Additive risks regression model for middle censored exponentiated-exponential lifetime data

Jammalamadaka and Mangalam introduced middle censoring which refers to data arising in situations, where the exact lifetime becomes unobservable if it falls within a random censoring interval. In the present article, we propose an additive risks regression model for a lifetime data subject to middle censoring, where the lifetimes are assumed to follow exponentiated exponential distribution. The regression parameters are estimated using the Expectation-Maximization algorithm. Asymptotic normality of the estimator is proposed. We report a simulation study to assess the finite sample properties of the estimator. We then analyze a real-life data on survival times of larynx cancer patients studied by Karduan.     

On goodness-of-fit tests for Aalen's additive model based on left-truncated right-censored or doubly censored data

ABSTRACT

Gandy and Jensen (2005 Gandy, A., Jensen, U. (2005). On goodness-of-fit tests for Aalen's additive risk model. Scan. J. Stat. 32:425–445.[Crossref], [Web of Science ®] , [Google Scholar]) proposed goodness-of-fit tests for Aalen's additive risk model. In this article, we demonstrate that the approach of Gandy and Jensen (2005 Gandy, A., Jensen, U. (2005). On goodness-of-fit tests for Aalen's additive risk model. Scan. J. Stat. 32:425–445.[Crossref], [Web of Science ®] , [Google Scholar]) can be applied to left-truncated right-censored (LTRC) data and doubly censored data. A simulation study is conducted to investigate the performance of the proposed tests. The proposed tests are illustrated using heart transplant data.     

Semiparametric mixed-effects models for clustered doubly censored data

The Cox proportional frailty model with a random effect has been proposed for the analysis of right-censored data which consist of a large number of small clusters of correlated failure time observations. For right-censored data, Cai et al. [3] proposed a class of semiparametric mixed-effects models which provides useful alternatives to the Cox model. We demonstrate that the approach of Cai et al. [3] can be used to analyze clustered doubly censored data when both left- and right-censoring variables are always observed. The asymptotic properties of the proposed estimator are derived. A simulation study is conducted to investigate the performance of the proposed estimator.     

Additive hazards model with truncated and doubly censored data

In longitudinal studies, the additive hazard model is often used to analyze covariate effects on the duration time, defined as the elapsed time between the first and the second event. In this article, we consider the situation when the first event suffers partly interval censoring and the second event suffers left truncation and right-censoring. We proposed a two-step estimation procedure for estimating the regression coefficients of the additive hazards model. A simulation study is conducted to investigate the performance of the proposed estimator. The proposed method is applied to the Centers for Disease Control acquired immune deficiency syndrome blood transfusion data.     

Estimating survival curves with left truncated and interval censored data via the ems algorithm

It is well-known that the nonparametric maximum likelihood estimator (NPMLE) of a survival function may severely underestimate the survival probabilities at very early times for left truncated data. This problem might be overcome by instead computing a smoothed nonparametric estimator (SNE) via the EMS algorithm. The close connection between the SNE and the maximum penalized likelihood estimator is also established. Extensive Monte Carlo simulations demonstrate the superior performance of the SNE over that of the NPMLE, in terms of either bias or variance, even for moderately large Samples. The methodology is illustrated with an application to the Massachusetts Health Care Panel Study dataset to estimate the probability of being functionally independent for non-poor male and female groups rcspectively.     

The Cox-Aalen model for left-truncated and mixed interval-censored data

Scheike and Zhang [An additive-multiplicative Cox-Aalen regression model. Scand J Stat. 2002;29:75–88] proposed a flexible additive-multiplicative hazard model, called the Cox-Aalen model, by replacing the baseline hazard function in the well-known Cox model with a covariate-dependent Aalen model, which allows for both fixed and dynamic covariate effects. In this paper, based on left-truncated and mixed interval-censored (LT-MIC) data, we consider maximum likelihood estimation for the Cox-Aalen model with fixed covariates. We propose expectation-maximization (EM) algorithms for obtaining the conditional maximum likelihood estimators (cMLE) of the regression coefficients for the Cox-Aalen model. We establish the consistency of the cMLE. Numerical studies show that estimation via the EM algorithms performs well.     

