“冬病夏治”治疗支气管哮喘94例疗效观察

目的：探讨“冬病夏治”对支气管哮喘缓解期的临床疗效。方法：将94例支气管哮喘患者随机分为两组：治疗组64例,对照组30例,治疗组以中药穴位贴敷配合口服达源咳喘丸,对照组为单纯贴药组,两组均于每年三伏天贴药,连续贴敷3年为1个观察周期进行统计疗效。结果：穴位贴敷配合口服中药治疗组的显效率、总有效率均明显高于对照组,经统计学处理具有显著性差异（P均≤0．01）。     

穴位埋线联合穴位贴敷治疗咳嗽变异性哮喘的随机对照研究

目的:探讨穴位埋线联合穴位贴敷治疗咳嗽变异性哮喘患者的临床效果和安全性分析。方法:采用前瞻性分析法,选取咳嗽变异性哮喘患者120例。采用简单数字的随机方法随机分为治疗组和对照组,每组60例。治疗组给予常规治疗加穴位埋线联合穴位贴敷;对照组给予常规治疗加孟鲁司特咀嚼片口服。观察两组患者治疗前后细胞因子水平、症状积分变化及临床疗效,比较治疗后2组患者不良反应的发生率。结果:治疗后治疗组在细胞因子子(Hs-CRP、IL-8、TNF-α)水平、症候积分(咳嗽、咯痰、胸膈满闷)方面比较有显著性差异(P0.05);治疗组临床疗效总有效率为93.33%,对照组临床疗效总有效率为83.33%,2者比较差异有统计学意义(P0.05)。治疗组不良反应的发生率低于对照组(P0.05)。结论:穴位埋线联合穴位贴敷能够有效地缓解咳嗽变异性哮喘患者患者临床症状,安全性高,值得进一步推广及应用。     

伏九贴疗法合匹多莫德片治疗儿童咳嗽变异性哮喘的临床观察

目的评价伏九贴疗法配合口服匹多莫德片治疗儿童咳嗽变异性哮喘的临床疗效。方法将2008年6月～2009年6月就诊符合儿童过敏性咳嗽诊断标准的64例门诊患儿,按随机数字表分为治疗组和对照组。治疗组32例,给予贴敷伏九贴配合口服匹多莫德片;对照组32例,仅给予口服匹多莫德片。治疗期间停止一切影响免疫功能的药物。两组均以1年为1个疗程,1个疗程结束后统计疗效。结果治疗组痊愈16例,有效13例,无效3例,总有效率为90.6%;对照组痊愈7例,有效12例,无效13例,总有效率为59.3%,治疗组疗效优于对照组（P〈0.05）。结论伏九贴疗法配合口服匹多莫德片对控制儿童咳嗽变异性哮喘患儿有较好疗效,且穴位贴敷疗法无痛无创、副作用小,易于坚持,适合临床推广应用。     

中药穴位贴敷治疗咳嗽变异型哮喘临床观察

目的:探讨中药穴位贴敷对咳嗽变异型哮喘(CVA)的临床疗效。方法:采用对照、随机的原则将CVA的患者分为对照组和治疗组各48例,两组患者均应用舒利迭吸入,治疗组同时给予中药穴位贴敷,3年为1个疗程,观察患者临床症状、体征、肺功能的改善情况。结果:治疗组的临床疗效明显优于对照组,具有统计学意义(P<0.05)。结论:中药穴位贴敷对CVA疗效确切。     

芥子咳喘膏穴位贴敷治疗小儿急性支气管炎的疗效

目的：比较自拟芥子咳喘膏与远红外止咳贴治疗小儿急性支气管炎的疗效．方法：将急性支气管炎患儿120例随机分为试药组和对照组各60例,在西医一般对症治疗的基础上,采用穴位贴敷治疗．试药组应用芥子咳喘膏外用穴位贴敷,对照组用远红外止咳贴,两组贴敷部位和疗程均相同．数据采用SPSS11．0软件进行统计学处理．结果：试药组显效率明显高于对照组（P〈0．05）,但两组总有效率差异未达到显著水平;试药组对咳嗽、咯痰、肺部罗音起效时间均优于对照组;试药组的咳嗽和肺部罗音量化积分均低于对照组（P〈0．05）,两组咯痰量化积分无显著差异（P〉0．05）．结论：芥子咳喘膏穴位贴敷治疗小儿急性支气管炎可明显改善症状,缩短病程,易为患儿接受．     

