绝经后妇女血维生素B12、叶酸水平与骨密度相关性的初步研究

目的探讨绝经后妇女血维生素B12、叶酸水平与骨密度的相关性。方法应用双能X线骨密度仪测定受试者腰椎及股骨骨密度,按1994年WHO标准将其分为3组,即骨质疏松组、骨量减少组及骨量正常组;采取空腹静脉血进行维生素B12、叶酸的集中检测;并分别进行维生素B12、叶酸与不同部位骨密度的相关性分析。结果①骨质疏松组的血维生素B12的水平(512.55±209.85)pg/ml,低于骨量减少组(551.29±237.71)pg/ml和骨量正常组(565.71±189.03)pg/ml。②骨质疏松组的血叶酸的水平(11.27±6.04)pg/ml,低于骨量减少组(13.18±6.14)pg/ml和骨量正常组(11.9±3.73)pg/ml。③绝经后妇女血维生素B12的水平与全髋BMD呈正相关(r=0.25,P<0.01),与股骨颈BMD呈正相关(r=0.212,P<0.05),与股骨干BMD呈正相关(r=0.257,P<0.01),与股骨大转子BMD呈正相关(r=0.239,P<0.05);血维生素B12的水平与L1~L4BMD无相关性(r=0.141,P>0.05)。④绝经后妇女血叶酸的水平与全髋BMD、股骨颈BMD、股骨干BMD、股骨大转子BMD和L1~L4BMD均无相关(r分别为0.005,0.021,0.017,-0.021和0.078,P>0.05)。结论绝经后妇女血维生素B12的水平的缺乏可能是骨质疏松发生的一个重要风险因素,叶酸的缺乏并非骨质疏松发生的风险因素。     

维生素D、维生素B12和同型半胱氨酸水平与绝经后女性骨密度的相关性研究

目的探索绝经后非骨质疏松症和骨质疏松症女性患者高半胱氨酸、维生素D、维生素B_(12)和骨密度(bone mineral density,BMD)之间的关系。方法选取2017年8～12月在我院就诊的138名女性作为研究对象,根据骨密度将绝经后女性分为骨质疏松组(n=58)和非骨质疏松组(n=80)。记录两组患者的体质量指数(body mass index,BMI)、年龄、腰围等一般资料,检测腰椎L_(1～4)前后位、左侧股骨近端的BMD,测定血清同型半胱氨酸、维生素B_(12)、维生素D、碱性磷酸酶、钙、磷水平。分析两组患者不同指标的差异以及高半胱氨酸、维生素D、维生素B_(12)和BMD之间的相关性。结果两组患者的年龄、BMI、腰围、同型半胱氨酸、维生素D、维生素B_(12)、腰椎L_(1～4)和左股骨颈骨密度比较差异有统计学意义(P均0.05);Rho相关性和回归分析表明,同型半胱氨酸与维生素D和B_(12)在绝经后非骨质疏松症和同型半胱氨酸与维生素B_(12)在绝经后骨质疏松症女性中呈显著负相关。结论高水平同型半胱氨酸可以通过绝经后非骨质疏松症患者维生素D水平和绝经后骨质疏松症女性维生素B_(12)水平预测。     

Effects of tibolone and raloxifene on bone mineral density in osteopenic postmenopausal women

SUMMARY: A randomized trial was conducted in osteopenic postmenopausal women to compare the efficacy of tibolone versus raloxifene on BMD of the lumbar spine and hip. Tibolone increased lumbar spine and total hip BMD to a statistically significantly greater extent than raloxifene after two years of treatment. INTRODUCTION: Both tibolone, a selective tissue estrogenic activity regulator (STEAR), and raloxifene, a selective estrogen receptor modulator (SERM), are known to prevent postmenopausal bone loss. However, no head-to-head studies to compare the efficacy on bone have been performed. METHODS: A double-blind, randomized trial was conducted in osteopenic postmenopausal women aged 60-79 years to compare the effects of tibolone 1.25 mg/day to raloxifene 60 mg/day on bone mineral density (BMD). Serum osteocalcin and serum type I collagen C-telopeptides were measured as biochemical markers of bone metabolism. RESULTS: Three hundred and eight subjects were allocated to treatment. Both treatments significantly increased lumbar spine BMD, however the increase was significantly larger after tibolone treatment than after raloxifene treatment (at year 1: 2.2% versus 1.2%, p<0.01 and at year 2: 3.8% versus 2.1%, p<0.001). After 2 years of treatment, the increase in total hip BMD in the tibolone group was significantly larger than in the raloxifene group (p<0.05). Both treatments significantly reduced type I collagen C-telopeptides and osteocalcin levels when compared to baseline. CONCLUSIONS: Tibolone 1.25 mg/day for 2 years prevents postmenopausal bone loss in older women and results in a larger increase of BMD both at the lumbar spine and hip than raloxifene.     