Analysis of Type-II hybrid censored competing risks data

Kundu and Gupta [Analysis of hybrid life-tests in presence of competing risks. Metrica. 2007;65:159–170] provided the analysis of Type-I hybrid censored competing risks data, when the lifetime distributions of the competing cause of failures follows exponential distribution. In this paper, we consider the analysis of Type-II hybrid censored competing risks data. It is assumed that latent lifetime distributions of the competing causes of failures follow independent exponential distributions with different scale parameters. It is observed that the maximum likelihood estimators of the unknown parameters do not always exist. We propose the modified estimators of the scale parameters, which coincide with the corresponding maximum likelihood estimators when they exist, and asymptotically they are equivalent. We obtain the exact distribution of the proposed estimators. Using the exact distributions of the proposed estimators, associated confidence intervals are obtained. The asymptotic and bootstrap confidence intervals of the unknown parameters are also provided. Further, Bayesian inference of some unknown parametric functions under a very flexible Beta-Gamma prior is considered. Bayes estimators and associated credible intervals of the unknown parameters are obtained using the Monte Carlo method. Extensive Monte Carlo simulations are performed to see the effectiveness of the proposed estimators and one real data set has been analysed for the illustrative purposes. It is observed that the proposed model and the method work quite well for this data set.     

Imputation methods for doubly censored HIV data

In medical research, it is common to have doubly censored survival data: origin time and event time are both subject to censoring. In this paper, we review simple and probability-based methods that are used to impute interval censored origin time and compare the performance of these methods through extensive simulations in the one-sample problem, two-sample problem and Cox regression model problem. The use of a bootstrap procedure for inference is demonstrated.     

Generalized empirical likelihood inference in partial linear regression model for longitudinal data

In this paper, empirical likelihood inference for longitudinal data within the framework of partial linear regression models are investigated. The proposed procedures take into consideration the correlation within groups without involving direct estimation of nuisance parameters in the correlation matrix. The empirical likelihood method is used to estimate the regression coefficients and the baseline function, and to construct confidence intervals. A nonparametric version of Wilk's theorem for the limiting distribution of the empirical likelihood ratio is derived. Compared with methods based on normal approximations, the empirical likelihood does not require consistent estimators for the asymptotic variance and bias. The finite sample behaviour of the proposed method is evaluated with simulation and illustrated with an AIDS clinical trial data set.     

On adaptive progressively Type-II censored competing risks data

In this article, a competing risks model based on exponential distributions is considered under the adaptive Type-II progressively censoring scheme introduced by Ng et al. [2009, Naval Research Logistics 56:687-698], for life testing or reliability experiment. Moreover, we assumed that some causes of failures are unknown. The maximum likelihood estimators (MLEs) of unknown parameters are established. The exact conditional and the asymptotic distributions of the obtained estimators are derived to construct the confidence intervals as well as the two different bootstraps of different unknown parameters. Under suitable priors on the unknown parameters, Bayes estimates and the corresponding two sides of Bayesian probability intervals are obtained. Also, for the purpose of evaluating the average bias and mean square error of the MLEs, and comparing the confidence intervals based on all mentioned methods, a simulation study was carried out. Finally, we present one real dataset to conduct the proposed methods.     

Regression modelling of interval censored data based on the adaptive ridge procedure

A new method for the analysis of time to ankylosis complication on a dataset of replanted teeth is proposed. In this context of left-censored, interval-censored and right-censored data, a Cox model with piecewise constant baseline hazard is introduced. Estimation is carried out with the expectation maximisation (EM) algorithm by treating the true event times as unobserved variables. This estimation procedure is shown to produce a block diagonal Hessian matrix of the baseline parameters. Taking advantage of this interesting feature in the EM algorithm, a L0 penalised likelihood method is implemented in order to automatically determine the number and locations of the cuts of the baseline hazard. This procedure allows to detect specific areas of time where patients are at greater risks for ankylosis. The method can be directly extended to the inclusion of exact observations and to a cure fraction. Theoretical results are obtained which allow to derive statistical inference of the model parameters from asymptotic likelihood theory. Through simulation studies, the penalisation technique is shown to provide a good fit of the baseline hazard and precise estimations of the resulting regression parameters.     

Maximum likelihood estimation,from doubly censored samples,of the mean of a normal distribution with known coeffucient of variation

Let x be a random variable having the normal distribution with mean μ and variance c²μ², where c is a known constant. The maximum likelihood estimation of μ when the lowest r₁ and the highest r₂ sample values censored have been given the asymptotic variance of the maximum likelihood estimator is obtained.     