穴位贴敷配合艾灸治疗中风后排尿障碍的疗效观察

目的:观察穴位贴敷配合艾灸关元穴对中风后排尿障碍的临床疗效.方法:将96例中风后尿失禁患者随机分为贴敷组(对照组)和隔姜艾灸组(治疗组),对照组患者46例只接受穴位贴敷于神阙穴治疗,治疗组50例患者先于关元穴隔姜艾灸后,再于神阙穴行穴位贴敷.7d为一个疗程,2个疗程后判定疗效.结果:两组对患者排尿障碍的改善均有明显效果,但治疗组疗效明显优于对照组.结论:穴位贴敷配合隔姜艾灸关元穴治疗可以提高中风后排尿障碍患者的临床疗效,优于单纯穴位贴敷组,具有补肾气、理三焦、通尿闭之功效,疗效较满意.     

消喘膏穴位贴敷配合穴位注射治疗支气管哮喘114例临床观察

目的观察消喘膏三伏天穴位贴敷配合穴位注射防治支气管哮喘的临床疗效.方法 219例患者随机抽取分为穴位贴敷组和穴位贴敷加穴位注射组,分析两组疗效及治疗前后免疫功能的改变.结果两组临床症状和免疫指标均有改善,但穴位贴敷加穴位注射组疗效明显优于穴位贴敷组.结论三伏天穴位贴敷加穴位注射能明显改善支气管哮喘患者的临床症状,提高机体免疫力.     

穴位贴敷法预防支气管哮喘的临床研究

目的 探讨穴位贴敷预防支气管哮喘的临床疗效及安全性,为中药“喘敷贴”临床推广应用提供依据。方法 将143例患者随机分为穴位贴敷组（治疗组）75例和安慰剂组（对照组）68例。治疗组于三伏天采取穴位贴敷方法,同期对照组贴敷安慰剂,治疗32d为1个疗程。通过观察两组患者治疗前后的临床症状及发作次数来评价“喘敷贴”预防哮喘的临床疗效。结果 治疗组综合疗效总有效率为94.67%,发作次数总有效率为86.67%,对照组则分别为52.94%、44.12%,两组间比较差异均有统计学意义（P〈0.05）。结论 中药“喘敷贴”三伏天穴位贴敷可显著减轻和控制哮喘发作。     

中药煮散剂配合穴位贴敷治疗小儿急性咳嗽临床观察

目的:观察中药煮散剂配合穴位贴敷治疗小儿急性咳嗽的临床疗效.方法:选取2018年3月—2019年5月在安阳市中医院门诊就诊的120例诊断为急性咳嗽的患儿,分为对照组和治疗组,每组各60例.对照组常规西医治疗.治疗组口服中药煮散剂加穴位贴敷治疗.疗程为6d.比较两组临床疗效、中医症候积分、不良反应等.结果:治疗组疗效有效率、症候总积分减少和不良反应率均明显优于对照组,差异有统计学意义(P<0.05).结论:中药煮散剂配合穴位贴敷可明显提高小儿急性咳嗽的临床疗效,值得临床推广.     

疏风宣肺止咳汤联合穴位贴敷治疗风邪犯肺证咳嗽变异性哮喘患者的效果

目的观察疏风宣肺止咳汤联合穴位贴敷治疗风邪犯肺证咳嗽变异性哮喘(CVA)患者的效果。方法选取2018年3月至2019年3月洛阳市第一人民医院收治的80例风邪犯肺证CVA患者,按照随机数表法分为对照组和观察组,各40例。对照组接受常规西医治疗,观察组在对照组基础上接受疏风宣肺止咳汤联合穴位贴敷治疗。对比两组治疗效果、治疗前后症状。结果观察组治疗总有效率[97.50%(39/40)]高于对照组[80.00%(32/40)](P<0.05)。治疗2周后,两组咳嗽、咯痰、胸膈满闷评分均较治疗前降低,且观察组咳嗽、咯痰、胸膈满闷评分均较对照组低(均P<0.05)。结论疏风宣肺止咳汤联合穴位贴敷治疗风邪犯肺证CVA,能显著提高治疗效果,缓解临床症状。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.