Relation of early menarche to high bone mineral density

The study of background factors in individuals with high bone mineral density (BMD) may provide useful information in the prevention of osteoporosis. We investigated the relationship of reproductive factors to BMD. In 519 female volunteers (327 postmenopausal and 192 premenopausal women) ranging in age from 21 to 74 (mean 52.3 ±11.8) years, spinal BMD values were obtained using both quantitative computed tomography and dual x-ray absorptiometry. The z score was calculated from the mean BMD in each 5-year age group, and high BMD and low BMD was defined as BMD with z score >+1.5 and <-1.5, respectively. Normal BMD was defined as BMD within the range-1.0 <z score <+1.0. Long reproductive period, early menarche, and late menopause were associated with high BMD. Among these, the reproductive period showed the strongest association with BMD. In postmenopausal women, early menopause had a significant relationship with low BMD, and early menarche also had some relation to high BMD. In premenopausal women, there was a significant relationship between early menarche and high BMD. The age at menarche may have a strong association with peak bone mass, as suggested by the positive correlation of early menarche with high BMD observed in this study. It is considered important to prevent risk factors that disturb the beginning of menstruation in adolescent girls.     

The association of homocysteine and its determinants MTHFR genotype, folate, vitamin B12 and vitamin B6 with bone mineral density in postmenopausal British women

We studied the association between plasma total homocysteine (tHcy), its determinants folate, vitamin B(12), vitamin B(6) and MTHFR genotype, and bone mineral density (BMD) in 328 postmenopausal British women. When the subjects were assigned to one of 3 groups (control, osteopenic or osteoporotic) according to their BMD at the os calcis, those in the osteoporotic group had, compared with the controls, a significantly lower serum folate concentration, a significantly higher % of current smokers and a significantly higher incidence of recent fracture. In the population as a whole, we found significant associations of BMD with tHcy (r=-0.130, p=0.033, log tHcy) and folate (r=0.132, p=0.025, log folate). The association of folate with BMD was maintained after correction for age, weight and height (r=0.124, p=0.042, log folate), but the association of tHcy with BMD weakened after correction for age, weight, height and creatinine (r=-0.117, p=0.059, log tHcy).Vitamins B(12) and B(6) were not associated with BMD, but were significantly associated with tHcy, vitamin B(12) (r=-0.34, p<0.0001), vitamin B(6) (r=-0.16, p=0.007), as was folate (r=-0.41, p<0.0001). There was an increasing frequency of the MTHFR TT genotype across the 3 BMD groups, but this did not attain significance. Individuals with the TT genotype had significantly higher plasma tHcy but there was no difference between the genotypes (CC, CT, TT) for folate or BMD. Smoking was associated with a highly significant reduction in BMD and lower weight, and a significant reduction in circulating folate and vitamin B(6) concentrations, but no change in tHcy or vitamin B(12) concentrations when compared with non-smokers. We conclude that low serum folate is a significant risk factor for osteoporosis, with plasma tHcy having a lesser effect. Both vitamins B(12) and B(6), by acting through tHcy, may also have an effect on the skeleton, albeit a weaker one than folate. Cigarette smoking is a strong determinant of BMD, and may act through effects on folate and vitamin B(6).     

