5%咪喹莫特乳膏外用治疗基底细胞癌2例

目的观察5%咪喹莫特乳膏治疗基底细胞癌的疗效。方法 5%咪喹莫特乳膏外用基底细胞癌皮肤破损处,每晚用药1次,每2周复查1次,共观察8周。结果 1例治疗6周达到临床病理治愈,随访15个月无复发。另1例治疗8周达到临床治愈。结论 5%咪喹莫特乳膏治疗非浸袭性基底细胞癌疗效满意,耐受性好。     

5%咪喹莫特乳膏治疗基底细胞癌Meta分析

目的以循证医学的方法对5%咪喹莫特乳膏治疗基底细胞癌的疗效与安全性进行系统评价。方法检索PubMed、Ovid、Web of Science、UMI、elsevier,以及Cochrane图书馆,纳入比较5%咪喹莫特乳膏与安慰剂的随机对照试验,由两名评价者独立提取资料并进行方法学质量评估。试验数据的统计分析采用Cochrane协作网提供的Rev Man4.2.8软件进行。结果最终纳入7个RCT,对其治疗浅表型基底细胞癌与结节型基底细胞癌进行了Meta分析,显示其与对照组相比,差异具有统计学意义,合并后前者RR=12.66(95%CI,3.56~45.06),后者RR=5.24(95%CI,2.54~10.81),没有报道与5%咪喹莫特乳膏临床应用相关的严重系统性不良反应。结论现有临床证据表明,5%咪喹莫特乳膏治疗浅表型基底细胞癌有确切的疗效与较好的安全性。疗效与剂量具有相关性,但每日2次与每日1次应用5%咪喹莫特乳膏临床疗效无差异。     

咪喹莫特治疗基底细胞癌致白癜风一例

正临床资料患者,女,68岁。主因右侧肩胛背部无痛性黑色斑片2年,于2012年3月12日就诊。2年前,患者右侧肩胛背部小片皮肤出现粗糙感,面积缓慢增大,无主观不适,未予诊治。发病以来,患者精神饮食可,二便正常,无消瘦。否认白癜风病史及家族史,否认系统疾病史,否认过敏史。皮肤科情况:右侧肩胛背部可见一面积1.5 cm×2.0 cm大小类圆形斑片,表面散在分布黑色点状结痂,境界清楚(图1)。皮损组织病理示:真皮内花蕾样和不规则形肿瘤细     

5%咪喹莫特乳膏治疗眼睑结节型基底细胞癌4例

本组患者采用5％咪喹莫特乳膏治疗眼险结节型基底细胞癌，疗效显著，治疗过程中无明显不良反应，而且通过2年的随访，患者皮损未见复发。     

结节型基底细胞癌

<正>患者女,55岁。主诉:右侧面颊红色斑块、反复破溃伴色素沉着20余年。现病史:20余年前,患者右侧面颊外伤后出现红色斑块,伴破溃、糜烂,反复不愈,皮损范围逐渐变大,后期皮损萎缩、凹陷,偶伴轻度瘙痒,未觉疼痛。未予治疗。既往史、个人史及家族史:无特殊。     

结节型基底细胞癌

患者女,93岁。主诉：面部黑色丘疹2年。现病史：2年前无诱因鼻旁出现芝麻大褐色丘疹,无自觉症状。2年内皮损缓慢扩大,色素稍加深,现呈黄豆大小,无破溃史。起病以来,无其他不适。     

结节型基底细胞癌

<正>患者女,93岁。主诉:面部黑色丘疹2年。现病史:2年前无诱因鼻旁出现芝麻大褐色丘疹,无自觉症状。2年内皮损缓慢扩大,色素稍加深,现呈黄豆大小,无破溃史。起病以来,无其他不适。既往史及家族史:既往体健,无高血压、糖尿病、心脏病等慢性疾病史。家族中无类似患者。体格检查:一般情况好,营养良好,精神可。全身浅表淋巴结未扪及。眼、耳、口、鼻未见异常。心、肺、     

5％咪喹莫特乳膏治疗14例非侵袭性基底细胞癌

Sexton等和Milroy等根据镜下表现。将基底细胞癌（BCC）分为结节型、浅表型、微结节型、浸润型、硬斑病型、混合型，在生物学行为上将前两型归为非侵袭性BCC，后四型归为侵袭性BCC。2003年我们从门诊患者中选择14例非侵袭性BCC，单独用5％咪喹莫特乳膏治疗，治疗结果报道如下。     

