灶细胞和原发灶细胞属于同一类型。而在转移过程中,有大量的蛋白质分子参与了这个过程,各个蛋白质分子在转移过程中表达水平的改变、翻译后的修饰、[第一段] 相似文献
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肿瘤血管形成与肿瘤浸润转移的研究进展 总被引:1,自引:0,他引:1
肿瘤血管形成是肿瘤发生、生长和浸润与转移的重要条件,近些年在研究方面进展迅速,并取得了很大进展。主要就肿瘤血管形成与肿瘤浸润转移的有关研究进展加以综述。 相似文献
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陈朱波 《中国肿瘤生物治疗杂志》2008,15(3)
肿瘤转移是导致肿瘤患者死亡的重要原因,对于肿瘤转移的机制以及如何预防和抑制肿瘤的转移一直是肿瘤研究的重点和热点。目前研究认为,肿瘤相关淋巴管的形成能够促进肿瘤的转移扩散,所以现在有很多研究聚焦于如何抑制肿瘤环境淋巴管的形成。 相似文献
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肿瘤转移是恶性肿瘤进展的重要特征,也是导致肿瘤患者治疗失败和死亡(〉90%)的最主要原因。微环境中复杂的信号通路,肿瘤细胞基因表型、上皮表型和表面粘附分子表达的改变,肿瘤转移的器官归巢现象等都将影响肿瘤转移结局。肿瘤转移分子机制迄今尚不清楚。近年来,上皮细胞-间质细胞转化(epithelial—mesenchymal transition,EMT)被认为是肿瘤转移早期的关键步骤。 相似文献
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《Asian Pacific journal of cancer prevention》2013,14(3):1661-1664
Recently there have been numerous advances in understanding the genetic basis of cancer which have resultedin more appropriate treatments. In this paper we describe the experience of the Burzynski Clinic, involved intreatment of numerous patients based on personalized approach using novel combinations for difficult-to-treatmalignancies, with gynecological cancers. This retrospective study was conducted by extracting data fromBurzynski Clinic’s medical records and comprehensive review. Among the advanced refractory ovarian cancerscases (N=33), an objective response (OR) was found in 42.4%. We anticipate that with improved technology andnovel therapeutics this rate will increase and adverse events will be reduced. 相似文献
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KATO HOICHI; IIZUKA TOSHIFUMI; WATANABE HIROSHI; HIRATA KATSUJI; SAITO TAKAO; HIRASHIMA TOSHIO; ITABASHI MASAYUKI; HIROTA TERUYUKI 《Japanese journal of clinical oncology》1981,11(2):315-320
Among a total of 1,137 patients with esophageal cancer, therewere 44 cases of esophageal cancer associated with gastric cancer,an incidence of 3.9%. The majority of the patients were between60 and 70 yr old. Forty-two patients were male and two werefemale. Eleven of these patients had a third cancer. Six had multiplecancers in the esophagus and/or stomach. Eighteen patients hadearly gastric cancer. Thirty-two of the cancers were synchronousand 12 were metachronous. Of these 44 patients, 21 had familyhistories of cancer, 37 were smokers, and 36 were drinkers.Twenty-five patients received surgery for all of their cancers,and two patients received resection of only esophageal cancer.Of these 27 patients. five patients lived more than 5 yr. Themost frequent cause of death in our series was esophageal cancer(52.9%). Surgical treatment of all of the cancers is desirable. Whenthis is impossible, the surgery must be emphasized for the esophagealcancer in most cases. 相似文献
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Catalona WJ Bailey-Wilson JE Camp NJ Chanock SJ Cooney KA Easton DF Eeles RA FitzGerald LM Freedman ML Gudmundsson J Kittles RA Margulies EH McGuire BB Ostrander EA Rebbeck TR Stanford JL Thibodeau SN Witte JS Isaacs WB 《Cancer research》2011,71(10):3442-3446
Compelling evidence supports a genetic component to prostate cancer susceptibility and aggressiveness. Recent genome-wide association studies have identified more than 30 single-nucleotide polymorphisms associated with prostate cancer susceptibility. It remains unclear, however, whether such genetic variants are associated with disease aggressiveness--one of the most important questions in prostate cancer research today. To help clarify this and substantially expand research in the genetic determinants of prostate cancer aggressiveness, the first National Cancer Institute Prostate Cancer Genetics Workshop assembled researchers to develop plans for a large new research consortium and patient cohort. The workshop reviewed the prior work in this area and addressed the practical issues in planning future studies. With new DNA sequencing technology, the potential application of sequencing information to patient care is emerging. The workshop, therefore, included state-of-the-art presentations by experts on new genotyping technologies, including sequencing and associated bioinformatics issues, which are just beginning to be applied to cancer genetics. 相似文献
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R. WESTON 《European journal of cancer care》1994,3(3):105-110
Since the beginning of the Europe Against Cancer (EAC) programme in 1989, much support and emphasis has been given to informing both health professionals and the public about cancer. This has come from the government and the many cancer-related charities and organizations. A week focused on cancer throughout the European Union (EU) has been encouraged each October. This paper describes the gradual development of these weeks to provide a more planned, co-ordinated and evaluated strategy. Collaboration with European partners is also addressed, emphasizing the positive benefits of such activities. Finally, the issue of monitoring and evaluation is addressed in some detail. 相似文献
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Khaled El‐Shami MD PhD Kevin C. Oeffinger MD Nicole L. Erb BA Anne Willis MA Jennifer K. Bretsch MS CPHQ Mandi L. Pratt‐Chapman MA Rachel S. Cannady BS Sandra L. Wong MD MS Johnie Rose MD PhD April L. Barbour MD MPH FACP Kevin D. Stein PhD Katherine B. Sharpe MTS Durado D. Brooks MD MPH Rebecca L. Cowens‐Alvarado MPH 《CA: a cancer journal for clinicians》2015,65(6):427-455
Answer questions and earn CME/CNE Colorectal cancer (CRC) is the third most common cancer and third leading cause of cancer death in both men and women and second leading cause of cancer death when men and women are combined in the United States (US). Almost two‐thirds of CRC survivors are living 5 years after diagnosis. Considering the recent decline in both incidence and mortality, the prevalence of CRC survivors is likely to increase dramatically over the coming decades with the increase in rates of CRC screening, further advances in early detection and treatment and the aging and growth of the US population. Survivors are at risk for a CRC recurrence, a new primary CRC, other cancers, as well as both short‐term and long‐term adverse effects of the CRC and the modalities used to treat it. CRC survivors may also have psychological, reproductive, genetic, social, and employment concerns after treatment. Communication and coordination of care between the treating oncologist and the primary care clinician is critical to effectively and efficiently manage the long‐term care of CRC survivors. The guidelines in this article are intended to assist primary care clinicians in delivering risk‐based health care for CRC survivors who have completed active therapy. CA Cancer J Clin 2015;65:427–455 . © 2015 American Cancer Society. 相似文献