溃疡性结肠炎患者血浆同型半胱氨酸和叶酸及维生素B12的检测水平及其临床意义

目的探讨溃疡性结肠炎（UC）患者中血浆同型半胱氨酸（Hcy）、叶酸（FA）和维生素B12（VitB12）水平的改变及其临床意义。方法采用高效液相荧光检测法（HPLC—FD）检测112例UC患者和110名健康对照人群血浆Hcy水平．应用ELISA方法检测76例UC患者和12名健康对照人群血浆FA和VitB12水平。结果UC患者中血浆Hcy水平为（11．27±7．26）μmol／L,明显高于对照组的（8．19±4．81）μmol／L（P〈0．01）;UC患者中血浆Hcy水平与UC病情分度、病变范围及病程均无关（P〉0．05）。UC患者中血浆FA和VitB12水平分别为（7．64±1．95）nmol／L和（108．64±32．22）pmol／L,明显低于对照组[（9．14±1．23）nmol／L和（112．64±33．33）pmol／L,均P〈0．01]。高Hcy组患者血浆FA和VitB12水平显著低于低Hcy组（P〈0．05）。UC患者中血浆FA水平与UC病程呈负相关（P〈0．01）;而VitB12水平则与病程无相关性（P〉0．221）。结论UC患者血浆Hcy水平升高,可能与FA和VitB12水平下降有关。     

Relation of folates, vitamin B12 and homocysteine to vertebral bone mineral density change in postmenopausal women. A five-year longitudinal evaluation

Elevation of homocysteine is associated with an increased risk for bone fractures. Whether the risk is due to homocysteine or to the reduced levels of cofactors necessary for its metabolisation, such as folates or vitamin B12, is not completely clear. In this study we wanted to determine whether in postmenopausal women, levels of folates, homocysteine or vitamin B12 are predictive of the rate of vertebral bone mineral density (BMD) change. The study was conducted at the centre for the menopause of our university hospital. Between September 2001 and March 2002, 161 healthy postmenopausal women volunteered for a cross-sectional evaluation of BMD and levels of serum folates, homocysteine and vitamin B12. Women were recalled for a second evaluation of vertebral BMD after about 5 years. Women having used anti-resorptive therapies for more than 1 year were excluded. The analysis was possible in 117 postmenopausal women. The annual rate of vertebral BMD change was independently related to levels of folates (coefficient of regression (CR): 2.040; 95%CI: 0.483, 3.596; p=0.011), and initial BMD values (CR: -0.060; 95%CI: -0.117, -0.003; p=0.040). No significant relation was found between the change of vertebral BMD and homocysteine or vitamin B12. BMD values at the first (r=0.225; p=0.016) and the second (r=0.206; p=0.027) evaluation were related to levels of folates, but not of homocysteine or of vitamin B12. These data suggest an important role for folates deficiency in the vertebral BMD decline of postmenopausal women.     

维生素B12和叶酸干预对绝经后骨质疏松症妇女的骨代谢及同型半胱氨酸水平的影响

目的观察叶酸和维生素B12对绝经后骨质疏松症妇女的骨代谢及同型半胱氨酸水平的影响。方法 80例绝经后骨质疏松症妇女参加研究。所有参与者随机接受叶酸和维生素B12(n=40)或安慰剂(n=40)治疗。在干预前的基线及干预后3个月和6个月,测量两组患者血清同型半胱氨酸、维生素B12和骨代谢标志物的水平。结果治疗前,两组患者血清同型半胱氨酸、维生素B12和骨代谢标志物水平比较差异无统计学意义(P0.05)。治疗后,两组患者同型半胱氨酸均下降,但比较差异无统计学意义(P0.05)。6个月后各组间血清维生素B12、骨钙素、CTX的变化均有显著改变且差异有统计学意义(P0.05)。结论绝经后骨质疏松症妇女补充叶酸和维生素B12可以一定程度改善同型半胱氨酸及骨代谢指标水平。     

沈阳地区绝经后妇女绝经年限与股骨近端骨密度的关系分析

目的 探讨绝经年限与股骨近端BMD的关系。方法 随机调查沈阳地区285例健康的绝经后妇女，调查其年龄和绝经年限，测量其身高、体重、股骨近端骨密度(BMD)，应用SPSS软件统计分析。结果 随绝经年限的增加股骨近端各部位BMD有下降的趋势，随绝经年限的增加股骨近端各部位BMD下降速度减慢，并且相对而言Neck、Ward’s区的BMD下降速度高于其他部位。以年龄和体重指数(BMI)为协变量，经协方差分析显示Ward’s区BMD与绝经年限具有显著相关，而其他部位无显著相关。结论 对绝经后妇女应注意绝经早期的股骨近端BMD变化。     