痣样基底细胞癌综合征1例及文献复习

报告1例痣样基底细胞癌综合征.患者男,68岁.头部、面部、躯干及双下肢多发米粒至鸽蛋大黑褐色丘疹、结节及斑块7年.皮肤科检查:皮损主要分布于头皮,界限清楚,部分表面破溃;双手掌可见点状凹陷.皮损组织病理检查:表皮部分缺失,棘层轻度增生,真皮可见基底细胞组成的肿瘤细胞团块,肿瘤团块与正常组织间可见裂隙,考虑基底细胞癌.诊...     

微小结节型基底细胞癌

组织病理特征 本文2张组织病理图片的主要特征为:表皮角化过度.表皮萎缩,真皮内有大量肿瘤团块,大小不等,肿瘤团块的主要细胞是基底样细胞.部分瘤体与表皮相连,周边细胞呈栅栏状排列.瘤体周围可见收缩间隙.肿物团块在真皮上部较大,下部较小.越往真皮深部,瘤体越小,瘤体周边的细胞栅栏状排列不明显.与周围基质的裂隙也不明显.     

Axillary basal cell carcinoma: case report and literature review

Axillary basal cell carcinoma (BCC) has been rarely reported. The axilla is a site that is less likely to be monitored by the patient, thus there is a potential for delay in diagnosis and treatment. Surgical excision is the most widely used treatment method for its effectiveness, simplicity and histologic control. BCC is easily treated when it is detected early. There are 33 cases of axillary BCCs reported in the literature, and only one case has been reported in Asia. Herein we report on the second case of primary axillary BCC in an Asian female.     

Clear cell basal cell carcinoma with pulmonary metastasis: case report and literature review

Clear cell basal cell carcinoma is a rare histological variant of basal cell carcinoma, which has been well described in the literature. We herein report a case of a 56-year-old man who developed lung metastasis from a rather aggressive tumor that grew very rapidly to involve the parotid gland, the mandibular bone, and even the petrous portion of the temporal bone, the middle ear, and the dura mater. Histological diagnosis was clear cell carcinoma, and initially a salivary origin was suspected. Only in the resection specimen, we found areas of more conventional basal cell carcinoma, and final diagnosis was clear cell basal cell carcinoma. We herein report a case of this rare variant and comment on the histopathological differential diagnosis and the possible relation between these tumors and Gorlin-Goltz syndrome.     

Cutaneous basal cell carcinosarcoma: case report and literature review

Carcinosarcomas are malignant neoplasms with biphasic carcinomatous and sarcomatous or sarcoma‐like components. In general, the sarcomatous component is accepted to be the result of divergent mesenchymal differentiation of the epithelial component. Although well characterized in some anatomic locations (e.g. uterus, upper aerodigestive tract and lung), carcinosarcomas of the skin are rare. Reported epithelial components include squamous, adnexal, neuroendocrine and basaloid. Including this case, only 47 cases of primary cutaneous basal cell carcinosarcoma have been reported in the literature to date. We performed an extensive immunophenotypic evaluation in our case, which confirmed the previously reported coexpression of p53 in both components, and revealed a hitherto unreported coexpression of p16 and p63. Additionally, this report reviews the clinical, pathologic, immunophenotypic characteristics and outcomes of the basal cell carcinosarcomas reported in the literature, in order to emphasize the overall uniform characteristics and clinical behavior of this neoplasm.     

Metastatic basal cell carcinoma of the posterior neck: case report and review of the literature

Although primary basal cell carcinoma (BCC) represents an extremely common malignancy, metastases derived from BCC are exceedingly rare. The prognosis for metastatic BCC is poor, and little consensus exists regarding predictive factors or optimal treatment strategies. Here, we present the case of a 63-year-old man with BCC of the neck who subsequently developed multiple metastases to subcutaneous tissue, lymph nodes, and the parotid gland. Risk factors and clinical features of metastatic BCC are reviewed, as is the relationship of histopathologic subtype to metastatic behavior. Current chemotherapeutic and targeted therapies also are discussed in the context of recent advances in molecular biology.     

Metastatic basal cell carcinoma: case series and review of the literature

Metastatic basal cell carcinoma is exceedingly uncommon, with a poorly defined natural history, and its incidence, risk factors, patterns of spread, prognosis and potential treatment options are not well understood. This retrospective single institution case series aims to shed light on these issues. Aggressive local management in patients with locoregional disease may result in long‐term survivors.     