Two-sample prediction for progressively Type-II censored Weibull lifetimes

Prediction on the basis of censored data has an important role in many fields. This article develops a non-Bayesian two-sample prediction based on a progressive Type-II right censoring scheme. We obtain the maximum likelihood (ML) prediction in a general form for lifetime models including the Weibull distribution. The Weibull distribution is considered to obtain the ML predictor (MLP), the ML prediction estimate (MLPE), the asymptotic ML prediction interval (AMLPI), and the asymptotic predictive ML intervals of the sth-order statistic in a future random sample (Y_s) drawn independently from the parent population, for an arbitrary progressive censoring scheme. To reach this aim, we present three ML prediction methods namely the numerical solution, the EM algorithm, and the approximate ML prediction. We compare the performances of the different methods of ML prediction under asymptotic normality and bootstrap methods by Monte Carlo simulation with respect to biases and mean square prediction errors (MSPEs) of the MLPs of Y_s as well as coverage probabilities (CP) and average lengths (AL) of the AMLPIs. Finally, we give a numerical example and a real data sample to assess the computational comparison of these methods of the ML prediction.     

Reliability analysis for stress-strength model from a general family of truncated distributions under censored data

Abstract

Under progressive Type-II censoring, inference of stress-strength reliability (SSR) is studied for a general family of lower truncated distributions. When the lifetime models of the strength and stress variables have arbitrary and common parameters, maximum likelihood and pivotal quantities based generalized estimators of SSR are established, respectively. Confidence intervals are constructed based on generalized pivotal quantities and bootstrap technique under different parameter cases as well. In addition, to compare the equivalence of the strength and stress parameters, likelihood ratio testing of interested parameters is provided as a complementary. Simulation studies and two real-life data examples are provided to investigate the performance of proposed methods.     

The LAD estimation of the change-point linear model with randomly censored data

Abstract

In this paper, a change-point linear model with randomly censored data is investigated. We propose the least absolute deviation estimation procedure for regression and change-point parameters simultaneously. The asymptotic properties of the change-point and regression parameter estimators are obtained. We show that the resulting regression parameter estimator is asymptotically normal, and the change-point estimator converges weakly to the minimizer of a given random process. The extensive simulation studies and the analysis of an acute myocardial infarction data set are conducted to illustrate the finite sample performance of the proposed method.     

Analysis of left censored data from the generalized exponential distribution

The generalized exponential distribution proposed by Gupta and Kundu [Gupta, R.D and Kundu, D., 1999, Generalized exponential distributions. Australian and New Zealand Journal of Statistics, 41(2), 173–188.] is an important lifetime distribution in survival analysis. In this paper, we consider the maximum likelihood estimation procedure of the parameters of the generalized exponential distribution when the data are left censored. We obtain the maximum likelihood estimators of the unknown para-meters and the Fisher information matrix. Simulation studies are carried out to observe the performance of the estimators in small sample.     

Local likelihood density estimation for interval censored data

The authors propose a class of procedures for local likelihood estimation from data that are either interval‐censored or that have been aggregated into bins. One such procedure relies on an algorithm that generalizes existing self‐consistency algorithms by introducing kernel smoothing at each step of the iteration. The entire class of procedures yields estimates that are obtained as solutions of fixed point equations. By discretizing and applying numerical integration, the authors use fixed point theory to study convergence of algorithms for the class. Rapid convergence is effected by the implementation of a local EM algorithm as a global Newton iteration. The latter requires an explicit solution of the local likelihood equations which can be found by using the symbolic Newton‐Raphson algorithm, if necessary.     

Estimation of the association for bivariate doubly censored data

We study the problem of estimating the association between two related survival variables when they follow a copula model and the bivariate doubly censored data is available. A two-stage estimation procedure is proposed and the asymptotic properties of the proposed estimator are established. Simulation studies are conducted to investigate the finite sample properties of the proposed estimate.     

Computing maximum likelihood estimates from type II doubly censored exponential data

It is well-known that, under Type II double censoring, the maximum likelihood (ML) estimators of the location and scale parameters, θ and δ, of a twoparameter exponential distribution are linear functions of the order statistics. In contrast, when θ is known, theML estimator of δ does not admit a closed form expression. It is shown, however, that theML estimator of the scale parameter exists and is unique. Moreover, it has good large-sample properties. In addition, sharp lower and upper bounds for this estimator are provided, which can serve as starting points for iterative interpolation methods such as regula falsi. Explicit expressions for the expected Fisher information and Cramér-Rao lower bound are also derived. In the Bayesian context, assuming an inverted gamma prior on δ, the uniqueness, boundedness and asymptotics of the highest posterior density estimator of δ can be deduced in a similar way. Finally, an illustrative example is included.