福善美对绝经后妇女骨密度的影响

目的　评价福善美 (Fosamax)治疗绝经后骨质疏松症妇女的近期及中期疗效 ,以及改善骨量作用。方法　绝经 1年以上女性 80名 ,分成 4组 ,A组 :14例 ,年龄 5 4 . 97± 5. 5 1(47～ 6 2 )岁 ,绝经年限≤10年 ,疗程 6个月～ 1年 ;B组 :2 3例 ,年龄 5 5 . 5 5± 3. 6 6 (5 0～ 6 2岁 ) ,绝经年限≤ 10年 ,疗程 1年以上 ;C组 :18例 ,年龄 6 8. 18± 5 . 5 9(5 9～ 78岁 ) ,绝经年限 >10年 ,疗程 6个月～ 1年 ;D组 :2 5例 ,年龄6 7. 2 5± 6 .19(5 2～ 80岁 ,绝经年限 >10年 ,疗程 1年以上。患者每天接受口服福善美 10mg和元素钙5 0 0mg,疗程 6个月～ 2 8年。治疗前、后应用双能X线吸收仪 (HologicQDR 2 0 0 0型 )进行骨密度(BMD)测定。结果　 4组不论绝经年限长短 ,通过 6个月～ 2年以上福善美治疗 ,腰椎BMD平均增加百分率 3 74 %～ 5 4 5 % ,较基础值均有明显增加 (P <0 . 0 0 1) ,4组间差异无统计学意义 (P >0 . 0 5 )。股骨颈部位治疗后BMD平均增加百分率为 0 84 %～ 4 2 1% ,其中绝经年限相同时 ,疗程长者高于短者 ,即B组高于A组 ,D组高于C组 ;疗程相同时 ,绝经年限长者高于短者 ,即C组高于A组 ,D组高于B组 ,但 4组间差异无显著性 (P >0 . 0 5 )。大转子部位治疗后BMD增加平均变化百分率 1 4. 2 %～     

Association of red blood cell 5-methyltetrahydrfoate folate with bone mineral density in postmenopausal Iranian women

Recent studies have suggested that hyperhomocystenemia and low plasma folate are associated with fracture and also bone mineral density (BMD) and that they may contribute to the pathogenicity of osteoporosis in postmenopausal women. However, as plasma total homocysteine (tHcy) and plasma folate can be regarded as short-term markers when compared to a long-term variable such as BMD, in this study we tested the hypothesis that low red blood cell 5-methyltetrahydrofolate (RBC 5-MTHFR) as a long-term marker of the folate status may be a better predictor of BMD than plasma 5-MTHF, and its deficiency may contribute to the pathogenecity of osteoporosis in postmenopausal Iranian women. The BMD at the femoral neck and lumbar spine (measured by dual-energy X-ray absorptiometry, DXA) together with anthropometric and biochemical components of the homocysteine re-methylation pathway including plasma tHcy, 5-MTHF and vitamin B12, RBC 5-MTHF and creatinine were determined in 366 postmenopausal women. RBC 5-MTHF was more highly correlated with BMD at the lumbar spine ( r =0.21, P =0.001) and femoral neck ( r =0.19, P =0.004) than was plasma 5-MTHF (lumbar spine; r =0.14, P =0.03 and femoral neck; r =0.17, P =0.006). Stepwise multiple linear regression analyses revealed that RBC 5-MTHF was one of the predictors of BMD explaining 4.3 and 4.0% variance of BMD at the lumbar spine and femoral neck, respectively, whereas plasma 5-MTHF was excluded in the model and not determined to be a predictor of BMD at both the lumbar spine and femoral neck when adjusted for age, BMI, years since menopause and RBC 5-MTHF. This study suggests that RBC 5-MTHF is a better predictor of BMD than plasma 5-MTHFR when compared to a long-term marker such as BMD, and its deficiency is associated with low BMD that may contribute to the pathogenecity of osteoporosis in postmenopausal women.     

The relationship of vitamin D status to bone mineral density in an Italian population of postmenopausal women

Several authors have found a relationship between vitamin D status and bone mineral density (BMD). To our knowledge, no previous studies on this topic have been carried out on the Italian postmenopausal population. We studied this relationship retrospectively in 156 Italian postmenopausal women. We also investigated the relationship between parathyroid hormone (PTH) and BMD. Measurements of BMD were taken at the lumbar spine and upper femur by dual X-ray absorptiometry. Serum 25(OH)D (calcidiol), 1,25(OH)2D (calcitriol), PTH, calcium, phosphorus, creatinine, osteocalcin and urinary calcium and phosphorus were measured according to the current laboratory methods of analysis. We found a positive statistically significant correlation between BMD, both at the spine and hip, and 25(OH)D, and a negative statistically significant correlation between BMD and PTH. No statistically significant correlation was found between BMD and 1,25(OH)2D. Crude logistic regression showed age, 25(OH)D and PTH were significant predictors of low BMD, while 1,25(OH)2D was not. Backward logistic regression showed 25(OH)D was the best predictive model for spine osteoporosis together with age, and on its own it was the best predictive model for femoral neck osteoporosis.No funding sources supported this publication.     