Squamous cell carcinoma and basal cell carcinoma arising in a naevus sebaceous of Jadassohn: case report and literature review

The development of a basal cell carcinoma within a naevus sebaceous of Jadassohn (NSJ) has commonly been reported. However, the development of a squamous cell carcinoma (SCC) is rare. There have been several reports of SCC arising within a NSJ but many contain little or ambiguous clinical information. A thorough review of the current English language literature has identified only three other well documented cases of SCC arising in a NSJ. Of these only one was a case of simultaneous occurrence of squamous and basal cell carcinoma. We report the second case of both malignancies arising within the same NSJ.     

Granular cell basal cell carcinoma: A case report

Granular cell basal cell carcinoma (BCC) is a rare histopathological variant of BCC. Our review of the literature revealed only 17 previously identified cases. We report the case of a 47‐year‐old man who presented with an ulceration on his right upper lip which was subsequently removed. Histopathologic examination revealed that the tumor was composed solely of granular cells with numerous cytoplasmic eosinophilic round inclusion bodies. Mitotic figures ranged from 8 to 15 per 10 high‐power fields, with a Ki‐67 proliferative index of ~5%. Immunohistochemically, the granular cells showed strong and diffuse positivity for Ber‐EP4, pan‐cytokeratin, AE1/AE3, CK5/6 and p63 and focal positivity for lysozyme, CD68 (clone KP1) and Bcl‐2.     

Lacrimal caruncle primary basal cell carcinoma: case report and review

BACKGROUND: Basal cell carcinoma (BCC) is a common malignant skin neoplasm. The surface of the caruncle contains sebaceous glands, hair follicles, and lacrimal and sweat gland elements. Consequently, the caruncle may spawn any neoplasm that occurs in the conjunctiva, skin, or lacrimal gland. We report a patient with a primary BCC located on the lacrimal caruncle. METHODS: An 80-year-old man with a 5-month history of a gradually enlarging left caruncular neoplasm was seen. The lesion was nodular and irregularly brown-black colored, with no involvement of adjacent conjunctiva or skin. He had a history of sun exposure, but no personal or family history of other malignant neoplasms. RESULTS: The mass was excised completely. Histopathologic examination revealed a BCC originating in the basal layer of the conjunctival epithelium. No tumor recurrence has been noted after 7 years of follow-up. Primary BCC of the caruncle is unusual, and only four cases have been described in the PubMed. BCC should be considered in the differential diagnosis of caruncle and adjacent skin lesions.     

Clear cell papillary renal cell carcinoma: A case report and review of the literature

Clear cell papillary renal cell carcinoma (ccpRCC) was recently established as a distinct type of epithelial neoplasm by the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia. Here, we report a case of partial nephrectomy for a ccpRCC detected during the routine follow-up of a previously treated liposarcoma in a 70-year-old male patient. The patient was referred to the urology department for a right-sided renal mass (size: 2 cm) detected during routine annual imaging follow-up for a malignant right inguinal fibrous histocytoma and liposarcoma that had been diagnosed 6 and 4 years earlier, respectively, and treated with surgery and adjuvant radiation therapy. Following partial nephrectomy, the renal mass was pathologically diagnosed as ccpRCC, and immunohistochemistry revealed carbonic anhydrase 9 (CA9) expression. No recurrences or metastases were detected on follow-up imaging for 6 months. This is the first report of partial nephrectomy for incidentally discovered CA9-positive ccpRCC.     

Multiple skin cysts in nevoid basal cell carcinoma syndrome: a case report and review of the literature

We report a 72-year-old man with nevoid basal cell carcinoma syndrome (NBCCS) who presented with 25 skin cysts on his trunk and extremities. Fourteen of 25 skin cysts (56%) were observed on his hands. Histological examination demonstrated that most of the excised cysts had an epithelial wall with typical epidermal keratinization. However, 4 skin cysts (4/16; 25%) showed a corrugated or festooned inner surface of wall without a granular cell layer, which resembled an odontogenic keratocyst, a characteristic feature of skin cysts in NBCCS. A review of the literature suggested that acral localization of skin cysts is a distinctive feature of NBCCS. In addition, the histological findings of skin cysts resembling an odontogenic keratocyst might be a hallmark of NBCCS.