绝经妇女绝经后年限及年龄与骨量丢失率关系

目的探讨绝经后妇女的绝经年限及年龄与骨量丢失率关系。方法1999年5月-2003年4月,对已绝经的1467例妇女进行骨密度测定,并对不同绝经后妇女年龄、绝经年限与骨密度关系进行分析。结果1467例绝经后妇女中,以绝经1-5年期间和40-45岁时各部位骨密度作为基线值比较,绝经已超过35年或年龄大于80岁时各部位骨密度最低。其中按绝经年限腰椎、股骨颈、大转子、华氏三角区在绝经后6-10年间和超过35年时丢失速度最快;按年龄腰椎在56-65岁、股骨颈和华氏三角区在61-65岁、大转子在71-75岁及各部位大于80岁时丢失速度最快。结论绝经后妇女绝经年限及年龄增加,腰椎、股骨颈、粗隆、华氏三角区骨量丢失增加。绝经年限及年龄不同,各部位丢失速度不同。     

老年女性血HCY水平与骨密度的相关性研究

目的探讨老年女性血清同型半胱氨酸(homocysteine,HCY)、脂质水平与骨质减少的关系。方法收集2016年9月至2017年3月我院门诊及住院的老年女性126例,根据DXA法测得的骨密度水平将其分为骨量正常组(41例)、骨量减少组(43例)和骨质疏松组(42例),测量记录年龄、绝经年龄、绝经时间、身高、体重,检测血钙(calcium,Ca)、磷(phosphorus,P)、碱性磷酸酶(alkaline phosphatase,ALP)、甘油三酯(triglycerides,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDLC)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDLC),酶联免疫法(enzyme linked immunosorbent assay,ELISA)测定HCY。结果骨质疏松组血清HCY、LDL-C水平明显高于骨量减少组及骨量正常组,骨质疏松组绝经年龄、体重低于骨量正常组,差异有统计学意义(P0.05)。低体重、血清HCY、LDL-C水平升高是骨质减少的危险因素,OR(95%CI)分别为0.932(0.886~0.979)、2.284(1.487~3.509)、3.160(1.081~9.337),差异有统计学意义(P0.05)。结论老年女性骨量减少组和骨质疏松组中HCY、LDL-C水平增高,HCY、LDL-C与骨密度水平呈负相关,HCY、LDL-C水平可作为老年女性评价骨量丢失的参考指标。     

阿伦膦酸盐对绝经后骨质疏松妇女骨密度的影响

为了解阿伦膦酸盐对骨密度的影响及其安全性和耐受性,对２０名绝经后骨质疏松的妇女中进行阿伦膦酸盐（ａｌｅｎｄｒｏｎａｔｅ）１０ｍｇ／天和安慰剂的随机、双盲、前瞻性研究,为期一年。结果显示,１年后阿伦膦酸盐组与安慰剂组相比,骨密度平均增长率：椎骨分别为４．８７％与－０．２３％;股骨颈分别为６．８９％与－１．８４％,（Ｐ＜０．０５）。副反应仅为轻微胃肠道反应。结论：阿伦膦酸盐能有效增加骨密度,且药物安全,耐受性好     

绝经后妇女血脂水平与骨密度的关系

目的 明确绝经后妇女血脂水平与骨密度有否联系。方法 测定85例绝经后妇女的甘油三酯和胆固醇水平，双能X线法测定腰椎k2-4和股骨颈的骨密度(BMD)。结果 与未绝经妇女相比，绝经后妇女甘油三酯(t=3．74，P=0．000)和胆固醇(t=3．75，P=0．000)水平均显著升高；而BMD腰椎k(t=2．43，P=0．017)和股骨颈(t=3．32，P=0．002)均显著降低；绝经后妇女甘油三酯水平与股骨颈的BMD经BMI校正后有显著负相关，偏相关系数r=-0．324，P=0．003；而与腰椎k2-4 BMD无相关。胆固醇水平则与股骨颈及腰椎k2-4的BMD均无相关性。结论 绝经后妇女甘油三酯水平的升高可能是绝经后骨量减少及骨质疏松发生的因素之一。     

太极对预防绝经后女性骨密度的荟萃分析

目的 评价太极对预防绝经后女性骨密度的影响。方法 通过检索数据库搜集太极对绝经后女性骨密度影响的文献。采用Revman5.1软件进行分析,评价指标为骨密度。结果 共纳入7篇文献,5篇随机对照试验提示初学太极的绝经女性经过太极训练后可减少其骨密度的丢失;2篇横断面研究提示长期有规律的进行太极锻炼可预防绝经后女性的骨密度流失。但方法学上存在差异,Meta分析的结果显示,太极未可改善绝经后女性骨密度。结论 目前尚未有足够的证据指出,太极对预防绝经后女性骨密度的影响积极有效。     

Relations between calcidiol serum levels and bone mineral density in postmenopausal women with low bone density

The relationship between vitamin D and bone density was studied in 150 selected, mature (45–74), postmenopausal women with a lumbar spine Z score below 0. Vitamin D status was evaluated using calcidiol serum levels. Serum calcitriol and parathyroid hormone (PTH) values were also evaluated in some subjects. Bone mass was evaluated by ascertaining bone density and Z and T scores in the lumbar spine and femur region. The reference group consisted of 25 premenopausal women. The postmenopausal group was divided into subgroups according to age, i.e., under or over 60 years old. Additionally, the whole group was also subdivided according to their lumbar spine Z scores into group I (Z>-1), group II (Z<-1; >-2), and group III (Z<-2). Group III of postmenopausal women had higher PTH and lower calcitriol levels than premenopausal women. Calcidiol serum levels were lower in postmenopausal women groups II or III than in the group I and premenopausal women. Calcidiol serum levels and the bone mass values for the lumbar spine were correlated positively in all the postmenopausal women; in the women over 60 years of age, calcidiol levels also correlated with the bone mass values expressed as the bone density in three femur regions: femoral neck, trocanter, and Ward's triangle. In conclusion, mature postmenopausal woman showed high PTH levels and low calcidiol and calcitriol values. Calcidiol status is significantly related to bone mineral density in the lumbar spine and in women over 60 years, calcidiol levels also correlated with bone density in the femur regions.     

颈动脉内膜中层厚度和绝经后妇女骨密度相关性研究

目的探讨绝经后骨质疏松症患者颈动脉内膜中层厚度(CIMT)的差异及CIMT和斑块增大的风险。方法进行横断面研究,包括60位绝经后骨质疏松症妇女和60位非骨质疏松症绝经后妇女。CIMT采用B型超声测量。结果绝经后骨质疏松症妇女与无骨质疏松症妇女的平均CIMT差异无统计学意义(P 0.05)。骨质疏松症组CIMT升高的风险与非骨质疏松症组相似。骨质疏松症妇女斑块出现的风险是正常人的三倍。然而,调整了易使妇女患有心血管疾病的年龄和基础疾病后,两组之间斑块的存在并无显着差异(校正比值比=0.85;95%可信区间0.10～6.464)。结论绝经后妇女与无骨质疏松症患者的平均CIMT无差异。绝经后骨质疏松症女性的CIMT升高风险与无骨质疏松症的绝经后妇女相当。两组之间斑块的存在没有显着差异。     

阿仑膦酸钠治疗绝经后骨质疏松性骨痛的研究

目的 观察用阿仑膦酸钠治疗６０例绝经后妇女的骨质疏松有痛的疗效。方法 对照阿仑膦酸钠使用６个月前后疼痛,骨密度的变化。结果 经治疗６个月后效果良好,骨痛缓解有效率达９３．３％,骨密度增加显,－／ｘ±ｓ由用药前的０．４６７ｇ／ｃｍ＾２±０．０３６增加到用药后的０．５２８ｇ／ｃｍ＾２±０．０３７,Ｐ〈０．０１。结论 阿仑膦酸钠通过抑制骨吸收的作用使失衡的骨代谢得以恢复,为治疗绝经后骨质疏松提供了一个